• Title/Summary/Keyword: A-type $K^+$ channels

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Designing of Conceptual Models on Typhoon and Changma Utilizing GK-2A Satellite Data (GK-2A 위성자료 활용을 위한 태풍 및 장마 개념모형의 도안)

  • Moon, Suyeon;Ha, Kyung-Ja;Moon, Mincheol;Jhun, Jong-Ghap;Moon, Ja-Yeon
    • Atmosphere
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    • v.26 no.2
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    • pp.215-226
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    • 2016
  • Conceptual models to analyze both typhoon and Changma using products extracted by the GEO-KOMPSAT-2A (GK-2A) are suggested in this study. The GK-2A which is scheduled to be launched in 2018 has a high resolution, 16 channels, and 52 products. This means GK-2A is expected to obtain high quality images and products, which can detect severe weather earlier than the Communications, Ocean and Meteorological Satellite (COMS). Since there are not enough conceptual models for typhoon and Changma using satellite images and products, our conceptual model can increase both the applicability of satellite data and the accuracy of analysis. In the conceptual model, typhoons are classified as three types by prevailing factors; 1) heavy-rainfall type, 2) wind type, and 3) complex type. For Changma, two types are divided by the characteristics; band type and heavy-rainfall type. Among the high resolution 52 products, each type of typhoon and Changma are selected. In addition, the numerical products and dynamic factors are considered in order to improve conceptual models.

DEVELOPMENT OF AN IMPROVED FARE TOOL WITH APPLICATION TO WOLSONG NUCLEAR POWER PLANT

  • Lee, Sun Ki;Hong, Sung Yull
    • Nuclear Engineering and Technology
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    • v.45 no.2
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    • pp.257-264
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    • 2013
  • In Canada Deuterium Uranium (CANDU)-type nuclear power plants, the reactor is composed of 380 fuel channels and refueling is performed on one or two channels per day. At the time of refueling, the fluid force of the cooling water inside the channel is exploited. New fuel added upstream of the fuel channel is moved downstream by the fluid force of the cooling water, and the used fuel is pushed out. Through this process, refueling is completed. Among the 380 fuel channels, outer rows 1 and 2 (called the FARE channel) make the process of using only the internal fluid force impossible because of the low flow rate of the channel cooling water. Therefore, a Flow Assist Ram Extension (FARE) tool, a refueling aid, is used to refuel these channels in order to compensate for the insufficient fluid force. The FARE tool causes flow resistance, thus allowing the fuel to be moved down with the flow of cooling water. Although the existing FARE tool can perform refueling in Korean plants, the coolant flow rate is reduced to below 80% of the normal flow for some time during refueling. A Flow rate below 80% of the normal flow cause low flow rate alarm signal in the plant operation. A flow rate below 80% of the normal flow may cause difficulties in the plant operation because of the increase in the coolant temperature of the channel. A new and improved FARE tool is needed to address the limitations of the existing FARE tool. In this study, we identified the cause of the low flow phenomena of the existing FARE tool. A new and improved FARE tool has been designed and manufactured. The improved FARE tool has been tested many times using laboratory test apparatus and was redesigned until satisfactory results were obtained. In order to confirm the performance of the improved FARE tool in a real plant, the final design FARE tool was tested at Wolsong Nuclear Power Plant Unit 2. The test was carried out successfully and the low flow rate alarm signal was eliminated during refueling. Several additional improved FARE tools have been manufactured. These improved FARE tools are currently being used for Korean CANDU plant refueling.

Observation of the Incidence of Acrosome Reaction in Human Spermatozoa Treated with Mibefradil as a T-type $Ca^{2+}i$ Channels Inhibitor (T-형 $Ca^{2+}$ 채널 길항제인 Mibefradil을 첨가한 인간 정자의 첨체반응 관찰)

  • Lee, Jae-Ho;Son, Weon-Young;Lee, Jung-Ha;Lee, In-Sun;Kim, Young-Chan;Han, Ching-Tack
    • Clinical and Experimental Reproductive Medicine
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    • v.27 no.1
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    • pp.9-14
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    • 2000
  • Objective: The sperm acrosome reaction is a $Ca^{2+}$-dependent exocytotic event that is triggered by adhesion to the mammalian egg's zona pellucida. Previous studies suggested a role of $Ca^{2+}$ channels in acrosome reactions. This study was conducted to investigate the T-type calcium channel is operated in acrosome reaction of human spermatozoa. Method: Human semen samples were obtained from healthy donors with normal criteria. The spermatozoa were divided into five groups: Group 1 were non-treated as a control; Group 2 where spermatozoa were exposed to 5 ${\mu}M$ $Ca^{2+}$ A23187 $(Ca^{2+}i)$; Group 3 where spermatozoa were exposed 5 ${\mu}M$ $Ca^{2+}i$ and mibefradil; Group 4 where spermatozoa were exposed 5 ${\mu}M$ $Ca^{2+}i$ and nifedipine, and Group 5 where spermatozoa were treated with 5 ${\mu}M$ $Ca^{2+}i$ and both of mibefradil and nifedipine. Spermatozoa in all groups were retrieved after incubation for 15 and 30 minutes at $37^{\circ}C$. After staining with PSA-FITC, fluorescence was observed under a fluorescence microscope, and AR was evaluated on a total>100 spermatozoa/side. Result and Conclusion: We observed on acrosome reaction inhibition rate in human spermatozoa the various of concentration of mibefradil, nifedipine. Maximum response was noted with 1.0 ${\mu}M$ mibefradil and the decrease of acrosome reaction inhibition rate 45%. Nifedipine in acrosome reaction inhibition rate was only about 25%. The $Ca^{2+}i$-induced AR of spermatozoa was significantly suppressed by mibefradil. Incidence of the suppression was depending on concentration of mibefradil. Results from the present study suggest that the human spermatozoa possess T-type channel. The observation that reversible inhibitor of T channels in male germ cells provides a new mechanism of contraceptive action.

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A Study on Design Automation of Cooling Channels in Hot Form Press Die Based on CATIA CAD System (CATIA CAD 시스템 기반 핫폼금형의 냉각수로 설계 자동화에 관한 연구)

  • Kim, Gang-Yeon;Park, Si-Hwan;Kim, Sang-Kwon;Park, Doo-Seob
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.19 no.3
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    • pp.147-154
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    • 2018
  • This paper focuses on the development of a support system that can rapidly generate the design data of a hot-form die with cooling channels, commonly known as hot stamping technology. We propose a new process for designing hot-form dies based on our (automated) system, whose main features are derived from the analysis of the design requirements and design process in the current industry. Our design support system consists of two modules, which allow for the generation of a 3D geometry model and its 2D drawings. The module for 3D modeling automation is implemented as a type of CATIA template model based on CATIA V5 Knowledgeware. This module automatically creates a 3D model of a hot-form die, including the cooling channels, that depends on the shape of the forming surface and the number of STEELs (subsets of die product) and cooling channels. It also allows for both the editing of the positions and orientations of the cooling channels and testing for the purpose of satisfying the constraints on the distance between the forming surface and cooling channels. Another module for the auto-generation of the 2D drawings is being developed as a plug-in using CAA (CATIA SDK) and Visual C++. Our system was evaluated using the S/W test based on a user defined scenario. As a result, it was shown that it can generate a 3D model of a hot form die and its 2D drawings with hole tables about 29 times faster than the conventional manual method without any design errors.

Low-Complexity Massive MIMO Detectors Based on Richardson Method

  • Kang, Byunggi;Yoon, Ji-Hwan;Park, Jongsun
    • ETRI Journal
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    • v.39 no.3
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    • pp.326-335
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    • 2017
  • In the uplink transmission of massive (or large-scale) multi-input multi-output (MIMO) systems, large dimensional signal detection and its hardware design are challenging issues owing to the high computational complexity. In this paper, we propose low-complexity hardware architectures of Richardson iterative method-based massive MIMO detectors. We present two types of massive MIMO detectors, directly mapped (type1) and reformulated (type2) Richardson iterative methods. In the proposed Richardson method (type2), the matrix-by-matrix multiplications are reformulated to matrix-vector multiplications, thus reducing the computational complexity from $O(U^2)$ to O(U). Both massive MIMO detectors are implemented using a 65 nm CMOS process and compared in terms of detection performance under different channel conditions (high-mobility and flat fading channels). The hardware implementation results confirm that the proposed type1 Richardson method-based detector demonstrates up to 50% power savings over the proposed type2 detector under a flat fading channel. The type2 detector indicates a 37% power savings compared to the type1 under a high-mobility channel.

Effects of Ginsenosides and Their Metabolites on Voltage-dependent Ca2+ Channel Subtypes

  • Lee, Jun-Ho;Jeong, Sang Min;Kim, Jong-Hoon;Lee, Byung-Hwan;Yoon, In-Soo;Lee, Joon-Hee;Choi, Sun-Hye;Lee, Sang-Mok;Park, Yong-Sun;Lee, Jung-Ha;Kim, Sung Soo;Kim, Hyoung-Chun;Lee, Boo-Yong;Nah, Seung-Yeol
    • Molecules and Cells
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    • v.21 no.1
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    • pp.52-62
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    • 2006
  • In previous reports we demonstrated that ginsenosides, active ingredients of Panax ginseng, affect some subsets of voltage-dependent $Ca^{2+}$ channels in neuronal cells expressed in Xenopus laevis oocytes. However, the major component(s) of ginseng that affect cloned $Ca^{2+}$ channel subtypes such as ${\alpha}_{1C}$(L)-, ${\alpha}_{1B}$(N)-, ${\alpha}_{1A}$(P/Q)-, ${\alpha}_{1E}$(R)- and ${\alpha}_{1G}$(T) have not been identified. Here, we used the two-microelectrode voltage clamp technique to characterize the effects of ginsenosides and ginsenoside metabolites on $Ba^{2+}$ currents ($I_{Ba}$) in Xenopus oocytes expressing five different $Ca^{2+}$ channel subtypes. Exposure to ginseng total saponins (GTS) induced voltage-dependent, dose-dependent and reversible inhibition of the five channel subtypes, with particularly strong inhibition of the ${\alpha}_{1G}$-type. Of the various ginsenosides, $Rb_1$, Rc, Re, Rf, $Rg_1$, $Rg_3$, and $Rh_2$, ginsenoside $Rg_3$ also inhibited all five channel subtypes and ginsenoside $Rh_2$ had most effect on the ${\alpha}_{1C}$- and ${\alpha}_{1E}$-type $Ca^{2+}$ channels. Compound K (CK), a protopanaxadiol ginsenoside metabolite, strongly inhibited only the ${\alpha}_{1G}$-type of $Ca^{2+}$ channel, whereas M4, a protopanaxatriol ginsenoside metabolite, had almost no effect on any of the channels. $Rg_3$, $Rh_2$, and CK shifted the steady-state activation curves but not the inactivation curves in the depolarizing direction in the ${\alpha}_{1B}$- and ${\alpha}_{1A}$-types. These results reveal that $Rg_3$, $Rh_2$ and CK are the major inhibitors of $Ca^{2+}$ channels in Panax ginseng, and that they show some $Ca^{2+}$ channel selectivity.

Expression and Characterization of G Protein-activated Inward Rectifier $K^+$ Channels in Xenopus Oocytes

  • Kim, Han-Seop;Lee, Chang-Ho;Min, Churl K.
    • Animal cells and systems
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    • v.2 no.4
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    • pp.471-476
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    • 1998
  • The G protein-activated inwardly rectifying $K^+$ channel (GIRK1) was coex-pressed in Xenopus oocytes along with the $5-HT_{1A}$ receptor, a 7-helix receptor known to be coupled to $K^+$ channels in many neural tissues. Thus, the activation of the $5-HT_{1A}$ receptor by its agonist leads to the opening of GIRK1. The GIRK1 current was measured using the two electrode voltage clamp technique with bath application of 5-HT in the presence of various external potassium concentrations $[K^+]_0$. GIRK1 showed a strong inward rectification since only hyperpolarizing voltages evoked inward currents. $K^{+}$ was the major ion carrier as evidenced by about 44㎷ voltage shift corresponding to a 10-fold external 〔$K^+$〕 change. 5-HT induced a concentration-dependent inward $K^+$ current ($EC_{50}{\equation omitted}10.7nM$) which was blocked by $Ba^{2+}$. Pertussis toxin (PTX) pre-treatment reduced the $K^+$ current by as much as about 70%, suggesting that PTX-sensitive G protein ($G_i or G_o$ type) are involved in the $5-HT_{1A}$ receptor-GIRK1 coupling in Xenopus oocytes.

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On the Performance of Turbo Codes-Based Hybrid ARQ with Segment Selective Repeat in WCDMA

  • Shi Tao;Cao Lei
    • Journal of Communications and Networks
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    • v.8 no.2
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    • pp.212-219
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    • 2006
  • In this paper, a new turbo codes-based hybrid automatic repeat request (TC-HARQ) scheme with segment selective repeat (SSR) is proposed. The main strategy is, upon retransmission, to repeat the data that are most important for the next round of decoding based on the distribution of residual errors after current decoding. The performance in terms of reliability and throughput is analyzed. To adapt to correlated fading channels where an inter-leaver is always employed before transmission, we further modify the SSR strategy so that data having experienced correlated deep fading are selected for retransmission. Finally, this proposed scheme is applied to the wideband code division multiple access (WCDMA) system under frequency selective fading channels. Simulation results demonstrate that in all single and multiple user cases, SSR-based TC-HARQ leads to significant throughput improvement with similar bit error rate (BER) performance as compared to type-I TC-HARQ.

Community structures of the benthic macrofaunal assemblages in Kyonggi Bay and Han Estuary, Korea

  • Yoo, Jae-Won;Hong, Jae-Sang
    • Journal of the korean society of oceanography
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    • v.31 no.1
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    • pp.7-17
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    • 1996
  • The species composition and distribution patterns of the subtidal benthic faunal assemblage in Sokmo and Yomha Channels and Kyonggi Bay were studied in spring and fall of 1989 and correlated to some environmental variables: temperature, salinity and substrate type. For both seasons, a total of 7,779 organisms were counted belonging to 244 species. Of these, 3,647 organisms in 185 species were counted for spring (March 1989) and 4,132 in 189 species for fall (September 1989). The oyster, Cressostrea gigas and the tellinidean bivalve, Moerella rutilla were the two most abundant species in the spring, constituting 17.22%and 6.47% of the total abundance respectively. While in the fall, the barnacle, Balanus reticulatus and macrura, Ogyrides orientalis dominated comprising 13.72% and 6.87 % of the total number of individuals. Community structure analysis revealed good correlations with the variations of salinity in Yomha and Sokmo Channels and sedimentary facies in Kyonggi Bay, Korea.

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On Neural Network Adaptive Equalizers for Digital Communication

  • Hongrui Jiang;Kwak, Kyung-Sup
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.26 no.10A
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    • pp.1639-1644
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    • 2001
  • Two decision feedback equalizer structures employing recurrent neural network (RNN) used for non-linear channels with severe intersymbol interference (ISI) and non-linear distortion are proposed in this paper, which skillfully put the traditional decision feedback structure for linear channels equalization into RNN, replace decision feedback signal with training signal in the learning process and adaptively adjust the learning step. Simulative results of the first type of two new equalizer structures have shown that it has better equalization performances than traditional recurrent neural network equalizer (RNNE) under the same condition.

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