• Radiation Oncology Journal
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• v.20 no.1
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• pp.41-52
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• 2002

Purpose : 3D conformal radiotherapy, the optimum dose delivered to the tumor and provided the risk of normal tissue unless marginal miss, was restricted by organ motion. For tumors in the thorax and abdomen, the planning target volume (PTV) is decided including the margin for movement of tumor volumes during treatment due to patients breathing. We designed the respiratory gating radiotherapy device (RGRD) for using during CT simulation, dose planning and beam delivery at identical breathing period conditions. Using RGRD, reducing the treatment margin for organ (thorax or abdomen) motion due to breathing and improve dose distribution for 3D conformal radiotherapy. Materials and Methods : The internal organ motion data for lung cancer patients were obtained by examining the diaphragm in the supine position to find the position dependency. We made a respiratory gating radiotherapy device (RGRD) that is composed of a strip band, drug sensor, micro switch, and a connected on-off switch in a LINAC control box. During same breathing period by RGRD, spiral CT scan, virtual simulation, and 3D dose planing for lung cancer patients were peformed, without an extended PTV margin for free breathing, and then the dose was delivered at the same positions. We calculated effective volumes and normal tissue complication probabilities (NTCP) using dose volume histograms for normal lung, and analyzed changes in doses associated with selected NTCP levels and tumor control probabilities (TCP) at these new dose levels. The effects of 3D conformal radiotherapy by RGRD were evaluated with DVH (Dose Volume Histogram), TCP, NTCP and dose statistics. Results : The average movement of a diaphragm was 1.5 cm in the supine position when patients breathed freely. Depending on the location of the tumor, the magnitude of the PTV margin needs to be extended from 1 cm to 3 cm, which can greatly increase normal tissue irradiation, and hence, results in increase of the normal tissue complications probabiliy. Simple and precise RGRD is very easy to setup on patients and is sensitive to length variation (+2 mm), it also delivers on-off information to patients and the LINAC machine. We evaluated the treatment plans of patients who had received conformal partial organ lung irradiation for the treatment of thorax malignancies. Using RGRD, the PTV margin by free breathing can be reduced about 2 cm for moving organs by breathing. TCP values are almost the same values $(4\~5\%\;increased)$ for lung cancer regardless of increasing the PTV margin to 2.0 cm but NTCP values are rapidly increased $(50\~70\%\;increased)$ for upon extending PTV margins by 2.0 cm. Conclusion : Internal organ motion due to breathing can be reduced effectively using our simple RGRD. This method can be used in clinical treatments to reduce organ motion induced margin, thereby reducing normal tissue irradiation. Using treatment planning software, the dose to normal tissues was analyzed by comparing dose statistics with and without RGRD. Potential benefits of radiotherapy derived from reduction or elimination of planning target volume (PTV) margins associated with patient breathing through the evaluation of the lung cancer patients treated with 3D conformal radiotherapy.

• Korean Journal of Applied Biomechanics
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• v.18 no.2
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• pp.85-94
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• 2008

The purpose of this study is to provide basic materials for amateur golf players or golf maniacs to learn desirable iron swing motions. This study compared and analyzed the swing motions of iron clubs(3, 6, 9) by using 3-D in three elite golf players. 1. There was no a great difference in the total of swing time by club and the time by phase was nearly similar. 2. There was no a difference in the change in a head location at address and impact by club. 3. The angle change in a right knee joint was similar by club except the difference according to the length of the club. 4. There was a subtle difference in hip rotation angle by club. 5. In each club, the same rotation angle of shoulder joint at address and impact motions contributed to accurate swing, and the maintenance of more than $90^{\circ}$ of shoulder rotation angle in top swing increased swing rotation. 6. Although subtle, the forward angle of upper body was increased with a shorter club. $30-36^{\circ}$ of forward angle of upper body was maintained at address, top swing, and impact motions.

• Journal of Korean Neurosurgical Society
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• v.30 no.5
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• pp.611-621
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• 2001

Objective : We analyzed the clinical and endocrinological results of the transsphenoidal microsurgery for ACTH secreting pituitary adenomas. Marerials and Methods : From October 1995 to August 2000, 18 patients underwent transsphenoidal microsurgery for Cushing's disease. We analyzed the surgical results of 17 patients, one patient who was previously operated from other hospital was excluded. Age of the patients were 18 to 61 years old(mean 37.7), male to female ratio was 1 : 3.3, and follow-up period was 3 to 50 months(mean 20.3). The selection of candidates for transsphenoidal exploration was based on endocrinologic criteria. Magnetic resonance imaging was the preferred radiologic test. Selective inferior petrosal sinus sampling of adrenocorticotropic hormone futher refined the diagnosis when endocrinologic and radiologic procedures were not definitive. Results : Results of the preoperative endocrinological test were : level of serum ACTH 29.4 to $225{\mu}g/dL$(mean $93.88{\mu}g/dL$) ; serum cortisol 11.9 to $47.5{\mu}g/dL$(mean $27.49{\mu}g/dL$) ; 24-hour urine free cortisol 235 to $1019{\mu}g/day$(mean $571.0{\mu}g/day$). Inferior petrosal sinus sampling for ACTH was performed in 11 patients and all were confirmed by Cushing's disease and we could predict the laterality of the tumor in 9 of 11 patients. We performed transsphenoidal selective adenomectomy in 5 patients, adenomectomy and subtotal hypophysectomy in 2 patients, adenomectomy and partial hypophysectomy in 9 patients, and in the remaining one patient, hemihypophysectomy followed by total hypophysectomy due to remission failure. Fifteen of 17 patients(88.2%) showed endocrinological remission. Glucocorticoid replacement therapy was performed in all the patients who showed remission for 1 to 24 months(mean 5.9 months), and 6 patients received steroid over 6 months. Conclusion : We conclude that the direct demonstration of a tumor in the pituitary gland by MRI is the most important and definitive diagnostic tool and the location of a mass should be confirmed with increased level of ACTH by the inferior petrosal sinus sampling. Transsphenoidal microsurgery is effective treatment modality for Cushing's disease and the immediate postoperative evaluation of the surgical resection of the tumor is very important. The patients should show hypocortisolism, decreased, subnormal serum ACTH and cortisol levels and 24-hours urine free cortisol. We performed 18 transsphenoidal microsurgery for Cushing's disease in 17 patients and 15 patients(88.2%) showed endocrinological remission.

• Journal of Life Science
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• v.30 no.11
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• pp.947-955
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• 2020

The foot-and-mouth disease virus (FMDV), a member of the Aphthovirus genus in the Picornaviridae family, affects wild and domesticated ruminants and pigs. During replication of the FMDV RNA (ribonucleic acid) genome, FMDV-encoding RNA polymerase 3D acts in a highly location-specific manner. This suggests that specific RNA structures recognized by 3D polymerase within non-coding regions of the FMDV genome assist with binding during replication. One such region is the cis-acting replication element (CRE), which functions as a template for RNA replication. The FMDV CRE adopts a stem-loop conformation with an extended duplex stem, supporting a novel 15-17 nucleotide loop that derives stability from base-stacking interactions, with the exact RNA nucleotide sequence of the CRE producing different RNA secondary structures. Here, we show that CRE sequences of FMDVs isolated in Korea from 2010 to 2017 exhibit A and O genotypes. Interestingly, variations in the RNA secondary structure of the Korean FMDVs are consistent with the phylogenetic relationships between these viruses and reveal the specificity of FMDV infections for particular host species. Therefore, we conclude that each genetic clade of Korean FMDV is characterized by a unique functional CRE and that the evolutionary success of new genetic lineages may be associated with the invention of a novel CRE motif. Therefore, we propose that the specific RNA structure of a CRE is an additional criterion for FMDV classification dependent on the host species. These findings will help correctly analyze CRE sequences and indicate the specificity of host species for future FMDV epidemics.

• Asian-Australasian Journal of Animal Sciences
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• v.20 no.11
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• pp.1662-1669
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• 2007

The high mobility group AT-hook1 (HMGA1) proteins are known to be related to the regulation of gene transcription, replication and promotion of metastatic progression in cancer cells. The loss of expression by disrupting the HMGA1 gene affects insulin signaling and causes diabetes in the mouse. Previously identified single nucleotide polymorphism (SNP) of HMGA1 was significantly associated with fat deposition traits in the pig. In this study, we identified 3,935 bp nucleotide sequences from exon 5 to exon 8 of the bovine HMGA1 gene and its mRNA expression was observed by quantitative real-time PCR. Six single nucleotide polymorphisms in the bovine HMGA1 gene were detected and the allele frequencies of these SNPs were investigated using the PCR-RFLP method in nine cattle breeds including Limousin, Simmental, Brown Swiss, Hereford, Angus, Charolais, Hanwoo, Brahman and Red Chittagong cattle. The map location showed that the bovine HMGA1 gene was also closely located with a previously identified meat quality QTL region indicating this gene is the most likely positional candidate for meat quality traits in cattle.

• The Journal of the Korea institute of electronic communication sciences
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• v.15 no.1
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• pp.9-14
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• 2020

In this paper, we studied on-board antenna(primary link/secondary link/satellite link) used in UAV Data-link system. As a result, it is ideal to configure the Data-link as a triple link to secure the flight stability of the UAV, but the communication link should be configured according to the operating platform. As a result of overseas R&D trend analysis, the on-board Data-link antenna is installed and operated in a location where it is easy to secure LOS. The primary link consists of a directional antenna for basic operation and an omni-directional antenna for emergency operation. The secondary link uses a monopole/dipole antenna in the UHF/C band. Satellite link has been developed to apply phased array antenna to improve UAV operability.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.31 no.1
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• pp.39-46
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• 2018

In this paper, an unbonded post-tensioning anchorage for a single-stranded wire that allows more efficient stress distribution in the post-tensioned anchorage zone was developed by using a finite element analysis using a commercial program. The stress analysis was carried out using a 3D model in the anchorage zone of the concrete member using the developed anchorage. The result of analysis ensured that the developed anchorage reduced the maximum bursting stress in anchorage zone compared to the case of existing anchorage and the location where maximum bursting stress also occurred closer to the anchorage. Bursting force was calculated using AASHTO, modified $M{\ddot{o}}rsch$ and Stone. As a result, it was concluded that an effective reinforcement design of the anchorage zone can be designed by modified $M{\ddot{o}}rsch$.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.11
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• pp.5677-5679
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• 2012

Background and Aim: Gastric cancer is the second most common cancer worldwide. In this study the clinical and histological features of gastric cancer in the cardia and distal stomach were evaluated. Method: Proximal and distal gastric cancer diagnosed and treated in eight provinces of Iran from 2010-2011 were reviewed in all collected cases. The age standardized incident rates were calculated and tumor location and histological type were recorded. Results: The age-standardized incidence rate for the eight centers was 40.6 per 100,000 populations per year with an upper and lower range of 22.1 and 102.4 per 100,000 population per year. Thirty four percent of the tumors were located in the cardia, 3% in fundus, and 63% in the distal stomach. In 7 provinces the prevalence of distal tumors was significantly greater than proximal tumors (p=0.006). A significant relationship was observed between diffuse form of gastric cancer and distal gastric tumors (p=0.007) and between poor tumor differentiation and distal gastric tumors (p<0.001). Conclusions: the result of this study shows that distal gastric cancer is more common than proximal gastric cancer in Iran.

• Journal of the Korean Society of Environmental Restoration Technology
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• v.22 no.6
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• pp.63-76
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• 2019

UAVs are unmanned, autonomous or remotely piloted aircraft. As UAVs become smaller, lighter and more economical, their applications continue to expand. Researches on UAVs in the field of remote sensing show development methods and purposes similar to those on satellite images, and they are widely used in studies such as 3D image composition and monitoring. In the field of environmental impact assessment(EIA), satellite information and data are mainly used. However, only low-resolution images covering long distances and large-scale data allowing for rough examination are being provided, so their uses are seriously limited. Therefore, in this paper, we construct spatial information of forest area by using unmanned aerial vehicle and seek efficient utilization and policy improvement in the field of environmental impact assessment. As a result, high-resolution images and data from UAVs can be used to identify the location status of SEIA, EIA, and small scale EIA project plans and to evaluate detailed environmental impact analysis. In addition, when provided together with infographics about Post-environmental impact investigation, it was confirmed that the possibility of periodic spatial information construction and evaluation can be used throughout the entire project contents and project post-process.In order to provide sophisticated infographics for the EIA, drone photography and GCP surveying methods were derived.The results of this study will be used as a basis for improving high-resolution monitoring and environmental impact assessment in the forest sector.

• Korean Journal of Human Ecology
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• v.19 no.1
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• pp.119-126
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• 2010

We need to develop a target market for elderly women by increasing the ratio of functional apparel. The purpose of this study was to provide basic data for developing a Leisure Sports Jumper and improving the quality of life of clothing for female elderly consumers. This study reviewed the current situation on the production of the functional Leisure Sports Jumper for the elderly women in literature. For the experimental study, we selected Leisure Sports Jumpers from five apparel brands, and evaluated a sensory test on 20 subjects representing the average body shape of the elderly women aged from 65 to 75. After the first sensory test, we manipulated the patterns for samples of the Leisure Sports Jumper. In the second sensory test, visual and cognitive appropriateness of the Leisure sports jumpers were assessed by the elderly women. The results of the study were as follows: the Leisure Sports Jumper of brand 'C' showed the highest appropriateness in terms of neck, armholes, and sleeves among the 5 brands. The Leisure Sports Jumper of brands 'B' and 'D' showed the lowest appropriateness in the width of the armpits among the 5 brands. Except for the length of the Leisure Sports Jumper, the margin, location of the pocket, and armholes had the lowest score in the first test showing over 3.5 points.