• 대한한의학회지
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• 제39권4호
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• pp.51-61
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• 2018

Introduction: This study evaluated whether body mass index (BMI) and waist circumference (WC) cut-offs for predicting metabolic syndrome (MetS) were different according to Sasang constitutional type. Methods: Data were obtained from 3,117 South Koreans (20-90 years old), and MetS was defined according to the revised NCEP-ATPIII criteria. Age-adjusted BMI and WC cut-offs were calculated according to Sasang constitutional type (Soyangin [SY], Taeeumin [TE], and Soeumin [SE]), sex, and age (men: ${\geq}40$ vs. <40 years, women: ${\geq}50$ vs. <50 years). Results: The prevalences of MetS were 29.9% (<40-year-old men), 35.1% (${\geq}40$-year-old men), 14.8% (<50-year-old women), and 47.7% (${\geq}50$-year-old women). The BMI ($kg/m^2$) and WC (cm) cut-offs for <40-year-old men were 25.9 and 89.9 (SY), 25.5 and 90.5 (TE), and 21.8 and 86.2 (SE). The cut-offs for ${\geq}40$-year-old men were 23.1 and 88.9 (SY), 25.0 and 89.9 (TE), and 22.2 and 87.5 (SE). The BMI and WC cut-offs for <50-year-old women were 22.5 and 81.2 (SY), 25.1 and 83.0 (TE), and 21.5 and 79.8 (SE). The cut-offs for ${\geq}50$-year-old women were 22.2 and 80.5 (SY), and 25.2 and 89.1 (TE), and 21.9 and 80.3 (SE). Conclusions: The BMI and WC cut-offs for identifying MetS varied according to Sasang constitution type.

• 사상체질의학회지
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• 제30권2호
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• pp.28-41
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• 2018

Objectives The purpose of this study is to evaluate the quality of case reports about Sasang Constitutional Medicine(SCM). Methods Case reports published from March, 2015 to March, 2018 in Journal of SCM were identified by searching from Oriental Medicine Advanced Searching Integrated System(OASIS). We assessed the quality of reporting of them based on CAse REport (CARE) guideline. Results A total of 39 case reports were finally included for the assessment. Overall quality of reporting was acceptable because case report even less reporting items mentioned 70.4% of them. However, the quality level was uneven because the maximum report rate was 77.8 %, the minimum 44.4 %, and the median 66.7 % when rigorously assessed. More than 50% of 39 case reports did not report 6 items about intervention adherence and tolerability, Diagnostic challenges, patient's perspective on interventions, informed consent, timeline, and adverse events, and did not sufficiently report 4 items about inclusion of terms such as case reports or SCM in keyword, symptoms of patient in abstract, information such as occupation relevant with psychosocial history, and the rationale for conclusions. Conclusions Efforts to improve the quality of reporting in SCM, and to develop case reporting guidelines appropriate for SCM are required.

• 동의생리병리학회지
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• 제18권4호
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• pp.1192-1198
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• 2004

Sasang Constitutional Medicine is a major branch of Korean Traditional Medicine. The differences of disease susceptibility to be shown in Sasang constitution may be due to genetic factors. Therefore, I examined interrelationship among cerebral infarction (CI), apolipoprotein E (apo E) gene polymorphism, and Sasang constitutional classification. Apo E is a key protein modulating the highly atherogenic apoB containing lipoproteins and is a candidate gene for the development of coronary artery disease (CAD). The ε2 and/or ε4 alleles were the first to be implicated in premature CAD, which resulted in this polymorphism being extensively studied. I investigated the association between apo E genotype and CI by case-control study in a Korean population. I also classified CI patients and control group into groups according to Sasang Constitutional Medicine. 218 CI patients and 379 controls without CI were examined. Apo E genotype was determined by 8% polyacrylamide gel separation after DNA amplification. A frequency of apo E ε3/ε3 in the apo E genotype distribution was higher in the CI patients compared with that in controls. Also, it was widely known that Taeumin was easily attacked with CI, but there was no association between apo E polymorphim and Taeumin. However, the Taeumin constitution did not enhance the relative risk for CI in the subjects with apo E ε2 and/or ε4 alleles. No differences in the apo E genotypes frequencies were observed in the Taeumin compared with that in the other constitutions. In addition, I investigated whether the DD(deletion/deletion) or ID(insertion/deletion) genotype of angiotensin converting enzyme (ACE) gene, a candidate gene for CI, was associated with CI, Taeumin constitution, and apo E polymorphism. As a result, the frequency of Taeumin constitution was significantly higher in CI patients with both apo E ε3/ε4 and ACE ID/DD genotypes than in the remaining Sasang constitutions. In summary, it was concluded that the apo E polymorphism is a major risk factor for CI in Koreans and the ACE ID/DD genotype enhanced the relative risk for CI in the subjects with apo E ε3/ε4 genotype and Taeumin constitution.

• 사상체질의학회지
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• 제22권4호
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• pp.1-9
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• 2010

1. Objectives This paper investigates the origin, the progressive changes and the constructive principles of Palmulgunja-tang (八物君子湯). 2. Methods Palmulgunja-tang and other related prescriptions were analyzed in terms of their pathological indications, based on previous literature including "Donguisusebowon Chobongwon (東醫壽世保元 草本卷)", "Donguisusebowon Gabobon (東醫壽世保元 甲午本)", "Donguisusebowon Sinchukbon (東醫壽世保元 辛丑本)" and "Dongmuyugo (東武遺稿)". 3. Results and Conclusions 1) The Palmulgunja-tang most likely originates from Paljin-tang introduced in "Donguisusebowon Chobongwon (東醫壽世保元 草本卷)". Paljin-tang progressively transformed into Seungyangpalmul-tang ("Donguisusebowon Gabobon (東醫壽世保元 甲午本)") and ultimately into Palmulgunja-tang ("Donguisusebowon Sinchukbon (東醫壽世保元 辛丑本)"), a prescription appropriate for usage in the Ulgwang symptomatology (鬱狂證). Also, Seungyangikgi-tang in "Donguisusebowon Sinchukbon (東醫壽世保元 辛丑本)" can be presumed to have been affected by Seungyangpalmul-tang. 2) The variational prescriptions (變方) of Palmulgunja-tang shows increasing Seungyang (升陽) effect in order of Baekhaogunja-tang, Sipjeondaebo-tang, Palmulgunja-tang, and Doksampalmul-tang. 3) Palmulgunja-tang is composed of 8 herbs. Of these, Paeoniae Radix Alba (白芍藥), Glycyrrhizae Radix(甘草), Angelicae gigantis Radix (當歸), and Cnidii Rhizoma (川芎) fortify the Soeumin Spleen Element (脾元). Ginseng Radix (人蔘) and Astragali Radix (黃芪) support the ascension of Yang, whereas Atractlodis Rhizoma White (白朮) and Citrus unshiu (陳皮) encourage the descension of Yin.

• 사상체질의학회지
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• 제28권2호
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• pp.147-162
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• 2016

Objectives The objective of this study is to develop a taeeumin animal-experimental model induced lung fibrosis with Bleomycin and evaluate the effect on obesity in this animal-experimental model.Methods The subjects were divided into 3 groups : normal group, high fat diet(HFD) control group, and HFD group administered with bleomycin(n=10 per group). To develop taeeumin animal-experimental model with reduced respiratory metabolism, 8-week-old C57BL/6 mice were administered with 0.03ml solution of bleomycin 1U/ml dissolved in distilled water, intratracheal(IT), once. Then, the HFD control group and the experimental group were fed with high fat diet for 6 weeks. Airway hyperresponsiveness(AHR) to methacholine was measured at the 1st and 3rd week after bleomycin was administered. Food intake and body weight were measured at regular time weekly. After the final experiment, blood was gathered by cardiac puncture for bloodchemical examination and organs(liver, fatty tissue) were remoed, weighted, and mRNA was analyzed.Results and Conclusions Through the experiment, it was found that Bleomycin induced Taeeumin animal-experimental models have leptin resistace. In the experimental group administered with Bleomycin, fatty acid synthesizing gene expression increased and energy metabolizing gene expression decreased. As mRNA expression of adiponectin decreased, it was found that Taeeuim animal-experimental model is susceptible to metabolic syndrome and cardiovascular diseases.

• 동의생리병리학회지
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• 제16권6호
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• pp.1308-1313
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• 2002

Backgroud and Purpose ; I intented to be helpful to treat diabetes through a clinical study of effect of soyangin Yangkyuksanwha-tang(凉膈散火湯). Methods : I studied 5 patients with upper diabetes who were diagnosed by Soyangin at department of Sasang constitutional Medicine in Dongeui Oriental Hospital during 1 year from August. 2001 to July. 2002. and then I investigated the clinical symptoms of the diabetics and analyzed level of examination after administration of Yangkyuksanwha-tang. Results and Conclusion ; Yangkyuksanwha-tang was administered to five diabetic patients, So-yang-in for 8 weeks. The symptoms such as frequent urination(P<0.05), thirst with frequent drinking water(P<0.01) have improved after the treatment. As results, level of FBS(P<0.01), total protein(P<0.05) and blood pressure(P<0.05) significantly decreased after administration of Yangkyuksanwha-tang.

• 사상체질의학회지
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• 제19권1호
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• pp.60-77
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• 2007

1. Objectives This is the comparative study with hand-operated measurement method and Automatic measurement method, in order to convert the automatic measurement method. 2. Methods We measured the body of patients(hand-operated Width 5 Places and hand-operated circumference 8 place,Automatic Width 5 and automatic circumference 8 place by 3D body measuring instrument) and analyzed the anthropometric data divding into sex&age. 362 patient's data are used in the analysis. 3. Results and Conclusions 1) 1th circumference variable which standing was not a sasang constitutional difference. 2) Diagnostic accuracy rate of the body measurement was 50-80%. 3) Diagnostic accuracy rate of man is higher than Diagnostic accuracy rate of women 4) Diagnostic accuracy rate of Automatic & hand-operated measuring was not a big difference.

• 사상체질의학회지
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• 제21권1호
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• pp.139-149
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• 2009

1. Objectives The roots of Sophora flavescens Aiton (SFA) are widely used as a herbal remedy for allergic inflammation. In this study, we invested the effect of SFA on passive cutaneous anaphylaxis reaction and histamin releas and we demonstrated that SFA suppressed the production of pro-inflammatory cytokines, such as tumor necrosis factor-${\alpha}$ (TNF-${\alpha}$), interleukin- 6 (IL-6), and interleukin -8 (IL-8), through inhibition of the $NF{\kappa}B$, JNK and p38 pathway in the human mast cell line, HMC-1. 2. Methods To accomplish this, we invested passive cutaneous anaphylaxis reaction and histamin release at an animal experiment. In addition, we investigated the effect of SFA on the production of inflammation-related cytokines in HMC-1 cells that were co-treated with PMA and A23187, which can induce production of pro-inflammatory cytokines. 3. Results and Conclusions SFA induced passive cutaneous anaphylaxis reaction and histamin releas and supressed the expression of TNF-${\alpha}$, IL-6, and IL-8. In addition, the protein levels of TNF-${\alpha}$ were also decreased by SFA treatment. Furthermore, SFA inhibited the nuclear translocation of nuclear factor $NF{\kappa}B$ through inhibition of the phosphorylation and degradation of $I{\kappa}B-{\alpha}$, which is an inhibitor of $NF{\kappa}B$. Moreover, SFA also inhibited induction of MAPKs (JNK, p38) and $NF{\kappa}B$ promoter-mediated luciferase activity. Taken together, these results suggest that SFA could be used as a treatment for mast cell-derived allergic inflammatory diseases.

• 대한암한의학회지
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• 제25권2호
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• pp.1-11
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• 2020

Objectives: The effectiveness of acupuncture on cancer pain is relatively well established, while there have been few clinical studies on pharmacopuncture on that. This research was aimed to investigate a trend of pharmacopuncture treatment for cancer pain and to propose information for further research. Methods: Clinical studies on pharmacopuncture for cancer pain were collected from 5 Korean medical databases. And the studies were analyzed by classifications of cancer, chief complaints, interventions, treating skills, additional treatments, treatment session, outcome measures, results and adverse effects. Results: The literatures were 8 case reports and 1 randomized controlled trial. Interventions were pharmacopunctures of soyeom, mountain ginseng, Harpagophyti Radix, snake venom, Trionycis Carapax, bee venom, Aconitum Ciliare Decaisne. Treatment skills, procedures, and indications of each pharmacopuncture were different. An adverse effects of bruising, bleeding, mild chilling, sore throat and pain were mentioned on snake venom and bee venom treatment. Conclusions: An appropriate interventions and treatment skills should be selected according to the type of cancer pain. And treatment procedures to ensure safety must be developed.

• 사상체질의학회지
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• 제18권2호
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• pp.83-95
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• 2006

1. Objectives and Methods The purpose of this study was to objectify the diagnosis of Sasang constitution. It analyzed the adult male and female voices into 23factors using PSSC-2004. The study was conducted by subjects inputting 2.5-3 sec of [a] in 586 men and women's voices to PSSC-2004. The statistical analyses are applied to three groups: total group, male group, female group. The group with a total of 586 was composed of 155 Soyangin, 230 Taeumin and 201 Soeumin. The male group was composed with 61 Soyangin, 127 Taeumin and 87 Soeumin. The female group was composed with 94 Soyangin, 103 Taeumin and 114 Soeumin. Taeyangin were excluded for a more accurate statistical analysis. 2. Results (I) In total group, Taeumin's peak sum was significantly high compared with the others(P=0.021). It was significant for distinction between Taeumin and Soyangin at the result of post mortem. (2) In total group, the Soyangin's rank6, rank7 and rank8 were significantly high compared with the others (P=0.050)(0.043)(0.034). (3) In total group, the Soyangin's rank9 was significantly high compared with the others(P=0.025). It was significant for distinction between Taeumin and Soyangin at the result of post mortem. (4) In male group, the Soyangin's code3 was significantly high compared with the others(P=0.050). (5) In male group, the Soyangin's code1 was significantly low compared with the others(P=0.004). It was significant for distinction between Taeumin and Soyangin at the result of post mortem. (6) In male group, the Soyangin's rank1, rank2, rank3 and rank4 were significantly high compared with the others(P=0.017)(0.008) (0.005)(0.002). They were significant for distinction between Taeumin and Soyangin at the result of post mortem. (7) In female group, the Taeumin's code1 was significantly low compared with the others(P=0.016). It was significant for distinction between Taeumin and Soeumin at the result of post mortem. 3. Conclusion From above result, there is the possibility of efficiency standard gide for constitutional diagnosis by analyzation of the voices.