• IMMUNE NETWORK
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• v.6 no.4
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• pp.204-210
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• 2006

Background: Nitric oxide (NO) in articular chondrocytes regulates dedifferentiation and inflammatory responses by modulating MAP kinases. In this study, we investigated whether the Src kinase in chondrocytes regulates NO-induced dedifferentiation and cyclooxygenase-2 (COX-2) expression. Methods: Primary chondrocytes were treated with various concentrations of SNP for 24 h. The COX-2 and type II collagen expression levels were determined by immunoblot analysis, and prostaglandin $E_2\;(PGE_2)$ was determined by using a $PGE_2$ assay kit. Expression and distribution of p-Caveolin and COX-2 in rabbit articular chondrocytes and cartilage explants were determined by immunohistochemical staining and immunocytochemical staining, respectively. Results: SNP treatment stimulated Src kinase activation in a dose-dependent manner in articular chondrocytes. The Src kinase inhibitors PP2 [4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo(3,4-d)pyrimidine], a significantly blocked SNP-induced p38 kinase and caveolin-1 activation in a dose-dependent manner. Therefore, to determine whether Src kinase activation is associated with dedifferentiation and/or COX-2 expression and $PGE_2$ production. As expected, PP2 potentiated SNP-stimulated dedifferentiation, but completely blocked both COX-2 expression and $PGE_2$ production. And also, levels of p-Caveolin and COX-2 protein expression were increased in SNP-treated primary chondrocytes and osteoarthritic and rheumatoid arthritic cartilage, suggesting that p-Caveolin may playa role in the inflammatory responses of arthritic cartilage. Conclusion: Our previously studies indicated that NO caused dedifferentiation and COX-2 expression is regulated by p38 kinase through caveolin-1 (1). Therefore, our results collectively suggest that Src kinase regulates NO-induced dedifferentiation and COX-2 expression in chondrocytes via p38 kinase in association with caveolin-1.

• Journal of the Institute of Electronics and Information Engineers
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• v.50 no.2
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• pp.60-69
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• 2013

Highlighted by recent security breaches including Google, Western Energy Company, and the Stuxnet infiltration of Iranian nuclear sites, Cyber warfare attacks pose a threat to national and global security. In particular, targeted attacks such as APT exploiting a high degree of stealthiness over a long period, has extended their victims from PCs and enterprise servers to government organizations and critical national infrastructure whereas the existing security measures exhibited limited capabilities in detecting and countermeasuring them. As a solution to fight against such attacks, we designed and implemented a security monitoring system, which shares security information and helps cooperative countermeasure. The proposed security monitoring system collects security event logs from heterogeneous security devices, analyses them, and visualizes the security status using 3D technology. The capability of the proposed system was evaluated and demonstrated throughly by deploying it under real network in a ISP for a week.

• Convergence Security Journal
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• v.12 no.4
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• pp.3-8
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• 2012

Smartphones have all the recent technology integration and NFC (Near Field Communication) Technology is one of them and become an essential these days. Despite using smartphones with NFC technology widely, not many security vulnerabilities have been discovered. This paper attempts to identify characteristics and various services in NFC technology, and to present a wide range of security vulnerabilities, prevention, and policies especially in NFC Contactless technology. We describe a security vulnerability and an possible threat based on human vulnerability and traditional malware distribution technic using Peer-to-Peer network on NFC-Enabled smartphones. The vulnerability is as follows: An attacker creates a NFC tag for distributing his or her malicious code to unspecified individuals and apply to hidden spot near by NFC reader in public transport like subway system. The tag will direct smartphone users to a certain website and automatically downloads malicious codes into their smartphones. The infected devices actually help to spread malicious code using P2P mode and finally as traditional DDoS attack, a certain target will be attacked by them at scheduled time.

• The Bulletin of The Korean Astronomical Society
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• v.41 no.2
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• pp.49.2-49.2
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• 2016

The number of discovery of asteroids with peculiar rotational states has recently increased, and hence a novel approach for lightcurve analysis is considered to be critical. In order to investigate objects such as Non-Principal Axis (NPA) rotator, we selected a NPA candidate, (5247) Kryolv as our target considering its Principal Axis Rotation (PAR) code and the visibility in early 2016. The observations of Krylov were made using Korea Microlensing Telescope Network (KMTNet) 1.6 m telescopes installed at the three southern sites with TO (Target of Opportunity) observation mode. We conducted R-band time-series photometry over a total of 51 nights from January to April 2016 with several exposures during each allocated run. The ensemble normalization photometry was employed using the AAVSO Photomtric All-Sky Survey (APASS) catalog for the standardization. We successfully confirmed its NPA spin state based on the deviation from the reduced lightcurve, and thus Krylov is recorded as the first NPA rotator of its kind in the main-belt, with its precession and rotation periods, $P{\varphi}=81.18h$ and $P_{\Psi}=67.17h$, respectively. In this paper, we present the spin direction, the 3D shape model and taxonomy of the newly confirmed NPA asteroid (5247) Krylov.

• IMMUNE NETWORK
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• v.10 no.2
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• pp.46-54
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• 2010

Background: Graft-versus-host disease (GVHD) is initiated when alloreactive donor T cells are primed by host APCs to undergo clonal expansion and maturation. Since there is a controversy regarding the role of nonhematopoietic cells in GVHD, we wanted to investigate the influence of MHC disparity on nonhematopoietic cells on the pathogenesis of GVHD in the MHC-haplomismatched C57BL/6 ($H-2^b$) or DBA/2 $(H-2^b){\rightarrow}$unirradiated ($C57BL/6{\times}DBA/2$) $F_1(BDF_1;\;H-2^{b/d})$ murine model of acute GVHD (aGVHD) or chronic GVHD (cGVHD). Methods: We generated ($BDF_1{\rightarrow}C57BL/6$), ($BDF_1{\rightarrow}DBA/2$), and ($BDF1{\rightarrow}BDF_1$) chimeras and examined GVHD-related parameters and donor cell engraftment in those chimeras. Results: Using this experimental system, we found that 1) severe aGVHD across MHC Ag barrier depends on the expression of nonhematopoietically rather than hematopoietically derived alloAgs for maximal GVHD manifestations; 2) host APCs were sufficient to break B cell tolerance to self molecules in cGVHD, whereas host APCs were insufficient to induce autoimmunity in aGVHD; 3) donor cell engraftment was greatly enhanced in the host with MHC-matched nonhematopoietic cells. Conclusion: Taken together, our results provide an insight into how MHC disparity on GVHD target organs contribute to the pathogenesis of GVHD.

• The Journal of Information Technology
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• v.4 no.3
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• pp.101-123
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• 2001

The competitive environments of the 2001s appears to demand not only information technology(IT), but also practical use of internet network in all business areas. Accordingly, Chief Information Officers(CIO) are recognizing that these objectives can only be achieved through conscious mind and business mind in digital management. Thus, the main concern of CIO in an organization is development and management of human resource in digital management innovation. To make a successful organizational innovation CIO needs to have the conscious mind for change of human resource management. To study the determinants of the level of management in Korean venture firms, Top management characteristics, resource dependence and organizational power perspective, rational expectations, There is direct successful factors of Venture firm, it is they got th notion that for venture an appropriate manager which is as important as the technical leadership itself. also they employed the people who are very good at skilled management.

• Information Systems Review
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• v.9 no.2
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• pp.85-108
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• 2007

Currently, most of big IT companies attempt to penetrate into Internet portal industry aggressively in order to expand their channels(sale, distribution, marketing, R&D, and so on) and to acquire competitive advantages. Existing Internet portals also have become larger and more complex with continuous developments. Therefore, it is necessary to acquire competitive contents to survive the extreme competition and to satisfy diverse needs of customers. In this paper, we have done qualitative analyses on the cases of domestic and foreign major Internet portals which have acquired contents through of M&A and strategic alliances. In our analyses, we identify five factors crucial to the successes and failures of Internet portals. From the analyses, we find that the acquisition of UCC based contents and subscribers over the critical mass point are the two most important factors that should be simultaneously satisfied for the successful M&As. Additional analyses suggest how to acquire synergy effects from successful M&As.

• Proceedings of KOSOMES biannual meeting
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• 2007.11a
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• pp.51-55
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• 2007

As for satellite programs, the multipurpose satellite 1(KOMPSAT-1) was successfully launched on Dec. 21, 1999 and operated for three years. It is still properly operated even though its life cycle was ended. The development of KOMPSAT-2 (Korea Multipurpose Satellite-2) is near completion and the development of KOMPSAT-3, KOMPSAT-5 and COMS (Communication, Ocean, Meterological Satellite) are proceeding swiftly. In KORDI(Korea Ocean Research and Development Institute), the KOSC (Korea Ocean Satellite Center) construction project is being prepared for acquisition, processing and distribution of sensor data via L-band from GOCI(Geostationary Ocean Color Imager) instrument which is loaded on COMS(Communication, Ocean and Meteorological Satellite); it will be launched in 2000. Ansan(the headquarter of KORDD has been selected for the location of KOSC between 5 proposed sites, because it has the best condition to receive radio wave. The data acquisition system is classified antenna and RF. Antenna is designed to be ${\emptyset}$ 9m cassegrain antenna which has 19.35 $G/T(dB/^{\circ}K)$ at 1.67GHz, RF module, is divided into LNA(Low noise amplifier) and down converter, those are designed to send only horizontal polarization to modem The existing building is re-designed and classified for the KOSC operation concept; computing room, board of electricity, data processing room, operation room Hardware and network facilities have been designed to adapt for efficiency of each functions. The distribution system which is one of the most important systems will be constructed mainly on the internet, and it is also being considered constructing outer data distribution system as a web hosting service for to offering received data to user under an hour.

• KEPCO Journal on Electric Power and Energy
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• v.3 no.2
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• pp.89-97
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• 2017

The substation is a critical node in the power network where power is transformed in the power generation, transmission and distribution system. The IEC 61850 is a global standard which proposes efficient substation automation by defining interoperable communication and data modelling techniques. In order to achieve this level of interoperability and automation, the IEC 61850 (Part 6) defines System Configuration description Language (SCL). The SCL is an XML based file format for defining the abstract model of primary and secondary substation equipment, communications systems and also the relationship between them. It enables the interoperable exchange of data during substation engineering by standardizing the description of applications at different stages of the engineering process. To achieve the seamless interoperability, multi-vendor devices are required to adhere completely to the IEC 61850. This paper proposes an efficient algorithm required for verifying the interoperability of multi-vendor devices by checking the adherence of the SCL file to specifications of the standard. Our proposed SCL validation algorithm consists of schema validation and other functionalities including information model validation using UML data model, the Vendor Defined Extension model validation, the User Defined Rule validation and the IED Engineering Table (IET) consistency validation. It also integrates the standard UCAIUG (Utility Communication Architecture International Users Group) Procedure validation for quality assurance testing. Our proposed algorithm is not only flexible and efficient in terms of ensuring interoperable functionality of tested devices, it is also convenient for use by system integrators and test engineers.

• Proceedings of the KIEE Conference
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• 2002.11c
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• pp.19-22
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• 2002

In this paper, we aims to develop a microcontroll er-based ECG monitoring system and portable pulse oximeter using Compact Flash Interface. First, portable pulse oximeter system is designed to record 2 channel of biosignals simultaneously, including 1 channel of $SpO_2$ and 1 channel of pulse rate. It is very small and portable. Besides, the system makes it possible to measure a patient's condition without an additional medical equipment. We tried to solve the problems generated by a patient's motion. That is, we added an analog circuit to a traditional pulse oximeter in order to eliminate the change of the base line. And we used 2D sector algorithm. As present, SpO2 modules are completed. But there are still many further development needed in order to enhance the function. Especially, compact falsh interface remains the most to complete. Second, ECG monitoring system uses almost same as present 3-lead ECG system. But we focus on the analog part, especially in filter. The proposed filter is composed of two parts. One is a filter to remove the power-line interface. The other is a filter to remove the baseline drift. A filter to remove the power-line and the baseline drift is necessarily used in the ECG system. The implemented filter have three features; minimizing the distortion in DC component, removing the harmonic component of power-line frequency. Using compact flash interface, we can easily transfer a patient's personal information and the measured signal data to a network based server environment. That means, it is possible to implement a patient's monitoring system with low cost.