• 한국수정란이식학회지
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• 제29권3호
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• pp.207-219
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• 2014

Three-dimensional (3D) culture system is useful technique for study of in vivo environment and it was used various experiments. This study was investigated to establish of embryo co-culture system and changes of PAs activity in 3D cultured endometrial cells of pigs. In results, growth of stromal cells into gel matrix were detected only with endometrial and myometrial cells. The most rapid growth of stromal cells were confirmed in $2.5{\times}10^5cells/ml$ and gel matrix containing 15% FBS. Expression of urokinase-PA (uPA) after treatment of hCG (0.5, 1.0, 1.5 and 2.0 IU/ml) were higher than without hCG, but, there are not significant difference among the treatment. On the other hand, expression of uPA after treatment of $IL-1{\beta}$ (0.1, 1, 10 and 100 ng/ml) were higher than without $IL-1{\beta}$, but, there are not significant difference. Expression of uPA after treatment of estrogen (0.2, 2, 20 and 200 ng/ml) were not difference, but PA activity was significantly decreased (p<0.05). Blastocyst was producing in PZM-3 medium containing FBS and endometrial cells were grown in PZM-3 medium. When embryos development with cultured endometrial cells, cleavage rates were not significant difference and blastocyst were not produced in co-culture with stromal cells and 3D culture system. 3D culture system had similar activity to in vivo tissue and these features are very useful for study of in vivo physiology. Nevertheless 3D culture system was not proper in embryo co-culture system. Therefore, we suggest that 3D culture system with embryo co-culture need continuous research.

• 대한물리의학회지
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• 제16권3호
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• pp.21-27
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• 2021

PURPOSE: This study examined the relationship between the severity of a hallux valgus (HV) deformity and the kinetic three-dimensional ground reaction force (GRF) through a motion analysis system with force platforms in individuals with a HV deformity during normal speed walking. METHODS: The participants were 36 adults with a HV deformity. The participants were asked to walk on a 6 m walkway with 40 infrared reflective markers attached to their pelvic and lower extremities. A camera capture system and two force platforms were used to collect kinetic data during gait. A Vicon Nexus and Visual3D motion analysis software were used to calculate the kinetic GRF data. RESULTS: This research showed that the anterior maximal force that occurred in the terminal stance phase during gait had a negative correlation with the HV angle (r = -.762, p < .01). In addition, the HV angle showed a low negative correlation with the second vertical maximal force (r = .346, p < .05) and a moderate positive correlation with the late medial maximal force (r = .641, p < .01). CONCLUSION: A more severe HV deformity results in greater abnormal translation of the plantar pressure and a significantly reduced pressure force under the first metatarsophalangeal joint.

• Korean Journal of Radiology
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• 제23권2호
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• pp.256-263
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• 2022

Objective: This study aimed to evaluate the image quality and dose reduction of low-dose three-dimensional (3D) rotational angiography (RA) for evaluating intracranial aneurysms. Materials and Methods: We retrospectively evaluated the clinical data and 3D RA datasets obtained from 146 prospectively registered patients (male:female, 46:100; median age, 58 years; range, 19-81 years). The subjective image quality of 79 examinations obtained from a conventional method and 67 examinations obtained from a low-dose (5-seconds and 0.10-μGy/frame) method was assessed by two neurointerventionists using a 3-point scale for four evaluation criteria. The total image quality score was then obtained as the average of the four scores. The image quality scores were compared between the two methods using a noninferiority statistical testing, with a margin of -0.2 (i.e., score of low-dose group - score of conventional group). For the evaluation of dose reduction, dose-area product (DAP) and air kerma (AK) were analyzed and compared between the two groups. Results: The mean total image quality score ± standard deviation of the 3D RA was 2.97 ± 0.17 by reader 1 and 2.95 ± 0.20 by reader 2 for conventional group and 2.92 ± 0.30 and 2.95 ± 0.22, respectively, for low-dose group. The image quality of the 3D RA in the low-dose group was not inferior to that of the conventional group according to the total image quality score as well as individual scores for the four criteria in both readers. The mean DAP and AK per rotation were 5.87 Gy-cm² and 0.56 Gy, respectively, in the conventional group, and 1.32 Gy-cm² (p < 0.001) and 0.17 Gy (p < 0.001), respectively, in the low-dose group. Conclusion: Low-dose 3D RA was not inferior in image quality and reduced the radiation dose by 70%-77% compared to the conventional 3D RA in evaluating intracranial aneurysms.

• 한국지반공학회:학술대회논문집
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• 한국지반공학회 1996년도 가을 학술발표회 논문집
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• pp.97-106
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• 1996

• 대한수학회보
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• 제58권3호
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• pp.729-744
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• 2021

In this paper we prove global existence and uniqueness of axisymmetric strong solutions for the three dimensional electro-hydrodynamic model based on the coupled Navier-Stokes-Poisson-Nernst-Planck system in the exterior of a cylinder. The key ingredient is that we use the axisymmetry of functions to derive the L^p interpolation inequalities, which allows us to establish all kinds of a priori estimates for the velocity field and charged particles via several cancellation laws.

• 대한토목학회논문집
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• 제4권3호
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• pp.75-83
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• 1984

사면(斜面)의 3차원(次元) 파괴(破壞)의 신뢰성(信賴性) 해석(解析)에 안전율(安全率) 대신 파괴확률(破壞確率)이 사용(使用)되었다. 강도정수(强度定數)는 정규분포(正規分布)와 베타분포(分布)로 가정하였고 특정(特定)한 신뢰도(信賴度)와 최우추정법(最尤推定法)에 의하여 구간추정(區間推定) 하였다. 정규분포(正規分布)와 베타분포(分布)의 무작위변수(無作爲變數)는 중심극한정리(中心極限定理)와 Rejection방법(方法)에 따라 일양분포변환방법(一樣分布變換方法)을 사용(使用)하여 발생(發生)시켰고 몬테칼로방법(Monte-Carlo Method)에 의한 파괴확률(破壞確率)은 다음과 같이 정의(定義)된다. $P_f=M/N$ N: 시행회수(施行回數) M: 파괴회수(破壞回數) 본(本) 연구(硏究) 결과(結果)는 다음과 같다. 1. $F_3$는 $F_2$보다 일반적으로 더 컸으나 작은 경우도 나타났다. 2. $F_3/F_2$의 비(比)는 c, ${\phi}$와 3차원(次元) 파괴(破壞)형상 그리고 경사에 따라 민감하나 흙의 단위중량에는 그렇지 않았다. 3. 어떤 완전율(安全率)에 대한 파괴확률(破壞確率)은 배타분포(分布)가 정규분포(定規分布)보다 대체로 크게 나타났다. 4. 어떤 특정(特定)한 사면파괴(斜面破壞)형상과 토질조건(土質條件)에 대하여 허용안전율(許容安全率) $FS_a=1.25$에 해한 $P_f$는 0.23 (정규분포(正規分布)), 0.29(베타분포(分布))로 나타났다.

• The Journal of Advanced Prosthodontics
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• 제14권5호
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• pp.305-314
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• 2022

PURPOSE. The aim of this study was to evaluate the flexural strength of a 3D-printed denture base resin (Cosmos Denture), after different immediate repair techniques with surface treatments and thermocycling. MATERIALS AND METHODS. Rectangular 3D-printed denture base resin (Cosmos Denture) specimens (N = 130) were thermocycled (5,000 cycles, 5℃ and 55℃) before and after the different repair techniques (n = 10 per group) using an autopolymerized acrylic resin (Jet, J) or a hard relining resin (Soft Confort, SC), and different surface treatments: Jet resin monomer for 180 s (MMA), blasting with aluminum oxide (JAT) or erbium: yttrium-aluminum-garnet laser (L). The control group were intact specimens. A three-point flexural strength test was performed, and data (MPa) were analyzed by ANOVA and Games-Howell post hoc test (α = 0.05). Each failure was observed and classified through stereomicroscope images and the surface treatments were viewed by scanning electron microscope (SEM). RESULTS. Control group showed the highest mean of flexural strength, statistically different from the other groups (P < .001), followed by MMA+J group. The groups with L treatment were statistically similar to the MMA groups (P > .05). The JAT+J group was better than the SC and JAT+SC groups (P < .05), but similar to the other groups (P > .05). Adhesive failures were most observed in JAT groups, especially when repaired with SC. The SEM images showed surface changes for all treatments, except JAT alone. CONCLUSION. Denture bases fabricated with 3D-printed resin should be preferably repaired with MMA+J. SC and JAT+SC showed the worst results. Blasting impaired the adhesion of the SC resin.

• 통합자연과학논문집
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• 제6권4호
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• pp.205-210
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• 2013

Human P-gp is a protein responsible for the multidrug resistance (MDR) and causes failure of cancer chemotherapy. Till date no X-ray crystal structure is reported for this membrane protein, which hampers active research in the field. We performed homology modeling to develop three dimensional (3D) model of P-gp, and docking studies of the verapamil and curcumin have been performed to gain insight into the interaction mechanism between inhibitors and P-gp. It was identified that the inhibitors docked into the upper part of P-gp and interacted through the hydrophobic interactions.

• Applied Biological Chemistry
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• 제51권2호
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• pp.119-123
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• 2008

3-치환된 5,5'-diphenylimidazolidine-2,4-dione 유도체(1-22)들의 fatty acid amide hydrolase (FAAH) 저해활성에 관한 3차원적인 정량적 구조와 활성과의 관계(3D-QSARs)를 비교 분자장 분석(CoMFA)과 비교분자 유사성 지수분석(CoMFA) 방법으로 각각 검토하였다. CoMFA A1 모델과 CoMSIA 2F 모델 모두 상관성과 예측성이 양호하였다. 두 모델의 정보에 의한 등고도에 따라 설계된 X=I, Y=$N_2{^+}$-치환체(P1: $Pred.pI_{50}$=6.55)는 FAAH에 대하여 가장 높은 저해활성을 나타내었다.

• 한국전자파학회논문지
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• 제29권6호
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• pp.401-406
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• 2018

본 논문에서는 E-대역에서 본드와이어의 기생성분을 예측하고, 그에 따른 전송손실을 줄이기 위한 정합회로를 설계하였다. 본드와이어의 임피던스는 3D EM 시뮬레이션을 통해 예측하였고, 정합회로는 간단한 구조로 구성하여 공간 활용 및 시스템 적용에 용이하도록 하였다. 설계된 정합회로는 WR-12 규격의 도파관 기구와 71~86 GHz의 사용주파수를 갖는 상용 LNA 소자에 적용하였다. 정합회로는 시스템의 전달계수를 최대 4.5 dB, 전력 이득은 최대 3.12 dB, $P_{1dB}$를 최대 2.2 dB 증가시켰으며 이득 평탄도를 ${\pm}1.07dB$ 개선시켰다.