• Archives of Pharmacal Research
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• v.28 no.7
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• pp.848-853
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• 2005

Synurus deltoides was previously found to possess significant anti-inflammatory activity especially against chronic inflammation, and strong analgesic activity in vivo. In this study, new anti-inflammatory formulation containing S. deltoides extract as a major ingredient was prepared and in vivo activity was evaluated. The plausible action mechanism was also investigated. The new formulation (SAG) contains 1 part of S. deltoides extract, 0.9 part of Angelica gigas extract and 0.9 part of glucosamine sulfate (w/w). SAG inhibited dose-dependently edematic response of arachidonic acid (AA)- and 12-O-tetradecanoyl 13-acetate (TPA)-induced ear edema in mice, which is an animal model of acute inflammation. SAG showed 44.1 % inhibition of AA-induced ear edema at an oral dose of 50 mg/kg. In an animal model of chronic inflammation, SAG clearly reduced the edematic response of 7 -day model of multiple treatment of TPA (38.1 % inhibition at 200 mg/kg/day). Furthermore, SAG (50-800 mg/kg/day) as well as S. deltoides extract (285 mg/kg/day) significantly inhibited prostaglandin $E_2$ production from the skin lesion of the animals of 7-day model. These results were well correlated with in vitro finding that SAG as well as S. deltoides extract reduced cyclooxygenase (COX)-1- and COX-2-induced prostanoid production, measured in mouse bone marrow-derived mast cells. Therefore, these results suggest that SAG possesses anti-inflammatory activity in vivo against acute as well as chronic inflammatory animal models at least in part by inhibition of prostaglandin production through COX-1/COX-2 inhibition. And COX inhibition of SAG is possibly contributed by S. deltoides extract among the ingredients. Although the anti-inflammatory potencies of SAG were less than those of currently used anti-inflammatory drugs, this formulation may have beneficial effect on inflammatory disorders as a neutraceutical.

• Journal of Korean Neurosurgical Society
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• v.63 no.6
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• pp.707-716
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• 2020

Objective : The function of B7H3, a member of the B7 family of proteins, in neuroblastoma (NB) remains poorly characterized. Here we examine the expression pattern of B7H3 in clinical NB specimens and characterize the phenotype of B7H3 knock-down in NB cell line. Methods : Immunohistochemical (IHC) staining was carried out to assess the expression of B7H3 in clinical NB specimens. Survival association was analyzed using five Gene Expression Omnibus (GEO) datasets (GSE85047, GSE45480, GSE62564, GSE16476, GSE49710). Clonogenic survival and flow cytometry were performed after B7H3 knockdown to assess the cellular proliferation and cell survival in vitro. Impact of B7H3 silencing on NB growth was examined in vivo using the SH-SY5Y xenograft model. Results : On IHC staining, B7H3 was widely expressed in clinical NB specimens. Analysis of the transcriptional profiles of five GEO datasets clinically annotated NB specimens revealed that decreased B7H3 expression was associated with improved overall survival. B7H3 knockdown suppressed the proliferation of the SH-SY5Y NB model in vitro and in vivo. Cell cycle analysis revealed that B7H3 silencing induced G1/S arrest. This arrest was associated with the suppression of E2F1 expression and induction of Rb expression. Conclusion : Our results demonstrate that B7H3 expression correlate with clinical survival in NB patients. Preliminary studies suggest that B7H3 may mediate the G1/S transition.

• Transactions of Materials Processing
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• v.21 no.7
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• pp.420-425
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• 2012

A new model is suggested for the prediction of radial displacements of a roll in order to analyze multi-high rolling mills. The model was developed from predictions based on finite element simulations. This model utilizes the compliance coefficient, which is expressed as a function of three dimensionless parameters, and is approximated by using the same interpolation function as used in the finite element method. The prediction accuracy of the model is demonstrated through comparison with the predictions from the FE model.

• International Journal of Railway
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• v.7 no.4
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• pp.109-116
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• 2014

For optimization of a low-noise track system, rail vibration and noise radiation needs to be investigated. The main influencing parameters for the noise radiation and the quantitative results of every track system can be obtained using a calculation model of generation and radiation of railway noise. This kind of model includes contact modeling and the calculation model of the dynamic properties of the wheel and the rail. This study used a nonlinear wheel/rail interaction model in the time domain to investigate the excitation of the rolling noise. Wheel/rail response is determined by time integrating Green's function of the rail together with force impulses from the wheel/rail contact. This model and the results of the study can be used for supporting calculation with the conventional model by an addition of the contributions due to nonlinearities to the roughness spectrum.

• Journal of the Korean Society for Railway
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• v.7 no.3
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• pp.180-185
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• 2004

The present study investigates the effect of fire growth model on fire development characteristics in a carriage. The parallel processing version of FDS code is used to simulate the fire driven flow in a carriage and two types of fire growth model which are flame spread model and t$^2$ model are examined for the same geometrical condition. The heat release rates(HRR) of both model are similar each other until 30 s after ignition, but the flame spread model predicts 5 times higher than those of the t$^2$ fire model during the quasi-steady fire period. Maximum heat release rate in the case of flame spread model reaches about to 12 MW at 100 s after fire ignition. Also, various database of fire properties for combustible materials and more elaborate combustion model considering the flame spreading phenomena are required for better predictions of fire development characteristics using numerical simulation.

• SUVANNABHUMI
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• v.7 no.2
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• pp.177-196
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• 2015

This study on Mahāsammata Model of Kingship in Mrauk U Period from the 15^th to 18^th centuries attempts to demonstrate how the kings of Mrauk U or royal officials tried to claim this legitimating model of kingship and how they accepted this model of kingship and under what conditions the legitimate order of this model was lost. Vital to the adaptation of Mahāsammata model of kingship in the Mrauk U period is the claim that Mrauk U's rulers were direct lineal descendants of the first Buddhist king of the world, Mahāsammata and thence the clan of Gotama Buddha, Sākiya clan. This ideological model of kingship has a recognizable effect on the political stability of Mrauk U kingdom. While the Mahāsammata model of kingship performed as a belief of legitimizing kingship within the arena of royal court, the kings of Mrauk U tried to perform the related models of Mahāsammata, the ideal models of Buddhist kingship as dhammarāja and a cakkavatti. However, the conditions that fail to maintain the Mahāsammata model of kingship saw the weakening of the other related models of kingship, which eventually led to the decline of the kingdom.

• Journal of the Korean Society of Clothing and Textiles
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• v.25 no.7
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• pp.1215-1226
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• 2001

The purpose of this study is to develop a model of adolescent's conspicuous consumption on clothes. For this study, questionnaires were administered to 400 adolescents in Kwang-Ju. Employing a sample of 283, data were analyzed by using the structural equation model of the Lisrel analysis, in addition to cronbach's alpha coefficient for reliability and confirmatory factor analysis for validity. The results of this study was found that a conceptual model for adolescent's conspicuous consumption on clothes was judged to provide acceptable goodness of fit. Specifically, materialism and clothing conformity had a direct effect on conspicuous consumption on clothes, and materialism, hedonic shopping orientation and clothing interests had a indirect effect on conspicuous consumption on clothes. The results indicated that clothing conformity had important influence on conspicuous consumption and its influence on adolescent's conspicuous consumption was mediated by materialism, hedonic shipping orientation and clothing interests.

• Korean Journal of Child Studies
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• v.20 no.4
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• pp.195-211
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• 1999

This study investigated developmental trends and sex differences in the relation between children's self-esteem and relevant variables by proposing and testing the causal model. The 763 children who participated in the study were 3rd, 5th, and 7th grade students. Major findings were that physical appearance was the most powerful determinant of self-esteem. Students with high self-esteem were more learning oriented, used more motivational behaviors and had higher academic achievement. The findings from this analysis of the causal model revealed remarkable developmental differentiation and stability.

• Journal of the Korean Society for Industrial and Applied Mathematics
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• v.7 no.1
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• pp.79-86
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• 2003

A myoelectric signal, under sustained isometric contraction of muscle the modelled as the output of a linear time-varying system whose input is constant number of pulse train. The proposed model considered localized muscle fatigue by metabolic by-products during sustained fatiguing contraction. To characterize muscle fatiguing model of myoelectric signal, We calculated median frequency of generated signal as fatiguing index of muscle during sustained isometric contraction.

• International Journal of Advanced Culture Technology
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• v.7 no.4
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• pp.208-221
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• 2019

The inference for this research was concentrated on client's data protection in cloud computing i.e. data storages protection problems and how to limit unauthenticated access to info by developing access control model then accessible preparations were introduce after that an access control model was recommend. Cloud computing might refer as technology base on internet, having share, adaptable authority that might be utilized as organization by clients. Compositely cloud computing is software's and hardware's are conveying by internet as a service. It is a remarkable technology get well known because of minimal efforts, adaptability and versatility according to client's necessity. Regardless its prevalence large administration, propositions are reluctant to proceed onward cloud computing because of protection problems, particularly client's info protection. Management have communicated worries overs info protection as their classified and delicate info should be put away by specialist management at any areas all around. Several access models were accessible, yet those models do not satisfy the protection obligations as per services producers and cloud is always under assaults of hackers and data integrity, accessibility and protection were traded off. This research presented a model keep in aspect the requirement of services producers that upgrading the info protection in items of integrity, accessibility and security. The developed model helped the reluctant clients to effectively choosing to move on cloud while considerate the uncertainty related with cloud computing.