• Biomolecules & Therapeutics
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• v.14 no.2
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• pp.90-95
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• 2006

CKD-602 exerts its antitumor effect via inhibition of topoisomerase I in cancer cells. Multicellular spheroid (MCS) and Multicellular layers (MCLs) are known as in vitro 3-dimensional models which closely represent tumor conditions in vivo. In order to investigate the potential of CKD-602 against human colorectal tumors, we evaluated the anti-proliferative activity and penetration ability of CKD-602 in MCS and MCL cultures of DLD-l human colorectal cancer cells, respectively. The maximum effects($E_{max}$) induced by CKD-602 were significantly lower in MCS compared to monolayers (48% vs 92%). With prolonged drug exposure, the $IC_{50's}$ of CKD-602 decreased to $23.5{\pm}1.0nM$ in monolayers after 24 h exposure and $42.3{\pm}1.7nM$ in MCS after 6 days, respectively. However, no further increase in effect was observed for exposure time longer than growth doubling time (Td) in both cultures. Activity of CKD-602 was significantly reduced after penetration through MCL and also with cell-free insert membrane. In conclusion, CKD-602 showed significantly decreased anti-proliferative activity in 3D cultures (MCS) of human colorectal cancer cells. Tumor penetration of CKD-602 could not be determined due to loss of activity after penetration through cell free insert membrane, which warrants further evaluation using a modified model.

• Journal of the Korean Society of Physical Medicine
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• v.15 no.3
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• pp.69-77
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• 2020

PURPOSE: The aim of this study was to measure changes in spine inclination and thoracolumbar structure and morphology according to upper-extremity movements with and without resistance in order to evaluate the spine stability in workers. METHODS: Forty-eight middle-aged male workers (mean age, 40.48 ± 6.27 years) participated in this study. Using the spine analysis system, changes in the inclination of the spine and structure as well as shape of the thoracolumbar spine were measured. For posture measurement, the postures of standing, lifting the right and left arms (shoulder joint 90° flexion), and lifting with both arms were measured in random order. In addition, variables were measured using a resistance of 3 kg for each posture. The statistical significance level was set at α = .05 for all variables. RESULTS: There were statistically significant differences between the front and back inclinations of the spine, kyphotic curve of the thoracic spine, lordotic curve of the lumbar spine, rotation changes in the thoracolumbar spine, and rotation changes in the T4 vertebra (p < .05). However, there was no significant difference in the left and right tilts of the spine. In the post-hoc analysis, rotation changes in the T4 vertebra showed a significant difference in posture when resistance was applied to the left and right sides CONCLUSION: Causes of musculoskeletal diseases include excessive thoracic spine rotation, torsion, and hyperlordosis of the lumbar spine. Therefore, it is necessary to improve the working environment in order to ensure a healthy posture and prevent musculoskeletal diseases that can reduce the ability to carry various and/or excessive loads.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.21 no.5
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• pp.391-404
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• 2009

A small hydropower plant(SHP) using cooling water discharged from the power plant was constructed in Samcheonpo. This study presents predicted and measured hydrological data in the construction process of small hydropower plant in order to evaluate characteristics of water level variation of cooling water discharge channel which is a key factor in the design of SHP since the water level rise of channel is related to impact on circulating water system of the existing power plant. Various methods were applied for prediction of water level variation in the design stage from simple empirical formula to sophisticated 3-dimensional CFD method. Measured results reveal that mean value was similar between measured and predicted, but measured results were larger than predicted in deviation. Moreover, simple formula, i.e. standard weir equation and Honma equation, were more useful before installation of SHP, but sophisticated methods during operation of SHP.

• Journal of Biomedical Engineering Research
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• v.18 no.2
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• pp.187-196
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• 1997

The three-dimensional flow analysis using the finite volume method is presented to compare the steady flow characteristics of blood with those of blood substitutes such as water and aqueous polymer solution in an idealized double branching model. The model is used to simlllate the region of the abdominal aorta near the celiac and superior mesenteric branches. Apparent viscosities of blood and the aqueous Separan solution are represented as a function of shear rate by the Carreau model, Water and aqueoiu Separan AP-273 500wppm solution are frequently used as blood substitutes in vitro experiments. Water is a typical Newtonian fluid and blood and Separan solution are non-Newtonian fluids. Flow phenomena such as velocity distribution, pressure variation and wall shear stress distribution of water, blood and polymer solution are quite different due to differences of the rheological characteristics of fluids. Flow phenomena of polymer solution are qualitatively similar to those of blood but the phenomena of water are quite different from those of blood and polymer solution. It is recommended that a lion-Newtonian fluid which exhibits very similar rheological behavior to blood be used in vitro experiments. A non-Newtonian fluid whose rheological characteristics are very similar to those of blood should be used to obtain the meaninylll hemodynamic data for blood flow in vitro experiment and by numerical analysis

• The Journal of Korean Institute of Communications and Information Sciences
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• v.15 no.1
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• pp.58-70
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• 1990

This paper describes a VLSI implementation of real-time two dimensional DCT processor for the subprimary rate video codec system. The proposed architecture exploits the parallelism and concurrency of the distributes architecture for vector inner product operation of DCT and meets the CCITT performance requirements of video codec for full CSIF 30 frames/sec. It is also shown that this architecture satisfies all the CCITT IDCT accuracy specification by simulating the suggested architecture in bit level. The efficient VLSI disign methodology to design suggested architecture is considered and the module generator oriented design environments are constructed based on SUN 3/150C workstation. Using the constructed design environments. the suggensted architecture have been designed by double metal 2micron CMOS technology. The chip area fo designed 8x8 2-D DA-DCT (Distributed Arithmetic DCT) processor is about 3.9mmx4.8mm.

• Journal of Korean Tunnelling and Underground Space Association
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• v.16 no.4
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• pp.361-372
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• 2014

A measurement of tunnel displacement plays an important role for stability analysis and prediction of possible fault zone ahead of tunnel face. In this study, we evaluated characteristics of tunnel behaviour due to the existence and orientation of fault zone based on 3-dimensional finite element numerical analysis. The crown settlement representing tunnel behaviour is acquired at 5 m away from tunnel face in combination with x-Rs control chart analysis based on statistics for trend line and L/C (longitudinal/crown displacement) ratio in order to propose risk management method for fault zone. As a result, x-Rs control chart analysis can enable to predict fault zone in terms of existence and orientation in tunnelling.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.43 no.3
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• pp.247-254
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• 2017

Optical Coherence Tomography (OCT) is a non-invasive imaging method that utilizes the optical scattering and interference for visualizing the surface as well as cross-sectional structures of tissue. OCT has been used for diagnosing diseases in early stage in various medical fields, but an application in cosmetics is still at early stage. In this study, OCT was adopted to evaluate skin texture and wrinkle. Results showed similar patterns of evaluation with PRIMOS in the assessment using replica. In addition, OCT produced smaller errors at different angles compared to the PRIMOS in the assessment using 3-dimensional models of wrinkles. The resolution of the image was also high enough to differentiate the images of before and after the application of makeup products. Possible use of OCT in the evaluation of fine wrinkle assessment was studied in this research. Further development of methods is necessary to provide more evidences of the effectiveness.

• Corrosion Science and Technology
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• v.11 no.2
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• pp.65-69
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• 2012

One dimensional(1D) $Na_2Ti_6O_{13}$ nanorods with 70 nm in diameter was synthesized by a molten salt method. Using the synthesized nanorods, about 750 nm thick $Na_2Ti_6O_{13}$ film was coated on Fluorine-doped tin oxide(FTO) glasss substrate by the Layer-by-layer self-assembly(LBL-SA) method in which a repetitive self-assembling of ions containing an opposite electric charge in an aqueous solution was utilized. Using the Kubelka-Munk function, the band gap energy of the 1D-$Na_2Ti_6O_{13}$ nanorods was nalyzed to be 3.5 eV. On the other hand, the band gap energy of the $Na_2Ti_6O_{13}$ film coated on FTO was found to be a reduced value of 2.9 eV, resulting from the nano-scale and high porosity of the film processed by LBL-SA method, which was favorable for the photo absorption capability. A significant improvement of photocurrent and onset voltage was observed with the $Na_2Ti_6O_{13}$ film incorporated into the conventional $Fe_2O_3$ photoelectrode: the photocurrent increased from 0.25 to 0.82 mA/$cm^2$, the onset voltage decreased from 0.95 to 0.78 V.

• Journal of KIBIM
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• v.6 no.3
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• pp.49-56
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• 2016

As project opportunities for the Architecture, Engineering and Construction (AEC) industry have grown more complex and larger, the utilization of Building Information Modeling (BIM) technologies for three-dimensional (3D) design and simulation practices has been increasing significantly; the typical applications of the BIM technologies include clash detection and design alternative based on 3D planning, which have been expanded over to the technology of construction management in the AEC industry for virtual design and construction. As for now, commercial BIM software has been operated under a single-user environment, which is why initial costs for its introduction are very high. Cloud computing, one of the most promising next-generation Internet technologies, enables simple Internet devices to use services and resources provided with BIM software. Recently in Korea, studies to link between BIM and cloud computing technologies have been directed toward saving costs to build BIM-related infrastructure, and providing various BIM services for small- and medium-sized enterprises (SMEs). This study addressed development of the usage metering functions of BIM software under cloud computing architecture in order to archive and use BIM data and create an optimal revenue structure so that the BIM services may grow spontaneously, considering a demand for cloud resources. For the reason, we surveyed relevant cases, and then analyzed needs and requirements from AEC industry. Based on the relevant cases, customizing for cloud BIM and design for the development was performed. We also surveyed any related-law to support cloud computing-based BIM service. Finally, we proposed herein how to optimally design and develop the usage metering functions of cloud BIM software.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2017.10a
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• pp.702-704
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• 2017

In case of dismantling of nuclear power generation facility or radiation accident, the accurate information of gammaray source is essential for rapid decontamination. In order to more efficiently represent the position of the gamma ray to be removed, we create a spatial domain based on the real image. And we can perform decontamination of gamma-ray source more quickly by expressing the distribution of radiation source. The developed gamma ray imaging device overlaps with the visible image after gamma - ray detection and provides only two - dimensional image, but it does not show the distance information to the source. In this paper, we have developed a operation environment using the 3D visualization model for reporting effective decontamination operation.