• Title/Summary/Keyword: 4-AP

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Effects of Acorn (Quercus acutissima CARR.) Supplementation on the Level of Acetylcholine and Its Related Enzyme Activities in the Brain of Dementia Mouse Model (도토리 급여가 치매모델 마우스 뇌조직의 아세틸콜린 및 관련효소 활성에 미치는 영향)

  • Lee, Sung-Hyeon;Kim, Dae-Ik;Cho, So-Yong;Jung, Hyun-Jin;Cho, Soo-Muk;Park, Hong-Ju;Lillehoj Hyun S.
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.34 no.5
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    • pp.738-742
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    • 2005
  • This study was designed to investigate the anti-dementia effects of acorn (Quercus acutissima CARR.) in brain of the mouse. Dementia model was induced by administration of scopolamin (30 mg/kg BW) Male ICR mouse $(30{\pm}2g\;BW)$ were fed basal diet (control group), and experimental diets (AP-5 and AP-10 groups) added $5\%\;and\;10\%$ of dried acorn powder to basal diet for 8 months. Acetylcholine content significantly increase in AP-5 and AP-10 groups ($4.2\%\;and\;11.3\%$, respectively) compared with control group. Acetylcholinesterase activities were significantly inhibited ($13.5\%\;and\;17.6\%$, respectively) in brain of AP-5 and AP-10 groups. Monoamine oxidase-B (MAO-B) activities were significantly inhibited ($10.0\%\;and\;12.7\%$, respectively) in brain of AP-S and AP-10 groups. These results suggest that acorn (Q. acutissima CARR.) may play an effective role in an attenuating various age-related changes such as dementia including learning and memory impairments in brain.

Utilization of Element-doping Titania-impregnated Granular Activated Carbon in a Plug-flow System for Removal of BTEX

  • Jo, Wan-Kuen;Shin, Seung-Ho;Hwang, Eun-Song;Yang, Sung-Bong
    • Asian Journal of Atmospheric Environment
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    • v.4 no.3
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    • pp.177-188
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    • 2010
  • The use of an activated carbon (AC) system alone has the limitation that the pollutants are not eliminated but only transferred to another phase with the consumed AC becoming hazardous waste itself. Therefore, the present study investigated the feasibility of using a combined system of granular AC (GAC) with S-doped visible-light-induced $TiO_2$ (GAC/S-doped $TiO_2$) to clean monocyclic aromatic hydrocarbons (MAHs) with concentrations at $\leq$ 3 mg $m^{-3}$, using a continuous air-flow reactor. This study conducted three different experiments: an adsorption test of pure GAC and GAC/S-doped $TiO_2$; a long-term adsorptional photocatalytic (AP) activity test of GAC/S-doped $TiO_2$; and an AP activity test of GAC/S-doped $TiO_2$ under different conditions. For the AP activity test, three parameters were evaluated: various weights of GAC/S-doped $TiO_2$ (0.9, 4.4, and 8.9 g); various flow rates (FRs) (0.5, 1 and 2 L $min^{-1}$); and various input concentrations (ICs) of the target MAHs (0.1, 1, 2 and 3 mg $m^{-3}$). The adsorption efficiencies were similar for the pure GAC and GAC/S-doped $TiO_2$ reactors, suggesting that S-doped $TiO_2$ particles on GAC surfaces do not significantly interfere with the adsorption capacity of GAC. Benzene exhibited a clear AP activity, whereas no other target MAHs did. In most cases, the AP efficiencies for the target MAHs did not significantly vary with an increase in weight, thereby suggesting that, under the weight range tested in this study, the weights or FRs are not important parameters for AP efficiency. However, ICs did influence the AP efficiencies.

Ignition of Solid Propellants at Subatmospheric Pressures (대기압 이하에서 고체 추진제의 점화 특성 향상 연구)

  • Kim, In-Cul;Ryoo, Baek-Neung;Jung, Jung-Yong
    • Journal of the Korean Society of Propulsion Engineers
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    • v.10 no.3
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    • pp.67-72
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    • 2006
  • Several propellants were investigated experimentally for ignition characteristics in subatmospheric pressure. The threshold ignition pressure was 4 psia for HTPB/AP composite propellant. The partial replacement of AP in HTPB/AP propellant by $5{\sim}l5%$ of HMX, HNIW showed that the improvements in ignition delay was over 50% and the threshold pressure was below 0.4 psia. This appears to be due to the characteristics of HMX and HNIW exothermic dissociated at the temperature(${\sim}220^{\circ}C$) love. than that of AP. The ignition substance $B/KNO_3$ was coated thinly on the propellant surface for better ignition performance. As a result, ignition delay time of 15% was improved. NC is applied to $B/KNO_3$ ignition substance as a secondary binder and $NC-B/KNO_3$ suspension solution is coated to the propellant surface.

Screening of Natural Compounds for Cancer Prevention by Cytotoxicities and AP-1 Reporter Gene Activities (천연물 지표성분들의 세포독성 및 AP-1 활성 평가를 통한 암예방 기능성 탐색)

  • Choi, Bu-Young;Cho, Seok-Cheol
    • Journal of Convergence for Information Technology
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    • v.7 no.6
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    • pp.89-95
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    • 2017
  • Cancer-inducing PMA stimulates cells to increase the expression of transcription factor c-Jun/c-fos and then increase the activity of AP-1 in the nucleus. The activity of AP-1 has been reported to cause cancer. In this study, We conducted cytotoxicity experiments to assess the safety of natural marker compounds and also observed inhibition of activator protein(AP-1) activity to predict cancer-preventing effects. The results of this experiment indicated that arctigenin, manassantin A, and B can predict the development of cancer prevention agents.

STEP 기반 자동차 PDM

  • 오유천
    • Proceedings of the CALSEC Conference
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    • 1997.11a
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    • pp.443-461
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    • 1997
  • ㆍProSTEP, PDES, Inc., and JSTEP announce agreement on PDM Schema ㆍ November 4, 1997 ㆍInteroperable with STEP AP203, AP2l0, AP214, and AP232 ㆍNeutral specification allows for the exchange of the following types - item master data (part identification, approval of part version) - item structure - item classification - item property (mass, costs) - document management (identification, revision… ) - work management (engineering change request, EC order, project) ㆍVendors of PDM systems are asked to join ProSTEP's PDM Round Table and PDES, Inc.'s PDMnet.(omitted)

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The Heterochromatin-1 Phosphorylation Contributes to TPA-Induced AP-1 Expression

  • Choi, Won Jun
    • Biomolecules & Therapeutics
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    • v.22 no.4
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    • pp.308-313
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    • 2014
  • Activator protein-1 (AP-1) is an inducible transcription factor that contributes to the generation of chronic inflammation in response to oxidative and electrophilic stress. Previous studies have demonstrated that the PI3K/Akt1 pathway plays an important role in the transcriptional regulation of AP-1 expression. Although the histone post-translational modifications (PTMs) are assumed to affect the AP-1 transcriptional regulation by the PI3K/Akt pathway, the detailed mechanisms are completely unknown. In the present study, we show that heterochromatin 1 gamma ($HP1{\gamma}$) plays a negative role in TPA-induced c-Jun and c-Fos expression. We show that TPA-induced Akt1 directly phosphorylates $HP1{\gamma}$, abrogates its suppressive function and increases the interaction between histone H3 and 14-3-$3{\varepsilon}$. Collectively, these our data illustrate that the activation of PI3K/Akt pathway may play a permissive role in the recruitment of histone readers or other coactivators on the chromatin, thereby affecting the degree of AP-1 transcription.

Design of WiFi-AP Doppler Detection based Wireless Security Services (WiFi-AP 도플러 검파 기반의 무선 보안서비스 설계)

  • Kang, Min-Goo
    • Journal of Satellite, Information and Communications
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    • v.9 no.4
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    • pp.16-19
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    • 2014
  • In this paper, the beacon signals of WiFi doppler frequency detection based WiFi-AP was designed with the subcarrier between a transmitter and a receiver of WLAN(wireless LAN). We can use such signals to identify human moving as an antenna array and tracking of RF beam. This wireless security services with the combination of WiFi doppler frequency and adaptive beacon time signal was proposed for wireless detection and motion based services.

Properties of HTPB/AP/Butacene propellants (HTPB/AP/Butacene 추진제 특성 연구)

  • Kim Chang-Kee;Yoo Ji-Chang;Hwang Gab-Sung;Yim Yoo-Jin
    • Proceedings of the Korean Society of Propulsion Engineers Conference
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    • v.y2005m4
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    • pp.75-78
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    • 2005
  • The present work has been studied to investigate the effect of formulation on friability of HTPB/AP propellants including Butacene and $Cr_{2}O_3$. The mechanical properties and burning rate of the propellants were measured using Inston tensile tester and strand burner, respectively. Friability was calculated by shot-gun and closed bomb test. The result showed that friability was higher, as the content of Butacene or AP $6{\mu}m$ in the propellant formulations was increased.

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SWoT Service Discovery for CoAP-Based Sensor Networks (CoAP 기반 센서네트워크를 위한 SWoT 서비스 탐색)

  • Yu, Myung-han;Kim, Sangkyung
    • KIPS Transactions on Software and Data Engineering
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    • v.4 no.9
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    • pp.331-336
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    • 2015
  • On the IoT-based sensor networks, users or sensor nodes must perform a Service Discovery (SD) procedure before access to the wanted service. Current approach uses a center-concentrated Resource Directory (RD) servers or P2P technique, but these can cause a point-of-failure or flooding of SD messages. In this paper, we proposes an improved SWoT SD approach for CoAP-based sensor networks, which integrates Social Web of Things (SWoT) concept to current CoAP-based SD approach that makes up for weak points of existing systems. This new approach can perform a function like a keyword or location-based search originated from SNS, which can enhances the usability. Finally, we implemented a real system to evaluate.

Ethanol-induced Activiationof Transcription Factor NF-$\kappa$B and AP-1 in C6 Glial Cells

  • Park, Jae -Won;Shim, Young-Sup
    • Preventive Nutrition and Food Science
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    • v.4 no.3
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    • pp.209-214
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    • 1999
  • In this study, the effectof ethanol and acetaldehyde on DNA binding activities of NF-$textsc{k}$B and AP-1 were evaluated in C6 rat glial cells. Both NF-$textsc{k}$B and AP-1 are important transcription factors for the expression of various cytokines in glial cells. Our data showed that neither ethanol nor acetaldehyde induced conspicuous cell death of C6 cells at clinically realistic concentrations. When the DNA binding activities of nuclear NF-$textsc{k}$B and AP-1 were estimated using electrophoretic mobility shift assay (EMSA), ethanol(0.3%) or acetaldehyde(1mM) induced transient activation of these transcription factors, which attained peak levels at 4~8 hours and declined to basal levels at 12 hours after treatement . The supershift analysis showed that the increased activities of NF-$textsc{k}$B in ethanol/acetaldehyde-treated C6 cells were due to the preferential induction of p65/p50 heterodimer complex. The DNA binding activities of these transcriptional factors decreased below basal levels when cells were cultured with either ethanol or acetaldehyde for 24 hours, and showed the inhibitory effect of chronic ehtanol /acetaldehyde treatment on the activities of these transsriptional factors. Our data indicate that either ethanol or acetaldehyde can induce functional changes of glial cells throught bi-directional modulation of NF-$textsc{k}$B and AP-1 DNA binding activities.

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