• Journal of Korean Biological Nursing Science
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• 제18권2호
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• pp.94-101
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• 2016

Purpose: This study aimed to evaluate weight changes in women during the period of TAC (docetaxel-doxorubicin-cyclophosphamide) chemotherapy after breast surgery and the differences in weight changes by disease characteristics among Korean women with breast cancer. Methods: The design of this study was retrospective survey research. The subjects of this study were 130 patients with fully completed TAC chemotherapy between January 2012 and April 2015. Body weight before their operation, and at 3 weeks, 6 weeks, 9 weeks, 12 weeks, 15 weeks, and 18 weeks after surgery, as well as general and disease characteristics, were reviewed via their medical charts. Results: The mean age of the patients was 51.2 years. The preoperative (baseline) mean weight was $59.4{\pm}8.44$. Significant weight losses were observed in the initial (1st 3 week) period of TAC chemotherapy compared to the baseline and significant weight losses were observed with the exception of the period 6 weeks after breast surgery. There were significant differences in mean weight changes according to the stage of breast cancer, radiotherapy, and hormone therapy among disease characteristics. Conclusion: It is necessary to study weight changes after breast surgery for the long periods of TAC chemotherapy. Through the accumulated results of studies, nursing programs for breast cancer patients must be developed for the prevention of weight gain in the periods of TAC chemotherapy.

• 대한한방소아과학회지
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• 제23권3호
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• pp.177-191
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• 2009

Objectives To evaluate the effect of InsamGobonHwan (IGH) on growth of rats. Methods We divided male Sprague-Dawley rats into 4 groups(IGHE1, IGHE2, IGHE3 and sham group). IGHE1, IGHE2, IGHE3 groups were administered with IGHE water extracts once a day at the dose of 1,000, 500 and 250mg/kg/$10m{ell}$ for 1 week, 2 weeks, and 3 weeks. Sham group was administered with normal saline with using the same method. We measured body weight, amount of body weight increasing, length of femur, serum Growth Hormone(GH), serum Insulin-like Growth Factor-I(IGF-I), serum Thyroid-stimulating Hormone(TSH) and serum testosterone at 1 week, 2 weeks, and 3 weeks of experiment. Results The body weight and the changes of body weight increased significantly in IGHE1 group compared to sham group after 2 and 3 weeks, and in IGHE2 group after 2 weeks. The lengths of the femur increased significantly in IGHE1 group as compared with sham group after 1, 2 and 3 weeks, and in IGHE3 group after 1 week. The level of IGF-I in the serum increased significantly in S1 group as compared tosham group after 1 and 3 weeks, and in IGHE13 group after 3 weeks. The level of TSH in the serum increased significantly in IGHE1group as compared to sham group after 2 and 3 weeks. The level of GH and testosterone in the serum does not change significantly. Conclusions SGT have an effect of promoting growth of rats and might be effect to treat various kinds of growth delay in children.

• The Journal of Korean Physical Therapy
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• 제14권1호
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• pp.99-108
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• 2002

The purpose of this study was to research the clinical of cerebral palsy taking physical therapy at the department of physical therapy of various clinics at Kyungnam${\cdot}$Pusan. Among the subjects that was born from January, 1985 to June, 2000, 226 parents was answered to questionary of this study. The results of the study were as follows: 1) During the embryonic period, the cerebral palsied children above 37weeks were 114 subjects(50.9%) and there was 51 subjects(22.8%) between 28weeks to 31weeks and 32weeks to 36weeks. The children below 28weeks were 8 subjects(3.6%) and showed the lowest rate. As compared to the delievery methods, the normal delievery, cesserian section delievery, and forceps delievery was 124 subjects(55.1%), 81(36.0%), 16(7.1%), nad 4(1.8%). Among them the mormal delievery indicated the highest percentage. 2) Compared to the weight during birth time, the above 2500g of 121 subjects(55.3%) showed the highest rate and the 28 subjects(12.8%) had the birth weight of 1000to 1499g. There was 4 subjects(1.8%) below the 1000g. 3) Compared to the birth weight of the pregnancy period, the weight of the cerebral palsied children below 28weeks were 1000g to 1499g and showed the highest rate of 4 subjects(50%). The children between 28weeks to 31weeks and 32weeks to 36weeks were 1500 to 2499g, each 23(47.9%), and 28(54.9%) subject. The weight of the children of the above 37weeks were above 2500g and 94 subjects(87.4%). Therefore, if the period of pregnancy is short, the weight birth would indicate the lower weight than the weight of the other times(p<0.05). 4) The spastic type of the pregnant period had the highest rate and the period was the below 28weeks to 31weeks. The cerebral palsied children of athetoid and mixed type were 6 subjects(13.3%) and 5 subjects(31.9%) between 28 and 31weeks. The mixed type of them was each 15 (31.9%) and 33 (30.6%) subjects between 32 to 36 weeks and the above 37weeks. The mixed type showed a slightly high rate (p<0.05). 5) The spastic type indicated the highest rate in the weight of birth time and especially showed the high rate in the case of 1000 to 1499g. The mixed type indicated a slightly high rate of 17 subjects (25.8%) and 32 subjects (29.1%) in case of 1500 to 2499g and the above 2500g (p<0.05).

• 동아시아식생활학회지
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• 제11권4호
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• pp.268-273
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• 2001

This study was performed to investigate the effects of HBM(Healthy Body Maker) on the weight loss and serum cholesterol level of rats. Twenty male Sprague-Dawley rats weighing 200$\pm$5g were grouped into 2. Rats were raised for 6 weeks with diet containing 0% and 5% of HBM. 1. There were no clinical signs for all the experimental period(6 weeks) in 0% and 5% groups. 2. At 3 and 6 weeks. body weight of 5% HBM group was significantly lower than that of control group. respectively(p<0.05, p<0.01). 3. At 4 weeks. the level of MCHC of 5% HBM group was significantly higher than that of control group(p<0.01) And at 6 weeks the level of RBC and Hct of 5% HBM group were significantly higher than those of control group(p<0.05) 4. At 6 weeks. the level of serum cholesterol of 5% HBM group was significantly lower than that of control group. 5. Absolute liver weight of 5% HBM group was significantly lower than that of control group(p<0.05). 6. Minor subaceous sickness of liver cell in the control group appeared but no symptom of liver cell in 5% HBM group. It is concluded that HBM was a safe and effective diet food which aided in inducing weight loss in rat without any observed harmful clinical side effects.

• Fisheries and Aquatic Sciences
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• 제8권3호
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• pp.128-131
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• 2005

The effects of alternate-week feeding strategies on growth and feed efficiency ratio of juvenile Nile tilapia were investigated in a recirculating aquaculture system. Twenty fish initially weighing 25.5 g were randomly distributed into each of 18 tanks to conduct three replicates for each of six different feeding strategies. Weight gain of fish in the control that were fed daily for 6-week feeding trial was significantly higher than those of fish subjected to various alternate-week feeding regimes. Weight gain of fish that were starved for 3 weeks and then fed daily for 3 weeks (3WS+3WF) was not significantly different from that of fish, starved and fed daily for alternate 1-week period during the trial (1WS+1WF), but was significantly higher than those of fish starved for 2 weeks, and fed for 2 weeks (2WS+2WF); fish starved for 4 weeks and fed for 2 weeks (4WS+2WF); and fish fed for 5 weeks and fed for 1 week (5WS+1WF.) The amount of feed supplied to fish in the groups of 1WS+1WF and 3WS+3WF was significantly lower than that fed to fish in the control group, but significantly higher than the amount feed supplied to fish in the other three groups. Feed efficiency ratio for fish in the control group did not differ from that for fish in the groups of 1WS+1WF, 2WS+2WF and 3WS+3WF, but was significantly higher than that for fish in the groups of 4WS+2WF and 5WS+1WF. In conclusion, juvenile Nile tilapia that were subject to starvation for 1 to 5 weeks did not exhibit compensatory growth sufficient to attain the same weight as fish fed daily for 6 weeks. In addition, fish subjected to starvation exhibited low feed efficiency ratio compared to fish fed daily, which were probably attributable to poor weight gain.

• Asian-Australasian Journal of Animal Sciences
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• 제23권3호
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• pp.302-307
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• 2010

The present study aimed to investigate the effects of maternal factors on body weight at hatching (day-old) and at six weeks of age in a commercial broiler line. A total of 6,765 records on body weight at day-old (BWTDO) and 115,421 records on body weight at six weeks of age (BWT6W), originated from a commercial broiler line during 14 generations, were used to estimate genetic parameters related to the effects of maternal traits on body weight of chicks immediately after hatch or six weeks thereafter. The data were analyzed using restricted maximum likelihood procedure (REML) and an animal model with DFREML software. Direct heritability ($h^{2}{_a}$), maternal heritability ($h^{2}{_m}$), and maternal environmental variance as the proportions of phenotypic variance ($c^{2}$) for body weight at day-old were estimated to be 0.050, 0.351, and 0.173, respectively. The respective estimated values for body weight at six weeks of age were 0.340, 0.022, and 0.030. The correlation coefficient between direct and maternal genetic effects for six-week-old body weight was found to be -0.335. Covariance components and genetic correlations were estimated using a bivariate analysis based on the best model determined by a univariate analysis. Between weights at hatching and at six week-old, the values of -0.07, 0.53 and 0.47 were found for the direct additive genetic variance, maternal additive genetic variance and permanent maternal environmental variance, respectively. The estimated correlation between direct additive genetic effect influencing weight at hatch and direct additive maternal effect affecting weight at six weeks of age was -0.21, whereas the correlation value of 0.15 was estimated between direct additive maternal effect influencing weight at hatch and direct additive genetic effect affecting weight at six-week-old. From the present findings, it can be concluded that the maternal additive genetic effect observed for weight at six weeks of age might be a factor transferred from genes influencing weight at hatch to weight at six-week-old.

• 한국건강관리협회지
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• 제3권1호
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• pp.24-34
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• 2005

Background: A reasonable weight reduction is to reduce fat-body mass while preserving free-fat mass. Recently, many people in Korea have been trying reckless diet therapy for weight reduction by low calory and protein diets, which gave rise to many side effects consequently. For reasonable weight reduction, this study was undertaken to investigate the influential diet factors that change body composition during short-term low calory diet. Methods: 26 healthy obese women aged 23-27 years whose BMI was greater than 24volunteered for the 6 week diet therapy from January to April in 2003. All subjects were instructed to eat approximately 1200kca1/day and write dietary diary. In the beginning of the study, the 3rd week and the 6th week, subjects' body weight and fat body weight were measured by BlA. In the 6th week, the analysis of dietary diary was conducted. Results : There was significant positive correlation between protein intake per ideal bodyweight in the first 3 weeks and free fat mass increase in the later 3 weeks (P<0.05). At the same time, fat intake in the first 3 weeks had positive correlation with free fat mass in the second 3 weeks, too(P<0.05). But, we could not find any significant values that had effect on free fat mass increase in multiple regression analysis. Conclusion: The protein intake in the first 3 weeks helps preserve fat free mass in the later 3 weeks, and has positive effects.

• Asian-Australasian Journal of Animal Sciences
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• 제29권1호
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• pp.43-50
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• 2016

Quantitative trait locus (QTL) is a particular region of the genome containing one or more genes associated with economically important quantitative traits. This study was conducted to identify QTL regions for body weight and growth traits in purebred Korean native chicken (KNC). F1 samples (n = 595) were genotyped using 127 microsatellite markers and 8 single nucleotide polymorphisms that covered 2,616.1 centi Morgan (cM) of map length for 26 autosomal linkage groups. Body weight traits were measured every 2 weeks from hatch to 20 weeks of age. Weight of half carcass was also collected together with growth rate. A multipoint variance component linkage approach was used to identify QTLs for the body weight traits. Two significant QTLs for growth were identified on chicken chromosome 3 (GGA3) for growth 16 to18 weeks (logarithm of the odds [LOD] = 3.24, Nominal p value = 0.0001) and GGA4 for growth 6 to 8 weeks (LOD = 2.88, Nominal p value = 0.0003). Additionally, one significant QTL and three suggestive QTLs were detected for body weight traits in KNC; significant QTL for body weight at 4 weeks (LOD = 2.52, nominal p value = 0.0007) and suggestive QTL for 8 weeks (LOD = 1.96, Nominal p value = 0.0027) were detected on GGA4; QTLs were also detected for two different body weight traits: body weight at 16 weeks on GGA3 and body weight at 18 weeks on GGA19. Additionally, two suggestive QTLs for carcass weight were detected at 0 and 70 cM on GGA19. In conclusion, the current study identified several significant and suggestive QTLs that affect growth related traits in a unique resource pedigree in purebred KNC. This information will contribute to improving the body weight traits in native chicken breeds, especially for the Asian native chicken breeds.

• 한국산업보건학회지
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• 제24권3호
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• pp.321-329
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• 2014

Objectives: This study was performed to produce data on the pulmonary toxicity of neodymium oxide($Nd_2O_3$) by intratracheal instillation. Methods: Two groups of rats were exposed to neodymium oxide by intratracheal instillation with doses of 0.5 mg and 2.0 mg, respectively. At two days, four weeks and 12 weeks after exposure, body weight change, organ weight change and histopathological change were observed. At 12 weeks after exposure, lung function change was measured. Results: The body weight of rats in the high concentration group decreased after 12 weeks by 4-5% compared with the control group. At four weeks and 12 weeks after the administration of neodymium oxide, the absolute weight of the lungs of the high concentration group were significantly increased when compared with the control group(p<0.05). At 12 weeks after the injection of neodymium oxide, breath frequency and respiratory minute volume were increased, but inhalation time and expiratory time were decreased. Bronchiolar epithelial hyperplasia, alveolar type II cell hypertrophy/hyperplasia and foreign body granulomatous inflammation were observed in the high exposure group. Conclusions: Body weight decrease, lung absolute weight and breath frequency increase, and pathological lung change were all observed. We found that pulmonary toxicity of neodymium oxide nanoparticles by intratracheal instillation could be confirmed.

• 대한한방부인과학회지
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• 제19권1호
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• pp.47-68
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• 2006

Purpose : This study was carried out to investigate the effects of Gagamdokhwalgisang-Tang on the morphometric changes of femur, and on the hormones and cytokines associated with bone metabolism in overiectomized rats. Methods : Twenty-four female Sprague-Dawley rats were divided into sham operated group(normal) ovariectomized group(control), and treated with extract of GD group(treated). Each group was evaluated the changes of body weight at 0, 3, 6, 8 weeks after ovariectomy. Morphometric analysis(femur weight, femur/body weight ratio, femur ash weight femur ash/body weight ratio cross sectional area of compact bone and concellous bone of femur) and histopathological examination were performed at 8 weeks after ovariectomy. Estrogen, Alkaline Phosphatase(ALP) and cytokine(Tumor necrosis $factor-{\alpha}$, $Interleukin-l{\beta}$, Inerleukin-6) assay were performed at 8 weeks after ovariectomy. Results : 1. The body weight of control and treated group was significantly increased(p<<0.001) compared with the normal group at 8 weeks. 2. The femur weight and femur/body weight ratio of treated group were significantly increased(p<<0.05, p<<0.01) compared with the control group at 8 weeks. 3. The femur ash weight showed no significantly different changes, but femur ash/body weight ratio of treated group was significantly increased(p<<0.05) compared with the control group at 8 weeks. 4. In the cross sectional area of cancellous bone of femoral body, the treated group was significantly increased(p<<0.001) compared with the control group at 8 weeks. 5. The serum estrogen level of treated group showed no significantly different changes compared with the control group at 8 weeks. 6. The serum ALP activity of treated group was significantly decreased(p<<0.01) compared with the control group at 8 weeks. 7. The serum Tumor necrosis $factor-{\alpha}(TNF-{\alpha})$ level of treated group was significantly decreased(p<<0.05) compared with the control group at 8 weeks. 8. The serum $Interleukin-l{\beta}(IL-1{\beta})$ level of treated group was significantly decreased(n<<0.001) compared with the control group at 8 weeks. 9. The serum Interleukin-6(IL-6) level of treated group was significantly decreased(P<<0.01)compared with the control group at 8 weeks. Conclusion : These results indicate that GD inhibits bone resorption in ovariectomized rats. And the major inhibitory mechanism may be related to the inhibitory effects of GD on the secretion of $TNF-{\alpha}$, $IL-1{\beta}$ and IL-6 in the pathogenesis of osteoporosis in estrogen deficient rats.