• BMB Reports
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• v.52 no.5
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• pp.295-303
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• 2019

Breakthroughs in stem cell technology have contributed to disease modeling and drug screening via organoid technology. Organoid are defined as three-dimensional cellular aggregations derived from adult tissues or stem cells. They recapitulate the intricate pattern and functionality of the original tissue. Insulin is secreted mainly by the pancreatic ${\beta}$ cells. Large-scale production of insulin-secreting ${\beta}$ cells is crucial for diabetes therapy. Here, we provide a brief overview of organoids and focus on recent advances in protocols for the generation of pancreatic islet organoids from pancreatic tissue or pluripotent stem cells for insulin secretion. The feasibility and limitations of organoid cultures derived from stem cells for insulin production will be described. As the pancreas and gut share the same embryological origin and produce insulin, we will also discuss the possible application of gut organoids for diabetes therapy. Better understanding of the challenges associated with the current protocols for organoid culture facilitates development of scalable organoid cultures for applications in biomedicine.

• Journal of the Korean Society of Clothing and Textiles
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• v.44 no.6
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• pp.1163-1177
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• 2020

The purpose of this study is to figure out the information needed to improve the shape and size suitability of face-applied mask sheets. The study analyzed the shape of the mask sheet from the scanned images of 50 products of 37 domestic brands. In addition, each measurement of 42 mask sheets were compared and analyzed multilaterally with the 3D measurement dimensions of the faces of men and women in their 20s from the 6th SizeKorea data. Analysis on the shapes of mask sheets indicated that domestic commercial mask sheets are mainly made of single or dual sheets, with slits for enhancing fitness to the three-dimensional face. In the dimensional analysis of Korean men, women and mask sheets, most of the lengths of the mask sheets were significantly larger or smaller than the actual faces of men and women. The horizontal length and vertical length of the forehead above the eyes are significantly shorter, thereby requiring adjustments in the dimensions of this area. In order to improve the size suitability of the mask, it is necessary to adjust the dimensions of the problem area according to the research results as well as diversify the dimensions considering the target layer.

• Journal of Technologic Dentistry
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• v.43 no.4
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• pp.153-159
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• 2021

Purpose: The purpose of this study was to assess the fitness of anterior and posterior interim crowns fabricated by three different additive manufacturing technologies. Methods: The working model was digitized, and single crowns (maxillary right central incisor and maxillary right first molar) were designed using computer-aided design software (DentalCad 2.2; exocad). On each abutment, interim crowns (n=60) were fabricated using three types of additive manufacturing technologies. Then, the abutment appearance and internal scan data of the interim crown was obtained using an intraoral scanner. The fitness of the interim crowns were evaluated by using the superimposition of the three-dimensional scan data (Geomagic Control X; 3D Systems). The one-way analysis of variance and Tukey posterior test were used to compare the results among groups (α=0.05). Results: A significant difference was found in the fitness of the interim crowns according to the type of additive manufacturing technology (p<0.05). The posterior interim crown showed smaller root mean square value than the anterior interim crown. Conclusion: Since the fitness of the posterior interim crown produced by three types of additive manufacturing technology were all within clinically acceptable range (<120 ㎛), it can be sufficiently used for the fabrication of interim crowns.

• Nuclear Engineering and Technology
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• v.55 no.9
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• pp.3213-3228
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• 2023

As an important part of the digital reactor, the pin-by-pin wise fine coupling calculation is a research hotspot in the field of nuclear engineering in recent years. It provides more precise and realistic simulation results for reactor design, operation and safety evaluation. CORCA-K a nodal code is redeveloped as a robust pin-by-pin wise neutronics and thermal-hydraulic coupled calculation code for pressurized water reactor (PWR) core. The nodal green's function method (NGFM) is used to solve the three-dimensional space-time neutron dynamics equation, and the single-phase single channel model and one-dimensional heat conduction model are used to solve the fluid field and fuel temperature field. The mesh scale of reactor core simulation is raised from the nodal-wise to the pin-wise. It is verified by two benchmarks: NEACRP 3D PWR and PWR MOX/UO₂. The results show that: 1) the pin-by-pin wise coupling calculation system has good accuracy and can accurately simulate the key parameters in steady-state and transient coupling conditions, which is in good agreement with the reference results; 2) Compared with the nodal-wise coupling calculation, the pin-by-pin wise coupling calculation improves the fuel peak temperature, the range of power distribution is expanded, and the lower limit is reduced more.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
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• v.36 no.2
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• pp.175-185
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• 2023

A hybrid supercapacitor is a promising energy storage device in view of its excellent capacitive performance. Commercial three-dimensional foam nickel (Ni) can be used as an ideal framework due to an interconnected network structure. However, its application as an electrode material for supercapacitors is limited due to its low specific capacity. Herein, we report a successful growth of MnO₂ on the surface of graphene by a one-step hydrothermal method; thus, forming a three-dimensional MnO₂-graphene-Ni hybrid foam. Our results show that the mixed structure of MnO₂ with nanoflowers and nanorods grown on the graphene/Ni foam as a hybrid electrode delivers the maximum specific capacitance of 193 F·g^-1 at a current density 0.1 A·g^-1. More importantly, the hybrid electrode retains 104% of its initial capacitance after 1,000 charge-discharge cycles at 1 A·g^-1; thus, showing the potential application as a stable supercapacitor electrode.

• Transactions of Materials Processing
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• v.32 no.4
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• pp.180-190
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• 2023

This study deals with residual stress prediction and hardness evaluation within cross ball grooved inner race fabricated by cold upsetting process consisted of upsetting and ejection steps. A raw workpiece material of AISI 5120H (SCr420H) is first spheroidized and annealed, then phosphophyllite coated to form solid lubricant layer on its outer surface. To investigate influences of the heat treatment, uni-axial compression tests and Vickers micro-hardness measurements are conducted. Three-dimensional elasto-plastic FE simulations on the upsetting step and the ejection one are performed to visualize the residual stress and the ductile (plastic deformation) damage. External feature of the fabricated inner race is fully captured by using an optical 3D scanner, and the micro-hardness is measured on internal cross-sections. Consequently, the dimensional compatibility between the simulated inner race and the fabricated one is ensured with a difference of under 0.243mm that satisfied permissible error range of ±0.50mm on the grooved surface, and the predicted residual stress is verified to have similar distribution tendency with the measured Vickers micro-hardness.

• Journal of Korean Tunnelling and Underground Space Association
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• v.20 no.6
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• pp.1061-1071
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• 2018

A subsea tunnel, being a super-sized underground structure must ensure safety at the time of earthquake, as well as at ordinary times. At the time of earthquake, in particular, of a subsea tunnel, a variety of response behaviors are induced owing to relative rigidity to the surrounding ground, or difference of displacement, so that the behavior characteristics can be hardly anticipated. The investigation aims to understand the behavior characteristics switched by earthquake of an imaginary subsea tunnel which passes through a fault zone having different physical properties from those of the surrounding ground. In order to achieve the aim, dynamic response behaviors of a subsea tunnel which passes through a fault zone were observed by means of indoor experiments. For the sake of improved earthquake resistance, a shape of subsea tunnel to which flexible segments have been applied was considered. Afterward, it is believed that a D/B can be established through 3-dimensional earthquake resistance interpretation of various grounds, on the basis of verified results from the experiments and interpretations under various conditions. The present investigation performed 1 g shaking table test in order to verify the result of 3-dimensional earthquake resistance interpretation. A model considering the similitude (1:100) of a scale-down model test was manufactured, and tests for three (3) Cases were carried out. Incident seismic wave was introduced by artificial seismic wave having both long-period and short-period earthquake properties in the horizontal direction which is rectangular to the processing direction of the tunnel, so that a fault zone was modeled. For numerical analysis, elastic modulus of the fault zone was assumed 1/5 value of the modulus of individual grounds surround the tunnel, in order to simulate a fault zone. Resultantly, reduced acceleration was confirmed with increase of physical properties of the fault zone, and the result from the shaking table test showed the same tendency as the result from 3-dimensional interpretation.

• Korean Journal of Environmental Agriculture
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• v.22 no.3
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• pp.203-209
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• 2003

In the course of screening for antifungal agents, a bacterial strain, DM3 was isolated from a mud sample collected at Daechon in Chungnam province and identified as Bacillus licheniformis based on API 50CHB test. It has antifungal activity against 12 plant pathogenic fungi in paper disc assay. At the 95% lethal dose of gamma radiation ($^{60}Co$, 10 kGy, $D_{10}=2.32\;kGy$), the antifungal activity deficient mutant (mDM3) against Colletotrichum gloeosporioides was induced From 2-D electrophoresis analysis, serine hydroxymethyltransferase (45.0 kDa), hypothetical protein(40.7 kDa), NifU protein homolog(15.4 kDa), and resolvase(12.5 kDa) homologous proteins were detected only in B. licheniformis DM3. Lysozyme(18.1 kDa) and alkyl hydroperoxide reductase(15.6 kDa) homologous proteins were expressed uniquely in B. licheniformis mDM3. Further studies are needed to reveal that these proteins from B. licheniformis DM3 could be closely related to the antifungal activity against plant pathogenic fungi.

• Journal of the Korea Computer Graphics Society
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• v.25 no.3
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• pp.143-152
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• 2019

This paper presents two new techniques for solving the two problems of the water curtain: 'shape distortion' caused by gravity and 'resolution degradation' caused by fine satellite droplets around the shape. In the first method, when the user converts a three-dimensional model to a vertical sequence of slices, the slices are evenly spaced. The method is to adjust the time points at which the equi-distance slices are created by the nozzle array. In this method, even if the velocity of a water drop increases with time by gravity, the water drop slices maintain the equal interval at the moment of forming the whole shape, thereby preventing distortion. The second method is called the minimum time interval technique. The minimum time interval is the time between the open command of a nozzle and the next open command of the nozzle, so that consecutive water drops are clearly created without satellite drops. When the user converts a three-dimensional model to a sequence of slices, the slices are defined as close as possible, not evenly spaced, considering the minimum time interval of consecutive drops. The slices are arranged in short intervals in the top area of the shape, and the slices are arranged in long intervals in the bottom area of the shape. The minimum time interval is pre-determined by an experiment, and consists of the time from the open command of the nozzle to the time at which the nozzle is fully open, and the time in which the fully open state is maintained, and the time from the close command to the time at which the nozzle is fully closed. The second method produces water drop sculptures with higher resolution than does the first method.

• Restorative Dentistry and Endodontics
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• v.32 no.1
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• pp.69-79
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• 2007

The purpose of this study was to investigate the effects of composite resin restorations on the stress distribution of notch shaped noncarious cervical lesion using three-dimensional (3D) finite element analysis (FEA). Extracted maxillary second premolar was scanned serially with Micro-CT (SkyScan1072 ; SkyScan, Aartselaar, Belgium). The 3D images were processed by 3D-DOCTOR (Able Software Co., Lexington, MA, USA). ANSYS (Swanson Analysis Systems, Inc., Houston, USA) was used to mesh and analyze 3D FE model. Notch shaped cavity was filled with hybrid or flowable resin and each restoration was simulated with adhesive layer thickness ($40{\mu}m$) A static load of 500 N was applied on a point load condition at buccal cusp (loading A) and palatal cusp (loading B). The principal stresses in the lesion apex (internal line angle of cavity) and middle vertical wall were analyzed using ANSYS. The results were as follows 1. Under loading A, compressive stress is created in the unrestored and restored cavity. Under loading B, tensile stress is created. And the peak stress concentration is seen at near mesial corner of the cavity under each load condition. 2. Compared to the unrestored cavity, the principal stresses at the cemeto-enamel junction (CEJ) and internal line angle of the cavity were more reduced in the restored cavity on both load con ditions. 3. In teeth restored with hybrid composite, the principal stresses at the CEJ and internal line angle of the cavity were more reduced than flowable resin.