• Proceedings of the Korea Water Resources Association Conference
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• 2021.06a
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• pp.120-120
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• 2021

2020년 8월 7일부터 8월 8일까지 호우는 용담댐, 섬진강댐, 합천댐 하류 유역의 막대한 침수피해를 일으켰다. 이들 다목적 댐 유입량의 신뢰도 높은 모의는 홍수기 댐 운영 및 하류하천의 홍수 해석에 필수다. 여기서는 일 유출 모의 기반으로 개발된 ONE 모형을 10분 단위, 1시간 단위로 적용한 결과를 제시하고자 한다. 보통 홍수모의는 사상별로 실시하지만, 여기서는 1월1일부터 12월 31일까지 연속으로 모의한 결과에서 해당 홍수사상 결과를 제시하였다. 3개 다목적 댐의 홍수사상은 8월6일부터 8월 10일까지 5일간으로 설정하였다. 유역면적은 용담댐, 섬진강댐, 합천댐, 각각 930km², 763km², 925km², 총강우량은 각각 490.7mm, 451.9mm, 452.4mm, 첨두유입량은 10분 단위는 각각 4,872.7m³/s, 3,533.7.0m³/s, 2,776.0m³/s, 1시간 단위는 각각 4,394.9m³/s, 3,401.8m³/s, 2,745.6m³/s, 총유입량은 각각 3억8,836만m³, 3억1,324만m³, 3억2,816만m³였다. 첨두유입량 상대오차가 0일 때의 매개변수로 모의한 결과를 제시하며, 총유입량 상대오차(Vq), R², RMSE, NSE 등으로 평가하였다. 용담댐 결과는 10분 단위 경우 최대면적강우량 7.3mm, 첨두유입량 4,872.4m³/s, 총유입량 3억 8,138만m³, Vq 1.9%, R² 0.968, RMSE 207.347, NSE 0.978였고, 1시간의 경우 최대면적강우량 29.6mm, 첨두유입량 4394.9m³/s, 총유입량 4억157만m³, Vq -8.4%, R² 0.970, RMSE 186.962, NSE 0.982였다. 섬진강댐 결과는 10분 단위 경우 최대면적강우량 9.2mm, 첨두유입량 3,533.3m³/s, 총유입량 2억7,223만m³, Vq 18.4%, R² 0.885, RMSE 808.296, NSE 0.925였고, 1시간의 경우 최대 면적강우량 37.9mm, 첨두유입량 3401.6m³/s, 총유입량 2억7,029만m³, Vq 13.7%, R² 0.907, RMSE 285.544, NSE 0.936였다. 합천댐 결과는 10분 단위 경우 최대면적강우량 5.5mm, 첨두유입량 2,776.2m³/s, 총유입량 3억3,667만m³, Vq -2.7%, R² 0.941, RMSE 191.896, NSE 0.965였고, 1시간의 경우 최대면적강우량 17.0mm, 첨두유입량 2,746.7m³/s, 총유입량 3억1,333만m³, Vq 4.5%, R² 0.965, RMSE 140.739, NSE 0.981였다. 이상 ONE 모형으로 10분, 1시간 단위의 댐 홍수 유입량 모의결과는 높은 신뢰도를 나타냈다.

• Journal of dental hygiene science
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• v.8 no.4
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• pp.367-373
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• 2008

The natural products are used to be development of new antibacterial substances against human pathogenic bacteria. Adherence to the tooth surface by S. mutans is an important step in initiation of dental caries. This study was to examine antibacterial activity and anti-adhesive effect of Scutellaria baicalensis extract against S. mutans. Extracts of S. baicalensis were tested for antimicrobial activities by paper disc methods and radial diffusion assay methods, and bacterial adherence assay using 3 type of hydroxyapatite. The antibacterial level of ethyl acetate extract, IPK-3 on the growth of S. mutans was 125 mg/ml of minimum inhibitory concentration (MIC). The maximum growth of S. mutans in medium added with IPK-3 extract (50 mg/ml) was delayed to 30 hr, while the highest at 24 hr in control medium. The pH values of the control medium was 5.63 at 18 hr, but the media supplemented with IPK-3 extract was pH 6.50 at 12 hr. In adhesive inhibition assay, S. mutans was labelled with the fluorescent indicator DAPI and measured with fluorescence microscope. Adhesion of S. mutans on hydroxyapatite beads was inhibited by IPK-3 extracts. These results suggest that S. baicalensis extract can be used as an effective material for antibacterial activity and adhesive inhibition against S. mutans.

• Journal of the Korean Ceramic Society
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• v.22 no.3
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• pp.67-71
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• 1985

2.5~40$mu extrm{m}$ 영역에서 $XAs_2S_3-(1-X)GeS_2$ 유리의 적외선 흡수에 관하여 연구했다/ Lucovsky와 그의 연구팀이 제창한 ""분자모델""에 의하면 $8-20\mu\textrm{m}$ 영역에서 위의 유리물질의 multiphonon 흡수대는 고립된 각 분자의 기본진동대의 overtone 및 combination 과 같다. 그러므로 multiphonon 흡수영역에서 AsY3 와 GeY3의 기본진동수를 모두 가지고 있는 combination 대는 관찰되지 않고 또한 혼합된 $XAs_2S_3-(1-X)GeS_2$ 유리의 흡수계수는 순수한 $As_2Y_3$ 및 $GeY_2$ 유리의 흡수계수를 더한 것으로 표현된다. 실험에서 얻은 흡수계수는 이 분자모델로부터 예상되는 값과 잘 일치한다.값과 잘 일치한다.

• Experimental and Molecular Medicine
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• v.50 no.11
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• pp.5.1-5.14
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• 2018

Oxidative stress-induced mitochondrial dysfunction is implicated in the pathogenesis of intervertebral disc degeneration (IVDD). Sirtuin 3 (SIRT3), a sirtuin family protein located in mitochondria, is essential for mitochondrial homeostasis; however, the role of SIRT3 in the process of IVDD has remained elusive. Here, we explored the expression of SIRT3 in IVDD in vivo and in vitro; we also explored the role of SIRT3 in senescence, apoptosis, and mitochondrial homeostasis under oxidative stress. We subsequently activated SIRT3 using honokiol to evaluate its therapeutic potential for IVDD. We assessed SIRT3 expression in degenerative nucleus pulposus (NP) tissues and oxidative stress-induced nucleus pulposus cells (NPCs). SIRT3 was knocked down by lentivirus and activated by honokiol to determine its role in oxidative stress-induced NPCs. The mechanism by which honokiol affected SIRT3 regulation was investigated in vitro, and the therapeutic potential of honokiol was assessed in vitro and in vivo. We found that the expression of SIRT3 decreased with IVDD, and SIRT3 knockdown reduced the tolerance of NPCs to oxidative stress. Honokiol ($10{\mu}M$) improved the viability of NPCs under oxidative stress and promoted their properties of anti-oxidation, mitochondrial dynamics and mitophagy in a SIRT3-dependent manner. Furthermore, honokiol activated SIRT3 through the AMPK-PGC-$1{\alpha}$ signaling pathway. Moreover, honokiol treatment ameliorated IVDD in rats. Our study indicated that SIRT3 is involved in IVDD and showed the potential of the SIRT3 agonist honokiol for the treatment of IVDD.

• Bulletin of the Korean Chemical Society
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• v.35 no.10
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• pp.2990-2994
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• 2014

The studies on design and synthesis of new monocyclic ${\beta}$-lactam esters 4(R/S)-(1'-methoxycarbonylpropyl- 2'(R/S)-thio)-3(R)-phenylacetamidoazetidin-2-one (3a) and 4(R/S)-(1'-methoxycarbonyl-2'-methylpropyl-2'- thio)-3(R)-phenylacetamidoazetidin-2-one (3b) were described. Compounds 3a and 3b were specifically designed to retain all penicillin substructures except the bicyclic system, which would be conceived by cleaving the C(3)-N(4) bond of penicillin G. Compounds 3a and 3b are of particular interest in the context of the structural elucidation of monocyclic ${\beta}$-lactams originated from penicillin. Key intermediates, ${\beta}$-mercapto esters 6a and 6b, were synthesized from conjugate acids 4a and 4b using three-step synthetic sequences, respectively, and 4(S)-acetoxy-3(S)-phenylacetamidoazetidin-2-one (7) was obtained from the degradation of penicillin G. Reactions of 6a and 6b with 7, thus obtained, provided the target compounds 3a and 3b, respectively.

• The Korean Journal of Emergency Medical Services
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• v.9 no.2
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• pp.207-221
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• 2005

Purpose: The purpose of this study was to develop and apply a simulation-problem based learning(S-PBL) package in basic life support(BLS). Methods: This study was used to developed BLS' S-PBL package throughout 12 steps of PBL package development model. Then, BLS' S-PBL methodology was implemented in second year student in the undergraduate emergency medical technology, and survey was done. Results: 1. S-PBL package model was presented based on conceptual model II of PBL ; PEL for professional action. 2. Quantitative analysis of survey was to the effectiveness of learning, 3.59 points ; 4.15 of BLS and 3.84 of integration and practical use of knowledge. 3. As to the satisfaction of student, S-PBL package management, tutor and self-satisfaction' score was 3.59, 3.82, 3.39 respectively. Conclusion: This study was suggested that S-PBL education would be necessary with improved tutor skill and achieved advantage of simulation and PBL.

• Journal of the Korea Society of Computer and Information
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• v.9 no.3
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• pp.45-53
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• 2004

The fact that the end-user response time could become unacceptable in the 2-tier C/S system has been well known to C/S system developers. But inexperienced new developers who want to provide mobile solutions using PDA sometimes do not realize the ominous consequences of the 2-tier C/S systems. Except for the easy of development. the 2-tier C/S system has many weak points like in application deployment, security, scalability, application reuse, heterogeneous DBMS support, availability. and response time. This paper analyzes the response time in the 2-tier and 3-tier C/S systems through simulation. Although the problem space is confined to the 2 and 3 tiers, the result could be equally applied to any multi-tier systems.

• Journal of Information Display
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• v.12 no.3
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• pp.159-165
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• 2011

This research entailed the production of stereoscopic 3D (S3D) contents using 2D-to-S3D conversion for exhibition at a museum and subjective evaluation. Hybrid production combining S3D images of existing live-action videos using the 2D-to-S3D conversion technology and computer graphic ones created via stereo rendering was conducted. Design and control of the chronological analysis of the parallactic angle was conducted on the produced contents, using binocular information as well as subjective evaluations, with the intent of conducting an investigation on the characteristics of such contents from the perspectives of the producers and viewers. An investigation was also conducted on the effects of the viewing position on the impressions of the S3D images.

• Proceedings of the KIEE Conference
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• 2000.07e
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• pp.35-39
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• 2000

$ZnIn_2S_4$ and $ZnGaInS_4:Er^{3+}$ single crystals crystallized in the rhombohedral (hexagonal) space group $C_{3v}^5(R3m)$, with lattice constants $a=3.852{\AA},\;c=37.215{\AA}$ for $ZnIn_2S_4$, and $a=3.823{\AA}$, and $c=35.975{\AA}$ for $ZnIn_2S_4:Er^{3+}$. The optical absorption measured near the fundamental band edge showed that the optical energy band structure of there compounds had a direct and indirect band gap, the direct and indirect energy gaps are found to be 2.778 and 2.682 eV for $ZnIn_2S_4$, and 2.725 and 2.651eV for $ZnIn_2S_4:Er^{3+}$ at 293 K. The photoluminescence spectra of $ZnIn_2S_4:Er^{3+}$ measured in the wavelength ranges of $500nm{\sim}900nm$ at 10 K. Eight sharp emission peaks due to $Er^{3+}$ ion are observed in the regions of $549.5{\sim}550.0nm,\;661.3{\sim}676.5nm$, and $811.1{\sim}834.1nm$, and $1528.2{\sim}1556.0nm$ in $CdGaInS_4:Er^{3+}$ single crystal. These PL peaks were attributed to the radiative transitions between the split electron energy levels of the $Er^{3+}$ ions occupied at $C_{2v}$, symmetry of the $ZnIn_2S_4$ single crystals host lattice.

• Journal of the Korean Chemical Society
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• v.24 no.1
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• pp.8-14
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• 1980

Solvolysis rate constants for methylchloroformate, $CH_3O$(CO)Cl, methylthiono-chloroformate, $CH_3O$(CS)Cl, and methylthiolchloroformate, $CH_3S$(CO)Cl, have been determined conductometrically in acetone-water and acetonitrile-water mixtures, and activation parameters, ${\Delta}H^{\neq}$ and ${\Delta}S^{\neq}$, have been derived. Results show that in water-rich regions the order of rate increases as $$CH_3O(CO)Cl while in dipolar aprotic solvent-rich region this order reverses. The plots of log k vs. solvent parameters, Y, $\frac{D-1}{2D+1}$ and log($H_2$) show that the order of rate increase in water-rich region is the results of increase in $S_N1$ character. It is concluded that $CH_3S$(CO)Cl solvolyzes via $S_N1$ mechanism whereas $CH_3O$(CO)Cl reacts via $S_N2$ and $CH_3O$(CS)Cl via intermediate mechanism in water-rich region.