• Title/Summary/Keyword: 3-dimensional packing

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Packing effects on the intracavitary radiation Therapy 3-Dimension plan of the uterine cervix cancer (자궁경부암 강내조사 3차원 치료계획 시 Packing의 유용성 분석)

  • Si, Chang-Keun;Jo, Jung-Kun;Lee, Du-Hyun;Kim, Sun-Yeung;Kim, Tae-Yoon
    • The Journal of Korean Society for Radiation Therapy
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    • v.17 no.1
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    • pp.1-8
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    • 2005
  • Purpose : An effect of a packing to uterine treatment of a cervical cancer using a dose-volume histogram for a point dose and a volume dose of the bladder and the rectum was analyzed by establishing a three-dimensional treatment plan using a CT image. Materials and methods : Reference points of the bladder and the rectum were marked, respectively at a treatment plan device (plato brachytherapy V14.2.4) by photographing CT(marconi, USA) when the packing was used and removed under the same condition and a treatment plan was performed to Apoint depending on ICRU38. However, in case of the rectum, a maximum point was looked up and compared with the above point because the point presented from the ICRU is not proper as a representative value of a rectum point dose. Further, the volume dose depending on volume of $50\%,\;80\%,\;and\;100\%$ point doses of the rectum and the bladder was measured. The measured values were used to analyze the effect of the packing through a Wilcoxon Signed Rank Test (a SAS statistical analysis process program). Result : The reference points at the bladder and rectum doses when the packing was removed were $116.94\;35.42\%$ and $117.59\;21.08\%$, respectively. The points when the packing was used were $107.08\;38.12\%$ and $95.19\;21.32\%$, respectively. After the packing was used, the reference points at the bladder and the rectum were decreased by $9.86\%$ and $22.4\%$, respectively. When the packing was removed, the maximum points at the bladder and the rectum were $164.51\;50.89\%,\;128.81\;33.05\%$, respectively. When the packing was used, the maximum points at the bladder and the rectum were $142.31\;44.79,\;110.08\;37.03\%$, respectively. After the packing was used, the maximum points at the bladder and the rectum were decreased by $22.2\%$ and $18.73\%$, respectively. When the packing was removed, the bladder volume at $50\%,\;80\%,\;and\;100\%$ point doses of the rectum and the bladder were $48.62{\pm}18.09\%,\;16.12{\pm}11.15\%,\;and\;7.51{\pm}6.63\%$, respectively and its rectum volume were $23.41{\pm}14.44\%,\;6.27{\pm}4.28\%,\;2.79{\pm}2.27\%$, respectively. When the packing was used, the bladder volume at $50\%,\;80\%,\;and\;100\%$ point doses of the rectum and the bladder were $40.33{\pm}16.72,\;11.63{\pm}8.72,\;and\;4.87{\pm}4.75\%$, respectively and its rectum volume were $18.96{\pm}8.37\%,\;4.75{\pm}2.58\%,\;and\;1.58{\pm}1.06\%$, respectively. After the packing was used, the bladder volume at $50\%,\;80\%,\;and\;100\%$ point doses of the rectum and the bladder were decreased by $8.29\%,\;4.49\%,\;and\;2.64\%$, respectively and its bladder volume were decreased by $4.45\%,\;1.52\%,\;and\;1.21\%$, respectively. Conclusion : Values at Reference point doses of the bladder and the rectum recommended from the ICRU 38 were 0.0781 and 0.0781, respectively and values of their maximum point doses were 0.0156 and 0.0156, respectively, as a result of which an effect of the packing using at the uterine intracavitary treatment of an uterine cervical cancer through the three-dimensional treatment plan used CT were measured. That is, the values at reference point doses and the values at maximum point doses show similar difference. However, P value was 0.15 at over $50\%,\;80\%,\;and\;100\%$ volume doses and the value shows no similar difference. In other words, the effect of the packing looks like having a difference at the point dose, but actually shows no difference at the volume dose. The reason is that the volume of the bladder and the rectum are wide but the volume of the packing is only a portion. Therefore, the effect of decreasing the point dose was not great. Further, the farer the distance is, the more weak the intensity of radiation is because the intensity of radiation is proportional to inverse square of a distance. Therefore, the effort to minimize an obstacle of the bladder and the rectum by using the packing should be made.

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Application of the Annealing Method to the Three Dimensional Layout Design (3차원배치설계에 대한 어닐링법의 적용)

  • 장승호;최명진
    • Journal of the Korea Society for Simulation
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    • v.10 no.2
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    • pp.1-14
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    • 2001
  • The layout design of component plays an important role in the design and usability of many engineering products. The Engineering artifacts of today are becoming increasingly complicated. The simulated annealing method has been applied effectively to the layout and packing problems of wafer. The main characteristics of simulated annealing method is that an optimum can be obtained from the many local optimums by controlling the temperature and introducing the statistic flickering. The objective of this study is to suggest a method to apply the simulated annealing method to the three dimensional layout design of submergible boat which has multiple constraint conditions and evaluation criteria. We describe an approach to define cost function, constraints and generate layouts using a computer. In this research three dimensional LAYout Design Optimization Program(LAYDOP ver.2) has been developed. The layout result(the total value of evaluation criteria) designed by a human layout expert has been improved by 31.0% using this program.

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Flow analysis of non-isothermal three dimensional filling phase in injection molding and its application (사출성형에서의 비등온, 3차원 유동해서과 그 응용)

  • 김대업;정근섭;이귀영
    • Journal of the korean Society of Automotive Engineers
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    • v.15 no.1
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    • pp.17-24
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    • 1993
  • 사출성형 문제는 열전달과 유체유동이 복합된 문제라고 할수 있다. 사출성형 공정은 충진(filling), 보압(packing) 및 냉각과정(cooling phase)으로 이루어 진다. 충진과정은 높은 점성의 Non-Newtonian유체가 몰드내의 캐버티로 사출됨으로써 이루어지며 플라스틱의 점성도는 플라스틱의 온도 및 유동속도와 관련이 크며 이 flow-rate는 점도와 더불어 변화한다. CAE 유동해석 프로그램은 유체의 흐름과 열전달을 이용하여 충진과정을 이해하는데 이용되고 있다. 본 고에서는 사출성형 과정 중 충진과정에 대한 컴퓨터 시뮬레이션과 그 적용사례에 대하여 살펴본다.

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A GA-based Heuristic for the Interrelated Container Selection Loading Problems

  • Techanitisawad, Anulark;Tangwiwatwong, Paisitt
    • Industrial Engineering and Management Systems
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    • v.3 no.1
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    • pp.22-37
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    • 2004
  • An integrated heuristic approach based on genetic algorithms (GAs) is proposed for solving the container selection and loading problems. The GA for container selection solves a two-dimensional knapsack problem, determining a set of containers to minimize the transportation or shipment cost. The GA for container loading solves for the weighted coefficients in the evaluation functions that are applied in selecting loading positions and boxes to be loaded, so that the volume utilization is maximized. Several loading constraints such as box orientation, stack priority, stack stability, and container stability are also incorporated into the algorithm. In general, our computational results based on randomly generated data and problems from the literature suggest that the proposed heuristic provides a good solution in a reasonable amount of computational time.

Development of a Micro-Computer based Program for the Three Dimensional Packing Problem (3차원 물품 적재에 관한 마이크로 컴퓨터용 프로그램 개발)

  • Hwang, Hark;Lee, Kwan-Jae;Sun, Ji-Ung
    • Journal of Korean Institute of Industrial Engineers
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    • v.23 no.1
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    • pp.55-76
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    • 1997
  • This paper presents a heuristic solution for the three dimensional container loading problem with boxes which are different in size. The container loading problem is formulated as a zero-one mixed integer programming model whose objective is to maximize the container utilization. Due to its problem complexity, we propose a heuristic based on layered loading technique. Also, presented is a way to achieve the weighting balance of the stacked boxes. A micro-computer based program is developed which generates container loading pattern provided by the proposed heuristic. The results are displayed by computer-graphic. To evaluate the performance of the proposed heuristic, computational experiments are performed. The results indicate that in most of the cases the proposed heuristic performs better than an existing heuristic in terms of the container utilization.

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Treatment of ETA wastewater using GAC as particle electrodes in three-dimensional electrode reactor (활성탄 충진 3D 복극전기분해조를 이용한 ETA 처리)

  • Kim, Ran;Kim, Yu-Jin;Shin, Ja-Won;Kim, Jeong-Joo;Park, Joo-Yang
    • Journal of Korean Society of Water and Wastewater
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    • v.27 no.2
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    • pp.241-249
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    • 2013
  • Ethanolamine (ETA) is widely used for alkalinization of water in steam cycles of nuclear power plants with pressurized water reactor. When ETA contained wastewater was released, it could increase COD and T-N. The treatment of the COD and T-N from ETA wastewater was investigated using the GAC as particle electrodes in three-dimensional electrode reactor (TDE). This study evaluated the effectiveness of GAC as particle electrode using different packing ratio at 300 V. The results showed that GAC-TDE could reduce ETA much more efficiently than ZVI-TDE at the mass ratio of GAC to insulator, 1:2. Additionally, The effect of applied electric potential to COD and T-N reduction was investigated. The results showed the high COD, T-N reduction and current efficiency at the low electric potential. Using the GAC-TDE will provide a better ETA reduction with reducing electrical potential dissipation.

Optimization of Multiple Quality Characteristics for Polyether Ether Ketone Injection Molding Process

  • Kuo Chung-Feng Jeffrey;Su Te-Li
    • Fibers and Polymers
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    • v.7 no.4
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    • pp.404-413
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    • 2006
  • This study examines multiple quality optimization of the injection molding for Polyether Ether Ketone (PEEK). It also looks into the dimensional deviation and strength of screws that are reduced and improved for the molding quality, respectively. This study applies the Taguchi method to cut down on the number of experiments and combines grey relational analysis to determine the optimal processing parameters for multiple quality characteristics. The quality characteristics of this experiment are the screws' outer diameter, tensile strength and twisting strength. First, one should determine the processing parameters that may affect the injection molding with the $L_{18}(2^1{\times}3^7)$ orthogonal, including mold temperature, pre-plasticity amount, injection pressure, injection speed, screw speed, packing pressure, packing time and cooling time. Then, the grey relational analysis, whose response table and response graph indicate the optimum processing parameters for multiple quality characteristics, is applied to resolve this drawback. The Taguchi method only takes a single quality characteristic into consideration. Finally, a processing parameter prediction system is established by using the back-propagation neural network. The percentage errors all fall within 2%, between the predicted values and the target values. This reveals that the prediction system established in this study produces excellent results.

Design of ceramics powder compaction process parameters (Part Ⅰ : Finite element analysis) (세라믹스 분말 가압 성형 공정 변수 설계(1부: 유한요소 해석))

  • Jung S. C.;Keum Y. T.
    • Journal of the Korean Crystal Growth and Crystal Technology
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    • v.15 no.1
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    • pp.21-26
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    • 2005
  • In order to simulate the powder compaction process and to assess the effects of packing randomness and particle arrangement 2-dimensional model of rod array compaction using quasi-random multiparticle array is introduced. The elastic modulus of porous ceramics is computed by the homogenization method. With 3 Al₂O₃ and 3 Al particles the compaction processes associated with the porosities are simulated by the explicit finite element method, based on the elastic modulus found by the homogenization method. The simulation results are compared with both previous analytical ones and experimental measurements. Finally, in order to find the relationship between the friction coefficient of powder particles and the relative density, the sensitivity analysis is performed.

Characterization of Structural Variations in the Context of 3D Chromatin Structure

  • Kim, Kyukwang;Eom, Junghyun;Jung, Inkyung
    • Molecules and Cells
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    • v.42 no.7
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    • pp.512-522
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    • 2019
  • Chromosomes located in the nucleus form discrete units of genetic material composed of DNA and protein complexes. The genetic information is encoded in linear DNA sequences, but its interpretation requires an understanding of three-dimensional (3D) structure of the chromosome, in which distant DNA sequences can be juxtaposed by highly condensed chromatin packing in the space of nucleus to precisely control gene expression. Recent technological innovations in exploring higher-order chromatin structure have uncovered organizational principles of the 3D genome and its various biological implications. Very recently, it has been reported that large-scale genomic variations may disrupt higher-order chromatin organization and as a consequence, greatly contribute to disease-specific gene regulation for a range of human diseases. Here, we review recent developments in studying the effect of structural variation in gene regulation, and the detection and the interpretation of structural variations in the context of 3D chromatin structure.

Crystal Structure of cis-(Malonato)[(4R,5R)-4,5-bis(Aminomethyl)-2-Isopropyl-1,3-Dioxolane]Platinum(II), A Potent Anticancer Agent

  • Cho, Sang-Woo;Yongkee Cho;Kim, Dai-Kee;Wanchul Shin
    • Korean Journal of Crystallography
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    • v.11 no.1
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    • pp.22-27
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    • 2000
  • The structure of cis-(malonato)[(4R,5R)-4,5-bis(aminomethyl)-2-isopropyl-1,3-dioxolane]platinum(II) with a potent anticancer activity has been determined by the X-ray crystallographic method. Crystal data are as follows: Pt(C/sub 11/H/sub 20/N₂O/sub 6/), M/sub 4/=471.38, monoclinic, P2₁, a=7.112(1), b=33.615(3), c=7.135(1)Å, β=116.80(1)°, V=1522.6(3)Å, and Z=4. The two independent molecules with very similar structures are approximately related by pseudo two-fold screw axis symmetry, which makes the monolinic cell look like the orthorhombic cell with one molecule in the asymmetric unit and space group C222₁. The crystal packing mode is similar to that of the analogue with the dimethyl substituents instead of the isopropyl group. The Pt atom is coordinate to two O and two N atoms in a square planar structure. The six-membered chelate ring in the leaving ligand assumes a conformation intermediate between the half chair and the boat forms. The seven-membered ring in the carrier ligand assumes a twist-chair conformation and the oxolane ring assumes an envelope conformation. Crystal packing consists of the extensive hydrogen-bonding network in the two-dimensional molecular layers and weak van der Waals interactions between these layers.

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