• Applied Biological Chemistry
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• v.47 no.3
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• pp.300-306
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• 2004

Eight cation or anion-responsive polymer membranes were prepared by a casting procedure employing polyvinyl chloride, Bis (2-ethylhexyl)sebacate and each electroactive material in the ratio of 66 : 33 : 1. The resulting membranes were separately installed onto the sensitive area of the ionic electrodes to produce an 8-channel taste sensor array. The taste sensors of the array were connected to a high-input impedance amplifier and the amplified sensor signals were interfaced to a PC via an A/D converter. The taste evaluation system was applied to a discriminant analysis on six groups of marketed beverages like sikhye, sujunggwa, tangerine juice, ume juice, ionic drink and green tea. When the signal data from the sensor array were analyzed by principal component analysis after normalization, the 1st, 2nd and 3rd principal component explained most of the total data variance. The six groups of the analyzed beverages were discriminated well in the three dimensional principal component space. The half of the five groups of the analyzed beverages was also discriminated in the two dimensional principal component plane.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.37 no.4
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• pp.275-282
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• 2024

A recently proposed rapid-disassembly , carbon-minimized dismantle connection was tested using cyclic loading. To better understand the behavior of the test specimen, three-dimensional finite element (3D-FE) analyses were conducted using a "tied model" (bolted contact surfaces are tied together) and a "bolt-slip model" (contact surfaces slip and separate). The tied model suggests that plastic hinging of the beam occurs if the proposed connection behaves rigidly. The bolt-slip model suggests that the proposed connection, if manufactured and assembled properly, can dissipate energy to about 0.5 times that experienced by a rigid connection. However, when compared in a test, its moment-rotation hysteresis curve does not match well, which suggests that the low performance of the test specimen is attributable to a manufacturing deficiency. Regardless, the results corroborate the pinching phenomenon observed in the experimental hysteresis and fracture failure of the test specimen.

• The Korean Journal of Nuclear Medicine Technology
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• v.15 no.1
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• pp.58-64
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• 2011

Objective: The 3-dimensional reconstruction method with resolution recovery modeling has advantages of high spatial resolution and contrast because of its precise modeling of spatial blurring according to the distance from detector plane. The aim of this study was to evaluate one of the resolution recovery reconstruction methods (Astonish, Philips Medical), compare it to other iterative reconstructions, and verify its clinical usefulness. Materials and Methods: NEMA IEC PET body phantom and Flanges Jaszczak ECT phantom (Data Spectrum Corp., USA) studies were performed using Skylight SPECT (Philips) system under four different conditions; short or long (2 times of short) radius, and half or full (40 kcts/frame) acquisition counts. Astonish reconstruction method was compared with two other iterative reconstructions; MLEM and 3D-OSEM which vendor supplied. For quantitative analysis, the contrast ratios obtained from IEC phantom test were compared. Reconstruction parameters were determined by optimization study using graph of contrast ratio versus background variability. The qualitative comparison was performed with Jaszczak ECT phantom and human myocardial data. Results: The overall contrast ratio was higher with Astonish than the others. For the largest hot sphere of 37 mm diameter, Astonish showed about 27.1% and 17.4% higher contrast ratio than MLEM and 3D-OSEM, in short radius study. For long radius, Astonish showed about 40.5% and 32.6% higher contrast ratio than MLEM and 3D-OSEM. The effect of acquired counts was insignificant. In the qualitative studies with Jaszczak phantom and human myocardial data, Astonish showed the best image quality. Conclusion: In this study, we have found out that Astonish can provide more reliable clinical results by better image quality compared to other iterative reconstruction methods. Although further clinical studies are required, Astonish would be used in clinics with confidence for enhancement of images.

• The Korean Journal of Physiology and Pharmacology
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• v.17 no.6
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• pp.517-523
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• 2013

Naphthyridine compounds are important, because they exhibit various biological activities including anticancer, antimicrobial, and anti-inflammatory activity. Some naphthyridines have antimitotic effects or demonstrate anticancer activity by inhibiting topoisomerase II. These compounds have been investigated as potential anticancer agents, and several compounds are now part of clinical trials. A series of naphthyridine derivatives were evaluated for their in vitro cytotoxic activities against human cervical cancer (HeLa), leukemia (HL-60), and prostate cancer (PC-3) cell lines using an MTT assay. Some compounds (14, 15, and 16) were more potent than colchicine against all three human cancer cell lines and compound (16) demonstrated potency with $IC_{50}$ values of 0.7, 0.1, and $5.1{\mu}M$, respectively. Comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA) were used for quantitative structure-activity relationship (QSAR) molecular modeling of these compounds. We obtained accurate and predictive three-dimensional QSAR (3D-QSAR) models as indicated by the high PLS parameters of the HeLa ($q^2$, 0.857; $r^2$, 0.984; $r^2\;_{pred}$, 0.966), HL-60 ($q^2$, 0.777; $q^2$, 0.937; $r^2\;_{pred}$, 0.913), and PC-3 ($q^2$, 0.702; $q^2$, 0.983; $r^2\;_{pred}$, 0.974) cell lines. The 3D-QSAR contour maps suggested that the C-1 NH and C-4 carbonyl group of the naphthyridine ring and the C-2 naphthyl ring were important for cytotoxicity in all three human cancer cell lines.

• KIISE Transactions on Computing Practices
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• v.23 no.12
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• pp.660-669
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• 2017

In order to improve user accessibility and interactivity, system scalability, service speed, and a non-standard internet web environment, we developed a Web-based geovisualization system of oceanographic information using HTML5 and dynamic particles. In particular, oceanographic and meteorological data generated from a satellite remote sensing and radar measurement and a 3-dimensioanl numerical model, has the characteristics of a heterogeneous large-capacity multi-dimensional continuous spatial and temporal variability, based on geographic information. Considering those attributes, we applied dynamic particles represent the spatial and temporal variations of vector type oceanographic data. HTML5, WebGL, Canvas, D3, and Leaflet map libraries were also applied to handle various multimedia data, graphics, map services, and location-based service as well as to implement multidimensional spatial and statistical analyses such as a UV chart.

• Journal of the Society of Naval Architects of Korea
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• v.43 no.3 s.147
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• pp.351-361
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• 2006

The fatigue strength analysis of VLFS is carried out by using a 3-dimensional plate finite element model with a zooming technology which performs the modeling of wide portions of the structure by a coarse mesh but the concerned parts by a very fine mesh of t by t level. And a stepwise substructure modeling technique for global loading conditions is applied which uses the motion response of the global structure from 2-D plate hydroelastic analysis as the enforcing nodal displacements of the concern 3-D structural zooming model. Seven incident wave angles and whole ranges of frequency domains of wave spectrum are considered. In order to consider the effect of breakwater, the modified JONSWAP wave spectrum is used. Applying the wave data of installation region, the longterm spectrum analysis is done based on stochastic process and the fatigue life of the structure is estimated. Finally some design considerations from the view point of fatigue strength analysis of VLFS are discussed.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.37 no.4
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• pp.521-527
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• 2013

This study provides the elastic stress intensity factors, K, for circumferential and longitudinal surface cracked straight pipes under single or combined loads of internal pressure, bending, and torsion based on three-dimensional (3D) finite element (FE) analyses. FE results are compared with two different types of defect assessment codes (API-579-1 and RCC-MR A16) to prove the accuracy of the FE results and the differences between the codes. Through the 3D FE analysis, it is found that the stress intensity factors are sensitive to the number of elements, which they were believed to not be sensitive to because of path independence. Differences were also found between the FE analysis results for crack defining methods and the results obtained by two different types of defect assessment codes.

• Journal of Korea Game Society
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• v.11 no.4
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• pp.143-149
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• 2011

This paper presents a novel camera tracking method based on model with multiple planes. The proposed algorithm detects QR code that is one of the most popular types of two-dimensional barcodes. A 3D model is imported from the detected QR code for augmented reality application. Based on the geometric property of the model, the vertices are detected and tracked using optical flow. A clipping algorithm is applied to identify each plane from model surfaces. The proposed method estimates the homography from coplanar feature correspondences, which is used to obtain the initial camera motion parameters. After deriving a linear equation from many feature points on the model and their 3D information, we employ DLT(Direct Linear Transform) to compute camera information. In the final step, the error of camera poses in every frame are minimized with local Bundle Adjustment algorithm in real-time.

• Economic and Environmental Geology
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• v.51 no.2
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• pp.121-130
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• 2018

The KURT (KAERI Underground Research Tunnel) is a research tunnel which is located in KAERI (Korea Atomic Energy Research Institute) site. At KURT, researches on engineering and natural barrier system, which are the most important components for geological disposal system for high level radioactive waste, have been conducted. In this study, we synthesized the site characteristics obtained by various types of site investigation to introduce the geological model for KURT site, and induced the 3-D hydrogeological model for KURT site from the geological model. From the geological investigation at the surface and boreholes, four geological elements such as subsurface weathered zone, upper fractured rock, lower fractured rock and fracture zones were determined for the geological model. In addition, the geometries of these geological elements were also analyzed for the geological model to be three-dimensional. The results from 3-D geological model were used to construct the hydro-geological model for KURT site, which is one of the input data for groundwater flow modeling and safety assessment.

• Korean Journal of Agricultural and Forest Meteorology
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• v.17 no.2
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• pp.165-172
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• 2015

The extreme weather conditions become frequent and severe with global warming. To prevent and cope forest disaster like a forest fire, we need an accurate micrometeorological prediction system for mountainous regions. This study addressed the forest fires occurred at Bonghwa and Gangneung in March, 2013. We constructed and optimized the prediction system that were required to interpret and simulate the forest micrometeorology. At first, we examined WRF physical sensitivity. Subsequently, KMA AWS observation data were assimilated using three-dimensional variation data assimilation method. The effectiveness of the assimilation was examined by using AWS observations enhanced with the Forest Research Institute observations. Finally, The 100 meters spatial resolution wind data were obtained by using the MUKLIMO for the given wind vector from WRF.