• Journal of Gastric Cancer
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• v.8 no.4
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• pp.169-175
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• 2008

Purpose: The main target of 5-fluorouracil (5-FU) is thymidylate synthase (TS). A high TS expression has been identified as promoting resistance to 5-FU. For colorectal cancers, the response to 5-FU based adjuvant chemotherapy is different according to the microsatellite instability (MSI) status. The reports on the relationship between MSI and the TS expression in colorectal cancer have been inconsistent. No data is available for gastric cancer regarding the relationship between MSI and the TS expression. Therefore, we studied the relationship between MSI and the TS expression in gastric cancer. Materials and Methods: Ninety-nine consecutive patients who underwent radical gastrectomy for gastric cancer from January 2004 to May 2006 at Bundang CHA hospital were studied. MSI was assessed for five markers (BAT25, BAT26, D2S123, D5S346, and D17S250) by PCR and with using an ABI prism 3100 Genetic analyzer. The TS expression was analyzed by immunohistochemistry with using mouse anti-thymidylate synthase monoclonal antibody to the TS 106 clone. Results: Out of the ninety-nine patients, MSS/MSI-L was detected in 92 (92.1%) cases and 7 cases (7.1%) were MSI-H. A negative TS expression was found in 46 (46.5%) cases, a low TS expression was found in 33 (33.3%) and a high TS expression was found in 20 (20.2%). Out of 92 MSS/MSI-L patients, the number of patients with negative, low and high TS expressions were 46 (50%), 30 (32.6%) and 16 (17.4%), respectively. Out of the 7 MSI-H patients, the number of patients with negative, low and high TS expressions were 0 (0%), 3 (42.9%) and 4 (57.1%), respectively. The relationship between MSI-H and a high TS expression was statistically significant. Conclusion: Gastric cancer with MSI-H showed higher levels of a TS expression compared to the gastric cancer with MSS/MSI-L.

• 한국전산유체공학회:학술대회논문집
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• 2008.08a
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• pp.35.5-35.5
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• 2008

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.6
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• pp.3565-3568
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• 2013

Background: Cholangiocarcinoma is the most common cancer in males in Thailand. The outcome is poor although systemic chemotherapy has been used in attempts to improve disease control, quality of life and prolong survival in patient with unresectable and advanced disease. Materials and Methods: In this retrospective study the medical records of all patients diagnosed as having unresectable and metastatic cholangiocarcinoma and receiving systemic chemotherapy at Udonthani Cancer Hospital during January 2007 to December 2010 were reviewed. Results: Among the total of 105 patients, 21 received gemcitabine-based chemotherapy and 84 5FU-based chemotherapy. Most received platinum doublet regimens. 5FU-based regimens yielded an overall response rate (tumor control) of 23.8% and a median survival of 7.2 months while gemcitabine-based regimens yielded an overall response rate (tumor control) 19.1% and a median survival of 10.0 months. Conclusions: Tumor control and survival of patient with advanced cholangiocarcinoma treated with gemcitabine-based and 5FU-based chemotherapy do not markedly differ.

• Asian Oncology Nursing
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• v.10 no.1
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• pp.10-18
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• 2010

Purpose: This study was intended to identify the patterns of fatigue and its related factors in patients with stomach cancer during chemotherapy. Methods: Thirty participants (24 males and 6 females) were recruited for this study which utilized a longitudinal and descriptive approach. The research instruments included the Revised Piper Fatigue Scale, Symptom Distress Scale, and Linear Analogue Self Assessment Scale. The participants received 5-FU and Adriamycin at the first week and 5-FU only at the second and third week. The instruments were measured six times in total. The data were analyzed using SPSS 17.0. Results: It was found that fatigue scores in patients with stomach cancer, receiving 5-FU and Adriamycin (FA) regimen, reached the highest level on the third day (F=9.37, p=.024) after the initial infusion, and decreased gradually afterward. The symptom and psychological distress scores illustrated very similar pattern. The concept of multidimensionality of fatigue in patients with stomach cancer was supported in this study, showing that all four dimensions of the scale were positively correlated. Conclusion: The results of this study provided useful information of patients with stomach cancer on fatigue and other related symptoms which they experienced during weekly scheduled chemotherapy with FA regimen.

• The Journal of Korean Medical History
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• v.29 no.1
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• pp.11-31
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• 2016

Objectives : The goal of this paper is to research what affected diagrams of lung originated from Ming Tang Zang Fu Tu during the time they were changed in. Methods : Diagrams of lung in Traditional Chinese and Japanese medical books had been collected as many as possible. Besides being grouped by Huang Longxiang (黃龍祥)'s classification, they were analysed by 4 form factors, e.g. shape, number, veins and petiole of leafs. Results : Reliability of this methods had been checked on by the correspondence with Huang's 14 standard books, before 29 diagrams of lung were selected from 33 books including 13 books that Huang had already made his proposal. The lobes in most of diagrams resembled 6 lanceolate or long oval leafs, or a maple leaf with 5 indentations. In most of diagrams, veins of leafs were described variously, more or less than 9 nodes often drew in petioles. Conclusions : Suwen (素問), Nan Jing (難經) and Wang Bing would had steadily worked on 29 diagrams of lung, since diagram of lung stemmed from Ming Tang Zang Fu Tu, went out into the world in Zhen Jiu Ju Ying (鍼灸聚英). But they were not drawn through dissection during same periods.

• The Bulletin of The Korean Astronomical Society
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• v.40 no.1
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• pp.81.2-81.2
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• 2015

FU Orionis 형 천체는 태양 질량의 2배 이하인 T Tauri 별 중에서도 급격한 밝기 변화를 보이는 별들로서, 광도 증가폭이 최대 5등급에 이르는 것으로 알려져 있다. 이러한 현상의 원인은 FU Orionis를 둘러싼 강착 원반에서 나타나는 불안정성에 의해, 원반 안쪽의 물질이 한꺼번에 중심별로 쏟아져 내리기 때문인 것으로 분석된다. V1057 Cyg는 FU Orionis 형 천체 중 하나로, 1969년에 급격한 밝기 변화를 일으키며, 기존의 16등급에서 변화 직후 9등급 후반에 이르는 광도 증가를 보였다. 우리는 V, R, I 필터 대역에서 관측을 수행하였으며, 본 발표에서는 2013 ~ 2014년에 걸쳐 소백산, 레몬산 천문대 및 경희천문대에서 관측한 결과를 보고한다.

• Journal of the Korean Society of Clothing and Textiles
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• v.18 no.4
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• pp.566-573
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• 1994

The Purpose of this study is to the organization principles of mourning dresses in Confucianism. The results of this thesis summarised as follow: The organization of mourning dresses laying stress on LiGi, the book of rites has six kinds of contents, Fushu. It is established on the rules and regulations of a religious sect in Confucianism, ZongFa. The succession ideology of ZongFaism has played on important parts in formation and conservation of the large familly system by the medium of mourning dresses with 5 classified costumes, WuFu. And the familly system in mourning dresses makes the rules in kindship category and primogeniture by WuFu grades.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.8
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• pp.3395-3402
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• 2015

Background: Preoperative 5-fluorouracil (5-FU)-based chemoradiotherapy is a standard treatment for locally advanced colorectal cancer (CRC). However, CRC cells often develop chemoradiation resistance (CRR). Recent studies have shown that long non-coding RNA (lncRNA) plays critical roles in a myriad of biological processes and human diseases, as well as chemotherapy resistance. Since the roles of lncRNAs in 5-FU-based CRR in human CRC cells remain unknown, they were investigated in this study. Materials and Methods: A 5-FU-based concurrent CRR cell model was established using human CRC cell line HCT116. Microarray expression profiling of lncRNAs and mRNAs was undertaken in parental HCT116 and 5-FU-based CRR cell lines. Results: In total, 2,662 differentially expressed lncRNAs and 2,398 mRNAs were identified in 5-FU-based CRR HCT116 cells when compared with those in parental HCT116. Moreover, 6 lncRNAs and 6 mRNAs found to be differentially expressed were validated by quantitative real time PCR (qRT-PCR). Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis for the differentially expressed mRNAs indicated involvement of many, such as Jak-STAT, PI3K-Akt and NF-kappa B signaling pathways. To better understand the molecular basis of 5-FU-based CRR in CRC cells, correlated expression networks were constructed based on 8 intergenic lncRNAs and their nearby coding genes. Conclusions: Changes in lncRNA expression are involved in 5-FU-based CRR in CRC cells. These findings may provide novel insight for the prognosis and prediction of response to therapy in CRC patients.

• Mycobiology
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• v.49 no.3
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• pp.213-222
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• 2021

Two new species of Fulvifomes are described from specimens collected in rainforests of Nonggang Nature Reserve of southern China, based on morphological characteristics and molecular phylogenetic analysis of the internal transcribed spacer (ITS) and nuclear large subunit ribosomal DNA (nLSU) sequences. Fulvifomes nonggangensis sp. nov. is characterized by perennial, sessile and solitary basidiocarps, applanate pileus, small cystidioles of 9.9-15.4 × 2.9-3.5 ㎛, large pores of 5-6 per mm, a dimitic hyphal system, and broadly ellipsoid basidiospores of 4.3-5.3 × 3.3-4.2 ㎛. F. tubogeneratus sp. nov. is characterized by perennial, sessile, and imbricate basidiocarps, a duplex context, small pores of 7-8 per mm, a dimitic hyphal system, and ovoid to subglobose basidiospores of 5.72 × 5.00 ㎛.

• IEIE Transactions on Smart Processing and Computing
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• v.3 no.5
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• pp.251-258
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• 2014

This paper proposes an efficient token flow design methodology for a decoder in the MPEG Reconfigurable Media Coding (RMC) framework. The MPEG RMC framework facilitates a decoder to be configured with a set of modules called functional units (FUs) that are connected by tokens. Such a modular design philosophy of the MPEG RMC framework enables the reusability and reconfigurability of FUs. One drawback of the MPEG RMC framework is that the decoder performance can be affected by increasing the token transmissions between FUs. The proposed method improves the design of the FU network in the RMC framework toward real-time decoder implementation. In the proposed method, the merging of FU, the separation of token flow, and the merging of token transactions are applied to minimize the token traffic between FUs. The experimental results of the MPEG-4 SP decoder show that the proposed method reduces the total decoding time by up to 77 percent compared to the design of the RMC simulation model.