• Journal of Periodontal and Implant Science
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• v.46 no.2
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• pp.96-106
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• 2016

Purpose: Stress distribution and mandible distortion during lateral movements are known to be closely linked to bruxism, dental implant placement, and temporomandibular joint disorder. The present study was performed to determine stress distribution and distortion patterns of the mandible during lateral movements in Class I, II, and III relationships. Methods: Five Korean volunteers (one normal, two Class II, and two Class III occlusion cases) were selected. Finite element (FE) modeling was performed using information from cone-beam computed tomographic (CBCT) scans of the subjects' skulls, scanned images of dental casts, and incisor movement captured by an optical motion-capture system. Results: In the Class I and II cases, maximum stress load occurred at the condyle of the balancing side, but, in the Class III cases, the maximum stress was loaded on the condyle of the working side. Maximum distortion was observed on the menton at the midline in every case, regardless of loading force. The distortion was greatest in Class III cases and smallest in Class II cases. Conclusions: The stress distribution along and accompanying distortion of a mandible seems to be affected by the anteroposterior position of the mandible. Additionally, 3-D modeling of the craniofacial skeleton using CBCT and an optical laser scanner and reproduction of mandibular movement by way of the optical motion-capture technique used in this study are reliable techniques for investigating the masticatory system.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.29 no.5
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• pp.359-365
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• 2018

Herein, electromagnetic shielding structures to reduce the external noise coupling to printed spiral coils (PSCs) and a design method for improving the bandwidth of shielded PSCs have been proposed. It has been demonstrated that the bandwidth of shielded PSCs is limited due to the parasitic capacitance between the coils and the shielding structures and is confirmed by the transfer function simulation of the shielded PSCs with a transmission line as the radio-frequency interference noise source. A design method for the bandwidth improvement of the shielded PSCs has been proposed based on the equivalent circuit model analysis and the case studies depending on PSC designs with a three-dimensional field simulation. With the design method, an optimized shielded PSC design has been presented and successfully confirmed by experimental verification in that the optimized design results in a significant bandwidth improvement.

• The Journal of the Korea institute of electronic communication sciences
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• v.12 no.5
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• pp.737-746
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• 2017

In 2017, amid changes in the security market such as integrated security (IS) and convergence security (CS), a variety of security paradigms in terms of operation and management have been suggested. Rather than changing existing network infrastructure and bringing about fluid, multi-dimensional changes, these solutions and technologies focus entire security capacity on a primary protection, leading to network infrastructure suffering from unexpected inherent violations and problems in a continued manner. Therefore, it is time to propose and develop a flexible network section that can protect from attacks of similar pattern and concentrated traffic attacks by applying a new concept of WB (Water-Bubble) to network infrastructure and analyzing on the basis of experiment and installation. Methodology of the WB-based highly secure flexible network section proposed in this study is expected to provide materials for studies on how to achieve network section security taking into account three major limitations and security standards: fluidity, unpredictability, and non-area scalability by contact point ratio, by changing a network area predicted to be the final target of attack into resonant network section (area) with flexible area changes.

• BMB Reports
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• v.53 no.2
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• pp.118-123
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• 2020

Cardiac regeneration with adult stem-cell (ASC) therapy is a promising field to address advanced cardiovascular diseases. In addition, extracellular vesicles (EVs) from ASCs have been implicated in acting as paracrine factors to improve cardiac functions in ASC therapy. In our work, we isolated human cardiac mesenchymal stromal cells (h-CMSCs) by means of three-dimensional organ culture (3D culture) during ex vivo expansion of cardiac tissue, to compare the functional efficacy with human bone-marrow derived mesenchymal stem cells (h-BM-MSCs), one of the actively studied ASCs. We characterized the h-CMSCs as CD90^low, c-kit^negative, CD105^positive phenotype and these cells express NANOG, SOX2, and GATA4. To identify the more effective type of EVs for angiogenesis among the different sources of ASCs, we isolated EVs which were derived from CMSCs with either normoxic or hypoxic condition and BM-MSCs. Our in vitro tube-formation results demonstrated that the angiogenic effects of EVs from hypoxia-treated CMSCs (CMSC-Hpx EVs) were greater than the well-known effects of EVs from BM-MSCs (BM-MSC EVs), and these were even comparable to human vascular endothelial growth factor (hVEGF), a potent angiogenic factor. Therefore, we present here that CD90^lowc-kit^negativeCD105^positive CMSCs under hypoxic conditions secrete functionally superior EVs for in vitro angiogenesis. Our findings will allow more insights on understanding myocardial repair.

• Transactions of the Korean Society of Automotive Engineers
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• v.18 no.5
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• pp.108-114
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• 2010

The injection nozzle of an electro-hydraulic injector is being opened and closed by movement of a injector's needle which is balanced by pressure at the nozzle seat and at the needle control chamber, at the opposite end of the needle. In this study, the effects of needle movement in a piezo-driven injector on unsteady cavitating flows behavior inside nozzle were investigated by cavitation numerical model based on the Eulerian-Lagrangian approach. Aimed at simulating the 3-D two-phase flow behavior, the three dimensional geometry model along the central cross-section regarding of one injection hole with real design data of a piezo-driven diesel injector has been used to simulate the cavitating flows for injection time by at fully transient simulation with cavitation model. The cavitation model incorporates many of the fundamental physical processes assumed to take place in cavitating flows. The simulations performed were both fully transient and 'pseudo' steady state, even if under steady state boundary conditions. As this research results, we found that it could analyze the effect the pressure drop to the sudden acceleration of fuel, which is due to the fastest response of needle, on the degree of cavitation existed in piezo-driven injector nozzle.

• Journal of Animal Science and Technology
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• v.57 no.12
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• pp.44.1-44.9
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• 2015

Background: Heat shock proteins play an important role in protection from stress stimuli and metabolic insults in almost all organisms. Methods: In this study, computational tools were used to deeply analyse the physicochemical characteristics and, using homology modelling, reliably predict the tertiary structure of the blunt snout bream (Ma-) Hsp70 and Hsc70 proteins. Derived three-dimensional models were then used to predict the function of the proteins. Results: Previously published predictions regarding the protein length, molecular weight, theoretical isoelectric point and total number of positive and negative residues were corroborated. Among the new findings are: the extinction coefficient (33725/33350 and 35090/34840 - Ma-Hsp70/ Ma-Hsc70, respectively), instability index (33.68/35.56 - both stable), aliphatic index (83.44/80.23 - both very stable), half-life estimates (both relatively stable), grand average of hydropathicity (-0.431/-0.473 - both hydrophilic) and amino acid composition (alanine-lysine-glycine/glycine-lysine-aspartic acid were the most abundant, no disulphide bonds, the N-terminal of both proteins was methionine). Homology modelling was performed by SWISS-MODEL program and the proposed model was evaluated as highly reliable based on PROCHECK's Ramachandran plot, ERRAT, PROVE, Verify 3D, ProQ and ProSA analyses. Conclusions: The research revealed a high structural similarity to Hsp70 and Hsc70 proteins from several taxonomically distant animal species, corroborating a remarkably high level of evolutionary conservation among the members of this protein family. Functional annotation based on structural similarity provides a reliable additional indirect evidence for a high level of functional conservation of these two genes/proteins in blunt snout bream, but it is not sensitive enough to functionally distinguish the two isoforms.

• Transactions of the Korean Society of Automotive Engineers
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• v.6 no.2
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• pp.12-20
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• 1998

Exter ballistics of a typical high-speed projectile is studied through a flow-visualization experiment and an unstructured grid Navier-Srokes computation. Experiment produced a schlieren photograph that adequately shows the characteristic features of this complex flow, namely two kinds of oblique cone shocks and turbulent wake developing into the downstream. A hybrid scheme of finite volume-element method is used to simulate the compressible Reynolds-Averaged Navier-Stok- es solution on unstructured grids. Osher's approximate Riemann solver is used to discretize the cinvection term. Higher-order spatial accuracy is obtained by MUSCL extension and van Albada ty- pe flux limiter is used to stabilize the numerical oscillation near the solution discontinuity. Accurate Gakerkin method is used to discretize the viscous term. Explict fourth-order Runge-Kutta method is used for the time-stepping, which simplifies the application of MUSCL extension. A two-layer k-$\varepsilon$ turbulence model is used to simulate the turbulent wakes accurately. Axisymmetric folw and two-dimensional flow with an angle of attack have been computed. Grid-dependency is also checked by carrying out the computation with doubled meshes. 2-D calculation shows that effect of angle of attack on the flow field is negligible. Axi-symmetric results of the computation agrees well with the flow visualization. Primary oblique shock is represented within 2-3 meshes in numerical results, and the varicose mode of the vortex shedding is clearly captured in the turbulent wake region.

• Radiation Oncology Journal
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• v.20 no.1
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• pp.68-72
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• 2002

This study was done to implement intensity-modulated radiation therapy (IMRT) for the treatment of primary prostate cancer and to compare this technique with conventional treatment methods. A 72-year-old male patient with prostate cancer stage T2a was treated with IMRT delivered with dynamic multi-leaf collimation. Treatment was designed using an inverse planning algorithm, which accepts dose and dose-volume constraints for targets and normal structures. The IMRT plan was compared with a three-dimensional (3D) plan using the same 6 fields technique. Lower normal tissue doses and improved target coverage were achieved using IMRT at current dose levels, and facilitate dose escalation to further enhance locoregional control and organ movement during radiotherapy is an important issue of IMRT in prostate cancer.

• Proceedings of the KSRS Conference
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• 2005.10a
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• pp.182-185
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• 2005

Satellite cameras are calibrated before launch in detail and in general, but it cannot be guaranteed that the geometry is not changing during launch and caused by thermal influence of the sun in the orbit. Modem satellite imaging systems are based on CCD-line sensors. Because of the required high sampling rate the length of used CCD-lines is limited. For reaching a sufficient swath width, some CCD-lines are combined to a longer virtual CCD-line. The images generated by the individual CCD-lines do overlap slightly and so they can be shifted in x- and y-direction in relation to a chosen reference image just based on tie points. For the alignment and difference in scale, control points are required. The resulting virtual image has only negligible errors in areas with very large difference in height caused by the difference in the location of the projection centers. Color images can be related to the joint panchromatic scenes just based on tie points. Pan-sharpened images may show only small color shifts in very mountainous areas and for moving objects. The direct sensor orientation has to be calibrated based on control points. Discrepancies in horizontal shift can only be separated from attitude discrepancies with a good three-dimensional control point distribution. For such a calibration a program based on geometric reconstruction of the sensor orientation is required. The approximations by 3D-affine transformation or direct linear transformation (DL n cannot be used. These methods do have also disadvantages for standard sensor orientation. The image orientation by geometric reconstruction can be improved by self calibration with additional parameters for the analysis and compensation of remaining systematic effects for example caused by a not linear CCD-line. The determined sensor geometry can be used for the generation? of rational polynomial coefficients, describing the sensor geometry by relations of polynomials of the ground coordinates X, Y and Z.

• Plant Biotechnology Reports
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• v.4 no.3
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• pp.201-211
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• 2010

We present a highly effective T-DNA inserted gene screening method as part of a reverse genetics model system using the Chinese cabbage (Brassica rapa L. spp. pekinensis). Three-step two-dimensional (2D) matrix strategies are potentially accurate and useful for the identification of specific T-DNA inserted mutants from a large population. To construct our Chinese cabbage model, we utilized a forward genetics screening approach for the abnormal phenotypes that were obtained from transgenic plants of Brassica rapa generated with Agrobacteria tumefaciens containing the pRCV2 vector. From one transgenic plant with an abnormal phenotype, we observed that the st1 gene (which is related to senescence-associated process proteins) contained a T-DNA fragment, and that its expression level was decreased. This T-DNA insert was then used as a control to construct an effective screening pool. As a result, the optimum template concentration was found to be 0.1-1 ng in our PCR strategy. For other conditions, positive changes to the Gibbs free energy prevented the formation of oligo dimers and hairpin loop structures, and autosegment extension gave better results for long fragment amplification. Using this effective reverse genetics screening method, only 23 PCR reactions were necessary to select a target gene from a pool of 100 individual DNAs. Finally, we also confirmed that the sequence we obtained from the above method was identical to the flanking sequence isolated by rescue cloning.