• Proceedings of the KSLP Conference
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• 2015.03a
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• pp.31-31
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• 2015

• Tissue Engineering and Regenerative Medicine
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• v.15 no.6
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• pp.761-769
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• 2018

BACKGROUND: Bioprinting has recently appeared as a powerful tool for building complex tissue and organ structures. However, the application of bioprinting to regenerative medicine has limitations, due to the restricted choices of bio-ink for cytocompatible cell encapsulation and the integrity of the fabricated structures. METHODS: In this study, we developed hybrid bio-inks based on acrylated hyaluronic acid (HA) for immobilizing bio-active peptides and tyramine-conjugated hyaluronic acids for fast gelation. RESULTS: Conventional acrylated HA-based hydrogels have a gelation time of more than 30 min, whereas hybrid bio-ink has been rapidly gelated within 200 s. Fibroblast cells cultured in this hybrid bio-ink up to 7 days showed >90% viability. As a guidance cue for stem cell differentiation, we immobilized four different bio-active peptides: BMP-7-derived peptides (BMP-7D) and osteopontin for osteogenesis, and substance-P (SP) and Ac-SDKP (SDKP) for angiogenesis. Mesenchymal stem cells cultured in these hybrid bio-inks showed the highest angiogenic and osteogenic activity cultured in bio-ink immobilized with a SP or BMP-7D peptide. This bio-ink was loaded in a three-dimensional (3D) bioprinting device showing reproducible printing features. CONCLUSION: We have developed bio-inks that combine biochemical and mechanical cues. Biochemical cues were able to regulate differentiation of cells, and mechanical cues enabled printing structuring. This multi-functional bio-ink can be used for complex tissue engineering and regenerative medicine.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.22 no.2
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• pp.267-272
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• 2021

In this study, the output results of 3D printed exterior materials for application to buildings of various shapes are output tests using test specimens, in which 3D printing concrete is cast in a mold and accelerating agents are used to ensure stackability. The unit weight and strength characteristics of the body were analyzed. Compared to the unit weight of concrete placed in the mold, the unit weight of 3D printing concrete using accelerating agents tends to decrease by approximately 3.5% to 5.0%, and the compressive strength is the compressive strength of the concrete placed in the mold. In comparison, the compression strength of the output by 3D printing tended to decrease by approximately 36% to 46%. In the flexural strength, the compressive strength of the output through 3D printing decreased by approximately 36% to 46% compared to the compressive strength of concrete placed in the mold. The impact on the strength characteristics of 3D printed concrete using accelerating agents tended to decrease by approximately 2.0 to 5.8%. Therefore, 3D printing output accelerating agents can be used.

• Journal of the Korean Society of Radiology
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• v.15 no.5
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• pp.691-696
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• 2021

In order to prevent and treat a patient's disease, the anatomical structure of the lesion through medical imaging is one of the important processes. However, there is a limit to the image displayed on the screen, so many studies are underway to overcome this by using 3D printing technology. To this end, this study implemented a three-dimensional cardiovascular model using actual patient image data, printed it out using a 3D printer, and conducted a usefulness test on current medical professionals. As a result of the usefulness evaluation, when the questionnaire conducted by a total of 5 people was converted to the Likert scale, the average value of all items showed a high result of 4.83 points, and the result of the cross-analysis was (P) = 10.000 (0.265), which was equally positive among all the questionnaires survey results were presented. Based on the results, it is expected that 3D printing technology will help advance medical technology.

• The Journal of the Convergence on Culture Technology
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• v.4 no.1
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• pp.27-32
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• 2018

Recently, diverse bio-growth and object production experience learning contents have been developed for AR-based storytelling. In this paper, we will develop a storytelling-based growth type content using 3D printer which can add interest in and motivation of experiential learning. It is possible to increase the value of the characters produced by 3D printer as they can be used as personal collections. The bio-growth type content enables the learners and users to experience the local culture, history, and tourism ecology, which can enhance the educational effect by promoting their understanding in a fun way. The purpose of this study is to develop an application for experiential learning contents which creates a virtual environment in an object smart device where you can experience the culture and ecology of a learning community, and then produce the output using the 3D printer to keep as a personal souvenir. The developed contents application for experiential learning can be utilized not only for students but also for tourists. It is expected to serve as a source for further development of various contents through 3D printing technology.

• Korean journal of applied entomology
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• v.61 no.1
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• pp.249-254
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• 2022

Silkworms, which have for long been used as an insect resource for industrialization, have recently attracted attention as potential bio-factories for the production of novel biomaterials. In this regard, material production is typically achieved based on transformation technology, mediated via microinjection, in which a target gene is inserted into eggs containing an embryo. However, an essential step in the microinjection procedure is egg fixation, which can be a time-consuming and laborious task. Therefore, in this study, using the 3DCADian program, we adopted a 3D printing approach to model egg liners and glue drawers, which can contribute to facilitating egg alignment and fixation, thereby enhancing transformation efficiency by reducing time consumption and fatigue. After rendering using Fusion 360, the two supplementary tools were produced by printing with nylon resin (PA12) and Sinterit Lisa Pro. Subsequent analysis of the time required to fix eggs on glass slides using the two manufactured tools, revealed that the processing time was reduced by approximately 18.6% when the two tools were used compared with when these tools were not used. These innovations not only reduced fatigue but also contributed to more effective use of the microscope and manipulator for microinjection. Consequently, we believe that with additional research and refinement, the egg liner and glue drawer developed in this study could be used to enhance silkworm transformation efficiency and study similar transformation systems in other industrial insects.

• Journal of the Korea Fashion and Costume Design Association
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• v.22 no.2
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• pp.117-136
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• 2020

The purpose of this study is to analyze changes in high-tech fashion along with the types and characteristics of high-tech fashion that have appeared recently providing diverse material for the fashion field. High-tech fashion requires such research to learn how much distance one has in one's life. It is also meaningful to predict what direction high-tech fashion research may be needed. For research methods, previous research and literary studies were considered and photographs in which high-tech techniques were used were collected using the keyword 'high-tech fashion'. High-tech fashion types can be organized into the four types of luminescent types, mutual interaction types, 3D printing fashion, and virtual fashion. The research results were as follows. First, luminescent fashion was an important expression method of high-tech fashion. Materials for luminescent fashion first started with LED electric wire connections and many methods have been attempted with the appearance of electrically conductive clothing material, such as luminescent lasers and beam projectors. Second, interactive high-tech fashion often appears as variable fashion. The work of Hussein Chalayan, which was combined with advanced technology, set up a base for variable type interactive high-tech fashion in the 2000s. As bioengineering technology has developed, fashion that interacts with the environment without an energy source has appeared and the interaction among fashion, people, and the environment can be seen. Third, diverse forms of expressiveness in virtual reality such as 3D CLO shows a great difference with past high-tech fashion. Simple and diverse attempts made through virtual fittings reduce the limitations of time and space, permit interaction, and add a sense of reality through speed and dynamic physical beauty. Fourth, 3D printed fashion expresses complex and detailed clothing material that is different from those before with the development of computer 3D modeling technology. Modeling that can imitate geometric and bio-engineered structures is possible and mysterious feelings are passed on to people through creative expressions.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.22 no.2
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• pp.632-637
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• 2021

In order to develop future construction technology, research is actively being conducted on concrete construction technology using 3D printing, which is currently in the spotlight as a future industry in domestic and foreign construction industries and academia. However, 3D printing technology is currently being developed and does not meet the requirements for proper construction technology and the properties of concrete materials, and it is difficult to apply in the actual field. Research is also needed for the durability management and maintenance of constructed structures. This work compares the compressive and flexural strength to that produced in conventional molds by dividing the 3D printed concrete output by the laminated X, Y, and Z axes. The compressive strength of a test specimen in the II Z-axis test direction was 8-10% higher than that of the other test directions (I and III Y axes and X axis). The strength was 4% lower than that of a molded test specimen. As of 28th of the age, the bending strength of the test specimen in the Z-axis direction was 5 to 7% higher than that of the I and III Y, and X-axis test directions, and the strength was 2% lower than that of the molded test specimen.

• Maxillofacial Plastic and Reconstructive Surgery
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• v.42
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• pp.18.1-18.9
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• 2020

Background: Bone grafting has been considered the gold standard for hard tissue reconstructive surgery and is widely used for large mandibular defect reconstruction. However, the midface encompasses delicate structures that are surrounded by a complex bone architecture, which makes bone grafting using traditional methods very challenging. Three-dimensional (3D) bioprinting is a developing technology that is derived from the evolution of additive manufacturing. It enables precise development of a scaffold from different available biomaterials that mimic the shape, size, and dimension of a defect without relying only on the surgeon's skills and capabilities, and subsequently, may enhance surgical outcomes and, in turn, patient satisfaction and quality of life. Review: This review summarizes different biomaterial classes that can be used in 3D bioprinters as bioinks to fabricate bone scaffolds, including polymers, bioceramics, and composites. It also describes the advantages and limitations of the three currently used 3D bioprinting technologies: inkjet bioprinting, micro-extrusion, and laserassisted bioprinting. Conclusions: Although 3D bioprinting technology is still in its infancy and requires further development and optimization both in biomaterials and techniques, it offers great promise and potential for facial reconstruction with improved outcome.

• Journal of the Korean Society of Manufacturing Process Engineers
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• v.13 no.2
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• pp.1-7
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• 2014

Recent experimental observations support the hypothesis that mechanical stimuli play a role in regulating the specialized molecular expression of articular cartilage in vitro and in vivo. Other studies have demonstrated that the continuous passive motion(CPM)bioreactor for whole joints can provide a platform for possible future in vitro studies and applications, including possible interactions of bio-mechanical and biochemical signals. In this study, we have developed acustom-made bioreactor capable of bending and stretching with circular type motion, and a biomimetic knee joint model, using a 3D printer. This system could be used to investigate the effects of rehabilitative joint motion of dynamic culture.