• The Korean Journal of Physiology and Pharmacology
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• v.27 no.4
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• pp.375-381
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• 2023

Numerous studies have revealed the importance of tumor-derived exosomes in rectal cancer (RC). This study aims to explore the influence of tumor-derived exosomal integrin beta-1 (ITGB1) on lung fibroblasts in RC along with underlying mechanisms. Exosome morphology was observed using a transmission electron microscope. Protein levels of CD63, CD9, ITGB1, p-p65 and p65 were detected using Western blot. To determine ITGB1's mRNA expression, quantitative real-time polymerase chain reaction was used. Moreover, levels of interleukin (IL)-8, IL-1β, and IL-6 in cell culture supernatant were measured via commercial ELISA kits. ITGB1 expression was increased in exosomes from RC cells. The ratio of p-p65/p65 as well as levels of interleukins in lung fibroblasts was raised by exosomes derived from RC cells, while was reduced after down-regulation of exosomal ITGB1. The increased ratio of p-p65/p65 as well as levels of pro-inflammatory cytokines caused by exosomes from RC cells was reversed by the addition of nuclear factor kappa B (NF-κB) inhibitor. We concluded that the knockdown of RC cells-derived exosomal ITGB1 repressed activation of lung fibroblasts and the NF-κB pathway in vitro.

• Structural Engineering and Mechanics
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• v.21 no.4
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• pp.375-392
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• 2005

Cable supported structures offer an elegant and economical solution for bridging over long spans with resultant low material content and ease of construction. In this paper, a model of shallow cable supported footbridge with reverse profiled pre-tensioned cables is treated and its load deformation characteristics under different quasi-static loads are investigated. Effects of important parameters such as cable sag and pre-tension are also studied. Numerical results performed on a 3D model show that structural stiffness of this bridge (model) depends not only on the cable sag and cross sectional areas of the cables, but also on the pre-tension in the reverse profiled cables. The tension in the top supporting cables can be adjusted to a high level by the pre-tension in the reverse profiled bottom cables, with the total horizontal force in the bridge structure remaining reasonably constant. It is also evident that pre-tensioned horizontally profiled cables can greatly increase the lateral horizontal stiffness and suppress the lateral horizontal deflection induced by eccentric vertical loads.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2011.06a
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• pp.375-376
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• 2011

• Bulletin of the Korean Chemical Society
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• v.13 no.4
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• pp.375-381
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• 1992

In this study we have synthesized two spiro orthocarbonates, which can be polymerized with volume expansion, and determined their crystal structures. The crystal data are as follows; 3,4,10,11-Di(9,10-dihydro-9,10-ethanoanthracenyl)- 1,6,8,13-tetraoxa-6.6-tridecane 5: a = 16.898 (1), b = 9.299 (1), c = 24.359 (2) ${\AA}$, $\beta$ = 123.73 $(7)^{\circ}$, space group P21/c and R = 0.073 for 2954 reflections; compound 8: a = 15.244 (4), b = 15.293 (3), c = 10.772 (3) $\AA$, ${\beta}$ = 99.45 $(2)^{\circ}$, space group P21/c and R = 0.082 for 2346 reflections. The seven-membered rings of compound 5 are chair forms and all the six-membered rings are boat shaped. For a six-membered spiro orthocarbonate, 3,9-Di(9-fluorenylidenyl)-1,4,6,9-tetraoxa-5,5-und ecane 8, fluorene groups [C(1) atom through C(13) atom] are planar within ${\pm}0.09{\AA}$ and the six-membered rings have chair conformations. The whole molecule has pseudo-C2 symmetry. The water molecules in the crystal are linked with each other through the hydrogen bond with distance of 2.790 (20) ${\AA}$.

• Bulletin of the Korean Mathematical Society
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• v.43 no.2
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• pp.353-375
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• 2006

In this paper we establish a counting method for the Green classes of the Birget-rhodes expansion of finite groups. As an application of the results, we derive explicit enumeration formulas for the Green classes for finite groups of order pq and a finite cyclic group of order $p^m$, where p and q are arbitrary given distinct prime numbers.

• East Asian mathematical journal
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• v.24 no.4
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• pp.369-375
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• 2008

In this paper, we first introduce inwards set valued maps in hyperconvex metric spaces. Then we present fixed point theory for continuous condensing inward set valued maps.

• Journal of the Institute of Electronics Engineers of Korea SD
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• v.37 no.12
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• pp.70-78
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• 2000

A novel capacitance deviation-to-time interval converter based on ramp-integration is presented. It consists of two current mirrors, two schmitt triggers, and control digital circuits by the upper and lower sides, symmetrically. Total circuit has been with discrete components. The results show that the proposed converter has a linearity error of less than 1% at the time interval(pulse width) over a capacitance deviation from 295 pF to 375 pF. A capacitance deviation of 40pF and time interval of 0.2 ms was measured for sensor capacitance of 335 pF. Therefore, the high-resolution can be known by counting the fast and stable clock pulses gated into a counter for time interval. The application of a novel capacitance deviation-to time interval converter to a digital humidity controller is also presented. The presented circuit is insensitive to the capacitance difference in disregard of voltage source or temperature deviation. Besides the accuracy, it features the small MOS device count integrable onto a small chip area. The circuit is thus particularly suitable for the on-chip interface.

• BMB Reports
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• v.43 no.5
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• pp.375-381
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• 2010

In this study, the cDNA library of Chang-liver cells was immunoscreened using common ADAMs antibody to obtain ADAM related genes. We found one positive clone that was confirmed as a new gene by Blast, which is an uncharacterized helical and coil protein and processes protease activity, and named protease-related protein 1 (ARP1). The submitted GenBank accession number is AY078070. Molecular characterizations of ARP1 were analyzed with appropriate bioinformatics software. To analyse its expression and function, ARP1 was subcloned into glutathione S-transferase fusion plasmid pGEX-2T and expressed by E. coli system. The in vitro expression product of ARP1 was recognized by common ADAMs antibody with western blot. Interestingly, ARP1 cleaves gelatine at pH9.5, which suggests it is an alkaline protease. Semi-quantitative RT-PCR result indicates that ARP1 mRNA is strongly transcribed in the liver and the treated Chang-liver cells.

• Journal of the Korean Society of Physical Medicine
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• v.9 no.4
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• pp.375-389
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• 2014

PURPOSE: The purpose of this study is to develop medical services for the elderly and qualitatively enhance physical therapy for them by analyzing korean students' knowledge of the elderly. METHODS: A total of 1027 male/female undergraduate students majoring in physical therapy were selected to examine the knowledge of the elderly. The knowledge of physical, psychological, and social aspects were investigated and measured by FAQ I of palmore (1988) and a scale developed by Yunjin et al. (1982). T-test, One-way-ANOVA and Scheff test were used. RESULTS: The percentage of the students who correctly answered the questions on the elderly was 53.6%. In particular, the higher error rates were seen in the social (56.9%) and psychological (57.6%) aspects compared in the physical (33.7%) aspects. Those who answered the questions correctly were over 30s (63.69%, p=0.000), seniors (57%, p=0.000)and grown in cities (53.91%, p=0.001). In addition, students who took lessons on the elderly (57.71%, p=0.032)and had experiences in voluntary services (54.09%, p=0.023) were significantly higher in answering the questions correctly. CONCLUSION: When students learned about the elderly, social and psychological aspects should be reinforced. The knowledge levels of the elderly can be elevated though voluntary services. It is thought that a follow-up study would be continuously neede to improve physical therapists' knowledge on the elderly and quality of available services.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.16 no.4
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• pp.2656-2664
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• 2015

The purpose of this study is to compare the difference between stomach cancer stages and related factors according to the diagnosis path. The self-administered questionnaire was filled out by 375 inpatients with primary stomach cancers who had been scheduled at Chungnam National University Hospital were targeted for the survey during the period from August 1st 2010 to March 31st 2013. Rogistic regression model were estimated to identify related factors between Medical checkups group and symptom group. As a results, the study suggests that early checkups is important because ratio of early stomach cancer is higher in Medical checkups group than in symptom group(p=0.001). And if there was a symptom at diagnosis of stomach cancer, stomach cancer stage appeared to have a strong possibility(p=0.001). If cancer screening has been widely implemented and supported by a large scale prospective studies will be possible even in the most appropriate tests and interval estimation for the country.