• Asian Pacific Journal of Cancer Prevention
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• 제17권3호
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• pp.1357-1362
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• 2016

Metastatic gestational trophoblastic neoplasia (GTN) is an uncommon cancer. The principal treatment consists of chemotherapy with or without surgery or radiotherapy. We here retrospectively reviewed the outcomes of metastatic GTN treated at our institute between January, 1999 and December, 2013. Sixty-three patients met the criteria. The median age was 30.0 years and almost 90% were referral cases. Nearly 40% of the studied patients presented with vaginal bleeding while 22.2% were asymptomatic. The most common antecedent pregnancy was hydatidiform mole (57.1%) followed by term pregnancy (20.6%). The median interval time from antecedent pregnancy to the development of GTN was three months and the median pretreatment B-hCG was 58,274 mIU/ml. Stage III (74.6%) was the most common staging followed by stage IV (20.6%) and stage II (4.8%). The most frequent surgery was hysterectomy (31.7%). Thoracotomy and craniotomy were performed in three and two patients, respectively. The most common first line chemotherapy regimen was methotrexate and folinic acid (36.5%) followed by EMA (etoposide, methotrexate, actinomycin D) (34.9%), EMACO (etoposide, methotrexate, actinomycin D, cyclophosphamide, vincristine) (17.5%) with the remission rate of 66.7%. Nearly one-third of the patients were given a subsequent chemotherapy regimen after failure with the first line therapy and showed a final response rate of 73.0%. However, in stage IV, the response to first line treatment was only 38.5%. In conclusion, the outcomes of metastatic GTN were poor especially with the higher stages.

• Journal of Information Technology Applications and Management
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• 제18권2호
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• pp.1-21
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• 2011

In this era of convergence, which is characterized by the integration and combination of technology and industries, broadcasting and communications, offline and online, and devices and services, the content industry is also experiencing rapid changes including inter-genre exchange, the creation of new industries, and customized demand. Specifically, IT-based digital content industries such as the online game, e-book, mobile contents and web portal industries are no longer restricted to the boundaries of video, music and games but are being expanded into the realms of education, medicine, fashion and sports thanks to CT innovation of 3D, CG, AR/VR, VFX, etc. As such, various countries have come to recognize the convergent content industry as a new growth engine that will pick up where the IT industry left off, and are forming policies for its development accordingly. This research aims to optimize the system of content taxonomy which is currently genre-focused and unable to support technological development and convergence, and to discover and select star contents to be rigorously developed with governmental support. In this paper, 20 star contents in 8 areas were selected, and these are expected to create tremendous cultural and economic value through ongoing technological and industrial development.

• 한국멀티미디어학회논문지
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• 제16권11호
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• pp.1348-1356
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• 2013

Disney Animation has showed not only artistic excellence but also technological innovations through a lot of animation films that they released. Especially with the unique concept that free-willed game characters dive into different worlds of games in animation film, received both critical and commercial acclaim for its stunning visuals and outstanding CG (computer graphics) effects. The purpose of this study is to analyze different styles of game worlds, Disney's layout pipeline, and in-house camera capture system used in . This paper analyzes that three game worlds in this film such as Fix-It Felix Jr., Sugar Rush, and Hero's Duty express different styles by using appropriate character animation and camera movements. Especially Hero's Duty game which new in-house camera capture system is extensively used maximizes unseen visuals by perfectly making realistic and believable game world. Disney's newly developed in-house camera capture system, which is used in this film for the first time, allows real camera's motion and shake and real-time camera's movement and correction within animation set. Result of this study proves that this system improves directing of feature animation and enhance efficiency of the layout department's production process. Therefore, it contributes to a great extent to development of animation films' business.

• 한국디지털건축인테리어학회논문집
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• 제12권2호
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• pp.25-32
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• 2012

환경디자인은 건축, 도시, 조경 등 서로 다른 분야의 전문가 및 대상 지역 거주하는 일반시민 등 많은 참여자를 가지는 특징이 있다. 이러한 협조설계 단계에서는, 시행착오를 최소화시키기 위해서 디자인 초기단계에서부터 각 분야의 전문가들이 계획에 관해서 협의하여 디자인 내용을 변경해 나갈 필요가 있다. 또한 대상지 지역을 누구보다 잘 이해하고 있으며 계획 후 이 지역에 살게 될 주민들의 참여도 환경디자인 단계에서 고려해야 할 중요한 요소 중 하나이다. 여러 분야의 전문가 또는 비전문가들이 서로 커뮤니케이션하고 협조하기 위해서는 누구나가 쉽게 디자인 내용을 이해 할 수 있는 커뮤니케이션 툴이 필요하다. 이러한 필요성을 만족시키기 위해서는 빠른 구축속도, 대화형 기능, 빠른 표현속도, 사실적인 표현기술 등이 필수 조건이라고 할 수 있다. 본 연구에서는 이러한 환경디자인 분야의 전 분야에서 의사결정을 지원하고 디자인 안을 검토할 수 있는 3D CG 시스템을 개발하고 이 시스템을 실제 프로젝트에 적용시켜서 활용하면서 개발된 시스템의 기능강화를 추진하며, 실제 프로젝트 적용을 통한 시스템의 평가를 진행하여 본 연구에서 개발한 시스템의 유용성을 증명하는 것을 본 연구의 목표로 한다.

• 한국가금학회지
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• 제37권4호
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• pp.399-404
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• 2010

본 시험은 한국토종닭 3원 교잡종의 부화 및 육성 능력을 보고자 수행하였다. 공시계는 국립축산과학원에서 생산된 종란을 인수하여 부화시킨 3원 교잡종 병아리 암컷이다. 4가지 교배 조합으로 생산된 360수의 암평아리들을 3반복으로 반복당 30수씩 완전 임의배치하였다. 4개의 교배 조합은 A) 토착겸용종 C계통$\times$재래종 Y계통$\times$토착겸용종 C계통, B) 토착겸용종 C계통$\times$재래종 L계통$\times$토착겸용종 C계통, C) 토착 겸용종 C계통$\times$재래종 G계통$\times$토착겸용종 C계통, D) 토착겸용종 C계통$\times$재래종 W계통$\times$토착겸용종 C계통이다. 수정률은 A, B, C 및 D에서 각각 89.8, 91.2, 92.4 및 92.8%였으며, 부화율은 각 계통에서 69.8, 70.7, 75.5 및 77.4%였다. 육성률은 계통간 유의적인 차이가 없었다(P>0.05). 20주령 체중은 B계통에서 높게 나타났으며(P<0.05), 0~20주령까지의 사료요구율은 4계통에서 유의적인 차이는 없었다(P>0.05). 이런 결과들은 한국토종닭 3원 교잡종의 부화 및 육성 성적에 대한 기초적인 자료로서 이용될 것이라 사료된다.

• Archives of Pharmacal Research
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• 제24권1호
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• pp.44-50
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• 2001

To search for cytotoxic components from Allium victoriallis , MTT assays on each extract and an isolated component, gitogenin 3-O-lycotetroside, were performed against cancer cell lines. Cytotoxicities of most extract were shown to be comparatively weak, though $IC_50$ values of $CHCl_3$fraction was found to be <31.3-368.4 $\mu\textrm{g}/ml$. From the incubated methanol extract at $36^{\circ}C, eleven kinds of organosulfuric flavours were predictable by CG-MS performance. The most abundant peak was revealed to be 2-vinyl-4H-1,3-dithiin(1) by its mass spectrum. Further, this extract showed significant cytotoxicities toward cancer cell lies. Silica gel column chromatography of the n-butanol fraction led to the isolation of gitogenin 3-O-lycotetroside (3) along with astragalin (4) and kaempferol 3, 4'-di-O-$\beta$-D-glycoside (5). This steroidal saponin exhibited significant cytotoxic activities ($IC_50$, 6.51-36.5 $\mu\textrm{g}/ml$) over several cancer cell lines. When compound 3 was incubated for 24 h with human intestinal bacteria, a major metabolite was produced and then isolated by silica gel column chromatography. By examining parent and prominent ion peak in FAB-MS spectrum of the metabolite, the structure was speculated not to be any of prosapogenins of 3, suggesting that spiroketal ring were labile to the bacterial reaction. These suggest that disulfides produced secondarily are the antitumor principles.

• 한국재료학회지
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• 제22권11호
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• pp.615-619
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• 2012

Recently, ultrafine grained (ufg, typically 100 > d > 500 nm) Ti-Fe eutectic materials have been highlighted due to their extraordinarily high strength and good abrasion resistance compared to conventional coarse grained (cg, d > $1{\mu}m$) materials. However, these materials exhibit limited plastic strain and toughness during room temperature deformation due to highly localized shear strain. Several approaches have been extensively studied to overcome such drawbacks, such as the addition of minor elements (Sn, Nb, Co, etc.). In this paper, we have investigated the influence of the addition of Gd and Y contents (0.3-1.0 at.%) into the binary Ti-Fe eutectic alloy. Gd and Y are chosen due to their immiscibility with Ti. Microstructural investigation reveals that the Gd phase forms in the eutectic matrix and the Gd phase size increases with increasing Gd content. The improvement of the mechanical properties is possibly correlated to the precipitation hardening. On the other hand, in the case of Ti-Fe-Y alloys, with increasing Y contents, primary phases form and lamellar spacing increases compared to the case of the eutectic alloy. Investigation of the mechanical properties reveals that the plasticity of the Ti-Fe-Y alloys is gradually improved, without a reduction of strength. These results suggest that the enhancement of the mechanical properties is closely related to the formation of the primary phase.

• International Journal of Industrial Entomology and Biomaterials
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• 제9권1호
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• pp.47-51
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• 2004

To evolve silkworm hybrids with higher survival and productivity and easy and effective seed cocoon production, three new evolved bivoltine hybrids of silkworm (Bombyx mori L.), created with participation of sex-limited lines at eggs and larva stage were evaluated with control Super$_1$${\times}$Hessa$_2$ hybrid at Plovdiv Agrarian University during 2000 - 2002. ANOVA analysis was employed and the performance of hybrids was observed in respect of main quantitative traits. The results obtained show significant superiority of new hybrids T$_{15}$ 4/${\times}$TBV$_{2}$24/, XT$_{215}$38/${\times}$TV$_{3}$2/, XT$_{215}$38/${\times}$B$_{2}$6/ and their reciprocal crosses over the control. They were characterized with 99% hatchability of eggs, 93-95% silkworm survival, 2.32- 2.42 g cocoon weight, 53.5-55.7 cg shell weight, 22.9-23.1% shell ratio, 1,307-1,326 m filament length, 3.08-3.17 denier, 95-96% reelability, 44.4-45.1% silk ratio, 569-593 number of normal eggs per lying and 347-364 mg weight of normal eggs per lying. Newly evolved hybrids were manifested high productivity, 41.0-43.6 kg cocoon yield and 7.33-7.78 kg raw silk yield per one box (20,000$\pm$200 viable eggs), which significant surpass the control Super$_1$${\times}$Hessa$_2$ hybrid with 7.6-14.4% and 10.8-17.6%, respectively. T$_{15}$ 4/${\times}$TBV$_{2}$24/ and XT$_{215}$38/${\times}$TV$_{3}$2/ were considered as highly productive hybrids to local conditions and found suitable to rear in spring season.n.

• 생명과학회지
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• 제11권6호
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• pp.568-573
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• 2001

파래(Monostrima nitidum) 의 퇴색지연 방안을 모색하고자. 알칼리화제로써 이용 가능한 몇 종의 식품첨가물을 선정하고 이를 생 파래와 함께 9$0^{\circ}C$에서 10분간 blanching 하여 건조 및 분쇄한 후 $25^{\circ}C$의 암소에서 5개월 간 저장하면서 각 시료의 녹색도를 Hunter-lab colorimeter로 측정하고 휘발성 향을 CG-MS로 조사하였다. 저장 중 알칼리를 처리한 파래의 녹색도는 미처리한 시료에 비하여 조금 덜 퇴색되었으며, 특히 KHCO$_3$로 처리한 경우 다소 효과가 있었다. SDE장치(simultaneous distillation-extract apparatus)로 포집한 파래의 휘발성 향에서 31종의 화합물들이 확인되었다. 이들 중 파래의 특징적 향으로 기여하는 주요 화합물 $\beta$-cyclocitral, $\beta$-cyclohomocitral, ionene, $\alpha$-ionone and $\beta$-ionone으로 추정되었으며, 이 화합물들의 함량은 알칼리 처리에 의하여 감소되었지만, KHCO$_3$를 처리할 경우 다소 덜 감소되었다.

• The Journal of Advanced Prosthodontics
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• 제6권1호
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• pp.22-29
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• 2014

PURPOSE. This study aimed to investigate the potential clinical application of digitized silicone rubber impressions by comparing the accuracy of zirconia 3-unit fixed partial dentures (FPDs) fabricated from 2 types of data (working model and impression) obtained from a laser scanner. MATERIALS AND METHODS. Ten working models and impressions were prepared with epoxy resin and vinyl polysiloxane, respectively. Based on the data obtained from the laser scanner (D-700; 3Shape A/S, Copenhagen, Denmark), a total of 20 zirconia frameworks were prepared using a dental CAD/CAM system (DentalDesigner; 3shape A/S, Copenhagen, Denmark / Ener-mill, Dentaim, Seoul, Korea). The silicone replicas were sectioned into four pieces to evaluate the framework fit. The replicas were imaged using a digital microscope, and the fit of the reference points (P1, P2, P3, P4, P5, P6, and P7) were measured using the program in the device. Measured discrepancies were divided into 5 categories of gaps (MG, CG, AWG, AOTG, OG). Data were analyzed with Student's t-test ($\alpha$=0.05), repeated measures ANOVA and two-way ANOVA (${\alpha}=0.05$). RESULTS. The mean gap of the zirconia framework prepared from the working models presented a narrower discrepancy than the frameworks fabricated from the impression bodies. The mean of the total gap in premolars (P=.003) and molars (P=.002) exhibited a statistical difference between two groups. CONCLUSION. The mean gap dimensions of each category showed statistically significant difference. Nonetheless, the digitized impression bodies obtained with a laser scanner were applicable to clinical settings, considering the clinically acceptable marginal fit ($120{\mu}m$).