• Bulletin of the Korean Chemical Society
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• v.30 no.12
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• pp.2883-2886
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• 2009

A simple, highly efficient and environmentally benign method for the synthesis of 3-styrylchromones from 3-formylchromones and 4-nitrophenylacetic acid/4-nitrotolune in the presence of catalytic amount of basic ionic liquid 1-butyl-3-methylimidazolium hydroxide [(bmim)OH] carried out under the influence of microwave irradiation. This method gives remarkable advantages such as, short reaction times, simple work-up procedure and moderate to good yields. The ionic liquid was successfully reused for four cycles without significant loss of activity.

• YAKHAK HOEJI
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• v.47 no.6
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• pp.376-381
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• 2003

2-Arylchromones, also known as flavones, are among the most ubiquitous classes of natural products occurring in the plant kingdom. On the other hand, 2-styrylchromones are relatively scarce in nature and only a few compounds has been isolated from the blue-green algae species. Therefore, new 2-arylethenylchromone derivatives ( 4a∼n, 5a∼f) were synthesized by the aldol condensation of 2-methylchromone ( 3) with several aromatic aldehydes in order to evaluate their cytotoxicities using a MTT assay on three tumor cells. 2-Arylethenylchromone derivative 4a showed the significant cytotoxic activities on KB, HL-60 and P-388 cell lines with $IC_{50}$/ values of 25.2, 63.59 and 49.51 $\mu$M, respectively, indicating that 2-arylethenylchromone skeleton has a potential anti-tumor application.