• Title/Summary/Keyword: A-,D-,E-optimal design

Search Result 87, Processing Time 0.028 seconds

Effects of liposomal-curcumin on five opportunistic bacterial strains found in the equine hindgut - preliminary study

  • Bland, S.D.;Venable, E.B.;McPherson, J.L.;Atkinson, R.L.
    • Journal of Animal Science and Technology
    • /
    • v.59 no.6
    • /
    • pp.15.1-15.5
    • /
    • 2017
  • Background: The horse intestinal tract is sensitive and contains a highly complex microbial population. A shift in the microbial population can lead to various issues such as inflammation and colic. The use of nutraceuticals in the equine industry is on the rise and curcumin is thought to possess antimicrobial properties that may help to minimize the proliferation of opportunistic bacteria. Methods: Four cecally-cannulated horses were utilized to determine the optimal dose of liposomal-curcumin (LIPC) on reducing Streptococcus bovis/equinus complex (SBEC), Escherichia coli K-12, Escherichia coli general, Clostridium difficile, and Clostridium perfringens in the equine hindgut without adversely affecting cecal characteristics. In the first study cecal fluid was collected from each horse and composited for an in vitro, 24 h batch culture to examine LIPC at four different dosages (15, 20, 25, and 30 g) in a completely randomized design. A subsequent in vivo $4{\times}4$ Latin square design study was conducted to evaluate no LIPC (control, CON) or LIPC dosed at 15, 25, and 35 g per day (dosages determined from in vitro results) for 9 days on the efficacy of LIPC on selected bacterial strains, pH, and volatile fatty acids. Each period was 14 days with 9 d for acclimation and 5 d withdrawal period. Results: In the in vitro study dosage had no effect ($P{\geq}0.42$) on Clostridium strains, but as the dose increased SBEC concentrations increased (P = 0.001). Concentrations of the E. coli strain varied with dose. In vivo, LIPC's antimicrobial properties, at 15 g, significantly decreased (P = 0.02) SBEC when compared to 25 and 35 g dosages. C. perfringens decreased linearly (P = 0.03) as LIPC dose increased. Butyrate decreased linearly (P = 0.01) as LIPC dose increased. Conclusion: Further studies should be conducted with a longer dosing period to examine the antimicrobial properties of curcumin without adversely affecting cecal characteristics.

Optimal Mechanism Design of In-pipe Cleaning Robot (관로 청소 로봇의 최적 설계)

  • Jung, C.D.;Chung, W.J.;Ahn, J.S.;Shin, G.S.;Kwon, S.J.
    • Journal of the Korean Society of Manufacturing Technology Engineers
    • /
    • v.21 no.1
    • /
    • pp.123-129
    • /
    • 2012
  • Recently, interests on cleaning robots workable in pipes (termed as in-pipe cleaning robot) are increasing because Garbage Automatic Collection Facilities (i.e, GACF) are widely being installed in Seoul metropolitan area of Korea. So far research on in-pipe robot has been focused on inspection rather than cleaning. In GACF, when garbage is moving, the impurities which are stuck to the inner face of the pipe are removed (diameter: 300 mm or 400 mm). Thus, in this paper, by using TRIZ (Inventive Theory of Problem Solving in Russian abbreviation), an in-pipe cleaning robot of GACF with the 6-link sliding mechanism will be proposed, which can be adjusted to fit into the inner face of pipe using pneumatic pressure(not spring). The proposed in-pipe cleaning robot for GACF can have forward/backward movement itself as well as rotation of brush in cleaning. The robot body should have the limited size suitable for the smaller pipe with diameter of 300 mm. In addition, for the pipe with diameter of 400 mm, the links of robot should stretch to fit into the diameter of the pipe by using the sliding mechanism. Based on the conceptual design using TRIZ, we will set up the initial design of the robot in collaboration with a field engineer of Robot Valley, Inc. in Korea. For the optimal design of in-pipe cleaning robot, the maximum impulsive force of collision between the robot and the inner face of pipe is simulated by using RecurDyn(R) when the link of sliding mechanism is stretched to fit into the 400 mm diameter of the pipe. The stresses exerted on the 6 links of sliding mechanism by the maximum impulsive force will be simulated by using ANSYS$^{(R)}$ Workbench based on the Design Of Experiment(in short DOE). Finally the optimal dimensions including thicknesses of 4 links will be decided in order to have the best safety factor as 2 in this paper as well as having the minimum mass of 4 links. It will be verified that the optimal design of 4 links has the best safety factor close to 2 as well as having the minimum mass of 4 links, compared with the initial design performed by the expert of Robot Valley, Inc. In addition, the prototype of in-pipe cleaning robot will be stated with further research.

Dynamics and die design in continuous and patch slot coating processes (Continuous 와 pattern slot 코팅 공정에서의 유동특성과 다이 설계)

  • Kim Su-Yeon;Shim Seo-Hoon;Shin Dong-Myeong;Lee Joo-Sung;Jung Hyun-Wook;Hyun Jae-Chun
    • Proceedings of the Korean Society of Rheology Conference
    • /
    • 2006.06a
    • /
    • pp.81-84
    • /
    • 2006
  • Slot coating process, in continuous and patch modes, has been applied for the many precise coating products, e.g., flat panel displays and second batteries. However, manufacturing uniform coating products is not a trivial task at high-speed operations because various flow instabilities or defects such as leaking, bubbles, ribbing, and rivulets are frequently observed in this process. It is no wonder, therefore, that many efforts to understand the various aspects of dynamics and coating windows of this process have been made both in academia and industry. In this study, as the first topic, flow dynamics within the coating bead in slot coating process has been investigated using the one-dimensional viscocapillary model by lubrication approximation and two-dimensional model by Flow-3D software. Especially, operability windows in both 1D and 2D cases with various slot die lip designs have been successfully portrayed. Also, effects of process conditions like viscosity and coating gap size on slot coating window have been analyzed. Also, some experiments to find minimum coating thickness and coating windows have been conducted using slot die coater implemented with flow visualization device, corroborating the numerical results. As the second topic, flow dynamics of both Newtonian and Non-Newtonian fluids in patch or pattern slot coating process, which is employed in manufacturing IT products such as secondary batteries, has been investigated for the purpose of optimal process designs. As a matter of fact, the flow control in this system is more difficult than in continuous case because od its transient or time-dependent nature. The internal die and die lip designs for patterned uniform coating products have been obtained by controlling flow behaviors of coating liquids issuing from slot. Numerical simulations have been performed using Fluent and Flow-3D packages. Flow behavior and pressure distribution inside the slot die has been compared with various die internal shapes and geometries. In the coating bead region, efforts to reduce irregular coating defects in head and tail parts of one patterned coating unit have been tried by changing die lip shapes. It has been concluded that optimal die internal design gas been developed, guaranteeing uniform velocity distribution of both Newtonian and shear thinning fluids at the die exit. And also optimal die lip design has been established, providing the longer uniform coating layer thickness within one coating unit.

  • PDF

3D Visualization Approaches for Evaluating Location Solution Performances (시설물 접근성 분석을 위한 GIS의 3차원 시각화 기법 적용)

  • Kim, Young-Hoon;Jo, Myung-Hee
    • Journal of the Korean Association of Geographic Information Studies
    • /
    • v.6 no.3
    • /
    • pp.21-32
    • /
    • 2003
  • This paper discusses the design of location optimization visualization and feasibility of 3 dimensional visualization techniques. In generic GIS visualization of location analysis, 2 dimensional visualization techniques have been used to map location elements and model solution, such as displaying demand and supply points, drawing connecting lines(e. g. spider line) of optimal locations to their demands, and representing density of location variations. Nevertheless, current GIS and location analysis literatures have little attentions in 3D visualization applications for location optimization problems. Previous research has been neglected 3D visualization of solution performances and its evaluation of solution quality. Consequently, this paper demonstrates potential benefits of 3D visualization techniques and its appropriate GIS applications for location optimization analysis. The visualization effectiveness of 3D approaches is examined in terms of spatial accessibility, and solution performance of optimal location models is evaluated. Finally, this paper proposes extensive 3D visualization perspectives for location analysis and GIS research as a further research agenda.

  • PDF

Design Optimization of A Multi-Blade Centrifugal Fan with Navier-Stokes Analysis (삼차원 Navier-Stokes 해석을 이용한 원심다익송풍기의 최적설계)

  • Seo, Seoung-Jin;Kim, Kwang-Yong
    • Proceedings of the KSME Conference
    • /
    • 2003.04a
    • /
    • pp.2157-2161
    • /
    • 2003
  • In this paper, the response surface method using three-dimensional Navier-Stokes analysis to optimize the shape of a forward-curved blades centrifugal fan, is described. For numerical analysis, Reynolds-averaged Navier-Stokes equations with standard k-e turbulence model are transformed into non-orthogonal curvilinear coordinate system, and are discretized with finite volume approximations. Due to the large number of blades in forward-curved blades centrifugal fan, the flow inside of the fan is regarded as steady flow by introducing the impeller force models for economic calculations. Linear Upwind Differencing Scheme(LUDS) is used to approximate the convection terms in the governing equations. SIMPLEC algorithm is used as a velocity-pressure correction procedure. Design variables, location of cur off, radius of cut off, expansion angle of scroll and width of impeller were selected to optimize the shapes of scroll and blades. Data points for response evaluations were selected by D-optimal design, and linear programming method was used for the optimization on the response surface. As a main result of the optimization, the efficiency was successfully improved. It was found that the optimization process provides reliable design of this kind of fans with reasonable computing time

  • PDF

Manufacture of Novel Composites Synthesized with Ferromagnetic and Nano-Sized Prussian Blue and D eriving Optimum Conditions (강자성체와 나노사이즈의 프러시안 블루가 합성된 새로운 형태의 복합체 제조 및 최적의 적용 조건 도출)

  • Jong Kyu Kim
    • Korean Journal of Materials Research
    • /
    • v.33 no.4
    • /
    • pp.151-158
    • /
    • 2023
  • In this study, a new type of composite material combined with carbonyl iron, a relatively strong ferromagnetic material, was prepared to overcome the current application limitations of Prussian blue, which is effective in removing radioactive cesium. The surface of the prepared composite was analyzed using SEM and XRD, and it was confirmed that nano-sized Prussian Blue was synthesized on the particle surface. In order to evaluate the cesium removal ability, 0.2 g of the composite prepared for raw cesium aquatic solution at a concentration of 5 ㎍ was added and reacted, resulting in a cesium removal rate of 99.5 %. The complex follows Langmuir's adsorption model and has a maximum adsorption amount (qe) of 79.3 mg/g. The Central Composite Design (CCD) of the Response Surface Method (RSM) was used to derive the optimal application conditions of the prepared composite. The optimal application conditions achieved using Response optimization appeared at a stirring speed of pH 7, 17.6 RPM. The composite manufactured through this research is a material that overcomes the Prussian Blue limit in powder form and is considered to be excellent economically and environmentally when applied to a cesium removal site.

The Optimal Design of a Triple-Band Antenna with Additional Arm Resonating Structure for LTE, ISM and WLAN Application (LTE, ISM, WLAN에 적용 가능한 Arm 구조 삼중대역 안테나 최적 설계)

  • Lee, Seung-Je;Oh, Seung-Hun;Lee, Jeong-Hyeok;Kim, Hyeong-Seok
    • The Transactions of The Korean Institute of Electrical Engineers
    • /
    • v.63 no.12
    • /
    • pp.1655-1660
    • /
    • 2014
  • In this paper, we propose a design of a triple-band microstrip circular patch antenna. The proposed antenna generates the triple frequency resonance at 1.85GHz(LTE), 2.45GHz(ISM) and 5.5GHz(WLAN). Firstly, we design the dual-band antenna. The dual-band antenna consist of the circular patch, slits, and the slot. The circular patch and slot are designed for dual frequency of 2.45GHz and 5.5GHz, respectively. And then the dual-band antenna is combined with additional arm-shaped structure for the triple-band characteristic. The arm-shaped structure is operated as the dipole. It is designed for lowest frequency of 1.85GHz. Each part of the antenna unites to a new structure. In order to design the proposed antenna automatically and optimally, APSO algorithm is adopted. During APSO, the mismatch of the proposed antenna is resolved. The optimal designed antenna has an acceptable return loss(-10dB) at each bands(i.e, 1.85GHz, 2.45GHz and 5.5GHz).

A Study on the Application Method of Photovoltaic in Building (PV의 건축물 적용기법에 관한 연구)

  • Lee, E.J.;Kim, H.S.
    • Journal of the Korean Solar Energy Society
    • /
    • v.22 no.2
    • /
    • pp.1-10
    • /
    • 2002
  • This study is a study on the building integrated method of Photovoltaic. It was analyzed into a basic installation condition and an integrated form in this study. And it was confirmed through the 3D simulation & drawing work of an integrated situation to the real domestic building. The Photovoltaic installation of the country to an optimal efficiency for the year must be installed to the due south with an angle of thirty degrees. And also a module spacing must be more than doubled from the bottom to the top of module to prevent from efficiency falling by a shadow of photovoltaic module in a roof setting of flat roof. If Photovoltaic module is an adequate material that is a basic requirement as a building's finishing material, it's not only an efficiency of alternation with an existing finishing material but also a building's design element.

Process Control Analysis for Efficient Production Management of Customized Baseball Uniforms (맞춤형 야구복의 효율적 생산관리를 위한 공정관리 분석)

  • Choi, Kueng-Mi;Hwang, Hyun-Jung;Jun, Jung-Il;Park, Yong-Soo
    • Fashion & Textile Research Journal
    • /
    • v.14 no.4
    • /
    • pp.597-606
    • /
    • 2012
  • To increase the productivity and product quality of customized baseball jerseys, this study developed a multi-variable system for a production process that efficiently controls diverse production management factors. The working time was measured through the establishment of a standard process where skilled workers and Chinese factory workers manufactured 5 sets of the same basic design jerseys. Based on the measured working time (1,136 seconds/per unit), the multi-variable process control system was developed, where hourly production management is possible according to the involved workers and equipment types. Each process was assigned accoding to the production management factors for a total of 28 standard processes. The processes were developed based on consideration of work characteristics according to the order of needlework of open-type set baseball jerseys with sleeves(the basic design of baseball jerseys)to result in a customized production system structure that could be set up with multi-variables. As a result, a total 12 types of systems were developed in consideration of the personnel involved and the number of equipments. The optimal production management system (with the highest efficiency compared to the number of workers)was A-2, B-1, C-1. D-2, E-2, F-1, and G-1. This system had extremely high efficiency and showed 99% assignment efficiency for the 7-person team. Though not optimal, possible process assignment for each working personnel is proposed as a reserve process in case work modification is inevitable due to malfunctions and the absence of equipments.

GA Optimized S-Band Quadrafilar Antenna with the Lowest Back Radiation for a Communication Satellite

  • Kahng, Sung-Tek;Kim, Joong-Pyo
    • Journal of electromagnetic engineering and science
    • /
    • v.9 no.4
    • /
    • pp.223-228
    • /
    • 2009
  • In this paper, a quadrafilar antenna is designed to have a lower profile as an essential part of the size reduction technique and lower back radiation(i.e. higher forward radiation) for the S-band telemetry/telecommand(TM/TC) function of a communication satellite. Particularly, to meet the challenging requirements on the higher isolation between the TM/TC antennas and simultaneously a smaller size, the lowest back radiation and lowest cross-polarization, the optimal physical dimensions of the quadrafilar antenna are found by using the Genetic Algorithm(GA). To prove the validity of the proposed antenna design, its 3D electromagnetic analysis and measured results are compared, showing good agreement.