• Applied Biological Chemistry
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• 제17권3호
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• pp.184-192
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• 1974

2N 염산의 존재하에 N-bromosuccinimide는 8-aminoquinoline과 수용액 중에서 반응하여 5,7-dibromo-8-aminoquinoline를 생성한다. 이 반응은 실온에서 용이하게 또 정량적으로 진행 한다. 본 연구에서 이 반응기구가 검토되었으며 N-bromosuccinimide를 사용하여 8-aminoquinoline의 미량정량을 위한 새로운 적정법이 확립되었다. 본 분석방법은 간단하고 신속하며 주어진 정량 범위내에서 비교적 높은 정확성을 나타내며, 실험오차는 ${\pm}1.78$%를 넘지않는다. 본 방법과 Bromimetry에 의한 8-aminoquinoline의 비교분석 결과도 보고한다.

• Bulletin of the Korean Chemical Society
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• 제26권1호
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• pp.47-50
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• 2005

Solvatochromic fluorescence behavior of 8-aminoquinoline based benzothiazole derivative in varying solvent systems has been investigated. Benzothiazole appended 8-aminoquinoline 3 showed distinctive fluorescence color changes depending upon the solvent polarities and the fluorescence color changes occurred over relatively wide span in visible region from 486 nm to 598 nm which can be detected with naked eye. Compound 3 also exhibited significant spectral shifts in ${\lambda}_{em}$ as a function of water composition in binary aqueous solvent systems. The changes are due to the specific interaction of 3 by hydrogen bonding with water as well as general solvent effect. The observed solvatochromic fluorescence characteristics of 3 could be used as a new probe for the micro-environmental polarity changes as well as a sensitive sensor for the determination of water composition in binary aqueous solutions.

• Elastomers and Composites
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• 제12권1호
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• pp.27-32
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• 1977

The kinetics of azo-coupling reaction of N-acetyl-H-acid (1-acetamino-8-hydroxynaphthalene-3, 6-disulfonic acid) with several heterocyclic diasonium compounds such as diazotiged 3-aminopyridine, 3-aminoquinoline, 8-aminoauinoline and aniline was studied. It was found that reactions proceeded at remarkably different rate. Reaction rate was in increasing order; 3-aminopyridine, 3-aminoquinoline, 8-aminoauinoline and aniline. And the activation energies were 9.62, 10.10, 10.39, 10.70 Kcal/mole, respectively. Especially, the rate constant of 3-aminopyridine was 100 times larger than that of benzene diasonium compound even in strong acidity. Hammett plot was also made of the rate constants obtained against the heterocyclic substituent constants reported in the literature. A good linear relationship was obtained and the reaction constant of N-acetyl H-acid was calculated to be 3.14.

• Bulletin of the Korean Chemical Society
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• 제30권12호
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• pp.3061-3065
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• 2009

A series of mono- and 1,1'-bis(heteroaryl)-substituted ferrocenes were prepared by employing Frielander reaction of acetyl- and 1,1'-diacetylferrocene with a series of o-aminoaldehydes. Reactions of 1,1'-diacetylferrocene with two equivalents of 1-aminonaphthalene-2-carbaldehyde and 8-aminoquinoline-7-carbaldehyde afforded a mixture of mono- and 1,1'-bis(heteroaryl)-substituted ferrocenes in a ratio of 1 : 3.1 - 3.8, while the reaction with 4-aminoacridine-3-carbaldehyde did not provide any characterizable product presumably due to the redox instability of the product induced by low reduction potential of benzo[b]-1,10-phenanthroline. Structural and optical properties of the compounds prepared were described.

• Archives of Pharmacal Research
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• 제17권6호
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• pp.415-419
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• 1994

A simple nad rapid colorimetric method for the assay of amodiaquine hydrochloride, chloroquine phosphate and primaquine phosphate is described. The method is based on the interaction of the drug base with bromophenol blue to give a ion-pair complex. The spectra of the complex shows a maxima at 415-420 nm with high apparent molar absorptivities. Beer's law was obeyed in the concentration range 1-8, 2-10 and $2-12{\;}{\mu}{\cdot}ml^{-1}$ for amodiaquine hydrochloride, primaquine phosphate and chloroquine phosphate respectively. The proposed method was applied to the determination of these drugs in certain formulations and the results were favourably comparable to the official methods.

• Parasites, Hosts and Diseases
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• 제60권4호
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• pp.281-288
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• 2022

Malaria continues to be one of the most crucial infectious burdens in endemic areas worldwide, as well as for travelers visiting malaria transmission regions. It has been reported that 8-aminoquinolines are effective against the Plasmodium species, particularly primaquine, for anti-hypnozoite therapy in P. vivax malaria. However, primaquine causes acute hemolytic anemia in individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency. Therefore, G6PD deficiency testing should precede hypnozoite elimination with 8-aminoquinoline. Several point-of-care devices have been developed to detect G6PD deficiency. The aim of the present study was to evaluate the performance of a novel, quantitative G6PD diagnostics based on a metagenomic blue fluorescent protein (mBFP). We comparatively evaluated the sensitivity and specificity of the G6PD diagnostic modality with standard methods using 120 human whole blood samples. The G6PD deficiency was spectrophotometrically confirmed. The performance of the G6PD quantitative test kit was compared with that of a licensed control medical device, the G6PD strip. The G6PD quantitative test kit had a sensitivity of 95% (95% confidence interval (CI): 89.3-100%) and a specificity of 100% (95% CI: 94.3-100%). This study shows that the novel diagnostic G6PD quantitative test kit could be a cost-effective and time-efficient, and universally mandated screening tool for G6PD deficiency.