• 사상체질의학회지
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• 제23권3호
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• pp.361-373
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• 2011

1. Objectives: The purpose of this study was done to learn the Sasang constitutional distribution and to find out if there are differences in the type of diseases and symptoms according to the Sasang constitution in Japan. 2. Methods: We collected data from 366 patients who visited the Department of Oriental Medicine, Keio University and recruited 132 healthy persons in Tokyo, Japan. For sasang constitution diagnosis, they all have done SSCQ-P(Sasang Constitution Questionaire for Patients) questionnaire. and a sasang constitution specialist diagnosed the sasang constitution of them. And We classify the diseases and symptoms of 313 patients according to KCD(Korean Standard Classification of Diseases) and learn the prevalences of diseases and symptoms according to Sasang Constitution. 3. Results: 1) Among the total 498 subjects, distributional rate of Taeyangin, Soyangin, Taeeumin, and Soeumin were 2.0%, 26.3%, 29.9%, and 41.8%. Among the 366 patients, distributional rate of Taeyangin, Soyangin, Taeumin, and Soeumin were 0.8%, 27.3%, 28.7%, and 43.2%. Among the 132 healthy group, distributional rate of Taeyangin, Soyangin, Taeeumin, and Soeumin were 5.3%, 23.5%, 33.3%, and 37.9%. 2) The prevalences of 'V.Mental and behavioural disorders', 'XI.Diseases of the digestive system', 'XV.Pregnancy, childbirth and the puerperium' and 'feeling of coldness(X VIII.Symptoms, signs and abnormal clinical and laboratory findings, NEC)' of Soeumin were significantly higher than those of the other constitutions.(p-value<0.05) 4. Conclusions: The distributional rate of Sasangin of Japanese was different from that of Korean and especially the distributional rate of Soeumin of Japanese was significantly higher than that of Korean. There were significant differences on the prevalences of some diseases and symtoms according to KCD in Soeumin.

• 사상체질의학회지
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• 제30권2호
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• pp.42-54
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• 2018

Objectives This study was aimed to compare effects of Yukgunja-tang (YGJT) extract granule on functional dyspepsia (FD) by sasang constitution. Methods A placebo-controlled, double-blind, randomized, two-center trial was performed. We obtained 3D face images of FD patients participating in this study using face-only scanner and classified them into two types as narrow face and wide face by 3D facial shape diagnosis system (3-FSDS). 96 subjects (48 subjects per type) were enrolled and were randomly allocated into treatment or control groups in a 2:1 ratio. YGJT extract granule or placebo were administered to each group during the 8 week treatment period. One of sasang constitutional specialist diagnosed their constitutions by referring to questionnaires and 3D face images. The primary outcome was total dyspepsia symptom scale (TDS scale), the secondary outcomes were single dyspepsia symptom scale (SDS scale), visual analog scale (VAS) and so on. This trial was registered with clinical research information service identifier: KCT0001920, 15 May, 2016. Results In the Taeeumin treatment group, the TDS scale was significantly decreased after 8 weeks compared to the control group (t=2.331, p=0.025) and the SDS scale also significantly decreased. (t=2.042, p=0.048). The specific effects of the YGJT extract granule without the placebo effect on the Taeeumin with functional dyspepsia were 30.61% in TDS scale and 28.33% in SDS scale. Conclusions The effects of Yukgunja-tang extract granule on functional dyspepsia was different according to Sasang constitution. So the constitution should be considered in randomized controlled trials using herbal extract granules.

• Journal of Microbiology and Biotechnology
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• 제23권6호
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• pp.771-778
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• 2013

Essential oils are increasingly of interest for use as novel drugs acting as antimicrobial and antiviral agents. In the present study, we report the in vitro antiviral activities of 29 essential oils, extracted from Chinese indigenous aromatic plants, against the tobacco mosaic virus (TMV). Of these essential oils, those oils from ginger, lemon, tea tree, tangerine peel, artemisia, and lemongrass effected a more than 50% inhibition of TMV at 100 ${\mu}g/ml$. In addition, the mode of antiviral action of the active essential oils was also determined. Essential oils isolated from artemisia and lemongrass possessed potent inactivation and curative effects in vivo and had a directly passivating effect on TMV infection in a dose-dependent manner. However, all other active essential oils exhibited a moderate protective effect in vivo. The chemical constitutions of the essential oils from ginger, lemon, tea tree, tangerine peel, artemisia, and lemongrass were identified by gas chromatography and gas chromatography-mass spectrometry. The major components of these essential oils were ${\alpha}$-zingiberene (35.21%), limonene (76.25%), terpinen-4-ol (41.20%), limonene (80.95%), 1,8-cineole (27.45%), and terpinolene (10.67%). The curative effects of 10 individual compounds from the active essential oils on TMV infection were also examined in vivo. The compounds from citronellal, limonene, 1,8-cineole, and ${\alpha}$-zingiberene effected a more than 40% inhibition rate for TMV infection, and the other compounds demonstrated moderate activities at 320 ${\mu}g/ml$ in vivo. There results indicate that the essential oils isolated from artemisia and lemongrass, and the individual compound citronellal, have the potential to be used as an effective alternative for the treatment of tobacco plants infected with TMV under greenhouse conditions.

• Reproductive and Developmental Biology
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• 제33권4호
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• pp.223-228
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• 2009

We attempted to control the maturation promoting factor (MPF) activity and investigated the subsequent reprogramming of bovine somatic cell nuclear transfer (SCNT) embryos. Serum-starved adult skin fibroblasts were fused to enucleated oocytes treated with 2.5 mM caffeine or $150\;{\mu}M$ roscovitine. The MPF activity, nuclear remodeling patterns, chromosome constitutions and development of SCNT embryos were evaluated. Methylated DNA of embryos was detected at various developmental stages. The MPF activity was increased by caffeine treatment or reduced by roscovitine treatment (p<0.05). Blastocyst development was higher in the caffeine-treated groups (27.6%) than that of the roscovitine-treated group (8.3%, p<0.05). There was no difference in the apoptotic cell index among the three groups. However, the mean cell number of blastocysts was increased in the caffeine-treated group (p<0.05). Higher methylation levels were observed in the Day 3 embryos of the roscovitine-treated group (50.8%), whereas lower methylation levels were noted at Day 5 in the caffeine-treated group (12.5%, p<0.05). These results reveal that the increase in MPF activity via a caffeine-treatment creates a more suitable condition for nuclear reprogramming after SCNT.

• 대한한의학회지
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• 제26권3호
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• pp.80-97
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• 2005

Backgrounds : In recent years there has teen renewed interest in the importance of 8-constitution medicine as evidenced by growth of research in this field. Although diagnosis by 8-constitution depends on pulse types, it still is subjective and thus could be insignificant. Therefore, diagnosis based on objective characteristics is essential. Objectives : The purpose of this study was to find objective characteristics of the 4-constitution groups {木(Mok; hepatonia, cholecystonia), {土(To; pancreotonia, gastrotonia), {金(Gum; pulmotonia, colonotonia), {水(Soo; renotonia, vesicotonia)} in 8-constitution for further diagnosis and therapy. Also, some significant clinical tendencies of 4-constitution groups were studied. Methods : From Nov. 2001 to Apr. 2004, data were collected through a questionnaire given to 720 patients who were classified into one of 8 constitutions according to their pulse types and their responses to constitution-based acupuncture therapy. The questionnaire was composed of 80 items which were about personality, physical shape, habit, physiological and pathological symptoms, response to drugs, favorites and responses to various foods. The data were statistically analyzed by cross-tabulation and one-way analysis of variance, and SPSS V10.0.7PC was used. Results : The results are summarized as follows: 1) Among participants, proportions of hepatotonia, pancreotonia, and cholecystotonia were higher than those of vesicotonia, pulmotonia, colonotonia, renotonia, grstrotonia. 2) 52 items of 80 variances showed significant differences by gender, 3) 13 items were highly correlated with 4-constitution groups in males, and 26 items in fremales. 4) 22 items showed significant group differences among 4-constitution groups in males, and 41 items in females. Also, for each item 4-constitution groups were sorted according to their means, so that the constitutional tendencies were objectively figured out by personality, shape, habit, physiological and pathological symptoms, response to drugs, favorites and responses to foods. Conclusions : Most clinical characteristics of 4-constitution groups found in this study coincided with those from the previous ones in this fold. Thus, classifying patients into one of the 4-constitution groups based on significant objective characteristics is of great benefit to diagnosis and therapy. further study should be followed to improve proper therapy for each constitution.

• 한국콘텐츠학회논문지
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• 제9권8호
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• pp.360-366
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• 2009

본 연구는 하체 비만 해소를 위한 효과적인 방법을 모색하고자 실시하였다. 여대생을 대상으로 아로마에센셜 오일을 이용한 경락마사지를 한 후 그 결과를 살펴보고자 하였다. 연구 대상은 본 연구에 참여를 희망하는 여대생을 중심으로 선발하였으며, 기간은 2008년 4월부터 6월까지로 8주였다. 선발군은 체성분 분석기로 체지방량과 체중을 측정하고 그 평균을 측정치로 이용하였으며, 표준과 과체중 각 4명씩, 비만 8명으로 분류하고 비만을 실험군으로, 표준과 과체증을 대조군으로 삼았다. 각 군은 아로마 에센션 오일 중 비만 해소에 효과가 있다고 선행연구에서 밝혀진 쥬니퍼 베리, 사이프러스, 파출리를 1:1:0.8의 비율(5방울(약 1ml),5방울, 4방울)로 혼합한 후 베이스오일로 30ml의 호호바 오일과 혼합하여 사용하였으며 선발군에 에센셜 오일 테스트를 거친 후 30분씩 하체 부위에 경락마사지를 실시하는 실험을 하였다. 실험을 통해 실험군과 대조군 모두 체중, 허벅지와 종아리 치수, 체지방률이 줄어드는 결과를 얻었다. 체지방률에서는 실험군과 대조군 모두 체지방률이 감소하였다. 다만 대조군과 실험군에서 각각 한 명씩이 체지방률이 약간 증가하였다. 혈액측정을 통한 연구 결과는 실험군과 대조군 모두 총콜레스테롤, LDL, 중성지방, 혈당 수치가 감소하였으나, HDL은 수치가 증가하는 결과를 얻었다. 이를 통해 여대생들의 잘못된 비만 관리가 이상 수치를 일으킬 수 있음을 발견할 수 있었으며 실험자의 각오와 인내심에 따라 결과치가 다름을 알 수 있었다.

• 대한한의학회지
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• 제27권2호
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• pp.14-22
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• 2006

Objectives : The purpose of this study was to find the prevalences and risk factors of the metabolic syndrome according to Sasang constitution. Methods : The medical records of 364 subjects who had taken health examinations and diagnosis of Sasang constitution from January to June of 2003 at a health examination center of a hospital in Seoul were reviewed. The prevalences and the risk factors of the metabolic syndrome according to Sasang constitution were compared and analyzed. Results : 1) Among the 364 subjects, 88 (24.2%) were Soeumin, 101 (27.7%) were Soyangin, and 175 (48.1%) were Taeumin. 2) The prevalences of high WC, high TG, low HDL-c, high BP and high FBS of Taeumin were significantly higher than those of the other constitutions (p-value < 0.05). 3) The prevalence of the metabolic syndrome of Taeumin, Soyangin, and Soeumin were 46.3%, 16.8% and 9.1% respectively. The rates were significantly different according to Sasang constitution (p-value < 0.001). 4) Taeumin had higher risk of high WC than Soeumin (adjusted OR : 3.83, 95% CI : 1.19-12.29) and higher risk of high FBS than Soeumin (adjusted OR: 5.93,95% CI : 1.11-31.77). 5) Taeumin had higher risk of the metabolic syndrome than Soeumin (adjusted OR : 3.40, 95% CI : 1.25-9.23). Conclusions : There were significant differences in the prevalence of metabolic syndrome according to Sasang constitution. Sasang constitution was identified as an independent risk factor of metabolic syndrome.

• 대한한의학회지
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• 제27권1호
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• pp.118-129
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• 2006

Objectives : A human being is classified into 4 constitutions(Taeyangin, Soyangin, Taeumin, and Souemin) and each constitution has the different incidence, treatment and prevention of disease in Sasang Constutional Medicine[SCM], The purpose of this study is to find relative risk(RR)s of each risk factors including Sasang Constitution[SC] for incidence of ischemic stroke. Methods : In 344-case patients with ischemic stroke and 1446 healthy control subjects without ischemic stroke, we evaluated sex, age. height, weight, BMI, ECG abnormality, hypertension, diabetes mellitus, blood lipid level and SC. These data were statistically analysed to investigate the relations between risk factors and the incidence of ischemic stroke by chi-square test. And then significant factors were analysed to get each adjusted odds ratio[OR] by binary logistic regression analysis. Results : ECG abnormality, hypertension, diabetes mellitus, HDL(high density lipoprotein) cholesterol, and SC were significantly related to the incidence of ischemic stroke, while age, sex and BMI were adjusted in a binary logistic regression analysis. Especially in SC, the incidence of ischemic stoke in Tae-eumin and Soyangin were higher than that in Soeumin (Tae-eumin OR=11.68[95% CI: 6.26-21.80], Soyangin OR=4.64[95% CI: 2.66-8.10]). Conclusions : These results suggested that SC may be one of important risk factors for ischemic stroke and it should be a useful data for prediction of incidence of ischemic stroke.

• 동의신경정신과학회지
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• 제17권2호
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• pp.147-158
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• 2006

Objective : This Study is attempted to analyze characteristics of personality by Minnesota Multiphasic Personality Inventory responses in Vertigo patients. Method : 24 Vertigo patients and 28 control group were tested by MMPI and QSCCII. It is analyzed by one-way ANOVA, chi-square test, t-test, Duncan method is used as ex-post test. Result & Conclusion : 1. 24 Vertigo patients were classified into three constitutions by QSCCII. There were 6 of Soyangin(25.0%), 8 of Soeumin(33.3%) and 10 of Taeumin(41.7%) 2. In the analysis of personality disorder scale of MMPI, BDL scale score of Soyangin group was higher than that of other groups, and STY, AVD scale score of Soeumin group was higher than that of other groups. 3. In the analysis of personality disorder scale of MMPI, vertigo patients group showed higher scores than control in CPS, PAG, PAG, DEP, STY, SZD scale.

• 사상체질의학회지
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• 제8권2호
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• pp.151-163
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• 1996

VNTR 및 STR 분석은 유전자지문법 (DNA fingerprinting)에서 사용되는 방법으로 개체의 식별 등을 목적으로 하는 범죄수사 및 기타 유전적 분석 연구에서 많이 쓰이고 있는 유전적 분석 방법이다. 본 연구는 사상체질의 판별에 의해서 분류된 각 체질들이 유전적으로 차이가 있는지를 조사하기 위하여 각 체질인의 제놈 DNA를 대상으로 VNTR 및 STR의 분석을 실시하여서 사상체질의학의 객관화 및 그 임상활동에 관한 유용한 자료를 제공함을 목적으로 추진되었다. 본 연구에서 실시한 MCT118, YNZ22 locus를 이용한 VNTR 분석에서는 체질별로 나타난 allele의 분포 양상이 다양할 뿐만 아니라 각 체질에서 나타난 allele의 분포빈도가 체질별로 유의적인 차이를 보이지 않았다. 따라서 VNTR의 분석을 이용하여서는 사상체질의 네 가지 체질 그룹에 대한 유전적 동질성 및 그룹간 유전적 상이성을 유추해 내기가 어려운 것으로 사료되었다. 한편 allel 의 종류가 적고 따라서 그 분포 양상이 VNTR에 비해서 다양하지 않은 STR 중에서 본 연구에서는 TH01과 vWA locus에 대한 분석을 실시하였는데 그 결과 vWA locus에서는 각 allele No.의 분포 양상이 체질별로 다소 다르게 나타났다.