• Biomolecules & Therapeutics
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• 제18권3호
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• pp.262-270
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• 2010

CD95 receptor is a member of tumor necrosis factor receptor family that mediates apoptosis in many cell types when bound by CD95 ligand or cross-linked by agonistic anti-CD95 antibodies. To determine the role of neutral sphingomyelinase (nSMase) on CD95-mediatd apoptosis, human Jurkat T lymphocytes were exposed to recombinant human CD95 ligand. Treatment with CD95 ligand induced cell death in a concentration and time-dependent manner. CD95-induced cell death was suppressed by inhibitors of SMase such as AY9944 or desipramine. Transfection with human nSMase1 siRNA plasmid into CD95 ligand-treated cells significantly prevented CD95-mediated cell death. CD95-mediated elevation of intracellular ceramide level detected by FACS analysis with anti-ceramide antibody was also decreased by nSMase1 siRNA. Knock-down of nSMase1 expression also blocked cytochrome c release into cytosol and caspase-3 cleavage in CD95-treated cells. Taken together, these results suggest that nSMase1 may play an important role in CD95-mediated apoptotic cell death in Jurkat T cells.

• 한국전자파학회:학술대회논문집
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• 한국전자파학회 2001년도 종합학술발표회 논문집 Vol.11 No.1
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• pp.39-43
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• 2001

A system, IS-95C coupler that combines the signals of IS-95A/B and IS-95C BTS and compensates the differences between the signals of two systems and connected to optical repeater If no IS-95C coupler exist, Optical repeater can't service of signal balanced. A system carries on combination, amplification, level modulation function of the TX signals(IS-95A/B & IS-95C) and division and level modulation function of the RX signals. Isolation satisfied above 100dB.

• 성인간호학회지
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• 제29권2호
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• pp.109-118
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• 2017

Purpose: To identify the risk factors for suicidal ideation across the life cycle among Korean adults using data from 2015 Korean Psycho-social Anxiety Survey. Methods: The data were statistically analyzed using hierarchical logistic regression analysis. Results: The factors associated with suicidal ideation among the young adult group were education level (odds ratio [OR] 1.62, 95% confidence interval [CI] 1.05~2.49), self-esteem (OR 1.19, 95% CI 1.12~1.27), stress (OR 3.26, 95% CI 2.07~5.15), anger control problems (OR 3.58, 95% CI 2.34~5.50), and depression (OR 2.59, 95% CI 1.66~4.04) whereas among the middle-aged adults the factors were education level (OR 1.58, 95% CI 1.12~2.23), existence of a spouse (OR 2.55, 95% CI 1.72~3.78), self-esteem (OR 1.13, 95% CI 1.08~1.18), stress (OR 2.46, 95% CI 1.81~3.33), anger control problems (OR 1.70, 95% CI 1.22~2.36), and depression (OR 2.64, 95% CI 1.91~3.64). Among the older adult group the findings were the existence of a spouse (OR 2.16, 95% CI 1.37~3.39), self-esteem (OR 1.22, 95% CI 1.13~1.32), stress (OR 2.21, 95% CI 1.38~3.54), anxiety (OR 2.42, 95% CI 1.46~4.02), and depression (OR 2.48, 95% CI 1.30~4.72). Conclusion: The findings suggest that there may be a need for different suicide intervention programs to decrease suicidal ideation across the life cycle.

• 한국간담췌외과학회지
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• 제27권1호
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• pp.6-19
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• 2023

A systematic review was conducted in compliance with PRISMA statement standards to identify all studies reporting outcomes of laparoscopic resection of benign or malignant lesions located in caudate lobe of liver. Pooled outcome data were calculated using random-effects models. A total of 196 patients from 12 studies were included. Mean operative time, volume of intraoperative blood loss, and length of hospital stay were 225 minutes (95% confidence interval [CI], 181-269 minutes), 134 mL (95% CI, 85-184 mL), and 7 days (95% CI, 5-9 days), respectively. The pooled risk of need for intraoperative transfusion was 2% (95% CI, 0%-5%). It was 3% (95% CI, 1%-6%) for conversion to open surgery, 6% (95% CI, 0%-19%) for need for intra-abdominal drain, 1% (95% CI, 0%-3%) for postoperative mortality, 2% (95% CI, 0%-4%) for biliary leakage, 2% (95% CI, 0%-4%) for intra-abdominal abscess, 1% (95% CI, 0%-4%) for biliary stenosis, 1% (95% CI, 0%-3%) for postoperative bleeding, 1% (95% CI, 0%-4%) for pancreatic fistula, 2% (95% CI, 1%-5%) for pulmonary complications, 1% (95% CI, 0%-4%) for paralytic ileus, and 1% (95% CI, 0%-4%) for need for reoperation. Although the available evidence is limited, the findings of the current study might be utilized for hypothesis synthesis in future studies. They can be used to inform surgeons and patients about estimated risks of perioperative complications until a higher level of evidence is available.

• Asian Pacific Journal of Cancer Prevention
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• 제15권3호
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• pp.1345-1349
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• 2014

Although many epidemiologic studies investigated the methylenetetrahydrofolate reductase (MTHFR) polymorphisms and their associations with esophageal cancer, definite conclusions could not be drawn. To clarify the effects of MTHFR polymorphisms on the risk of esophageal cancer, a meta-analysis was here performed in Chinese populations. A total of 16 studies including 3,040 cases and 4,127 controls were involved in this metaanalysis. Overall, significant associations were found between the MTHFR C677T polymorphism and esophageal cancer risk when all studies in Chinese populations were pooled into the meta-analysis (T vs. C, OR = 1.19, 95% CI = 1.06-1.34; TT vs. CC, OR = 1.35, 95% CI = 1.07-1.70; TT+ CT vs. CC, OR = 1.29, 95% CI = 1.08-1.54; TT vs. CC + CT, OR = 1.19, 95% CI = 1.03-1.37). In subgroup analyses stratified by ethnicity and source of controls, the same results were found in Kazakh (TT vs. CC, OR = 1.38, 95% CI = 1.02-1.87; TT + CT vs. CC, OR = 1.50, 95% CI = 1.03-2.18), in not stated populations (T vs. C, OR = 1.24, 95% CI = 1.08-1.42; TT vs. CC, OR = 1.47, 95% CI = 1.10-1.96; TT + CT vs. CC, OR = 1.30, 95% CI = 1.05-1.60; TT vs. CC + CT, OR = 1.32, 95% CI = 1.12-1.56), and in hospital-based studies (T vs. C, OR = 1.34, 95% CI = 1.19-1.51; TT vs. CC, OR = 1.81, 95% CI = 1.37-2.39; TT + CT vs. CC, OR = 1.51, 95% CI = 1.26-1.83; and TT vs. CC + CT, OR = 1.39, 95% CI = 1.13-1.70). In conclusion, this meta-analysis provides evidence that the MTHFR C677T polymorphism contributes to esophageal cancer development in Chinese populations.

• Journal of Preventive Medicine and Public Health
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• 제51권6호
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• pp.298-309
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• 2018

Objectives: The objective of this study was to assess the relationship between systolic and diastolic blood pressure (SBP, DBP) and the risk of death from specific causes other than cardiovascular diseases. Methods: We calculated the risk of specific death by SBP and DBP categories for 506 508 health examinees in 2002-2003 using hazard ratios (HRs) and 95% confidence intervals (CIs) in a Cox proportional hazards model. Results: Compared to normal levels (SBP <120 or DBP <90 mmHg), stage I systolic and diastolic hypertension (SBP 140-159, DBP 85-89 mmHg, respectively) were associated with an increased risk of death from diabetes mellitus, alcoholic liver disease, and renal failure (HR, 1.83; 95% CI, 1.51 to 2.22; HR, 1.24; 95% CI, 1.06 to 1.46; HR, 2.30; 95% CI, 1.64 to 3.21; HR, 1.67; 95% CI, 1.27 to 2.20; HR, 1.99; 95% CI, 1.41 to 2.81; HR, 1.31; 95% CI, 0.99 to 1.73, respectively), but a decreased risk of death from intestinal pneumonia (HR, 0.64; 95% CI, 0.42 to 0.98; HR, 0.59; 95% CI, 0.39 to 0.91). Only stage II systolic hypertension (SBP ${\geq}160mmHg$) was associated with an increased risk of death from pneumonia, liver cirrhosis, and intestinal ischemia (HR, 1.54; 95% CI, 1.19 to 1.98; HR, 1.46; 95% CI, 1.00 to 2.15; HR, 3.77; 95% CI, 1.24 to 11.40, respectively), and stage I and II diastolic hypertension (SBP 140-159 and ${\geq}160mmHg$) were associated with an increased risk of death from intestinal ischemia (HR, 3.07; 95% CI, 1.27 to 7.38; HR, 4.39; 95% CI, 1.62 to 11.88, respectively). Conclusions: An increase in blood pressure levels may alter the risk of death from certain causes other than cardiovascular diseases, a well-known outcome of hypertension, although the mechanism of these associations is not well documented.

• 한국산학기술학회논문지
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• 제15권7호
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• pp.4279-4289
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• 2014

75세 이상 후기노인들의 주관적 건강상태와 관련 요인을 알아보고자 2011년 국민건강영양조사 자료에서 75세 이상 후기노인 468명에 대해 연구하였다. 75세 이상 후기노인의 주관적 건강상태에 영향을 미치는 요인을 알아보기 위하여 순서형 로지스틱 회귀분석을 한 결과, 성별(OR=0.456, 95%CI=0.257-0.805), 직업(OR=1.437, 95%CI=0.963-2.149), 배우자(OR=0.673, 95%CI=0.443 -1.022), 스트레스정도(OR=0.476, 95% CI=0.309-0.730), 우울증상(OR=0.410, 95% CI=0.238-0.704), 주관적 구강 상태(OR=1.874, 95% CI=1.332-2.643), 흡연(OR=0.738, 95% CI= 0.523-1.039), 음주(OR=1.251, 95% CI=1.017-1.540), 걷기실천(OR=1.698, 95% CI=1.188 -2.431)이 주관적 건강상태에 영향을 미치는 것으로 나타났다. 여자노인에 비해 남자노인이, 직업이 있을 경우, 배우자가 없을 경우, 스트레스정도가 낮을 경우, 우울증상이 없을 경우, 음주를 하고 있을 경우, 걷기를 실천할 경우에서 주관적 건강상태가 좋은 것으로 나타났다. 앞으로 이러한 특성들을 충분히 고려한 건강관리지원이 필요할 것이라 여겨진다.

• 한국콘텐츠학회논문지
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• 제17권6호
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• pp.479-489
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• 2017

본 연구는 2014년 노인실태조사를 이용하여 노인의 낙상에 영향을 미치는 요인을 파악하기 위해 실시된 서술적 조사연구이다. 연구대상자는 2014년 노인실태조사에 참여한 노인 중 주요 변수에 결측치가 없는 10,272명의 노인이다. 인구사회학적 특성, 건강관련 특성(주관적 건강상태, 만성질환 수, 복용 중인 약물의 수, 운동 일수, 시력 이상, 근력 상태, ADL, IADL, 인지기능, 낙상에 대한 두려움)을 조사하였다. 수집된 자료는 SPSS ver. 23.0의 복합표본분석을 이용하여 분석하였다. 노인의 낙상은 인구사회학적 특성, 건강 관련 특성에 따라 차이가 있었다(p<.001). 다중로지스틱회귀분석 결과, 연령(OR=1.262, 95%CI 1.111-1.433), 교육수준(OR=0.846, 95%CI 0.764-0.937), 주관적 건강상태(OR=1.172, 95% CI 1.041-1.320; OR=1.422, 95%CI 1.289-1.570), 만성질환 수(OR=1.438, 95%CI 1.050-1.968), 복용 중인 약물의 수(OR=0.798, 95%CI 0.659-0.967), 하지근력상태(OR=1.260, 95%CI 1.101-1.441) 및 낙상에 대한 두려움(OR=3.576, 95%CI 3.166-4.039; OR=14.236, 95%CI 12.637-16.038)이 노인의 낙상에 영향을 미치는 주요 요인으로 확인되었다(p<.05). 따라서 다양한 대상자의 특성을 고려한 낙상 예방 프로그램을 개발하여 집중적인 관리가 필요하다.

• 한국콘텐츠학회논문지
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• 제10권7호
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• pp.268-275
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• 2010

관상동맥 석회수치(CACS)는 조직학적으로 동맥경화반의 총량과 높은 상관관계를 보이며, 관상동맥의 협착을 예측하는 지표와 향후 허혈성 심장질환 발생의 독립적인 위험인자가 된다. 본 연구는 2006년 1월부터 2008년 12월까지 화순전남대학교병원 건강증진센터에서 건강검진을 목적으로 CACS검사를 시행한 1042명을 대상자로 심혈관질환 위험요소 및 관상동맥 석회수치와 Framingham Risk Scores(FRS)와의 상관관계를 알아보고자 하였다. CACS와 FRS는 남성(OR, 2.38; 95% CI, 1.83-3.11), 여성(OR, 2.12; 95% CI, 1.03-4.35) 모두 관상동맥 석회수치가 없는 군과 비교하여 통계적으로 유의하게 높았으며, CACS와 심혈관질환 위험요인과의 관계에서는 연령과 성별을 통제한 다변량분석에서 여자는 연령(OR, 1.10; 95% CI, 1.06-1.15), 고밀도지단백콜레스테롤(OR, 2.38; 95% CI, 1.04-5.44), 공복혈당(OR, 2.89; 95% CI, 1.16-7.21)이 남자에서는 연령(OR, 1.11; 95% CI, 1.08-1.14), 저밀도지단백콜레스테롤(OR, 2.12; 95% CI, 1.28-3.50), 감마-글루타밀전이효소(OR, 1.73; 95% CI, 1.17-2.55), 당뇨병(OR, 3.92; 95% CI, 1.73-8.89)이 관상동맥 석회수치의 유의한 위험인자로 나타났다.

• Asian Pacific Journal of Cancer Prevention
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• 제15권7호
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• pp.3035-3039
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• 2014

Background: Lung cancer is one of the most prevalent malignancies in the world and both incidence and mortality rates are continuing to rise in Pakistan. However, epidemiological studies to identify common lung cancer determinants in the Pakistani population have been limited. Materials and Methods: In this retrospective case-control study, 400 cases and 800 controls were enrolled from different hospitals of all provinces of Pakistan. Information about socio-demographic, occupational, lifestyle and dietary variables was extracted by questionnaire from all subjects. Odd ratios (ORs) and 95% confidence intervals (CIs) were calculated. and dose-response associations were also assessed for suitable factors. Results: Strong associations were observed for smoking (OR=9.4, 95%CI=6.9-12.8), pesticide exposure (OR=5.1, 95%CI=3.1-8.3), exposure to diesel exhaust (OR=3.1, 95%CI=2.1-4.5), red meat consumption (OR=2.9, 95%CI=1.8-4.7) and chicken consumption (OR=2.8, 95%CI=1.7-49). Other associated factors observed were welding fumes (OR=2.5, 95%CI=1.0-6.5), sedentary living (OR=2.0, 95%CI=1.6-2.6), family history (OR=2.0, 95%CI=0.8-4.9), wood dust (OR=1.9, 95%CI=1.2-3.1), tea consumption (OR=1.8, 95%CI=1.2-2.6), coffee consumption (OR=1.8, 95%CI=1.1-2.8), alcoholism (OR=1.7, 95%CI=1.1-2.5) and asbestos exposure(OR=1.5, 95%CI=0.5-4.4). Consumption of vegetables (OR=0.3, 95%CI=0.2-0.4), juices (OR=0.3, 95%CI=0.3-0.4), fruits (OR=0.7, 95%CI=0.5-0.9) and milk (OR=0.6, 95%CI=0.5-0.8) showed reduction in risk of lung cancer. Strongest dose-response relationships were observed for smoking ($X^2=333.8$, $p{\leq}0.0000001$), pesticide exposure ($X^2=50.9$, $p{\leq}0.0000001$) and exposure to diesel exhaust ($X^2=51.8$, $p{\leq}0.0000001$). Conclusions: Smoking, pesticide exposure, diesel exhaust and meat consumption are main lung cancer determinants in Pakistan. Consuming vegetables, fruits, milk and juices can reduce the risk of lung cancer risk, as in other countries.