• BMB Reports
• /
• 제49권10호
• /
• pp.529-535
• /
• 2016

The NLRP3 inflammasome is activated by a variety of external or host-derived stimuli and its activation initiates an inflammatory response through caspase-1 activation, resulting in inflammatory cytokine IL-1β maturation and secretion. The NLRP3 inflammasome activation is a kind of innate immune response, most likely mediated by myeloid cells acting as a host defense mechanism. However, if this activation is not properly regulated, excessive inflammation induced by overactivated NLRP3 inflammasome can be detrimental to the host, causing tissue damage and organ dysfunction, eventually causing several diseases. Previous studies have suggested that mitochondrial damage may be a cause of NLRP3 inflammasome activation and autophagy, which is a conserved self-degradation process that negatively regulates NLRP3 inflammasome activation. Recently, mitochondria-selective autophagy, termed mitophagy, has emerged as a central player for maintaining mitochondrial homeostasis through the elimination of damaged mitochondria, leading to the prevention of hyperinflammation triggered by NLRP3 inflammasome activation. In this review, we will first focus on the molecular mechanisms of NLRP3 inflammasome activation and NLRP3 inflammasome-related diseases. We will then discuss autophagy, especially mitophagy, as a negative regulator of NLPP3 inflammasome activation by examining recent advances in research.

• 한국컴퓨터정보학회논문지
• /
• 제15권3호
• /
• pp.111-119
• /
• 2010

인공조명의 특징은 중앙을 기준으로 수많은 방사형과 직선형 빛을 방출한다. 이러한 빛의 퍼짐을 3D로 표현하기는 매우 어렵고 복잡하다. 또한 빛의 효과에 따른 물체의 색상은 매우 다양하고 많은 변수 값 때문에 사용자가 정확히 물체를 표현하기 어렵다. 이러한 문제점을 해결하기 위하여 본 논문에서는 방사형과 직선형 빛을 손쉽게 표현하기 위한 모델을 제시하고 X3D를 사용하여 인공조명을 설계하였다. 그리고 사용자가 3D 물체의 색상을 정확하고 쉽게 표현할 수 있도록 물체의 색상을 요소별로 분리한 후 사용자가 직접 육안으로 각 요소의 색상 값을 관찰하며 조정하도록 온라인 시스템을 제안하였다. 제안된 시스템을 사용하여 다양한 인공조명을 손쉽게 생성할 수 있었다.

• 보존과학회지
• /
• 제35권1호
• /
• pp.71-80
• /
• 2019

This study examined the applicability of digital technologies based on three-dimensional(3D) scanning, modeling, and printing to the restoration of damaged artifacts. First, 3D close-range scanning was utilized to make a high-resolution polygon mesh model of a roof-end tile with a missing part, and a 3D virtual restoration of the missing part was conducted using a haptic interface. Furthermore, the virtual restoration model was printed out with a 3D printer using the material extrusion method and a PLA filament. Then, the additive structure of the printed output with a scanning electron microscope was observed and its shape accuracy was analyzed through 3D deviation analysis. It was discovered that the 3D printing output of the missing part has high dimensional accuracy and layer thickness, thus fitting extremely well with the fracture surface of the original roof-end tile. The convergence of digital virtual restoration based on 3D scanning and 3D printing technology has helped in minimizing contact with the artifact and broadening the choice of restoration materials significantly. In the future, if the efficiency of the virtual restoration modeling process is improved and the material stability of the printed output for the purpose of restoration is sufficiently verified, the usability of 3D digital technologies in cultural heritage restoration will increase.

• 한국의류학회지
• /
• 제45권3호
• /
• pp.439-452
• /
• 2021

The purpose of this thesis is to compare the efficiency of 3D digital design technology with traditional hand-drawn designs of a transformable dress for a small wedding. After reviewing the literature, this empirical study analyzed the tendencies of small wedding dress design, concluding that a transformable dress for a small wedding consists of a bodice, skirt, and outer skirt or gown with train, each of which has five possible designs, resulting in 15 virtual items within the 3D program. The 3D program provides the benefit of easy design development as well as reduced costs and design time. Specifically, the random combination of 15 items with layers in the 3D program produced 150 different styles in 5 hours, while hand-drawing 150 dresses took 50 hours. Moreover, the 3D program does not need any material, but 150 physical drawings required a sketchbook, pencil, eraser, and marker, total cost 31,100 won. Additionally, the 3D whole-body scan helps the bride decide which design she prefers through virtual try-ons. Eventually, the 3D program could help a bride decide what she prefers and produce it with virtual simulation, resulting in reduced time and costs.

• 한국세라믹학회지
• /
• 제24권1호
• /
• pp.70-76
• /
• 1987

The effect of C12A7 and OH group on the synthesis of C3A by the sol-gel process using aluminum-sec-butoxide and calcium nitrate was studied. C3A by sol-gel method was compared with C3A obtained by the conventional method with respect to their reactivity of formation and crystal size. The sol-gel process for initial formation of C12A7 and C3A at lower temperature (1100, 1200$^{\circ}C$) was superior, but that for complete crystallization of C3A at higher temperature (1300, 1400$^{\circ}C$) was inferior to oxide mixture process. When heat treated under the atmosphere oxygen-free dried nitrogen eliminate the influence of OH group in C12A7, the reactivity of C3A from sol-gel sample incorporated OH group were poor, whereas that from oxide mixture sample showed remarkable effect. The poor crystallization of C3A at higher temperature is presumed to be due to the fact that incorporated OH group in C12A7 formed at lowr temperature might interrupt the diffusion of CaO to C12A7 to from C3A. The crystal size and the hydration characteristics of both C3A obtained by different processes exhibited almost the same results.

• Spatial Information Research
• /
• 제15권1호
• /
• pp.53-65
• /
• 2007

지상라이다는 고정도의 3차원 영상을 제공하고 레이저빔을 현장이나 대상물에 발사하여 짧은 시간에 수백만점의 3차원좌표를 기록할 수 있는 최신 측량장비로서 다양한 응용분야에서 두각을 나타내고 있다 본 연구에서는 지상라이다를 이용한 아파트 건축물의 3차원 경계 추출을 다루었다. 실험측량결과 지상라이다로 아파트건축물의 3차원 경계를 신속하게 추출할 수 있었지만 지상기반시스템이므로 건축물 지붕 그리고 나무, 전주 때문에 건축물 저층부에서는 이것이 쉽지 않았다. 향후 토탈스테이션, 지상라이다, 항공라이다와 항공사진측량과의 결합을 통해 효율적인 3차원공간정보 획득이 가능할 것으로 기대된다.

• 한국식물병리학회지
• /
• 제11권3호
• /
• pp.271-277
• /
• 1995

The RNA nucleotide sequences of the 3/-noncoding regions (3'-NCRs) of two Korean strains of turnip mosaic virus (TuMV), Ca and cqs, have been determined from their cDNA clones that encompassed the 3'-terminal regions of the viral genomic RNAs. The 3'-NCRs of both strains were 209 nucleotides long, terminated with GAC residues and poly (A) tails. The potential polyadenylational signal motif, UAUGU, was located 140 nucleotides upstream from the poly (A) tail in each of the virus. A highly conserved hexanucleotide sequence [A G U G A/U G/C], which was common in the 3'-NCRs of the potyvirus RNAs, was also found at the regions of 119 bases upstream from the 3'-end. Comparison of the 3'-NCRs of the two Korean isolates with those of four strains from Canada, China and Japan showed significantly identical genotypes (94.3∼99.5%). The secondary structure of three loops with long stems was found within the 3'-NCRs by sequence analysis. The substituted bases in the region among the six TuMV strains did not alter their secondary structures. Length of the 3'-NCRs of the know 11 potyviral RNAs and TuMV RNAs was different from one another and their nucleotide sequences showed 55.7% to 24.0% of homology. The 3'-NCR, therefore, is considered to be useful for phylogenetic studies in potyviruses.

• 대한치과기공학회지
• /
• 제41권4호
• /
• pp.287-293
• /
• 2019

Purpose: To evaluate the accuracy of the 3D printed die models and to investigate its clinical applicability. Methods: Stone die models were fabricated from conventional impressions(stone die model; SDM, n=7). 3D virtual models obtained from the digital impressions were manufactured as a 3D printed die models using a 3D printer(3D printed die models;3DM, n=7). Reference model, stone die models and 3D printed die models were scanned with a reference scanner. All dies model dataset were superimposed with the reference model file by the "Best fit alignment" method using 3D analysis software. Statistical analysis was performed using the independent t-test and 2-way ANOVA (α=.05). Results: The RMS value of the 3D printed die model was significantly larger than the RMS value of the stone die model (P<.001). As a result of 2-way ANOVA, significant differences were found between the model group (P<.001) and the part (P<.001), and their interaction effects (P<.001). Conclusion: The 3D printed die model showed lower accuracy than the stone die model. Therefore, it is necessary to further improve the performance of 3D printer in order to apply the 3D printed model in prosthodontics.

• 패션비즈니스
• /
• 제20권3호
• /
• pp.30-42
• /
• 2016

The objective of this study was to perform 3D solid modeling from 3D scanned surface images of cotton and silk in order to calculate the thermal heat transfer responses using numerical simulations. Continuing from the previous methodology, which provided 3D surface data for a fabric through optical measurements of the fabric microstructure, a simplified 3D solid model, containing a defined unit cell, pattern unit and fabric structure, was prepared. The loft method was used for 3D solid-model generation, and heat transfer calculations, made for the fabric, were then carried out using the 3D solid model. As a result, comprehensive protocols for 3D solid-model generation were established based on the optical measurements of real fabric samples. This method provides an effective means of using 3D information for building 3D models of actual fabrics and applying the model in numerical simulations. The developed process can be used as the basis for other analogous research areas to investigate the physical characteristics of any fabrics.

• 대한산업공학회지
• /
• 제41권3호
• /
• pp.253-258
• /
• 2015

The 3D printing is any of various processes for making a three dimensional object of almost any shape from a 3D model. Recently, a rapidly expanding hobbyist and home-use market has become established with the inauguration of the open-source RepRap and Fab@Home projects. However, this causes problems regarding copyright protection and usage of illegal 3D data. In this paper, we developed a 3D printing open-market system, which guarantees copyright protection using the remote 3D printing without direct distribution of 3D design data. Because most of the home-use 3D printers are FFF (Fused Filament Fabrication) based on NC code system, open-market system uses FFF 3D printers. Also, open-market system inspects the uploaded 3D model data, so the system can prevent distribution of illegal model data such as weapons, etc.