• Journal of Integrative Natural Science
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• v.9 no.3
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• pp.190-198
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• 2016

Xanthine Oxidase is an enzyme, which oxidizes hypoxanthine to xanthine, and xanthine to uric acid. It is widely distributed throughout various organsincluding the liver, gut, lung, kidney, heart, brain and plasma. It is involved in gout pathogenesis. In this study, we have performed Comparative Molecular Field Analysis (CoMSIA) on a series of 2-(indol-5-yl) thiazole derivatives as xanthine oxidase (XO) inhibitors to identify the structural variations with their inhibitory activities. Ligand based CoMSIA models were generated based on atom-by-atom matching alignment. In atom-by-atom matching, the bioactive conformation of highly active molecule 11 was generated using systematic search. Compounds were aligned using the bioactive conformation and it is used for model generation. Different CoMSIA models were generated using different alignments and the best model yielded across-validated $q^2$ of 0.698 with five components and non-cross-validated correlation coefficient ($r^2$) of 0.992 with Fisher value as 236.431, and an estimated standard error of 0.068. The predictive ability of the best CoMSIA models was found to be $r{^2}_{pred}$ 0.653. The study revealed the important structural features required for the biological activity of the inhibitors and could provide useful for the designing of novel and potent drugs for the inhibition of Xanthine oxidase.

• Progress in Superconductivity
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• v.3 no.2
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• pp.198-212
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• 2002

The effects of reacted precursors on phase evolution, microstructure, $J_{c}$ and junctional characteristic of the inter-granular contacts were investigated in Ag-sheathed T1-1223 tapes prepared using three kinds of reacted precursors, and compared to those in the tape prepared using an unreacted precursor The precursors were prepared by heat-treating a mixture of Sr-Ba-Ca-Cu-O, $Tl_2$$O_3$, PbO and $Bi_2$$O_3$ powders at $805^{\circ}C$ (precursor I ), $840^{\circ}C$ (precursor II ) and $905^{\circ}C$(precursor III) for 20 min. Tl-1223 phase content, grain size and J\ulcorner in the tapes appeared to increase in an order of precursors I, II and III Compared to tapes prepared using an unreacted precursor, the tapes prewar ed using precursors II and III revealed reduced pore and impurity densities and an enhanced texture. Also characteristic of inter -granular contacts and fraction of strong-links were improved. The improved properties are attributed to enhanced densification resulting from using the reacted precursors.s.

• KSBB Journal
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• v.19 no.1
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• pp.42-49
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• 2004

A gene coding for epoxide hydrolase (EH) of Aspergillus niger LK, a fungus possessing the enantioselective hydrolysis activity for racemic epoxides, was characterized by phylogenetic analysis. The deduced protein of A. niger LK epoxide hydrolase shares significant sequence similarity with several bacterial EHs and mammalian microsomal EHs (mEH) and belongs to the a/${\beta}$ hydrolase fold family. EH from A. niger LK had 90.6% identity with 3D crystal structure of lqo7 in Protein Data Bank. Sequence comparison with other source EHs suggested that Asp$\^$l92/, Asp$\^$374/ and His$\^$374/ constituted the catalytic triad. Based on the multiple sequence comparison of the functional and structural domain sequence, the phylogenetic tree between relevant epoxide hydrolases from various species were reconstructed by using Neighbor-Joining method. Genetic distances were so far as 1.841-2.682 but characteristic oxyanion hole and catalytic triad were highly conserved, which means they have diverged from a common ancestor.

• The Transactions of the Korea Information Processing Society
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• v.4 no.11
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• pp.2840-2848
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• 1997

Recognition of 3D objects using computer vision is complicated by the fact that geometric features vary with view orientation. An important factor in designing recognition algorithms in such situations is understanding the variation of certain critical features. The features selected in this paper are the angles between landmarks in a scene. In a class of polyhedral objects the angles at certain vertices may form a distinct and characteristic alignment of faces. For many other classes of objects it may be possible to identify distinctive spacial arrangements of some readily identifiable landmarks. In this paper given an isotropic view orientation and an orthographic projection the two dimensional joint density function of two angles in a scene is derived. Also the joint density of all defining angles of a polygon in an image is derived. The analytic expressions for the densities are useful in determining statistical decision rules to recognize surfaces and objects. Experiments to evaluate the usefulness of the proposed methods are reported. Results indicate that the method is useful and powerful.

• The Journal of Advanced Prosthodontics
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• v.15 no.6
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• pp.290-301
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• 2023

PURPOSE. The study aimed to determine the influence of implant angulation on the trueness of multi-unit implant impressions taken through different techniques and strategies. MATERIALS AND METHODS. As reference models, three partially edentulous mandibular models (Model 1: No angulation; Model 2: No angulation for #33, 15-degree distal angulation for #35 and #37; Model 3: No angulation for #33, 25-degree distal angulation for #35 and #37) were created by modifying the angulations of implant analogues. Using a lab scanner, these reference models were scanned. The obtained data were preserved and utilized as virtual references. Three intraoral scanning (IOS) strategies: IOS-Omnicam, ISO-Quadrant, and IOS-Consecutive, as well as two traaditional techniques: splinted open tray (OT) and closed tray (CT), were used to create impressions from each reference model. The best-fit alignment approach was used to sequentially superimpose the reference and test scan data. Computations and statistical analysis of angular (AD), linear (LD), and 3D deviations (RMS) were performed. RESULTS. Model type, impression technique, as well as interaction factor, all demonstrated a significant influence on AD and LD values for all implant locations (P < .05). The Model 1 and SOT techniques displayed the lowest mean AD and LD values across all implant locations. When considering interaction factors, CT-Model 3 and SOT-Model 1 exhibited the highest and lowest mean AD and LD values, respectively. Model type, impression technique, and interaction factor all revealed significant effects on RMS values (P ≤ .001). CT-Model 3 and SOT-Model 1 presented the highest and lowest mean RMS values, respectively. CONCLUSION. Splinted-OT and IOS-Omnicam are recommended for multi-unit implant impressions to enhance trueness, potentially benefiting subsequent manufacturing stages.

• The Journal of the Convergence on Culture Technology
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• v.6 no.4
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• pp.669-675
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• 2020

In this study, 3D analysis was compared in evaluating the track deformation of subway structures during adjacent excavation. For the 3D analysis model, the boundary conditions of the tunnel model and the application level of the ground water were analyzed as variables. As the result of the effects of track irregularity using the 3D model, the analysis model considering the site ground water level instead of the design values and changing the constraint of the boundary condition is more reasonable. In addition, the influence of track irregularity due to the boundary condition and load condition of the analytical model is more obvious in the factors directly affected by the longitudinal relative displacement of the rail, such as alignment, cross level and gauge irregularity. Therefore, the evaluation on track stability according to adjacent excavation work was appropriate to analysed the longitudinal deformation of the track by using 3D model that could be investigate the deformation of rail. In addition, the boundary condition and load condition(ground water level) of the numerical model was important for accurate analysis results.

• Journal of KIBIM
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• v.13 no.3
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• pp.1-11
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• 2023

In order to use BIM as a tool for improving the productivity and quality of products in the construction industry, a BIM model must be created from the design stage first. Infrastructure structures such as bridges and tunnels are mainly created based on three-dimensional alignment in the generation of BIM models. Especially, generation of BIM models based on three-dimensional linearity has high task difficulty and algorithms for automating BIM modeling for railway infra structures have been suggested in previous studies. This study improved the BIM modeling automation algorithm of railway infrastructures and developed a system based on the algorithm so that it can be easily used by ordinary users. The system was built as an add-in system of Autodesk's Revit. As an improvement first, it is possible to arrange different libraries for each pattern, enabling various uses. In addition, it can be created models of several members with a single process and the system can automatically places structures that are added periodically, such as Rock Bolt and Fore Polling. Finally, 3D length information and volume for each pattern are automatically calculated for more accurate 3D-based volume calculation. This study contributes to increasing user accessibility by building a BIM modeling automation algorithm into a system. The system is expected to improve the efficiency of BIM modeling creation of linear-based infra structures, including railway infrastructure.

• Journal of Platform Technology
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• v.12 no.2
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• pp.23-33
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• 2024

The development of mixed reality (MR) technology has a great influence on the research and development of medical support equipment. In particular, it supports to respond effectively to emergencies occurring in the field. MR technology enables access to first aid and field support by combining virtual information with the real world so that users can see virtual objects in the real world. However, due to the nature of the equipment, there is a limitation in accurately matching virtual objects based on user vision. To improve these limitations, this paper proposes a 3D biometric object recognition and matching algorithm in the MR environment. As a result of the experiment, when a virtual object is rendered and visualized while equipped with an optical-based HMD from the user's side, it was possible to reduce the user's field of view error and eliminate the joint-loss phenomenon during skeleton recognition. The proposed method can reduce errors between the real user's field of view and the virtual image and provide a basis for reducing errors that occur in the process of virtual object recognition and matching. It is expected that this study will contribute to improving the accuracy of the telemedicine support system for first aid.

• Journal of the Optical Society of Korea
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• v.15 no.3
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• pp.289-292
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• 2011

Reactive mesogen (RM) is an organic liquid crystal molecule that can be self-aligned to have an optic axis of birefringence when coated over a polyimide alignment film. A free-standing optical wave-plate film consisting of RM and low-loss optical polymers was fabricated in this work, and the film was inserted across the polymer waveguide to form an integrated optical polarization converter. For convenient evaluation of the polarization converters, a waveguide polarizer and analyzer were fabricated in series. The polarization conversion efficiency was measured to be 25 dB for the wavelength range from 1520 to 1580 nm. The wave plate exhibited a temperature-dependent retardation of $4.5^{\circ}$ for a temperature change from 25 to $100^{\circ}C$.

• Journal of Magnetics
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• v.16 no.3
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• pp.300-303
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• 2011

The effect of the hot-compaction temperature on the microstructure and magnetic properties of anisotropic nanocrystalline magnets was investigated. The hot-compaction temperature was found to impact both the magnetic properties and the microstructure of die-upset magnets. The remanence of the isotropic precursor increases slightly with the improved hot-compaction temperature, and the grains start to grow on the flake boundary at higher hot-compaction temperatures. After hot deformation, it was found that the change in the magnetic properties was the inverse of that observed with the hot-compaction temperature. Microstructural investigation showed that die-upset magnets inherit the microstructural characteristics of their precursor. For the die-upset magnets, hot pressed at low temperature, scarcely any abnormal grain growth on the flake boundary can be seen. For those hot pressed at higher temperatures, however, layers with large equiaxed grains could be observed, which accounted for the poor alignment during the hot deformation, and thus the poor magnetic properties.