• 약학회지
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• 제59권3호
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• pp.127-134
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• 2015

The aim of this study was to investigate the correlation among age, symptoms and initial medication (IM), and the tolerance duration of IM in Korean people with Parkinson's disease (PD). We studied 60 patients with untreated early PD who were initially diagnosed in our hospital between Jun 2006 and Sep 2014. We collected data on sex, age at diagnosis, symptom duration until diagnosis, main motor symptoms, frequency and duration of IM through electronic medical records. We divided patients into groups depending on the number of drugs (MONO/COMBI) and whether to contain dopaminergic property (DOPA/NDOPA). We analyzed the correlation between age and symptoms in each two groups and calculated the mean tolerance duration of IM in each of the groups. The mean symptom duration until diagnosis was 12.2 months. The most frequent drug was levodopa formulations (80%) compared to dopamine agonists (58.3%). The number of patients in the COMBI group (63.3%) was more than that in the MONO group (36.7%). Half of the patients in the COMBI group were taking LDF+DA (50%). Except for tremor, no other symptom showed a significant correlation between with IM. The mean tolerance duration of IM was within 200 days. The mean duration for COMBI group (342.7 days) was longer than that for MONO group (209.8 days). Among regimens, the mean tolerance duration of DOPA group (293.3 days) was longer than for NDOPA group (251.4 days). There was no difference in survival curves between any of the two groups. We found that patients experienced symptoms for over a year in Korea. This indicates that diagnosis time is faster than reported in other previous studies. The longest tolerance duration among IM was for dopaminergic combination therapy. More research is needed to design the most appropriate treatment for PD in Korean patients.

• 약학회지
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• 제60권2호
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• pp.64-72
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• 2016

Jakyakgamcho-tang is a well-known traditional herbal medicine and has been used for the treatment of mainly pains in oriental medicine. In this study, analytical method for the quantitative determination of the eleven marker components, gallic acid (1), oxypaeoniflorin (2), paeoniflorin (3), albiflorin (4), liquiritin (5), isoliquiritin (6), ononin (7), liquiritigenin (8), benzoylpaeoniflorin (9), paeonol (10), and glycyrrhizin (11) in Jakyakgamcho-tang decoction was performed using an ultra-performance liquid chromatography-electrospray ionization-mass spectrometer. The analytical column for separation of the compounds 1~11 was used an UPLC BEH $C_{18}$ ($100{\times}2.1mm$, $1.7{\mu}m$) column and column oven temperature was maintained at $45^{\circ}C$. The mobile phase consisted of 0.1% (v/v) aqueous formic acid (A) and acetonitrile (B) by gradient elution. The flow rate was 0.3 ml/min and injection volume was $2.0{\mu}l$. Correlation coefficient in the calibration curves of the compounds 1~11 were showed a good linearity with more than 0.99. The limit of detection and limit of quantification values of the compounds 1~13 were detected in the ranges 0.06~18.43 ng/ml and 0.18~58.29 ng/ml, respectively. Among the compounds 1~11, the compounds 10 were not detected in this sample, while the ten compounds, 1~9 and 11, were detected $44.05{\sim}19,289.05{\mu}g/g$ in Jakyakgamcho-tang extract.

• 약학회지
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• 제60권3호
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• pp.112-117
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• 2016

A liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated for the determination of caffeine in forensic aqueous sample. The centrifuged sample ($100{\mu}l$) was diluted 50-fold with distilled water. The diluted sample ($400{\mu}l$) was then diluted further with $200{\mu}l$ of 0.1% formic acid solution and $400{\mu}l$ of acetonitrile containing 500 ng of caffeine-(3-methyl-$^{13}C_3$) prior to LC-MS/MS analysis. The mobile phase was composed of 0.1% formic acid in distilled water (A) and acetonitrile (B). Chromatographic separation was performed by using a Zorbax SB-C18 ($100mm{\times}2.1mm$ i.d., $3.5{\mu}m$) column and caffeine was eluted within 1.1 min. Linear least-squares regression with a 1/x weighting factor was used to generate a calibration curve with the coefficients of determination ($r^2=0.9983$). The lower limit of quantification was $25ng/ml$ for the analyte. The process efficiency was 98.6~100.1%. Intra- and inter-day precisions were not more than 2.1% and 1.7%, while intra- and inter-day accuracies were ranged from -6.8 to 4.5%, respectively. The suitability of the method was examined by analyzing unknown forensic aqueous samples.

• 한국통신학회논문지
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• 제29권10A호
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• pp.1147-1158
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• 2004

본 논문에서는 여러 STBC 기법들을 OFDM 시스템에 적용하여 STBC-OFDM 시스템을 설계하고 레일라이 페이딩 환경에서 채널추정 오차를 고려하여 각 시스템의 성능을 비교, 분석한다 먼저, 대표적인 STBC 방식들에 대한 시공간 부호화와 복조 알고리즘을 고찰한다. 또한, 이동통신 환경을 고려하여 OFDM 파라메타를 설정하고 전송율에 따라 QPSK, 8PSK, 16QAM, 64QAM, 256QAM 등의 변조방식을 선택할 수 있도록 STBC-OFDM 시스템을 설계하며 STBC-OFDM 시스템의 데이터 복조기와 채널 추정기의 구조를 제시한다. 끝으로, 레일라이 환경에서 전송율과 수신 안테나의 수에 따른 STBC-OFDM 시스템의 성능을 시뮬레이션을 통해 비교, 분석한다.

• 한국통신학회논문지
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• 제32권5C호
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• pp.469-477
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• 2007

소스 코딩을 통해 얻어지는 대다수의 멀티미디어 데이터 정보는 여러 등급의 다른 비트에러민감도를 가지고 있다. 그러므로 효율적인 시스템 구현을 위해서는 데이터 고유의 비트에러민감도에 따라 서로 다른 수준의 에러 방지를 제공해야 한다. 이 논문에서는 다중안테나 (multiple-in multiple-out : MIMO) 기반의 OFDM시스템에서 효과적인 멀티미디어 정보를 전송하기 위한 차등 에러 방지 기법(Unequal error protection : UEP)을 제안한다. 차등의 에러 방지를 제공하는 시공간 코딩 기법을 설명하고 그 성능을 평가한다. MIMO 기법과 BICM (Bit-interleaved coded modulations) 기술은 보통 RCPC (Rate compatible punctured convolutional codes) 기법과 연계되어 구동된다. 이때 다중안테나 채널 이퀄라이저와 채널코딩 사이에 터보디코딩 기법을 적용하여 최상의 성능을 얻을 수 있는데 기존의 시스템에서는 동일한 에러방지기법(Equal Error Protection : EEP)을 사용하고 있다. 이 논문에서는 이런 시스템 구조에서 보통 사용되는 동일 에러 방지 기법(EEP)와 비교하여 차등 에러방지 기법(UEP)를 사용함으로써 얻을 수 있는 이득을 사용되는 전송파워와 채널밴드 측면에서 설명한다. 특히 제안된 알고리즘을 둘 또는 세 개의 전송 안테나와 두 개의 수신안테나를 갖는 다중안테나 시스템에 적용하고 8PSK 신호를 이용하여 플랫 페이딩 채널에서 성능을 평가하였다.

• 약학회지
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• 제59권5호
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• pp.207-214
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• 2015

P2Y receptors, a type of P2 receptor family, are G-protein coupled receptors and 8 subtypes have been characterized ($P2Y_1$, $P2Y_2$, $P2Y_4$, $P2Y_6$, $P2Y_{11-14}$). Recently, several studies have shed light on the role of P2Y receptors in bone biology. Among them, little is known on the role of $P2Y_6$ receptor on osteoclast differentiation. Thus, we investigated the role of $P2Y_6$ receptor on osteoclastogenesis using $P2Y_6$ receptor selective antagonist, MRS 2578. When osteoblasts and bone marrow cells were co-cultured in the presence of $VitD_3$ and $PGE_2$, $P2Y_6$ antagonist increased the formation of TRAP positive osteoclasts. To elucidate the target cells of $P2Y_6$ antagonist, we first checked the effect of MRS 2578 on osteoblasts. Treatment of MRS 2578 did not affect OPG : RANKL mRNA ratio in osteoblasts. Next, we checked the effects of $P2Y_6$ antagonist on osteoclast precursors using mouse bone marrow macrophages (BMMs). Addition of MRS 2578 increased the number of osteoclasts in RANKL-treated BMMs. Although $P2Y_6$ antagonist had no effect on RANKL-induced NFATc1, c-Fos and MafB expression levels, it significantly stimulated RANKL-induced Blimp1 mRNA expression in BMMs. Taken together, these data indicate that $P2Y_6$ antagonist increases osteoclast formation by upregulation of Blimp1 expression.

• 약학회지
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• 제59권6호
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• pp.278-283
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• 2015

The computerized prospective Drug Utilization Review (DUR) program supported by the Korean government has provided alerts to physicians and pharmacists since December 2010. This study aims to propose and apply the tiering system in "drug combinations to avoid (DCA)" and "age-precaution" alerts based on severity to improve the compliance of users. To propose the severity and clinical importance of 647 DCA alerts and 140 age precautions, a Delphi evaluation survey was conducted. An expert panel comprising 5 clinical pharmacists and 5 physicians were participated in mail surveys. Based on the results of Delphi survey, DCA pairs were classified into 3 groups; group 1 (70.6%), 2 (26.9%), and 3 (2.8%). Drug-age precaution ingredients were also classified into three groups; group 1 (53.6%), group 2 (40.7%), and group 3 (5.7%). When this grouping was applied to claim data from 2011 to 2013, the majority of alerts had occurred in the groups of high severity. Presenting DUR alerts with severity level is expected to improve the compliance of clinicians. The implementation of tiering system in DUR criteria should be considered.

• 한국정보통신학회논문지
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• 제12권9호
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• pp.1654-1665
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• 2008

본 논문에서는 대표적인 반복 부호 알고리즘인 터보 부호, LDPC부호 TPC 등 세 가지 알고리즘에 대해 8PSK 이상의 다치 변조 방식 적용을 위해 수신단에서 비트 분리 방법을 제시한다. 수신된 I, Q 심볼만을 이용하여 세 비트 이상의 비트를 분리하기 위한 LLR 방식에 기초를 하여 LLR 방식의 단점인 복잡도를 개선하기 위해 Euclidean, MAX, sector, center focusing 방식에 대해 검토하였으며, 세 가지 반복 부호에 대해 최적의 비트 분리 방법을 제시하였다. 또한 DVB-S2에 적용되는 double ring 구조의 16-APSK, 지상파 DMB에 적용되는 격자구조의 16-QAM 방식에 대해 최적의 비트 분리 방법을 제시하였다.

• 약학회지
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• 제58권6호
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• pp.397-404
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• 2014

The Ministry of Health and Welfare proposed the "undergraduate program specializing in pharmaceutical industry" in 2013, as part of its roadmap to assist domestic pharmaceutical companies to become the top-tier pharma companies in near future and provide skilled personnel tailored for pharmaceutical industry. However, it is not clear whether this "undergraduate program" meets the needs of pharmaceutical industry, especially when the number of pharmacy students increased from 1,200 to 1,700 per year since 2009. The purpose of this paper is to identify which educational background is preferred by pharmaceutical companies, by surveying the CEOs of domestic pharmaceutical companies and referring to recruitment advertisements shown in medical newspapers, specified by the fields within the companies. Two independent reviewers referred to recruitment session in Yakup newspaper and Dailypharm from May 2012 until January 2014, focusing on recruitments from pharmaceutical companies targeting bachelors' degree holders with no prior experience. 749 recruitments were observed during the study period, more than 90% of which were provided by domestic pharmaceutical companies, and regardless of the companies being domestic or multinational, pharmaceutical companies' preference for pharmacists was remarkable (44.3% for domestic and 65.8% for multinational), and the preference was especially high in the fields such as Medical, R&D, Market Access (regulatory affair/pricing and reimbursement), Business Development, and Marketing. Survey results showed that the need of establishing the undergraduate program specializing in pharmaceutical industry is mixed, suggesting that although there is need for the educating personnel targeting pharmaceutical industry, the undergraduate program would not be an answer due to current PEET system. Our study concludes that in the example of pharmaceutical companies' recruitments shown in medical newspapers, pharmaceutical companies prefer pharmacy major in almost all fields of the pharmaceutical companies, yet the pharmaceutical companies still perceive the gap between current bachelor's degree holders(including pharmacy majors) and the ideal personnel required for advancing to the "top-class" pharmaceutical companies.

• 대한전자공학회논문지TC
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• 제46권10호
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• pp.28-33
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• 2009

본 논문에서는 항공시스템의 데이터 및 음성 통신을 위한 VHF (Very High Frequency) digital link mode-2 (VDL Mode-2) 시스템에 적합한 수신 알고리듬을 제안한다. VDL Mode-2 시스템은 패킷 방식으로 동작하며 이에 따라 최적화된 패킷 검출 알고리듬을 설계하여야 한다. 또한 VDL Mode-2 시스템에서는 송수신 여파기로 각각 제곱근 상승 코사인 여파기를 사용하는 일반적인 디지털 통신 시스템과 달리 점유 주파수 대역 요구사항에 따라 송신 여파기로 상승 코사인 여파기를 사용한다. 따라서 수신기에서는 ISI (inter-symbol interference)와 잡음 특성을 고려하여 최적화된 저역 통과 여파기를 설계하여야 한다. 이와 함께 VDL Mode-2 시스템의 안정적인 동작을 위해서는 송수신기의 반송파 주파수 차이와 도플러 주파수 천이에 의한 주파수 오프셋을 추정하고 보상하여야 한다. 본 논문에서는 VDL Mode-2 시스템을 위한 패킷 검출, 수신 여파기 및 주파수 오프셋 추정 및 보상 알고리듬들을 제안하고 제안한 기법들을 적용한 VDL Mode-2 시스템의 성능을 분석하였다.