• 제목/요약/키워드: A20

검색결과 100,309건 처리시간 0.097초

Aberrant Expression of miR-20a and miR-203 in Cervical Cancer

  • Zhao, Shan;Yao, De-Sheng;Chen, Jun-Ying;Ding, Nan
    • Asian Pacific Journal of Cancer Prevention
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    • 제14권4호
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    • pp.2289-2293
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    • 2013
  • MicroRNAs (miRNAs) are small, non-coding RNAs that are critical regulators of various diseases. MicroRNA-20a (miR-20a) and microRNA-203 (miR-203) have previously shown significant alteration in a range of cancers. In this study, the expression levels of miR-20a and miR-203 in 100 cervical cancer tissues were detected by qRT-PCR and compared to patient matched-nontumor cervical tissues. Correlations between expression level and clinicopathologic characteristics of cervical cancer were also analyzed. Finally, we studied the effect of miR-20a and miR-203 on cell proliferation in cervical cancer cell lines by MTT. We found that the expression level of miR-20a (P<0.001) was significantly higher in cervical cancer patients than in healthy controls, while that of miR-203 (P<0.001) was lower. Aberrant expression of miR-20a was correlated with lymph node metastasis (LNM), histological grade and tumor diameter, but down-regulated miR-203 was correlated with LNM only. Furthermore, we found that over-expression of miR-203 decreased cell proliferation, while reduction of miR-20a also prevented tumor progression. Our results support the involvement of miR-20a and miR-203 in cervical tumorigenesis. We propose that miRNAs might be used as therapeutic agents for cervical cancer.

A Case of Ring Chromosome 20 with Mental Retardation and Epilepsy (정신 지체와 간질을 동반한 20 환(Ring) 염색체 증후군 1례)

  • Jung, Yeon Kyung;Lee, Gyeong Hoon
    • Clinical and Experimental Pediatrics
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    • 제48권1호
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    • pp.108-111
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    • 2005
  • Ring chromosome 20 mosaicism [r(20)] is a rare chromosomal anomaly associated with minor dysmorphism, mental retardation, autistic behavior, and intractable epilepsy. The proposed mechanism of ring formation is breakage of both short and long arms of a chromosome with subsequent end-to-end fusion. We encountered an 18-month-old boy who presented with developmental delay and mental retardation with seizure episodes, but showed normal brain magnetic resonance imaging. Chromosome study from peripheral blood showed 46,XY, r(20)(p13q13.3) karyotype. The authors report a case of ring chromosome 20 with mental retardation and epilepsy, with a review of the literature.

Improving Oxygenation in the Murine Tumors by a perfluorochemical Emulsion (Fluosl-DA $20\%$ (Carbogen 흡입하에서 Fluosol-DA 20%의 투여가 이식동물 종양의 산소분압에 미치는 영향)

  • Lee Intae;Kim Gwi E.;Song Chang W.
    • Radiation Oncology Journal
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    • 제8권1호
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    • pp.1-6
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    • 1990
  • In the present study, a perfluorchemical emulsion (Fluosol-DA $20\%$) did not alter $D_o\;and\;D_q$ values on cell survival curve, indicating that the lack of a direct effect of Fluosol-DA $20\%$ on cellular radiosensitivity in vitro. The effect of Fluosol-DA $20\%$ injection in combination with carbogen breathing was determined on the hypoxic cell fraction in SCK tumors. The hypoxic cell fraction in control SCK tumors was 0.39. This value decreased to 0.05 when the mice were i.v. injected with 12 ml/kg of Fluosol-DA $20\%$ in a carbogen atomosphere. The measured mean and median $PO_2$ values with a microelectrode in the control tumors was 9 mmHg and 4 mmHg, respectively. The treatment of the SCK tumors in the host mice with injected Fluosol-DA $20\%$ in combination with carbogen breathing increased the mean and median $PO_2$ values to 67 mmHg and 62 mmHg, respectively. Using carbogen breathing alone caused a moderate increase of tumor $PO_2$. But Fluosol-DA $20\%$ injection alone caused little change $PO_2$ in the tumor. It was concluded that the combination of Fluosol-DA injection and carbogen breathing is an effective means to improve oxygenation of tumors.

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A 20-way Stripline Power Divider for an S band Linear Array Antenna with Low Loss and Low Side Lobe Level (S 대역 선형 배열 안테나 급전회로를 위한 저손실, 저부엽 20-출력 스트립라인 전력분배기)

  • Kwon, Tae-Min;Kim, Dong-Wook
    • Journal of the Institute of Electronics Engineers of Korea TC
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    • 제47권7호
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    • pp.128-134
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    • 2010
  • In this paper, a high-power 20-way stripline power divider with low insertion loss and low side lobe level is successfully designed, fabricated and measured as a feed network for an S-band linear array antenna having Dolph-Chebyshev current distribution which has a narrow beam width and very low side lobe level (SLL). The 20-way stripline power divider consists of an 8-way power divider, three 4-way power dividers and three ring hybrids. It utilizes a T-junction structure as a basic element for power dividing. Notches and modified input/output N-to-stripline transitions are used for improving insertion loss and return loss. The fabricated power divider shows insertion loss less than 0.3 ㏈ and rms phase mismatch less than 8o in the full bandwidth. A final 40-way power divider is synthesized by combining symmetrically two 20-way power dividers and is expected to have SLL over 40 dB, based on the measured results of the 20-way power divider.

Fermentation and Quality Characteristics of Cheonggukjang with Chinese Cabbage (배추 첨가 청국장의 제조 및 품질특성)

  • Kim, Jin Hak;Park, La Young;Lee, Shin Ho
    • Food Science and Preservation
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    • 제19권5호
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    • pp.659-664
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    • 2012
  • The fermentation and quality characteristics of Cheonggukjang with Chinese cabbage, which is produced as a by-product in the kimchi industry, were investigated. Cheonggukjang was prepared with cooked soybean without Chinese cabbage (control), with 10% Chinese cabbage (A10), and with 20% Chinese cabbage (A20), respectively. The A10 and A20 pH values did not show a significant difference compared with the control during fermentation for 72 h. The total aerobes of the Cheonggukjangs reached 8.65 (control), 8.73 (A10), and 9.11 (A20) log CFU/mL after fermentation for 72 h at $37^{\circ}C$, respectively. The numbers of lactic acid bacteria were found to be 5.62 (A10) and 5.87 (A20) log CFU/mL during fermentation for 72 h at $37^{\circ}C$, but lactic acid bacteria were not detected in the control. The amino nitrogen and viscous substance contents of A10 and A20 were lower than those of the control. The total polyphenol contents and DPPH radical scavenging abilities of the tested Cheonggukjang were increased by fermentation. The increasing ratio of polyphenol and the DPPH radical scavenging ability of A10 were higher than those of the control and of A20. The sensory quality of A10 was higher than that of the control and of A20 in taste, color, and overall acceptability.

The Theory of Tokyo in the 20th Century as a Garden City

  • Naito, Keita
    • Journal of East-Asian Urban History
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    • 제1권
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    • pp.99-134
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    • 2019
  • In the Edo period, there were many samurai residences with gardens in Edo. In the 20th century, some of these gardens were inherited and new gardens were also cultivated in Tokyo. Because of this, Tokyo in the 20th century has been a garden city since the Edo period. This study shows the characteristics of gardens inherited today from the 20th century and the succession process of these gardens in the 20th century.

Nitrogen Split Application of Direct-seeded Rice in Tillage and No-tillage Systems (경운과 무경운 조건에서 벼 건답휴립직파재배의 질소분시비율)

  • 이석순;홍승범;백준호
    • KOREAN JOURNAL OF CROP SCIENCE
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    • 제37권5호
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    • pp.405-412
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    • 1992
  • Growth characters of dry seeded paddy rice was studied at different levels of nitrogen(N) split application (basal : immediately after irrigation : 2 weeks after irrigation: 25 days before heading: heading stage with 10 : 20 : 30 : 20 : 20%, 20 : 30 : 20 : 20 : 10%, 30 : 40 : 0 : 20 : 10%, and 100% basal of slow release urea) in tillage and no-tillage systems. On May 17 in 1990, 6kg /10a of dry seeds of a breeding line of Milyang 95 was broadcasted and covered with a power tiller. Between tillage and no-tillage systems yield and its components, lodging related characteristics, and contents of cellulose, hemicellulose and lignin of culm base were similar. Leaf area index at heading stage was higher in tillage, but lodging index was lower compared with those in no-tillage plot. Culm length, effective tiller ratio, culm base weight, 1000-grain weight, harvest index in slow release N applied plot were higher compared with those in other N treatments. Grain yield of rice among levels of N split applications was similar in tillage, but it was higher in slow release N applied plot in no-tillage if 1kg /10a of additional N was applied as urea at panicle formation stage. At early growth stage N concentration and N uptake were lower in the slow release N applied plot, but higher after heading stage compared with other N treatments. The number of tillers was lowest in slow release N applied plot during the tillering stage, but the number of panicles per hill was similar to other N treatments.

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Molecular cloning and restriction endonuclease mapping of homoserine dehydrogenase gene (HOM6) in yeast saccharomyces cerevisiae (Aspartate계 아미노산 대사 효모 유전자 HOM6의 cloning 및 구조분석)

  • 김응기;이호주
    • Korean Journal of Microbiology
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    • 제24권4호
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    • pp.357-363
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    • 1986
  • Synthesis of threonine and methionine in yeast, Saccharomyces cerevisiae shares a common pathway from aspartate via homoserine. HOM6 gene encodes homoserine dehydrogenase (HSDH) which catalyzes the inter-conversion of beta-aspartate semialdehyde and homoserine. The level of HSDH is under methionine specific control. A recombinant plasmid (pEK1: 13.3kb), containing HOM6 gene, has been isolated and cloned into E. coli by complenemtary transformation of a homoserine auxotrophic yeast strain M-20-20D (hom6, trp1, ura3) to a prototrophic M20-20D/pEK1, using a library of yeast genomic DNA fragments in a yeast centromeric plasmid, YCp50(8.0kb). Isolation of HOM6has been primarily confirmed by retransformation of the original yeast strain M20-20D, using the recombinant plasmid DNA which was extracted from M20-20D/pEK1 and subsequently amplified in E. coli. Eleven cleavage sites in the insery (5.3kb) have been localized through fragment analysis for 8 restriction endonucleases; Bgl II(2 site), Bgl II(1), Cla I(3), Eco RI(1), Hind III(2), Kpn I (1), Pvu II(1) and Xho I(1).

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Fabrication of a AlGaAs high power (~20W) laser diode array (20W급 AlGaAs 레이저 다이오드 어레이의 제작)

  • 박병훈;손낙진;배정훈;권오대
    • Journal of the Korean Institute of Telematics and Electronics D
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    • 제34D권11호
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    • pp.20-24
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    • 1997
  • We have successfully fabricated high power (~20W) laser diode array, which are useful for pumping Nd:YAG lasers. The laser diode aray has 20 100.mu.m-wide cahnnels of which space was adjusted to 350.mu.m to improve thermal characteristics. And channel width is 100.mu.m. For an uncoated LD array, the output power of 15.66W has been obtained at 41A under quasi-CW operation, which results in about 0.42W/A slope efficiency. After aR(5%) and HR (95%) coatings on both facets, the output power was improved up to 21.18W at 40A under the same operation as above and the slope efficiency was 0.795W/A. On the other hand, by using a near field measurement system consisting of objective lens, eyepiece, CCD camera and image processing board, the typical near field patten of 1*20 LD array was observed.

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