• Proceedings of the PSK Conference
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• 2002.10a
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• pp.347.4-348
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• 2002

Recently it has been demonstrated that selective cyclooxygenase-2 (COX-2) inhibitors retain the antiinflammatory effect but with markedly reduced GI toxicity compared to non selective inhibitors such as traditional NSAIDs. As a consequence, intense efforts have been made to develop selective COX-2 inhibtors during the last decade. Two compounds in this class. celecoxib and rofecoxib. are already in the market and are proved as potent and selective COX-2 inhibitors with much better gastric tolerance. However. there are still strong domands for a COX-2 inhibitor with improved efficacy and safety profiles. Here we report the synthesis and biological profiles of 1.5- and 4.5-disubstituted imidazole analogues as structural equivalents of cefecoxib and refecoxib. The imidazole analogues are overlapped well whth the 3D srructures of celecoxib and rofecoxib.

• Proceedings of the IEEK Conference
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• 2003.07a
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• pp.35-38
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• 2003

We propose a switched beamforming to improve the reception performance of VSB system in severe Rayleigh fading channel. The VSB system has only about 3% of known training signal for the receiver in a data field and the reception performance of VSB receiver is degraded significantly when there are near-0 dB ghosts in receiving signal. The switched beamforming forms several beams in different directions and selects only one beam among them. For the selection of a beam with best channel condition for VSB equalizer, we extracted the channel profiles in time domain for all the beams by correlating the PN511 sequence in VSB field sync and selected optimal beam by comparing the channel profiles. The simulation results show that the proposed method improves the reception performance of VSB system in severe Rayleigh channel.

• Geomechanics and Engineering
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• v.5 no.4
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• pp.283-297
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• 2013

The aim of this paper is to investigate how the soil-structure interaction affects sloshing response of the elevated tanks. For this purpose, the elevated tanks with two different types of supporting systems which are built on six different soil profiles are analyzed for both embedded and surface foundation cases. Thus, considering these six different profiles described in well-known earthquake codes as supporting medium, a series of transient analysis have been performed to assess the effect of both fluid sloshing and soil-structure interaction (SSI). Fluid-Elevated Tank-Soil/Foundation systems are modeled with the finite element (FE) technique. In these models fluid-structure interaction is taken into account by implementing Lagrangian fluid FE approximation into the general purpose structural analysis computer code ANSYS. A 3-D FE model with viscous boundary is used in the analyses of elevated tanks-soil/foundation interaction. Formed models are analyzed for embedment and no embedment cases. Finally results from analyses showed that the soil-structure interaction and the structural properties of supporting system for the elevated tanks affected the sloshing response of the fluid inside the vessel.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.14 no.9
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• pp.766-773
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• 2002

Flow distributions in a rectangular duct with two branch ducts are measured by 5 W laser doppler velocity meter. The fluid flows are also computed by commercial soft-ware of STAR-CD for comparison between them. The Reynolds numbers in the main duct are from 4,226 to 17,491. The ratios distributed into two branches from the main duct are in-variant to Reynolds numbers according to both of numerical and experimental results. However computed velocity profiles at exit of each branch are somewhat different from measured profiles at the same location.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.33 no.9A
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• pp.900-908
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• 2008

This paper presents the implementation and performance test of a Digital IF transceiver for a SDR-based mobile communication base station. The transceiver is reconfigurable to HSDPA and to three profiles, 7 MHz, 3.5 MHz, and 1.75 MHz, each incorporating the IEEE 802.16d WiMAX standard. The transceiver can be reconfigured to other standard profiles through software downloaded onto identical hardware platforms. Experimental results show that the transceiver can be reconfigured to other systems and the performance of the transceiver satisfies the recommended performance criteria of each standard.

• Korean Journal of Organic Agriculture
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• v.24 no.3
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• pp.485-495
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• 2016

The aim of the present study was to determine the effect of dietary cultured wild ginseng root (CWGR) supplementation on goat milk composition and ginsenoside profiles. Sixteen Saanen dairy goats were allocated to two balanced groups based on lactation period, body weight ($38.6{\pm}3.2kg$), and dairy milk yield ($2.85{\pm}1.2kg$), and were kept in separate pens. Goats were fed a total mixed ration (TMR) feed (2.3 kg/d, dry matter basis) and 1.5 g of CWGR powder was supplemented in the experimental diet. The total feeding period was 3 weeks, and milk and blood samples were collected on the last three days of the experimental period. There was no effect of CWGR on daily milk yield and milk composition (fat, protein, lactose, and solid-not-fat). However, the CWGR-treatment group had significantly higher plasma IgG and protein contents than the control group (P < 0.05). Significant amounts of ginsenosides were observed in the milk of the CWGR-treatment group, whereas ginsenosides were not detected in the milk of the control group. In conclusion, dietary CWGR was a useful regimen to produce functional goat milk enriched in ginsenosides.

• Bulletin of the Korean Chemical Society
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• v.35 no.2
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• pp.575-580
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• 2014

We uniformly coated Eu(III)- and Tb(III)-doped yttrium oxide onto the surface of $SiO_2$ spheres and then characterized them by scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction crystallography and UV-Visible absorption. 2D and 3D photoluminescence image map profiles were reported for the core-shell type structure. Red emission peaks of Eu(III) were observed between 580 to 730 nm and assigned to $^5D_0{\rightarrow}^7F_J$ (J = 0 - 4) transitions. The green emission peaks of Tb(III) between 450 and 650 nm were attributed to the $^5D_4{\rightarrow}^7F_J$ (J = 6, 5, 4, 3) transitions. For annealed samples, Eu(III) ions were embedded at a $C_2$ symmetry site in $Y_2O_3$, which was accompanied by an increase in luminescence intensity and redness, while Tb(III) was changed to Tb(IV), which resulted in no green emission.

• Atmosphere
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• v.25 no.1
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• pp.149-154
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• 2015

As an attempt to improve fog predictability at Incheon International Airport (IIA) we couple the 3D weather forecasting model currently operational in Korea Meteorological Administration (regional Unified Model, UM_RE) with a 1D turbulence model (PAFOG). The coupling is done by extracting the meteorological data from the 3D model and properly inserting them in the PAFOG model as initial conditions and external forcing. The initial conditions include surface temperature, 2 m temperature and dew point temperature, geostrophic wind at 850 hPa and vertical profiles of temperature and dew point temperature. Moisture and temperature advections are included as external forcing and updated every hr. To validate the performance of the coupled system, simulation results of the coupled system are compared to those of the 3D model alone for the 22 sea fog cases observed over the Yellow Sea. Three statistical indices, i.e., Root Mean Square Error (RMSE), linear correlation coefficient (R) and Critical Success Index (CSI), are examined, and they all indicate that the coupled system performs better than the 3D model alone. These are certainly promising results but more improvement is required before the coupled system can actually be used as an operational fog forecasting model. For the RMSE, R, and CSI values for the coupled system are still not good enough for operational fog forecast.

• Asian-Australasian Journal of Animal Sciences
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• v.25 no.7
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• pp.1003-1008
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• 2012

One hundred and twenty weanling pigs in experiment 1 (Exp. 1) ($6.91{\pm}0.99kg$; 21 d of age) and Exp. 2 ($10.20{\pm}1.09kg$; 28 d of age) were used in two 42-d and 35-d experiments to evaluate the effect of medium-chain-triglyceride (MCT) on growth performance, apparent total tract digestibility (ATTD) of nutrients and blood profile. In both of Exp. 1 and Exp. 2, the same dietary treatments were utilized as follows : i) negative control (NC), ii) positive control (PC), NC+antibiotics (40 mg/kg Tiamulin, 110 mg/kg Tylosin, and 10 mg/kg Enramycin, iii) MCT3, NC+0.32% (phase 1, 2 and 3) MCT, and iv) MCT5, NC+0.55% (phase 1), 0.32% (phase 2 and 3) MCT. In Exp. 1, the pigs fed MCT5 diets had higher (p<0.05) ADG compared to NC treatment during the first 2 wk. From d 15 to 28, the ATTD of energy was improved (p<0.05) by MCT3 compared to the PC treatment. No effect has been observed on the blood profiles [red blood cell (RBC), white blood cell (WBC), immunoglobulin-G (IgG), lymphocyte concentration] measured in this study. In Exp. 2, the ADG were increased (p<0.05) by the MCT5 treatment than the PC treatment from d 0 to 14. Pigs fed PC treatment diet had lower ADFI (p<0.05) and better FCR (p<0.05) than NC treatment, whereas no differences were shown between MCT treatments and NC or PC treatment from d 15 to 35 and overall phase. The ATTD of DM and nitrogen were improved (p<0.05) by the effect of MCT5 related to the NC and PC treatment at the end of 2nd and 5th wk. The pigs fed MCT3 had higher (p<0.05) energy digestibility than PC treatment. No effects were seen in the blood profiles we measured (WBC, RBC, lymphocyte and immunoglobulin-G). In conclusion, the addition of MCT in the weanling pigs diet can improve the ADG and digestibility during the earlier period (first 2 wks), but had little effect on the blood characteristics.

• Restorative Dentistry and Endodontics
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• v.20 no.1
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• pp.71-95
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• 1995

Bacteria have been regarded as a one of major etiologic factors in root canal infections. In endodontic treatment the effective removal of pathogenic microorganisms in the root canal is the key to successful outcome. Bacterial cell wall components may play an important role in the development of pulpal and periapical disease. The purpose of this study was to evaluate the effect of sonic extracts of Streptococcus spp. on cultured L929 cells and to characterize cell wall protein profiles of Streptococcus spp. Streptococcus spp. were isolated from infected root canals and identified with Vitek Systems(Biomeriux, USA). Five streptococci, namely S. sanguis, S. mitis, S uberis, S. mutans (ATCC 10449) and S. faecalis (ATCC 19433) weere enriched in brain heart infusion broth. Cell pellets were sonicated and cell wall extracts were dialyzed and membrane filtered. Prepared cell wall proteins were applied to cultured L929 cell. The cell reaction were evaluated by monitoring DNA synthesis, cell numbers and the change of cell morphology. The total cell wall protein profiles of microorganisms were characterized by sodium dodecyl sulfate polyacrylamide-gel eledruphoresis(SDS-PAGE). DNA synthesis of L929 cells were reduced by the increasing concentration of sonic extracts. DNA synthesis was significantly suppressed in more than $50{\mu}g$/ml of sonic extract conentration in five streptococci. S. nutans (ATCC 10449) showed stronger suppression on DNA synthesis than remaining four streptococci, which had the similar effect on DNA synthesis. Analysis of DNA synthesis measured by [$^3H$]-thymidine uptake was more sensitvie method than cell counting. Sonic extracts affected the microscopic findings of L929 cells. The protein profiles indicated that all five strains shared two major proteins with molecular masses of 70.8 and 57.5 kD respectively. S. uberis and S. mutans shared common minor proteins of which molecular weights were 147.9 and 112.2 kD respectively. However some minor proteins were unique for S. mitis, S. uberis and S. faecalis.