• Journal of the Korea Institute of Building Construction
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• v.4 no.3
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• pp.153-159
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• 2004

The brand value of apartment which affects not only sale percent and profit but also the worth of real estate is raised as an important point of sale competition in the apartment market. But now the market is occupied by a few construction companies, which have well recognized brand. So it's difficult for a construction company without brand to enter the apartment market because of consumer's ignorance. domestic construction companies are spending lots of money and effort to advertise their characteristic brandapartment based on classified consumer's desire and offer consumers what they want. Therefor, This study investigated the factors of recently characteristic brandapartment focusing on design, environment, materials, home automation and surveyed residents preference of a brand by P.O.E methods. Based on such results of survey, this study suggest the basically reference information on characteristic strategy of an brandapartment.

• Journal of Hydrogen and New Energy
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• v.22 no.5
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• pp.625-633
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• 2011

Characteristics of a commercial metal hydride (MH) hydrogen supply system have been investigated and an operating strategy was developed based on the experimental data. As a prior step, charging/discharging capacity, thermal properties such as heat capacity, heat of reaction of MH system were experimentally measured. And then P-C-T data for various operating conditions were collected and a correlation between P, C and T predicting the behavior of MH was derived. Based on the basic experimental data, an operating strategy of MH system was developed, in which the hot water temperature supplied into the water jacket of MH was controlled depending on the pressure of MH, thereby the pressure of MH could be maintained at a suitable range. By adjusting the temperature of hot water from $40^{\circ}C$ to $60^{\circ}C$, the maximum discharging capacity of hydrogen could be increased by 4.7%, and consequently more stable hydrogen supply and longer operation time of fuel cell system could be achieved.

• International Area Studies Review
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• v.13 no.2
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• pp.770-788
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• 2009

This paper attempts to develop STP Strategy of EXPO 2012 Yeosu for attracting tourists. STP in marketing strategy refers to the process of market segmentation, market targeting, and positioning. I tested four demographic variables(age, occupation, nationality, and sex) to segment the market or the visitors of EXPO 2012 Yeosu effectively. The statistical result shows that age, occupation, and nationality are significant. Based on the three demographic factors and the visitor's purpose, I classified the expected visitors of EXPO into 12 groups, and selected 6 targeted groups: a group of Korean students with the purpose of study, a group of Korean professionals with the purpose of business, a group of foreign students with the purpose of study, a group of foreign professionals with the purpose of business, a group of Korean people in general with the purpose of tourism, and a group of foreign people in general with the purpose of tourism. In this paper, I have suggested a differentiated marketing mix for six targeted groups each.

• Molecules and Cells
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• v.45 no.10
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• pp.718-728
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• 2022

Splicing factor B subunit 4 (SF3B4), a component of the U2-pre-mRNA spliceosomal complex, contributes to tumorigenesis in several types of tumors. However, the oncogenic potential of SF3B4 in lung cancer has not yet been determined. The in vivo expression profiles of SF3B4 in non-small cell lung cancer (NSCLC) from publicly available data revealed a significant increase in SF3B4 expression in tumor tissues compared to that in normal tissues. The impact of SF3B4 deletion on the growth of NSCLC cells was determined using a siRNA strategy in A549 lung adenocarcinoma cells. SF3B4 silencing resulted in marked retardation of the A549 cell proliferation, accompanied by the accumulation of cells at the G0/G1 phase and increased expression of p27, p21, and p53. Double knockdown of SF3B4 and p53 resulted in the restoration of p21 expression and partial recovery of cell proliferation, indicating that the p53/p21 axis is involved, at least in part, in the SF3B4-mediated regulation of A549 cell proliferation. We also provided ubiquitination factor E4B (UBE4B) is essential for p53 accumulation after SF3B4 depletion based on followings. First, co-immunoprecipitation showed that SF3B4 interacts with UBE4B. Furthermore, UBE4B levels were decreased by SF3B4 depletion. UBE4B depletion, in turn, reproduced the outcome of SF3B4 depletion, including reduction of polyubiquitinated p53 levels, subsequent induction of p53/p21 and p27, and proliferation retardation. Collectively, our findings indicate the important role of SF3B4 in the regulation of A549 cell proliferation through the UBE4B/p53/p21 axis and p27, implicating the therapeutic strategies for NSCLC targeting SF3B4 and UBE4B.

• Journal of Ginseng Research
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• v.46 no.2
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• pp.248-254
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• 2022

Background: Zinc homeostasis is essential for human health and is regulated by several zinc transporters including ZIP and ZnT. ZIP4 is expressed in the small intestine and is important for zinc absorption from the diet. We investigated in the present study the effects of Panax ginseng (P. ginseng) extract on modulating Zip4 expression and cellular zinc levels in mouse Hepa cells. Methods: Hepa cells were transfected with a luciferase reporter plasmid that contains metal-responsive elements, incubated with P. ginseng extract, and luciferase activity was measured. Using ⁶⁵ZnCl₂, zinc uptake in P. ginseng-treated cells was measured. The expression of Zip4 mRNA and protein in Hepa cells was also investigated. Finally, using a luciferase reporter assay system, the effects of several ginsenosides were monitored. Results: The luciferase activity in cells incubated with P. ginseng extract was significantly higher than that of control cells cultured in normal medium. Hepa cells treated with P. ginseng extract exhibited higher zinc uptake. P. ginseng extract induced Zip4 mRNA expression, which resulted in an enhancement of Zip4 protein expression. Furthermore, some ginsenosides, such as ginsenoside Rc and Re, enhanced luciferase activity driven by intracellular zinc levels. Conclusion: P. ginseng extract induced Zip4 expression at the mRNA and protein level and resulted in higher zinc uptake in Hepa cells. Some ginsenosides facilitated zinc influx. On the basis of these results, we suggest a novel effect of P. ginseng on Zip4-mediated zinc influx, which may provide a new strategy for preventing zinc deficiency.

• Nutrition Research and Practice
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• v.15 no.5
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• pp.639-654
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• 2021

BACKGROUND/OBJECTIVES: Many adolescents in developing countries skip breakfast. Innovative nutrition education (NE) strategies are needed to enhance knowledge and skills related to the breakfasts of adolescents in a low socioeconomic setting. The objective was to evaluate short- and long-term effects of a multi-strategy, school-based NE intervention on adolescents' breakfast-related personal influences and behaviors. SUBJECTS/METHODS: An intervention study with a cluster randomized controlled trial design was conducted in 4 senior high schools in Makassar, Indonesia. The multi-strategy NE intervention was delivered for 3 months. Data were collected using a self-administered questionnaire and a 3-day breakfast recall (face-to-face interview). Wilcoxon, McNemar, and Mann-Whitney tests were used to determine intra- and intergroup differences. RESULTS: Unlike knowledge, improvement was observed in attitude and self-efficacy scores in the intervention groups (IGs) (P < 0.01); however, no significant changes were observed in the control group (CG). More students showed improved motivation in the IG than in the CG (P > 0.05). Changes in breakfast frequency and macronutrient intake from breakfast were greater in the IG than in the CG (P < 0.05). CONCLUSIONS: A multi-strategy NE intervention is effective in producing positive changes in breakfast-related attitude, self-efficacy, and motivation of adolescents from a low-middle socioeconomic setting. The intervention improved breakfast frequency and nutrient intake. This intervention has promise for sustaining the observed changes over the long-term.

• Korean Journal of Health Education and Promotion
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• v.30 no.4
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• pp.125-134
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• 2013

Objectives: The aim of this study is to develop the strategy of promoting participation on physical activity programs among the disabled through analysis of satisfaction on the Welfare Center for the Disabled-based program. Methods: The subjects were 151 disabled people who had physical disability or brain disorder. They had participated on the physical activity programs which were opened in 13 welfare centers for the disabled of Daegu and Gyeongbuk. The data were collected by the survey for 2 weeks in May, 2011. Results: There were no differences in the satisfaction on physical activity programs by general characteristics and health status. As for cognitive factors, it were significantly different on the satisfaction by the importance of physical activity and the fitness maintenance factor (p<0.05, p<0.01). Significant differences were found in the satisfaction by the participating attitude and the participation motives, such as goal-oriented and activity-oriented motives. It were significantly different on the satisfaction by the duration, frequency per week, time per once, and components in terms of the physical activity program. Conclusions: To revitalize the physical activity-for-all project for the disabled, it needs to develop the strategy and to enhance the health education to improve their health status.

• The Journal of Korean Academic Society of Nursing Education
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• v.18 no.2
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• pp.239-247
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• 2012

Purpose: This study is to assess the level of student perceptions, academic achievement, satisfaction, and their relationships in a medical-surgical nursing course using team-based learning (TBL). Method: Four-hour TBL sessions were given in a structured three-phase sequence in a cohort of 261 second year nursing students. Results: Mean perceptions of TBL was $6.64{\pm}5.11$, and $8.30{\pm}4.11$ for perceptions of teamwork. On a 7-point scale, the mean satisfaction score was $4.85{\pm}1.41$, and 64.0% of nursing students were satisfied with TBL compared to lecture. Group readiness assurance test score was significantly higher than individual readiness assurance test score (t=-16.76, p<.001). Perceptions of TBL (F=1.40, p=.245), perceptions of team work (F=1.55, p=.202) and satisfaction (F=0.81, p=.489) was not different by the level of students' academic achievement on items related TBL. Conclusion: Results indicates that TBL was an effective instructional strategy including favorable perceptions and satisfaction for nursing students. TBL could be an adjunct educational strategy for undergraduate nursing education.

• Journal of the Korea Convergence Society
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• v.10 no.8
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• pp.27-36
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• 2019

We investigated the relationship between depression, suicide risk, and related nutrient intakes in 50-60 year old Korean osteoarthritis patients. In the $6^{th}$ National Health and Nutrition Examination Survey, 4,112 people who have been diagnosed with osteoarthritis by a doctor were analysed. Anxiety and depression level, pain and discomport level, depressive mood and suicidal ideation were significantly higher in osteoarthritis group compared to the non-osteoarthritis group(p<0.05). Dietary intake of energy, protein, n-3 and n-6 fatty acids, calcium, phosphate, thiamin, riboflavin, and niacin were significantly higher in the normal group compared with all the osteoarthritis, depression and suicidal ideation groups(p<0.05). The presented convergence strategy would be applied for emotional health and health care improvement of osteoarthritis patients.

• The Korean Journal of Rehabilitation Nursing
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• v.4 no.1
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• pp.46-57
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• 2001

This study was done to investigate of instrumental activities of daily living(IADL) and quality of life and their relationships between the elderly. Data were collected from 150 elderly home residents. The data were collected from December 1st to December 20th, 2000. Structured questionnaires developed by Lawton & Brody and by Ro were adopted to measure IADL and Quality of life. Data were analyzed for percentage, means, t-test, ANOVA and Parson correlation coefficients using the SPSS program. The results were as follows: 1. The average score of the level of IADL was $20.68{\pm}2.98$ ($M{\pm}SD$) with a range of 7-26. 2. The average score of the level of Quality of life was 2. $96{\pm}0.25$ ($M{\pm}SD$). In the average score of each lower area, highest score was 3.22 for neighbor relationship and family relationship and then 3.00 for self-esteem, 2.95 for economic status, 2.86 for emotional status, and 2.85, lowest score, for physical condition and function. 3. Comparing IADL and Quality of life with general characteristics, IADL showed that there were significant difference in age(t=2.927, p=0.036) and separated children contact frequency(t=2.482, p=0.046), while Quality of life showed that there were significant difference in spouse existence(t=2.334, p=0.021), religion(t=4.089, p=0.008), family style(t=3.285, p=0.040), children number living together(t=5.332, p=0.006), communication with separated children frequency(t=4.129, p=0.003), and separated children contact frequency(t=3.908, p=0.005). 4. There was also significant positive correlation between IADL and Quality of life. The above results show that neighbor relationship and family relationship which have greatly an influence on IADL and Quality of life are very important. The elderly should be helped to satisfy their basic desire and show their potential living together with the younger generation interdependently without being isolated from family and society. Therefore, the nursing strategy that enhance IADL and Quality of life are needed and the nursing strategy that can improve IADL and Quality of life of Elderly Home Residents should be developed.