• Title/Summary/Keyword: 4',5,7-trihydroxy-6,8-diprenylisoflavone

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Antioxidant Effects of Isoflavones from the Stem Bark of Cudrania tricuspidata

  • Lee, Jin-Hwan;Lee, Byong-Won;Kim, Jin-Hyo;Seo, Woo-Duck;Jang, Ki-Chang;Park, Ki-Hun
    • Journal of Applied Biological Chemistry
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    • v.48 no.4
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    • pp.193-197
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    • 2005
  • Isoflavones 4'-O-methylalpinumisoflavone (1) and 5, 7, 4'-trihydroxy-6,8-diprenylisoflavone (2) were isolated from stem bark of Cudrania tricuspidata (Carr.) Bureau. These compounds were the first reported from this plant. Antioxidant activities 1 and 2 were evaluated by measuring their ability to scavenge DPPH and ABTS radicals. Diprenylisoflavone 2 showed strong scavenging activity against ABTS ($IC_{50}\;=\;16.3\;{\mu}M$), three-fold higher compared to genistein, which do not possess prenylated group which indicates strong scavenging activity against ABTS radical of isoflavone 2 was due to prenyl group.