• Design Convergence Study
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• v.17 no.3
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• pp.109-123
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• 2018

This exploratory research examines a new approach to the healing environment in the changed health paradigm, and seeks to conceptualize the extended characteristics of the healing environment in the context of mental health promotion. This study aims to, first, define the concepts of health, mental health, and the healing environment in the changed paradigm, and second, develop the healing characteristics of the physical environment for mental health promotion and create indicators. For these purposes, this study performed a theoretical exploration that could support the concept of the healing environment for mental health promotion by expanding its scope into not only architecture, psychology, and psychiatry but also philosophy of architecture and environment psychology, which concerns the relationship between humans and the environment. This study considers related theories and attempts to establish a new concept from a convergent perspective. The characteristics of the healing environment categorized as a result of exploratory research on previous studies and theories include (a) physical protection promotion, (b) psychological comfort promotion, (c) social exchange promotion, and (d) personal self-esteem promotion. Establishing the concept of the healing environment for mental health promotion is important to implement the actual healing environment. Based on the concept, more specific design indicators and guidelines could be developed to conduct applied research.

• Korean Journal of Microbiology
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• v.54 no.4
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• pp.420-427
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• 2018

The orthogonal pair of Saccharomyces cerevisiae tyrosyl-tRNA synthetase (Sc YRS) and a variant of E. coli initiator tRNA, fMam $tRNA_{CUA}$ which recognizes the amber stop codon is an effective tool for site-specific incorporation of unnatural amino acids into the protein in E. coli. To evolve the amber suppression activity of the orthogonal pair, we generated a mutant library of Sc YRS by randomizing two amino acids at 320 and 321 which involve recognition of the first base of anticodon in fMam $tRNA_{CUA}$. Two positive clones are selected from the library screening with chloramphenicol resistance mediated by amber suppression. They showed growth resistance against high concentration of chloramphenicol and their $IC_{50}$ values were approximately 1.7~2.3 fold higher than the wild type YRS. In vivo amber suppression assay reveals that mutant YRS-3 (mYRS-3) clone containing amino acid substitutions of P320A and D321A showed 6.5-fold higher activity of amber suppression compared with the wild type. In addition, in vitro aminoacylation kinetics of mYRS-3 also showed approximately 7-fold higher activity than the wild type, and the enhancement was mainly due to the increase of tRNA binding affinity. These results demonstrate that optimization of anticodon recognition by engineered aminoacyl tRNA synthetase improves the efficiency of unnatural amino acid incorporation in response to nonsense codon.

• Journal of the Korean Society for Nondestructive Testing
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• v.20 no.4
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• pp.314-321
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• 2000

A gap between a $Al_2O_3/Fe$ thermite and lower head vessel is formed in the lower-plenum arrested vessel attack(LAVA) experiment which is the 1st phase study of simulation of naturally arrested vessel attack in vessel(SONATA-IV). The gap measurement using a conventional ultrasonic method would be lack of a reliability due to the structure complexity and the metallurgical grain size change of the lower head HAZ occurred by a thermite $Al_2O_3/Fe$ melt or a $Al_2O_3$ melt at $2300^{\circ}C$. The grain echoes having false signals and lower S/N ratio signals are detected due to a multiple scattering, a mode conversion and an attenuation of a ultrasonic resulted from at the interface of increased grain size zone. In this test, the signals pattern was classified to understand the behavior of the ultrasonic in a multi-layer specimen of solid-liquid-solid of assuming that the thermite and the lower head vessel is immersed. The polarity threshold algorithm of frequency diversity gives us the enhancement about 6dB of the ratio S/N.

• Toxicological Research
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• v.32 no.3
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• pp.177-193
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• 2016

After more than half of century since the Warburg effect was described, this atypical metabolism has been standing true for almost every type of cancer, exhibiting higher glycolysis and lactate metabolism and defective mitochondrial ATP production. This phenomenon had attracted many scientists to the problem of elucidating the mechanism of, and reason for, this effect. Several models based on oncogenic studies have been proposed, such as the accumulation of mitochondrial gene mutations, the switch from oxidative phosphorylation respiration to glycolysis, the enhancement of lactate metabolism, and the alteration of glycolytic genes. Whether the Warburg phenomenon is the consequence of genetic dysregulation in cancer or the cause of cancer remains unknown. Moreover, the exact reasons and physiological values of this peculiar metabolism in cancer remain unclear. Although there are some pharmacological compounds, such as 2-deoxy-D-glucose, dichloroacetic acid, and 3-bromopyruvate, therapeutic strategies, including diet, have been developed based on targeting the Warburg effect. In this review, we will revisit the Warburg effect to determine how much scientists currently understand about this phenomenon and how we can treat the cancer based on targeting metabolism.

• Asian-Australasian Journal of Animal Sciences
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• v.5 no.4
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• pp.665-671
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• 1992

To investigate the effects of immunization against somatostatin (SRIF) on growth rate, feed efficiency and carcass quality; forth-eight Yorkshire gilts ($age=37.5{\pm}4.3d,\;wt=8.2{\pm}1.6kg$) were randomly assigned to one of the following three treatments (1) control, (2) bovine serum albumin (BSA) and (3) SRIF. Cyclic SRIF was conjugated to BSA as the antigen containing 1 mg of SRIF diluted in 3 ml of saline. The conjugate was injected subsutaneously together with bacterial cell protein (BP) adjuvant on both sides of the neck of each gilt as the initial injection with three subsequent booster injections. Throughout the experiment all pigs were fed ad libitum a corn-soy diet containing 20% protein. Body weight and feed intake were measured on a weekly basis. All pigs in the experiment were slaughtered when they approached 101 kg body weight on the weekly weigh day. After slaughter, carcass parameters were analyzed to assess carcass quality. Results revealed that there were no differences among SRIF, BSA and control treatments for average daily gain, feed efficiency and feed intake during the first 5 wk of the experiment and from 6 wk to slaughter. The results for carcass analysis indicated that active immunization against SRIF had no effect on fat content, lean yield, water content and Canadian carcass index These data, collectively, suggest that the protocol employed in the present investigation for active immunization against SRIF is not an effective method for the enhancement of pig growth and improvement of feed efficiency and carcass quality.

• Progress in Superconductivity
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• v.11 no.1
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• pp.47-51
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• 2009

For many large-scale applications of high-temperature superconducting materials, large critical current density ($J_c$) in high applied magnetic fields are required. A number of methods have been reported to introduce artificial pinning centers in $YBa_2Cu_3O_{7-{\delta}}$ films for enhancement of their $J_c$. We studied the microstructures and characteristic of $YBa_2Cu_3O_{7-{\delta}}$ films fabricated on $SrTiO_3$ (100) substrates with ZnO nanorods as pinning centers. Au catalyst nanoparticles were synthesized on STO substrates with self assembled monolayer to control the number of ZnO nanorods. The density of Au nanoparticles is approximately $240{\sim}260{\mu}m^{-2}$ with diameters of $41{\sim}49nm$. ZnO nanorods were grown on STO by hot-walled PLD with Au nanoparticles. Typical size of ZnO nanorod was around 179 nm in diameter and $2{\sim}6{\mu}m$ in length respectively. YBCO films deposited directly on STO substrates show the c-axis orientation, while YBCO films with ZnO nanorods exhibit any mixed phases without any typical crystal orientation.

• Convergence Security Journal
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• v.20 no.3
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• pp.89-97
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• 2020

Recently, security issues on industrial technology are undergoing rapid changes around the world. Developed countries are establishing response strategies to protect their own core technologies while creating conflicts with global value chains and foreign capital movement. Also in Korea, we are approaching industrial security issues in the mid- to long-term industrial competitiveness. The purpose of this study is to survey on the awareness of the industrial security ecosystem and derive key policy issues. Based on a three round survey, four policies were suggested as followings : systemization of industrial security control tower, enhancement of security company's technical skills and training of security specialists, improvement of technology leakage prevention system through retirement personnel and M&A, reinforcement of research security in R&D process and proactive technology protection. It is hoped that this study will serve as a basis for policy-making as an evidence-based study reflecting the policy demands of industrial security.

• Earthquakes and Structures
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• v.16 no.3
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• pp.295-310
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• 2019

This study attempts to develop new simplified approximate formulas to predict the fundamental natural periods of vibration (T) for bearing wall systems engaged with special reinforced concrete shear walls (RCSW) under seismic loads. Commonly, seismic codes suggested empirical formulas established by regression analysis of measured T for buildings during earthquake motions. These formulas depend on structure type, building height, number, height and length of SW, and ratio of SW area to base area of structure. In this study, a parametric investigation is performed for T of 110 selected models of bearing RCSW systems with varying structural height, configuration of horizontal plans including building width, number and width of bays, presence of middle corridors and core SWs. For this purpose, a 3D non-linear response time history (TH) analysis is implemented using ETABS v16.2.1. New formulas to estimate T are anticipated and compared with those obtained from formulas of IBC 2012 and ASCE/SEI 7-10. Moreover, the study examines responses of an arbitrarily two selected test model of 60 m and 80 m in height with presence of SWs having middle corridors. It is observed that the performance of the tested buildings is different through arising of considerable errors when using codes' formulas for estimating T. Accordingly, using the present proposed formulas exhibits more reasonable and safer design compared to codes' formulas. The results showed that equitable enhancement is promising to improve T formulas approaching enhanced and accurate estimation of T with reliable analysis, design, and evaluation of bearing RCSW systems.

• Journal of Digital Convergence
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• v.19 no.6
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• pp.29-38
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• 2021

The social studies, mathematics, and science textbooks of the elementary curriculum will begin to be authorized from 2022. This study explores the effect of textbooks based on a gamification motivation strategy on learner interest. For this purpose, this study analyzes whether the systematic application of the gamification motivation strategy to elementary studies textbooks, which will be authorized from 2022, can develop this textbook into a "learner-centered curriculum book that induces interest." More specifically, this study applied Kumsung Publishing's experimental social studies textbooks in class and conducted a questionnaire among 121 third graders to verify the effectiveness of the textbooks. The results show that studies textbooks based on a gamification motivation strategy greatly influence increased learner interest in the classroom. The textbooks also represent a positive influence in learner understanding, interest, and curiosity regarding the class content and assistance. Demonstrating that gamification motivation strategy is worthwhile to actively apply in future textbook development for the enhancement of learners' interests, this study is significant in that it has presented a meaningful textbook development model.

• Nuclear Engineering and Technology
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• v.54 no.11
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• pp.4265-4271
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• 2022

Determination of ¹³⁷Cs, ⁴⁰K and ²¹⁰Po in water, bottom sediments and suspended matter of river systems of the Can Gio Biosphere Reserve, Vietnam was carried out. The average activity concentration of ¹³⁷Cs in waters of Ca Gau and Long Tau was 0.89 ± 0.14 and 1.08 ± 0.15 Bq m^-3 and was comparable to the levels of this radioisotope in waters of the East Sea. The activity concentration of ¹³⁷Cs in bottom sediments was 2.23 ± 0.81 and 3.63 ± 1.24 Bq kg^-1. The activity concentration of ¹³⁷Cs in water and bottom sediments could be characterized as low. So, the water areas of the Ca Gau and Long Tau rivers could be attributed to areas with insignificant pollution by technogenic radionuclides. The ²¹⁰Po activity concentration in bottom sediments of the Ca Gau and Long Tau rivers ranged from 9.2 ± 1.2 to 25.5 ± 2.1 Bq kg^-1, which is typical for river bottom sediments. Such values indicate the absence of anthropogenic enhancement of the entry of this radionuclide into the Can Gio river systems. The ⁴⁰K activity concentration varied within 467 ± 42-651 ± 39 Bq kg^-1 and represented typical values of potassium content in the bottom sediments of coastal water bodies, subject to a significant influence of the lithogenic component of suspended matter.