• Advances in Traditional Medicine
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• v.4 no.2
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• pp.104-111
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• 2004

Sasang Constitutional Medicine is a major branch of Korean Traditional Oriental Medicine. The differences of disease susceptibility to be shown in Sasang constitution may be due to genetic factors. Therefore, we examined interrelationship among cerebral infarction (CI), apolipoprotein E (apoE) gene polymorphism, and Sasang constitutional classification. ApoE is a key protein modulating the highly atherogenic apoB containing lipoproteins and is a candidate gene for the development of coronary artery disease (CAD). The ${\varepsilon}2\;and/or\;{\varepsilon}4$ alleles were the first to be implicated in premature CAD, which resulted in this polymorphism being extensively studied. We investigated the association between apoE genotype and CI by case-control study in a Korean population. We also classified CI patients and control group into groups according to Sasang Constitutional Medicine. 196 CI patients and 379 controls without CI were examined. ApoE genotype was determined by 8% polyacrylamide gel separation after DNA amplification. A significant difference in the apoE genotype distribution was observed in the CI patients compared with that in controls ($X^{2}$=14.920, df=4, P=0.005). Also, the frequency of Taeumin constitution in patients with CI was significantly higher than that in controls (58.0% vs. 36.9%; P<0.001). However, the Taeumin constitution did not enhance the relative risk for CI in the subjects with apoE ${\varepsilon}2\;and/or\;{\varepsilon}4$ alleles. No differences in the apoE genotypes frequencies were observed in the Taeumin compared with that in the other constitutions. In addition, we investigated whether the DD genotype of angiotensin converting enzyme (ACE) gene, a candidate gene for CI, was associated with CI, Taeumin constitution, and apoE polymorphism. As a result, the frequency of Taeumin constitution was significantly higher in CI patients with both apoE ${\varepsilon}3/{\varepsilon}4$ and ACE ID/DD genotypes than in the remaining Sasang constitutions (14.5% vs. 8.3% and 0%) ($X^{2}$=13.521, df=6, P=0.035). In summary, we concluded that the apoE polymorphism is a major risk factor for CI in Koreans and the ACE ID/DD genotype enhanced the relative risk for CI in the subjects with apoE ${\varepsilon}3/{\varepsilon}4$ genotype and Taeumin constitution.

• Journal of Sasang Constitutional Medicine
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• v.12 no.2
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• pp.34-42
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• 2000

Background and Purpose ; Sasang Constitutional medicine is dividing individual's constitutions into four categories. Determination of an individual's constitution however, can be different according to what diagnostic standards apply. In this study, We investigated how different the applying results of the three diagnostic standards-the yong-mo(容貌), the body type(體形), and the mind(心性)-are and what the inter-diagnostic standard agreement is. Methods ; 36 patients in cerebral-infarction, admitted into the Dong-Eui Korean hospital from 1. May. 2000 to 12. October. 2000, were diagnosed by three diagnostic standards - the yong-mo(容貌), the body type(體形), and the mind(心性). Each patient was treated by Sasang constitutional medicine. The agreement of the final constitutional diagnosis and the result of each diagnostic standard was analyzed. Results 1. The number of Taeeumin was 13(40.6%), Soyangin was 10(31.3%), Soeumin was 9(28.1%). 2. In terms of analysis on the agreement of the final constitutional diagnosis and the result of each diagnostic standard, the yong-mo(容貌) showed the highest agreement of 93.8%, followed by 68.8% of the mind(心性), and the body type(體形) showed the lowest agreement of 53.1%. 3. The yong-mo(容貌) standard showed high diagnostic rate of the three constitutions(Soyangin, Taeeumin, Soeumin) generally and diagnostic rate of Soeumin was especially high. The body type(體形) standard showed low diagnostic rate of Taeeumin, and high diagnostic rate of Soeumin. The mind(心性) standard showed low diagnostic rate of Soeumin. 4. In terms of analysis on the agreement of inter-diagnostic standard result, the yong-mo(容貌) and the mind(心性) show the highest agreement, the mind(心性) and the body type(體形) showed the lowest agreement. 5. If the results come out that the three diagnostic standards have no concentration on one constitution, it was effective to choose the result of the yong-mo(容貌) standard. If it is the case the result of inter-diagnostic standard agreed more than two, it was better to follow the two agreed result than to follow the result of one specific characteristic standard.

• Journal of Sasang Constitutional Medicine
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• v.8 no.2
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• pp.239-255
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• 1996

The study was conducted for the purpose of finding out an objective classification method for the Sasang Constitutional medicine, which divides people into 4 groups of constitution and presents comprehensively physiology, pathology, diagnosis, theraphy and recuperation fit to each constitution. Questionnaire of Sasang Constitution collected during 9 months from March 1995 to November 1995. For the purposes of this study, the collected data were analyzed by crosstabs, variation analysis, discrimination analysis. The analyzing program was SPSS PC+V4.0. The results were as follows : 1. QSCC consists of the authorized questions studied by te oriental medicine specialists based on "four groups" given the diagnosis of Sasang Constitution Classification and variation analysis by scores of body constitution. 2. When human's body constitution is classified on the basis of QSCC scores of body constitutions and classified by the absolute size, group cases correctly classified was So-Yang-In 17.3%, Tae-Em-In 26.4%, So-Em-In 74.2%, Tae-Yang-In 100%. However, the number of examples are rare. Average percent of "group" cases correctly classified was 39.3%. 3. When human's body constitution is classified on the basis of QSCC scores of body constitutions and clasified by the relative size, group cases correctly classified was So-Yang-In 40.5%, Tae-Em-In 29.1%, So-Em-In 49.2%, Tae-Yang-In 100%. However, the number of examples are rare. Average percent of "group" cases correctly classified was 39.6%. 4. If the diagnosis of body constitution applies to the people after discrimination formula applies to them before the scores of body constitution is correctly analyzed, group cases correctly classified was So-Yang-in 50.5%, Tae-Em-In 36.9%, So-Em-In 55.9%, Tae-Yang-In 100%. However, the number of examples are rare. Average percent of "group" cases correctly classified was 44.03%. 5. As discrimination formula is applied and analyzed based on the questions of higher percent of reaction freqency, So-Yang-in 61.4%, Tae-Em-In 48.8%, So-Em-In 62.0%. Average percent of group cases correctly classified was 54.91% and it was percent increased compared to chance probability. 6. Therefore, it comes to the conclusion if we utilize QSCC, we are able to predict Sasang Constitution.

• Journal of Sasang Constitutional Medicine
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• v.18 no.1
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• pp.62-74
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• 2006

1. Objectives This is a statistical study on the Reliability and Validity of the Revised Questionnaire for the Sasang Constitution classification(QSCC II +). 2. Methods To analyze the reliability; we gathered the results of the QSCC II + of 266 people. Each person took the questionnaire three times, and the interval of the examinations were about one year. With the results, we used stratified analysis to check up the consistency rate of three examinations, and analyzed the tendency of agreement by crosstabs to get the kappa value. For the validity, we gathered the results of the QSCC II + of 587 people who were Taeumin, Soyangin, Soeumin. They took the questionnaire once, and SCM specialists strictly examined to diagnose their Sasang constitutions. We compare their results of the QSCC II + to the diagnostic result of their Sasang constitutions, and analyzed by crosstabs to get the rate of accuracy of the QSCC II +, and the kappa value for the measure of agreements. 3. Results and Conclusions The expected rate to get the same results was 54.5% in Soyangin, 68.1% in Taeumin, 65.7% in Soeumin, and kappa value was $0.311{\sim}0.414$, which means the reliability of the QSCC II + is analytically significant. The accuracy of the results of QSCC II +, compared to the diagnosis of the SCM specialists, was 58.4%, but increased up to 60.8%, and validity also became moderately good(K=0.412) by age limitation. Because in the 70's results of the QSCC II + isn't likely to agree to the diagnosis of the SCM specialists.

• Journal of Physiology & Pathology in Korean Medicine
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• v.18 no.4
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• pp.1192-1198
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• 2004

Sasang Constitutional Medicine is a major branch of Korean Traditional Medicine. The differences of disease susceptibility to be shown in Sasang constitution may be due to genetic factors. Therefore, I examined interrelationship among cerebral infarction (CI), apolipoprotein E (apo E) gene polymorphism, and Sasang constitutional classification. Apo E is a key protein modulating the highly atherogenic apoB containing lipoproteins and is a candidate gene for the development of coronary artery disease (CAD). The ε2 and/or ε4 alleles were the first to be implicated in premature CAD, which resulted in this polymorphism being extensively studied. I investigated the association between apo E genotype and CI by case-control study in a Korean population. I also classified CI patients and control group into groups according to Sasang Constitutional Medicine. 218 CI patients and 379 controls without CI were examined. Apo E genotype was determined by 8% polyacrylamide gel separation after DNA amplification. A frequency of apo E ε3/ε3 in the apo E genotype distribution was higher in the CI patients compared with that in controls. Also, it was widely known that Taeumin was easily attacked with CI, but there was no association between apo E polymorphim and Taeumin. However, the Taeumin constitution did not enhance the relative risk for CI in the subjects with apo E ε2 and/or ε4 alleles. No differences in the apo E genotypes frequencies were observed in the Taeumin compared with that in the other constitutions. In addition, I investigated whether the DD(deletion/deletion) or ID(insertion/deletion) genotype of angiotensin converting enzyme (ACE) gene, a candidate gene for CI, was associated with CI, Taeumin constitution, and apo E polymorphism. As a result, the frequency of Taeumin constitution was significantly higher in CI patients with both apo E ε3/ε4 and ACE ID/DD genotypes than in the remaining Sasang constitutions. In summary, it was concluded that the apo E polymorphism is a major risk factor for CI in Koreans and the ACE ID/DD genotype enhanced the relative risk for CI in the subjects with apo E ε3/ε4 genotype and Taeumin constitution.

• The Journal of Internal Korean Medicine
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• v.21 no.4
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• pp.565-573
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• 2000

Objective : This research was carried out to find out the general understanding of allergic diseases, the frequencies of allergic diseases and the attitude toward their oriental medical treatment(OMT) among common people. Methods : A total of 360 visitors at The 2nd International Exhibition on Oriental Medicine in 2000, participated in this research. We performed this survey with 22 items on the questionnaire. Results : Respondents knew the. fact that the allergic diseases were hereditary and could be affected by the living environment. 41.8% of the respondents had a past history of allergic diseases. Among the people who had allergic diseases, 63.5% had allergic rhinitis, which was the largest portion. Among them, 52.9% had a familial history. 81.5% of respondents with allergic diseases received western medical treatment for their allergies, 16.3% received both western and oriental medical treatment and 2.2% received OMT only. Among those who were treated for allergic disease, 62.0% were unsatisfied with the low effect of the treatment. To the point of excellence of OMT, 69.7%, which was the largest portion of respondents, believed that OMT could improve their constitutions. The problem with OMT was the high price of herbal medicine and this was the problem most frequently stated, by 51.4% of respondents. There was a positive attitude towards the effect of OMT, and respondents had a preference to receive OMT in the future(p<0.01). Conclusions : These days, it is a fact that the OMT for allergic diseases has a lower proportion to that of western treatment In order to increase the role of OMT, we think, oriental medical doctors need to develop an explanatory model of improving $people^{\circ}{\phi}s$ constitutions and should lower the cost of herbal medicine.

• Journal of Sasang Constitutional Medicine
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• v.8 no.2
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• pp.191-202
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• 1996

Sasang constitution classification is very important subject, so many medical men studied the Sasang constitution classification but there is no certain method to classify objectively. And the purpose of this study is to help classifying Sasang constitution through correlation with sound spectrogram. This study was done it under the suppose that Sasang costitution hag correlation with sound spectrogram. The following results were obtained about correlation between sound spectrogram and Sasang constitution by comparison and analysis the pitch and reading speed of Sasang constitutions; 1. There was a similar tendency in the composition reading speed between taeeumin, soeumin and soyangin. 2. Taeeumin's center was lower measured more than soeumin's and soyangin's in the pitch graph and graph by normal curve fit and there was a similar tendency between soeumin and soyangin. 3. There was a similar tendency in the pitch graph's width between all constitutions. 4. There was a significant difference between taeeumin and soeum in the mean of three constitution's pitch, this means that taeeumin uses lower voice more than soeumin. According to the results, it is considered that there is a correlation between pitch of sound spectrogram and Sasang constitution. And method of Sasang constitution classification through sound spectrogram analysis can be one method as assistant for the objectification of Sasang constitution classification.

• Corrosion Science and Technology
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• v.8 no.2
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• pp.89-92
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• 2009

Pure Ti as well as Ti-6Al-4V alloy exhibit excellent properties for dental implant applications. However, for a better biocompatibility it seems important to avoid in the composition the presence of V due to the toxic effects of V ion release. Thus Al and V free and composed of non-toxic element such as Nb, Zr alloys as biomaterials have been developed. Especially, Zr contains to same family in periodic table as Ti. The addition of Zr to Ti alloy has an excellent mechanical properties, good corrosion resistance, and biocompatibility. In this study, the electrochemical characteristics of Ti-Zr alloys for biomaterials have been investigated using by electrochemical methods. Methods: Ti-Zr(10, 20, 30 and 40 wt%) alloys were prepared by arc melting and homogenized for 24 hr at $1000^{\circ}C$ in argon atmosphere. Phase constitutions and microstructure of the specimens were characterized by XRD, OM and SEM. The corrosion properties of the specimens were examined through potentiodynamic test (potential range of -1500 ~ 2000 mV), potentiostatic test (const. potential of 300 mV) in artificial saliva solution by potentiostat (EG&G Co, PARSTAT 2273. USA).

• Journal of Physiology & Pathology in Korean Medicine
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• v.21 no.1
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• pp.338-346
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• 2007

For Objectivity development of the body shape that is an importance standard for the classification of sasang constitutional medicine diagnosis, We made a comparison between Automatic & Physical measuring. This study uses 2 attitude which lies down & standing. We measured the body of patients(Width 5 places and circumference 8 places) and analyzed the anthropometric data dividing into sex, age, BMI. 296 patients's data are used in the analysis.

• Journal of Sasang Constitutional Medicine
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• v.19 no.1
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• pp.78-89
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• 2007

1. Objectives This is the comparative study with hand-operated measurement method & Automatic measurement method, in order to convert the automatic measurement method. 2. Methods We measured the body of patients(hand-operated width 5 places and hand-operated circumference 8 places, Automatic width 5 places) and analyzed the anthropometric data dividing into sex, age, BMI. 1057 patients's data are used in the analysis. 3. Results and Conclusions 1) 5th Width variable which was measured during lying down was not a sasang constitutional difference. 2) Diagnostic accuracy rate of the body measurement by Width which was measured during lying down and Width which IBS standing was 40-60%. 3) Diagnostic accuracy rate of Automatic & hand-operated measuring was not a big difference.