• Asian Pacific Journal of Cancer Prevention
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• v.17 no.5
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• pp.2507-2511
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• 2016

Purpose: To study the diagnostic accuracies of serum human epididymis protein 4 (HE-4) levels, virtual organ computer-aided analysis (VOCAL) parameters and endometrial volume in endometrial cancer cases. Materials and Methods: One hundred and seven patients (37 with endometrial cancer and 70 with benign endometrial pathology) were included in this study. VOCAL parameters and serum HE-4 levels were compared between the groups. Results: Area under the curve (AUC) values were 0.702, 0.658, 0.706 for vascularization index (VI), the flow index (FI) and the vascularization flow index (VFI), respectively. A cut off value of 0.568 for VI demonstrated 70% sensitivity, 72% specificity, 56% positive predictive value (PPV) and a81% negative predictive value (NPV). A cut off value of 25.8 for showed a senitivith of 70% and a specificity of 58% with aPPV of 46% and NPV of 78%, and with a cut off value of 0.12 for VFI 70%, 69%, 54% and 81%, respectively. The area under the curve for HE-4 was 0.814. A cut off value of 458 pmol/L was predictive of malignancy with 86% sensitivity and 63% specificity. Conclusions: VOCAL parameters and serum HE-4 levels were statistically significantly higher in the endometrial cancer patients. Serum HE-4 levels provided a greater sensitivity compared to power doppler angiography for predicting malignancy or benign endometrial pathology.

• Progress in Superconductivity and Cryogenics
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• v.19 no.4
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• pp.45-50
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• 2017

This paper presents a conceptual design and analysis for a 1-kW-class high-temperature superconducting rotating machine (HTSRM) rotor. The designed prototype is a small-scale integration system of a HTSRM and a HTS contactless rotary excitation device (CRED). Technically, CRED and HTSRM are connected in the same shaft, and it effectively charges the HTS coils of the rotor field winding by pumping fluxes via a non-contact method. HTS coils in rotor pole body and toroidal HTS wire in CRED rotor are cooled and operated by liquid nitrogen in cryogen tank located in inner-most of rotor. Therefore, it is crucial to securely maintain the thermal stability of cryogenic environment inside rotor. Especially, we critically consider not only on mechanical characteristics of the rotor but also on cryogenic thermal characteristics. In this paper, we conduct two main tasks covering optimizing a conceptual design and performing operational characteristics. First, rotor parameters are conceptually designed by analytical design codes. These parameters consider to mechanical and thermal performances such as mechanical strength, mechanical rigidity, and thermal heat losses of the rotor. Second, mechanical and thermal characteristics of rotor for 1-kW-class HTSRM are analyzed to verify the feasible operation conditions. Hence, three-dimensional finite element analysis (3D-FEA) method is used to perform these analyses in ANSYS-Workbench platform.

• Bulletin of the Society of Naval Architects of Korea
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• v.26 no.2
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• pp.49-63
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• 1989

Wave drift forces which are small in magnitudes compared to the first order wave exciting forces can cause very large motion of a vessel in waves. In this paper a theoretical and experimental analysis is made of the mean and slowly varying wave dirft forces on the semi-submersible platform. Theoretical calculations are performed by using near field method with three dimensional diffraction theory and model tests are carried out in regular and irregular waves with a 1/60 semi model. Test results are compared with theoretical calculations and the mooring spring effects in the test are discussed.

• Journal of Periodontal and Implant Science
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• v.46 no.2
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• pp.96-106
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• 2016

Purpose: Stress distribution and mandible distortion during lateral movements are known to be closely linked to bruxism, dental implant placement, and temporomandibular joint disorder. The present study was performed to determine stress distribution and distortion patterns of the mandible during lateral movements in Class I, II, and III relationships. Methods: Five Korean volunteers (one normal, two Class II, and two Class III occlusion cases) were selected. Finite element (FE) modeling was performed using information from cone-beam computed tomographic (CBCT) scans of the subjects' skulls, scanned images of dental casts, and incisor movement captured by an optical motion-capture system. Results: In the Class I and II cases, maximum stress load occurred at the condyle of the balancing side, but, in the Class III cases, the maximum stress was loaded on the condyle of the working side. Maximum distortion was observed on the menton at the midline in every case, regardless of loading force. The distortion was greatest in Class III cases and smallest in Class II cases. Conclusions: The stress distribution along and accompanying distortion of a mandible seems to be affected by the anteroposterior position of the mandible. Additionally, 3-D modeling of the craniofacial skeleton using CBCT and an optical laser scanner and reproduction of mandibular movement by way of the optical motion-capture technique used in this study are reliable techniques for investigating the masticatory system.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.29 no.5
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• pp.359-365
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• 2018

Herein, electromagnetic shielding structures to reduce the external noise coupling to printed spiral coils (PSCs) and a design method for improving the bandwidth of shielded PSCs have been proposed. It has been demonstrated that the bandwidth of shielded PSCs is limited due to the parasitic capacitance between the coils and the shielding structures and is confirmed by the transfer function simulation of the shielded PSCs with a transmission line as the radio-frequency interference noise source. A design method for the bandwidth improvement of the shielded PSCs has been proposed based on the equivalent circuit model analysis and the case studies depending on PSC designs with a three-dimensional field simulation. With the design method, an optimized shielded PSC design has been presented and successfully confirmed by experimental verification in that the optimized design results in a significant bandwidth improvement.

• The Journal of the Korea institute of electronic communication sciences
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• v.12 no.5
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• pp.737-746
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• 2017

In 2017, amid changes in the security market such as integrated security (IS) and convergence security (CS), a variety of security paradigms in terms of operation and management have been suggested. Rather than changing existing network infrastructure and bringing about fluid, multi-dimensional changes, these solutions and technologies focus entire security capacity on a primary protection, leading to network infrastructure suffering from unexpected inherent violations and problems in a continued manner. Therefore, it is time to propose and develop a flexible network section that can protect from attacks of similar pattern and concentrated traffic attacks by applying a new concept of WB (Water-Bubble) to network infrastructure and analyzing on the basis of experiment and installation. Methodology of the WB-based highly secure flexible network section proposed in this study is expected to provide materials for studies on how to achieve network section security taking into account three major limitations and security standards: fluidity, unpredictability, and non-area scalability by contact point ratio, by changing a network area predicted to be the final target of attack into resonant network section (area) with flexible area changes.

• BMB Reports
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• v.53 no.2
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• pp.118-123
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• 2020

Cardiac regeneration with adult stem-cell (ASC) therapy is a promising field to address advanced cardiovascular diseases. In addition, extracellular vesicles (EVs) from ASCs have been implicated in acting as paracrine factors to improve cardiac functions in ASC therapy. In our work, we isolated human cardiac mesenchymal stromal cells (h-CMSCs) by means of three-dimensional organ culture (3D culture) during ex vivo expansion of cardiac tissue, to compare the functional efficacy with human bone-marrow derived mesenchymal stem cells (h-BM-MSCs), one of the actively studied ASCs. We characterized the h-CMSCs as CD90^low, c-kit^negative, CD105^positive phenotype and these cells express NANOG, SOX2, and GATA4. To identify the more effective type of EVs for angiogenesis among the different sources of ASCs, we isolated EVs which were derived from CMSCs with either normoxic or hypoxic condition and BM-MSCs. Our in vitro tube-formation results demonstrated that the angiogenic effects of EVs from hypoxia-treated CMSCs (CMSC-Hpx EVs) were greater than the well-known effects of EVs from BM-MSCs (BM-MSC EVs), and these were even comparable to human vascular endothelial growth factor (hVEGF), a potent angiogenic factor. Therefore, we present here that CD90^lowc-kit^negativeCD105^positive CMSCs under hypoxic conditions secrete functionally superior EVs for in vitro angiogenesis. Our findings will allow more insights on understanding myocardial repair.

• Transactions of the Korean Society of Automotive Engineers
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• v.18 no.5
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• pp.108-114
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• 2010

The injection nozzle of an electro-hydraulic injector is being opened and closed by movement of a injector's needle which is balanced by pressure at the nozzle seat and at the needle control chamber, at the opposite end of the needle. In this study, the effects of needle movement in a piezo-driven injector on unsteady cavitating flows behavior inside nozzle were investigated by cavitation numerical model based on the Eulerian-Lagrangian approach. Aimed at simulating the 3-D two-phase flow behavior, the three dimensional geometry model along the central cross-section regarding of one injection hole with real design data of a piezo-driven diesel injector has been used to simulate the cavitating flows for injection time by at fully transient simulation with cavitation model. The cavitation model incorporates many of the fundamental physical processes assumed to take place in cavitating flows. The simulations performed were both fully transient and 'pseudo' steady state, even if under steady state boundary conditions. As this research results, we found that it could analyze the effect the pressure drop to the sudden acceleration of fuel, which is due to the fastest response of needle, on the degree of cavitation existed in piezo-driven injector nozzle.

• Journal of Animal Science and Technology
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• v.57 no.12
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• pp.44.1-44.9
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• 2015

Background: Heat shock proteins play an important role in protection from stress stimuli and metabolic insults in almost all organisms. Methods: In this study, computational tools were used to deeply analyse the physicochemical characteristics and, using homology modelling, reliably predict the tertiary structure of the blunt snout bream (Ma-) Hsp70 and Hsc70 proteins. Derived three-dimensional models were then used to predict the function of the proteins. Results: Previously published predictions regarding the protein length, molecular weight, theoretical isoelectric point and total number of positive and negative residues were corroborated. Among the new findings are: the extinction coefficient (33725/33350 and 35090/34840 - Ma-Hsp70/ Ma-Hsc70, respectively), instability index (33.68/35.56 - both stable), aliphatic index (83.44/80.23 - both very stable), half-life estimates (both relatively stable), grand average of hydropathicity (-0.431/-0.473 - both hydrophilic) and amino acid composition (alanine-lysine-glycine/glycine-lysine-aspartic acid were the most abundant, no disulphide bonds, the N-terminal of both proteins was methionine). Homology modelling was performed by SWISS-MODEL program and the proposed model was evaluated as highly reliable based on PROCHECK's Ramachandran plot, ERRAT, PROVE, Verify 3D, ProQ and ProSA analyses. Conclusions: The research revealed a high structural similarity to Hsp70 and Hsc70 proteins from several taxonomically distant animal species, corroborating a remarkably high level of evolutionary conservation among the members of this protein family. Functional annotation based on structural similarity provides a reliable additional indirect evidence for a high level of functional conservation of these two genes/proteins in blunt snout bream, but it is not sensitive enough to functionally distinguish the two isoforms.

• Radiation Oncology Journal
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• v.20 no.1
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• pp.68-72
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• 2002

This study was done to implement intensity-modulated radiation therapy (IMRT) for the treatment of primary prostate cancer and to compare this technique with conventional treatment methods. A 72-year-old male patient with prostate cancer stage T2a was treated with IMRT delivered with dynamic multi-leaf collimation. Treatment was designed using an inverse planning algorithm, which accepts dose and dose-volume constraints for targets and normal structures. The IMRT plan was compared with a three-dimensional (3D) plan using the same 6 fields technique. Lower normal tissue doses and improved target coverage were achieved using IMRT at current dose levels, and facilitate dose escalation to further enhance locoregional control and organ movement during radiotherapy is an important issue of IMRT in prostate cancer.