• Journal of Periodontal and Implant Science
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• v.30 no.1
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• pp.11-27
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• 2000

The purpose of this study was to evaluate the clinical effects of Dipotassium glycyrrhizinate, Allantoin, Hinokitiol, Cetylpyridinium chloride containing gel($Dentheth^{(R)}$) on periodontitis. 41 patients with sites having pocket depth of 4-6mm were selected for the study. We classified 2 groups which consisted of 21 patients in the test group(exp.) and 20 patients in the control(placebo) respectively. Following a baseline examination, plaque and calculus were removed and then the experimental gel were handed out to the patients and topical application regimens were initiated. During the 4-week experimental period, pocket depth, bleeding on probing, gingival index, plaque index as a clinical parameters were measured in the baseline, 2 weeks, 4 weeks respectively. A questionnaire was delivered to each patients in 2 weeks, 4 weeks respectively. The results were as follows : 1. Probing pocket depth showed a significant difference in the Exp. group compared with the control group in the changes from baseline to 2 weeks(p<0.05), but there was no significant difference between the groups in the changes from baseline to 4 weeks, from 2 weeks to 4 weeks(p<0.05). 2. The Exp. group showed a significant difference compared with the control group in the changes from baseline to 2 weeks, from baseline to 4 weeks, from 2 weeks to 4 weeks in bleeding on probing(p<0.05). 3. The gingival index showed a significant difference compared with the control group in the changes from baseline to 2 weeks, from baseline to 4 weeks, from 2 weeks to 4 weeks after 4 weeks use of a gel(p<0.05). 4. The plaque index showed a significant difference in the Exp. group compared with the control group in the changes from baseline to 2 weeks(p<0.05), but there was no significant difference between the groups in the changes from baseline to 4 weeks, from 2 weeks to 4 weeks(p<0.05). 5. A questionnaire was consisted of 5 kinds as to bleeding, pus discharge, pain, burning sensation, patient's satisfaction and all of the questions showed a significant difference compared with the control group in the changes from 2 weeks to 4 weeks(p<0.05). 6. During the 4-week experimental period, important side-effects were not finded out, but each groups had one patient appealed nausea or discomfort respectively. These results indicate that application of periodontitis medical gel was useful as an additional aid of mechanical treatment.

• Korean Journal of Veterinary Research
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• v.29 no.4
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• pp.417-424
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• 1989

This study was conducted in order to observe the changes in cellular association of seminiferous tubules from 4 to 22 weeks of age and to obtain the cycle and relative duration of seminiferous epithelia from 24 weeks of age in male ducks. Fifety-five male ducks were used in the experiment and divided into 11 groups, consisting of 5 male ducks each, with 2 weeks intervals from 4 to 24 weeks of age. The results were summarized as follows: 1. The body and testes weight showed most rapid increase during 4 to 6 weeks and 18 to 22 weeks of age, respectively. The seminiferous tubules were obruptly enlarged in diameter of tubules during 18 to 22 weeks of age. 2. Gonocytes were seen from 4 to 6 weeks of age, however they were not observed as from 8 weeks of age. Both type Ap spermatogonia and type Ad spermatogonia occured from 8 to 12 weeks of age, while spermatocytes and spermatids were beginning to appear at 16 weeks and 18 weeks of age, respectively. Spermatozoa were first observed at 20 weeks of age. Full spermatogenic activity was completed at the age of 20 weeks. 3. Average paired weight of the testes in male ducks was 78g at 24 weeks of age and its ratio to the body weight was approximately 2.5 percent. 4. Average diameter of seminiferous epithelium at 22 weeks of age was $232{\mu}m$, and average numbers of Sertoli cell, spermatogonia, spermatocyte, spermatids and spermatozoa in the cross section of seminiferous epithelium were 15.30, 59.08, 41.78, 71.11 and 165.30, respectively. Spermatogonia and spermatids were classified into 2 and 4 types, respectively. 5. The cycle of the seminiferous epithelium could be divided into 5 stages at 24 weeks of age. The relative frequencies of stages from I to V were 13.5%, 25.0%, 22.3%, 20.6% and 18.7% respectively. Thus, establishment of spermatogenesis in male ducks were beginning to appear at 20 weeks of age.

• Journal of Periodontal and Implant Science
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• v.35 no.2
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• pp.371-381
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• 2005

The masticatory function of tooth is maintained by the periodontal health, and periodontal health is also maintained by the masticatory function. Bite forces are withstanded by the PDL, and this thought to be through the viscoelastic theory. Mobility test and Bite force test are used to evaluate the viscoelastic theory of the PDL. In this study, the bite force test was used. In the same conditions of quantity of the supporting tissue, the maximum bite force according to the quality of the supporting tissue was evaluated. The study was conducted on 40 patients with moderate adult periodontitis, who were indications to the modified widman flap treatment. The maximum bite force in the premolar and molar regions were tested before treatment, 3weeks and 4 weeks after treatment. and the results were as follows. 1. In the premolar region, 3 weeks and 4 weeks after treatment showed higher maximum bite force than before treatment. And in the molar region the maximum bite force decreased 3 weeks after treatment, but increased after 4 weeks, compared to before treatment. 2. In the 1st premolar, there were only significant difference between before and 3 weeks after treatment, and between and 4 weeks after treatment. 3. In the 2nd premolar, there were only significant difference between before and 3 weeks after treatment, and between and 4 weeks after treatment. 4. In the 1st molar, there were no significant difference between before, 3 weeks after treatment, 4 weeks after treatment. 5. In the 2nd molar, there were no significant difference between before, 3 weeks after treatment, 4 weeks after treatment. From the results above, it shows that there were improvements in the maximum bite force through specific periodontal treatments, and thus it can be considered in clinical situations, that selection of the prosthodontic material, decisions of extraction, evaluation of the prognosis after periodontal treatment is a helpful method.

• Journal of Veterinary Clinics
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• v.32 no.4
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• pp.392-397
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• 2015

Blood chemistry values according to ages have rarely been investigated in indigenous Korean calves. The present study aimed to clarify the changes in blood chemistry values of indigenous Korean calves with age. Blood samples were collected from 29 calves (11 females and 18 males) reared at the Gyeongsangbukdo Livestock Research Institute and the levels of various chemical components in the serum were analyzed. The total protein, albumin and globulin concentration in the calves increased gradually over time. The glucose concentration increased significantly at 2 weeks after birth, and then decreased slightly 4 weeks after birth. The blood urea nitrogen concentration increased from 2 weeks after birth, and the levels in females were higher than those in males at 2 and 4 weeks after birth. The creatinine concentration decreased significantly from 2 weeks after birth, and the levels in females were higher than those in males at 2 weeks and 6 months after birth. The total bilirubin concentration decreased gradually from 2 weeks after birth. The glutamic oxaloacetic transaminase and glutamic pyruvic transaminase concentration increased gradually from 2 weeks after birth. The triglyceride concentration tended to increase from 2 weeks after birth. The total cholesterol concentration increased significantly at 2 weeks after birth, and then decreased slightly 4 weeks after birth. The total high density lipoprotein cholesterol concentration increased significantly from 2 weeks after birth. The calcium concentration was maintained between $9.8{\pm}0.8mg/dL$ and $11.6{\pm}0.9mg/dL$ throughout the investigation period, although some levels fluctuated at 4 weeks and 6 months after birth. The phosphorus concentration increased significantly at 2 weeks after birth, and then decreased slightly 4 weeks after birth. In conclusion, the data obtained from this study may be valuable for use as a standard for interpreting results of blood biochemical analyses in indigenous Korean calves.

• The Journal of Korean Academy of Orthopedic Manual Physical Therapy
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• v.12 no.2
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• pp.42-51
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• 2006

The purpose of this study was effect of pilates exercise program on obesity pre-obese adult sixteen (men 3, women 13). The pilates exercise program was provided to subject for 4weeks (3 time a week) Measurements of pre and post 2weeks, and post 4weeks experiment were BMI (Body Mass Index), WHR(Waist-hip Ratio). The result were as follows: 1. The BMI was decreased in pre - exercise 2weeks, pre - exercise 4weeks but there was no statistically. There was significant difference between pre - exercise-4weeks. 2. The WHR was no significant difference between pre - exercise-2 weeks and pre - exercise-2 weeks and 2-4 weeks everybody.

• Korean Journal of Microbiology
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• v.21 no.1
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• pp.15-26
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• 1983

Commercial deerhorns were extracted in boiling water, the deerhorn extracts were per os introduced into rabbits, and then the effects of the extracts on the antibody productions aginst Escherichia coli antigens were investigated for 4 weeks. The experimental rabbits were divided into 4 groups ; control, only deerhorn, only antigen, and antigen plus deerhorn treated groups. The effects of the treatments were measured by counting the number of blood cells, weighing, and immunoelectrophoresis. The rabbits' body weights gained up to 185% in the deerhorn group, and the other groups gained nearly 120%. The numbers of red blood cells in the antigen plus deerhorn group increased somewhat. However, the numbers of leucocytes gradually increased after one week in the antigen group, and at 4 weeks increased up to 290%. In the antigen plus deerhorn group the numbers of leucocytes increased suddenly up to 189% at one week, but after one week the numbers recovered to normal state. Strangely in the deerhorn group the numbers decreased up to 40%. The amounts of serum globulin increased in the control after one week, but maintained about 130%. In the deerhorn group the amounts increased like the control, but after 4 weeks increased up to 175%. In the antigen group the amounts were not changed until 2 weeks, but after 3 weeks abruptly increased over 175%. In the deerhorn plus antigen group the amounts increased gradually up to 262% until 3 weeks, after 3 and 4 weeks the amounts did not increase. The amounts of serum .gamma.-globulin decreased in the control group, and in the deerhorn group and antigen group the amounts did not change until 2 weeks, but after 3 weeks abruptly increased over 175%. In the deerhorn plus antigen group the amounts increased gradually up to 262% until 3 weeks, after 3 and 4 weeks the amounts did not increase. The amounts of serum ${\gamma}-globulin$ decreased in the control group, and in the deerhorn group and antigen group the amounts did not change until 3 weeks, but after 4 week the amounts slightly increased up to 110%. However, the amounts in the deerhorn plus antigen group did not change until 2 weeks, but after 2 weeks abruptly increased up to 174%. The recognized immunoglobulins were IgG and IgM, and the enhanced immunoglobulin was IgG.

• Journal of Korean Dental Science
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• v.11 no.1
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• pp.5-13
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• 2018

Purpose: Surface treatment with pH buffering agent has been developed to achieve higher and faster osseointegration. The aim of this study was to evaluate its influence by measuring removal torque and analyzing histological characteristics. Materials and Methods: Titanium implants with following surfaces were used in this study: sand-blasted acid-etched (SA) surface (SA group as control I group), SA surface in calcium chloride aqueous solution (CA group as control II group) and SA surface coated with pH buffering agent (pH group as test group). Removal torque test after 2 weeks and bone-to-implant contact and bone area analyses at 2 and 4 weeks were performed. Result: The rotational torque values at 2 weeks were significantly higher in pH group ($107.5{\pm}6.2Ncm$, P<0.05). The mean values of bone-to-implant contact at 2 and 4 weeks were both higher in pH group ($93.0%{\pm}6.4%$ at 2 weeks, $88.6%{\pm}5.5%$ at 4 weeks) than in SA group ($49.7%{\pm}9.7%$ at 2 weeks, $47.3%{\pm}20.1%$ at 4 weeks) and CA group ($73.7%{\pm}12.4%$ at 2 weeks, $72.5%{\pm}10.9%$ at 4 weeks) with significances (P<0.05). The means of bone area showed significantly higher numbers in pH group ($39.5%{\pm}11.3%$ at 2 weeks, $71.9%{\pm}10.9%$ at 4 weeks, P<0.05). Conclusion: Our findings demonstrated that surface modification with pH buffering agent improved early osseointegration with superior biomechanical property.

• The korean journal of orthodontics
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• v.28 no.3 s.68
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• pp.453-459
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• 1998

The dental implants for edentulous Patients have been used for more than 20 years. After the introduction of osseointegration by $Br{\aa}nemark$, the commercially pure titanium implants were accepted by most practitioners. Recently dental implants are used for orthodontic anchorages as well as prosthetic abutment. Many researchers have reported implants as a good orthodontic anchorage through basic research and clinical evaluation. But previous researches were done after the healing time for osseointegration of inserted implants. If dental implants are to be used for prosthetic abutment the healing time for osseointegration is necessary, but orthodontic forces to implants are different from bite force regarding its amount of force, duration and direction. The authors evaluated the effect of orthopedic force to implants on bone tissue before osseointegration. 48 implants were placed at 12 rabbits. 2 implants into left side and 2 implants into right side were inserted along the long axis of femur respectively 2 weeks (2 weeks group), 4 weeks (4 weeks group) and 6 weeks (6 weeks group) after implants placement, 300g force had been applied to the implants at left side femur by Ni-Ti close coil spring for 4 weeks (experimental group) and no force applied to implants at right side femur (control group). After the force application for 4weeks, rabbits were sacrificed and microscopic evaluation was done by hematoxylin-eosin stain and Masson trichrome stain. The result3 were followed. 1. All implants in experimental group remained rigid after the force application for 4 weeks. 2. More fibrous tissue between bone and implants were noticed at 2 weeks experimental group than 2 weeks control group 3. More bone remodeling was noticed at 4weeks group than 2 weeks group and it was difficult to find out fibrous tissue between bone and implants at both experimental and control group of 4 weeks group. 4. It was hard to distinguish experimental group from control group at 6 weeks group. Therefore if initial stability can be obtained on implant insertion, it can be possible to use implants as a orthodontic anchorage before the healing time for osseointegration.

• Korean Journal of Poultry Science
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• v.10 no.2
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• pp.83-89
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• 1983

Sixteen crosses from two strains of White Cornish and White Plymouth Rock were reared seperately on floors and abdominal fat was measured every two weeks interval from two weeks to twelve weeks of age. The abdominal fat weights surgically removed were slightly heavier in female than male. Estimates of general combining ability variances of body weight showed significant at all weeks of age in both sexes but those of abdominal fat weight were significant at 2, 8, 10 and 12 weeks of age in female and 2, 6 and 12 weeks of age in male. In percentage of abdominal fat to body weight, the significant differences were observed at 10 and 12 weeks of age only in female. The specific combining ability variances were significant at 4, 6, 10 and 12 weeks of age in female and 4, 8 and 12 weeks of age in male in body weight. In abdominal fat weight, there were significant differences at 4, 8, 10 and 12 weeks of age in female but no significant differences in male. The specific combining ability variances of percentage of abdominal fat to body weight showed significant differences at 4 and 8 weeks of age in female but no significant difference in male.

• Journal of Acupuncture Research
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• v.18 no.1
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• pp.170-185
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• 2001

Objective : This experimental study was designed to investigate the effect of Chaenomelis fructus herbal acupuncture on the soleus muscle and tibialis anterior muscle of hindlimb-suspended rats. The measurement have been performed on the composition of type I, type IIa and type IIb muscle fibers in the soleus muscle and tibialis anterior muscie - histochemical study. Materials and Methods : Sprague-Dawley rats weighing about 250g were subjected to hindlimb suspension and divided into six groups; 1. Normal group: normai group 2. Control group: group of hindlimb suspension for 7 days 3. NT group: non-treatment group for 2 or 4 weeks after 7days of hindlimb suspension. 4. EX gtoup: running exercise group for 2 or 4 weeks after 7days of hindlimb suspension. 5. HA group: administration of Chaenomelis fructus herbal acupuncture during 2 or 4 weeks after 7 days of hindlimb suspension. 6. EXHA group: administration of Chaenomelis fructus herbal acupuncture and running exercise during 2 or 4 weeks after 7 days of hindlimb suspension. Results Results : 1. The composition of type I muscle fibers in the soleus muscle significantly increased in 2 or 4 weeks HA and EXHA groups more than control group, and the composition of type IIa muscle fibers in the soleus muscle significantly decreased in 2 or 4 weeks HA and EXHA goups more than control group. 2. The composition of type I muscie fibers in the tibialis anterior muscle significantly increased in 2 or 4 weeks HA and EXHA groups more than control group, and the composition of type IIb muscle fibers in the soleus muscle significantly decreased in 2 or 4 weeks HA and EXHA groups more than control group. 3. The size of type I muscle fibers in the soleus muscle significantly increased in 2 or 4 weeks HA and EXHA groups more than control group, and the size of type IIa muscle fibers in the soleus muscle significantly increased in 2 weeks EXHA group and 4 weeks HA and EXHA groups more than control group. 4. The size of type I, IIa muscle fibers in the tibialis anterior muscle significantly increased in 2 or 4weeks HA, EXHA and EX groups more than control group, and the size of type IIb muscle fibers significantly increased in 2 weeks EXHA group and 4 weeks HA, EXHA and EX groups more than control group. 5. The capiliaries number per fiber of muscle fibers in the soleus and tibialis anterior muscle showed no differences in all experimental groups more than control group. Conclusion : According to the above results, it is shown that Chaenomelis fructus herbal acupuncture could be effective in the treatment of muscle atrophy.