• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.19 no.3
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• pp.173-178
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• 2019

To analyze the diffraction properties of optical signals by periodic blazed 2D diffraction gratings, Toeplitz dielectric tensor is first defined and formulated by 2D spatial Fourier expansions associated with asymmetric blazed grating profile. The characteristic modes in each layer is then based on eigenvalue problem, and the complete solution is found rigorously in terms of modal transmission-line theory (MTLT) to address the pertinent boundary-value problems. Toeplitz matrix of symmetric and sawtooth profiles is derived from that of asymmetric blazed grating profile, and the diffraction properties for each profile are numerically simulated. The numerical results reveal that the asymmetric and symmetric profiles behave as anti-reflection GMR filter while the sawtooth profile works better as anti-transmission one rather than anti-reflection filter.

• Asian-Australasian Journal of Animal Sciences
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• v.17 no.9
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• pp.1296-1302
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• 2004

This study was conducted to evaluate the possible application of 2 D-SDS-PAGE (2 DE)-based proteome analysis techniques to the assessment of extreme proteolysis in postmortem skeletal muscle. Eight Hanwoo longissimus muscles were incubated immediately after slaughter for 24 h at 5$^{\circ}C$, 15$^{\circ}C$ or 36$^{\circ}C$. Warner Bratzler (WB)-shear force and ultrastructural configuration were determined at 24 h, and rate of proteolysis to 24 h was determined by 1 D-SDS-PAGE (1 DE) and 2 DE. In addition, tentative protein identification was performed from peptide mass fingerprints of MALDI-ToF analysis of major protein groups on 2 DE profiles. The result showed that although ultrastructural configuration was similar between the 5$^{\circ}C$ and 36$^{\circ}C$ treatments, meat at 5$^{\circ}C$ had higher WBshear force (approximately 5 kg greater). A higher rate of protein degradation at 36$^{\circ}C$ was observed based on Troponin-T degradation, 1 DE, and 2 DE analysis. This indicates that proteolysis during the early postmortem period was a significant determinant of shear force at 24 h. Little difference in proteolysis between 5$^{\circ}C$ and 15$^{\circ}C$ treatments was found based on classic 1 DE profile assessment. Meanwhile, considerable differences in the 2 DE profiles between the two treatments were revealed, with substantially higher rate of proteolysis at 15$^{\circ}C$ compared to 5$^{\circ}C$. Nuclease treatment improved 2 DE profile resolution. 400 ${\mu}$g and 600 ${\mu}$g of sample loading appeared to be appropriate for 24 cm pH 3-10 and pH 5-7 IPG strips, respectively. Protein detection and quantification of the 5$^{\circ}C$, 15$^{\circ}C$ and 36$^{\circ}C$ 2 DE profiles revealed 78, 163 and 232 protein spots respectively that were differentially modified in terms of their electrophoretic properties between approximately pI 5.3-7.7 with the molecular weight range of approximately 71-12 kDa. The current results demonstrated that 2 DE was a superior tool to 1 DE for characterising proteolysis in postmortem skeletal muscle.

• Polymer(Korea)
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• v.28 no.4
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• pp.335-343
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• 2004

Carmustine (l,3-bis(2-chloroethyI)-1-nitrosourea, BICNU) used as antineoplastic drug for the treatment of brain tumor is not appropriate for the long term delivery, because it has short biological half life. Therefore, poly(D,L-lactide-co-glycolide) (PLGA) is useful as drug carrier for the long term delivery due to bulk erosion property. Glycolide monomer is applied to release of BICNU owing to non-toxic and monomeric components after biodegradation of PLGA. In this study, BICNU-loaded PLGA wafers with or without glycolide monomer were fabricated by conventional direct compression method for the sustained release of BICNU. These wafers were observed for their release profiles of BICNU and degradation rates by SEM, NMR, and GPC. Furthermore, we make multi-layer wafers and compare them with release profiles of conventional wafer. From these results, drug release of BICNU-loaded PLGA wafers was increased with increasing the glycolid monomer contents. We confirmed that glycolide monomer and BICNU contents in barrier-layer influenced the drug release profiles and degradation rate.

• Journal of the Korean Society of Radiology
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• v.81 no.3
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• pp.632-643
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• 2020

Purpose To investigate the correlation between magnetic resonance (MR) image-based radiomics features and the genomic features of breast cancer by focusing on biomolecular intrinsic subtypes and gene expression profiles based on risk scores. Materials and Methods We used the publicly available datasets from the Cancer Genome Atlas and the Cancer Imaging Archive to extract the radiomics features of 122 breast cancers on MR images. Furthermore, PAM50 intrinsic subtypes were classified and their risk scores were determined from gene expression profiles. The relationship between radiomics features and biomolecular characteristics was analyzed. A penalized generalized regression analysis was performed to build prediction models. Results The PAM50 subtype demonstrated a statistically significant association with the maximum 2D diameter (p = 0.0189), degree of correlation (p = 0.0386), and inverse difference moment normalized (p = 0.0337). Among risk score systems, GGI and GENE70 shared 8 correlated radiomic features (p = 0.0008-0.0492) that were statistically significant. Although the maximum 2D diameter was most significantly correlated to both score systems (p = 0.0139, and p = 0.0008), the overall degree of correlation of the prediction models was weak with the highest correlation coefficient of GENE70 being 0.2171. Conclusion Maximum 2D diameter, degree of correlation, and inverse difference moment normalized demonstrated significant relationships with the PAM50 intrinsic subtypes along with gene expression profile-based risk scores such as GENE70, despite weak correlations.

• Transactions of the Korean Society of Pressure Vessels and Piping
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• v.11 no.2
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• pp.61-67
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• 2015

3D FEM modeling based on 3D CAD data has been performed to evaluate the efficiency of CP system in a real operating nuclear power plant. The results of it successfully produced sophisticated profiles of electrolytic potential and current distributions in the soil of an interested area. This technology is expected to be a breakthrough for detection technology of damages on buried pipes when it comes into combining with a brand of area potential earth current (APEC) and ground penetrated radar (GPR) technologies. 2D current distribution and 2D current vectors on the earth surface from the APEC survey will be used as boundary conditions with exact 3D geometry data resulting in visualization of locations and extents of corrosion damages on the buried pipes in nuclear power plants.

• Wind and Structures
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• v.5 no.2_3_4
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• pp.317-328
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• 2002

A numerical investigation on the turbulent flows over a three-dimensional steep hill is presented. The numerical model developed for the present work is based on the finite volume method and the SIMPLE algorithm with a non-staggered grid system. Standard $k-{\varepsilon}$ model and Shih's non-linear model are tested for the validation of the prediction accuracy in the 3D separated flow. Comparisons of the mean velocity and turbulence profiles between the numerical predictions and the measurements show good agreement. The Shih's non-linear model is found to predict mean flow and turbulence better than the Standard $k-{\varepsilon}$. Flow patterns have also been examined to explain the difference in the cavity zone between 2D and 3D hills.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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• v.36 no.1
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• pp.17-24
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• 2018

DEM (Digital Elevation Model) is a useful dataset which represents the earth surface. Beside many applications, production and frequent update of DEM is a costly task. Recently global satellite based DEMs are available which has huge potential for application. To check the accuracy, this study compares two global DEMs: AW3D30 (Advanced Land Observing Satellite World 3D 30m) and SRTM30 (Shuttle Radar Topography Mission Global 30m) with reference resampled LiDAR DEM 30m in a test area around Chuncheon, Korea. The comparison analysis was based on statistics of each DEM, their difference, profiles, slope, basin and stream orders. As a result, it is found that SRTM30 and AW3D30 were much similar but inconsistent in the test area compared to the LiDAR30 DEM. In addition, SRTM30 shows less difference with LiDAR30 compared to the AW3D30 DEM. But, DEMs should be very carefully examined for area which has temporal or season changes. For basin and stream analysis, global DEMs can be used only for regional scale analysis not local large scales.

• Journal of the Korean Solar Energy Society
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• v.25 no.4
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• pp.101-110
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• 2005

An experimental study of heat transfer of submerged water jet impinging normally on a flat plate is presented. Heat transfer measurements obtained with Reverse cone type nozzle(Rcone) were compared to those obtained with Cone type nozzle(Cone) and Square edged type nozzle(Vert) of the same diameter(D=8mm) for different jet velocities in the range of $3{\sim}7m/s(Re_D=30000{\sim}70000)$ and various nozzle-to target spacings($H/D=2{\sim}10$). The local Nusselt number profiles exhibited a sharp drop for $r/D{\leq}0.5$ and 2nd, 3rd peaks revealed at r/D=2, 3 respectively, followed by a slower decrease there after. The peaks were weakened with increasing the nozzle-to target spacing and decreasing the jet velocity. The stagnation Nusselt number of the Reverse cone type nozzle was larger than those of the other two nozzles for H/D=2. 10, but Cone type nozzle had the highest value for $H/D=4{\sim}8$. Also average Nusselt number of the Reverse cone type nozzle was higher than those of the other two nozzles at $H/D=2{\sim}10$, except for $V_o=7ms$ of H/D=6.

• Nutritional Sciences
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• v.9 no.3
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• pp.179-189
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• 2006

Objective: We investigated the efficacy of a 12-week supplementation of soy isoflavone with L-carnitine on the development of obesity in high fat-induced obese C57BL/6J mice, which are known as a good model of diet-induced obesity. Methods: We measured body weights, adipose tissue mass, serum/liver lipid profiles and fat cell size/number in C57BL/6J mice fed diets containing either low fat (4%) or high fat (35%), or high fat supplemented with soy isoflavone powder containing 10% isoflavone and L-camitine for 12 weeks. Results: Body weight gain, abdominal adipose tissue and liver weight were lower by 31% 78% and 31.4% respectively, in mice on high fat diet containing soy isoflavone+L-carnitine (SC mixture) compared with high fat diet group. Also, SC mixture improved serum lipid profiles such as total cholesterol (TC), triglycerides (TG), and liver lipid profiles such as total lipids and TG. As subsequent results, this SC mixture prevented high-fat diet from accumulating TG in the liver. The size of fat cell was also significantly decreased in SC mixture fed mice. At the end point of this experiment, our results showed that feeding with soy isoflavone for 12 weeks finally increased camitine palmitoyltransferase 1 (CPT 1) activity through elevating the level of CPT1 expression. Conclusions: This study suggests that long-tenn supplementation with dietary soy isoflavone and L-carnitine is more synergistically beneficial for the suppression of high-fat diet induced obesity by inhibiting liver TG accumulation and the gain in abdominal adipose tissue weight than that with soy isoflavone. The antiobesity effects of SC mixture might be attributed, at least in part, to the induction of fatty acid catabolism by soy isoflavone, genistein.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 1993.10a
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• pp.417-422
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• 1993

In order to minimize turnaround of machining in FMS lines, CAD/CAM/CAT integrated system called MascCAM was developed. Developing enhanced CAM and inspection modules in the MascCAM environment, 2D came, 2 $^{1}$2/ D prismatic parts and 3D free-formed surfaces were able to be automatically designed, manufactured and inspected on the machine tools by using AutoCAM and Z-map. Introducing Z-map technique, the MascCAM was able to be interfaceed with and CAD system. Developed QPPGT module generates a quick and fool-proof inspection work to users. A vertical and a horizontal machining center equipped with FANUC OMC were used for experiments. Performance of the system was confirmed by a large amount of experiments.