• Title/Summary/Keyword: 8-Chloroadenosine-3`5`-cyclic monophosphate

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The Facile and Efficient Synthesis of 8-Chloroadenosine $3^I,5^I$-cyclic monophosphate by phosphorylative cyclization of 8-chloroadenosine and its characterization by$^1 H and 13^C$ NMR spectroscopy

  • Woo, Nam-Tae;Jin, Sun-Yong;Cho, Dae-Jin;Kim, Nam-Sun;Bae, Eun-Hyung;Jung, Jee-Hyung;Ham, Won-Hun;Jung, Young-Hoon
    • Archives of Pharmacal Research
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    • v.20 no.2
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    • pp.176-179
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    • 1997

  • Purine nucleosides were chlorinated by the reaction of acyl chloride in DMF with MCPBA under mild conditions with moderate yields. And, satisfactory method for the synthesis of ribonucleoside-$3^{I},5^{I}$-cyclic phosphates and its characterization by$^{1}H$ and $^{13}C$ nmr spectroscopy is described.

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