• 대한조선학회논문집
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• 제35권1호
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• pp.98-106
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• 1998

멤브레인형 가스운반선의 경우 화물창들 사이에 cofferdam을 두어 격리시키고 있는데 이 경우 극 저온 액체 화물의 영향으로 cofferdam 실내 온도는 약 $-40^{\circ}C$내외로 떨어지게 된다. 그 결과 cofferdam 및 화물창을 구성하는 bulkhead는 구조 부재로서의 허용 강도를 만족하는 온도를 유지할 수 없게 된다. 결국 heating system을 사용하여 cofferdam 실내 온도를 최소한 $5^{\circ}C$까지 올려야 하는데, 소요 pipe의 길이 산정을 위한 heat flux 산출과 pipe의 배치가 우선적으로 요청된다. 본 연구에서는 다양한 설계 조건에서의 cofferdam 내 heat flux를 각 compartment들 간의 연성 효과를 고려하여 구하고 이를 기존 계산서들과 비교 검토하여 그 타당성을 검증하였고 이를 토대로 heating system에 필요한 pipe의 길이를 산정하였다. 아울러 현재의 heating system의 대안으로 fin을 부착한 pipe로 구성된 heating coil system을 제시하고 그 효율을 비교하였다.

• 한국시뮬레이션학회논문지
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• 제26권3호
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• pp.1-11
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• 2017

격실 내부에서의 폭발로 인한 인원의 피해를 분석하였다. 특히 격실 내에서 폭압 전파에 영향을 미치는 돌출된 장애물의 유무에 따른 인원 피해를 비교하였다. 격실 내에 장애물이 없는 경우에 경험적 고속처리모델을 이용하여 폭압을 예측할 수 있다. 하지만 격실 내부에서는 폭압 프로파일이 개활지에서와 달리 복잡하며 의자와 같은 구조물이 존재하는 경우에는 경험적 고속처리모델 적용이 불가하다. 따라서 장애물이 있는 격실 내부 폭압은 유한요소해석을 이용해 획득하였다. 또한 개활지의 폭압 프로파일을 기준으로 개발된 Friedlander 압력-충격량 곡선을 격실 내부에서의 복잡한 폭압 전파로 인해 피해평가에 적용할 수 없어, Axelsson 단자유도 모델을 적용하여 인원 피해를 분석하였다. 장애물이 있는 경우 인원의 흉벽 속도는 26에서 76 퍼센트(%) 만큼 감소되었으며 격실내 인원피해 또한 감소되었다.

• 대한약리학회지
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• 제31권2호
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• pp.251-259
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• 1995

Pharmacokinetics and pharmacodynamics of metoprolol, a selective beta-l blocker, were examined for 360 minutes after intravenous bolus administration of metoprolol to 6 dogs. Plasma concentration and excreted amount in the urine metoprolol were measured by liquid chromatography with fluorescence detection. PR interval and heart rate were measured by ECG monitoring. Blood pressure was monitored through intraarterial catheter in femoral artery and cardiac output by thermodilution method using Swan-Ganz catheter. To analyze the effect site concentration-response relationship, plasma concentration and pharmacological effects were simultaneously fitted to a two pharmacokinetic compartment linked to pharmacodynamic model with NONLIN program. Results are as follows. 1) The plasma concentration of metoprolol after intrvenous injection decreased biexponentially. The terminal half-life estimated was $1.33{\pm}0.40$ hours and the volume of distribution at steady state (Vdss) and the total body clearance were $1.04{\pm}0.4\;L/kg,\;6.55{\pm}2.21\;L/hr$, respectively. The central compartment volume of distribution and peripheral compartment volume of distribution were $0.35{\pm}0.14L/kg\;and\;0.69{\pm}0.34L/kg$. The renal clearance and intercompartment clearance were $0.53{\pm}0.25\;L/min\;and\;0.35{\pm}0.19\;L/min$. 2) Simulated biophase concentration-response curve shows hyperbolic relationship and the estimated concentration-effect relationship was best explained by Emax model when the prolongation of PR interval and the reduction of the heart rate were used as pharmacodynamic parameters. Emax and EC50 were estimated to be $26.3{\pm}4.7\;msec\;and\;88.8{\pm}82.3\;g/ml$ for PR interval, and $48.7{\pm}18.8\;beats/min\;and\;113.5{\pm}78.7\;ng/ml$ for heart rate, respectively. 3) The changes of cardiac output-effect site concentration relationship was best fitted by a linear model and the slope of the relationship was $0.005{\pm}0.003$. Diastolic blood pressure-effect site concentration relationship was also explained by the linear model and the slope of the relationship was $0.038{\pm}0.034$.

• 한국CDE학회논문집
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• 제10권4호
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• pp.244-253
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• 2005

In the initial ship design stage of shipyards, the hull form design, the basic design (compartment modeling and ship calculation), and the hull structural design are being performed by different systems. Thus, the problem on interfaces between these systems occurs. To solve this, we developed the hull form design system 'EzHULL' and the compartment modeling and ship calculation system 'EzCOM-PART' for developing finally an integrated ship design system. And, in this study, we present an object-oriented hull structural design .system 'EzSTRUCT', which is developed recently. A structural design in an initial design stage can be frequently changed, because the design is not firmly determined yet. Therefore, designers perform the simplified structural modeling with bigger structural parts (or objects) such as deck, longitudinal bulkhead, etc. in the initial design stage, and the detailed structural modeling with smaller structural parts such as plate, seam, slot, etc. in the detailed design stage. However, the existing hull structural CAD system used in a shipyard is not efficient in generating a 3D CAD model in the initial design stage, because it has difficulty in handling frequent changes in design. Therefore, designers initially draw 2D drawings in the initial design stage, and generate the 3D CAD model from these 2D drawings in the detailed design and production design stages. In this study, the hull structural design system, which can efficiently generate a 3D CAD model through rapid modeling at an initial design stage, was developed in this study To evaluate the applicability of the developed system, we applied it to hull structural modeling of various ships such as a VLCC, a bulk carrier, etc. As a result, it could efficiently generate a 3D CAD model of a hull structure.

• Journal of Radiation Protection and Research
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• 제30권1호
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• pp.45-54
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• 2005

원자력시설로부터 삼중수소 사고 누출시 시설 주변 농작물의 삼중수소 오염 평가를 위한 동적격실모델 ECOREA-H3를 개발하였다. 모델의 격실은 크게 대기, 토양, 농작물로 구성되며 농작물은 엽채류 곡물류, 근군류의 3개 소그룹으로 분류하여 각각 독립적으로 모델링하였다. 벼에 대한 삼중수소 피폭실험 해석을 통해 모델의 예측 정확도가 조사되었다. 모델링 결과 추수시 벼이삭의 TFWT 농도는 입력데이터 중 공기의 절대습도, 뿌리흡수비 강우량에 OBT 농도는 공기의 절대습도, 이삭의 성장기간, 유기물의 수소함량의 영향을 상대적으로 크게 받는 것으로 나타났다. 벼이삭 OBT 농도에 대한 모델 계산과 실험 측정값은 잘 일치하였다.

• 한국안전학회지
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• 제31권4호
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• pp.1-8
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• 2016

The behavior of backdraft in the compartment with different ignition locations and times was numerically investigated. The Fire Dynamics Simulator (FDS) v5.5.3 with a model-free simulation option was used in the numerical simulation of backdraft. The ignition source was located near the inside wall, at the compartment center and near the window opening, respectively. The ignition was started at the instance when the fresh air reached the ignition location or when a sufficient time passed compare to the instance of the arriving of the fresh air to the ignition location. As a result, for the ignition source was located near the inside wall, a strong fire ball was observed at once and the result was similar to the previous experimental result. For the ignition source was located at the center of the compartment, a strong fire ball was occurred and two strong fire balls were observed consecutively for the ignition time was delayed. For the ignition source was located near the window opening and longer time was given for the ignition compare the duration of the fresh air arriving to the ignition location, the rapid temperature variation was not observed because there was no flame. However, for the ignition was started at the instance when the fresh air reached the ignition location, the ignition could be initiated and a intensive fire ball was observed. The pressure measured at the upper inside part of the window opening provided a similar trend with the previous experimental result of compartment backdraft.

• 한국분무공학회지
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• 제13권3호
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• pp.156-161
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• 2008

The present article reports a numerical study on the fire characteristic change by water-mist in under-ventilated compartments. The natural gas and heptane pool fires are used as fire sources, which are located in the bottom center of the 2/5 reduced-scaled model of the ISO 9705 standard room. The fire modeling using the FDS (Fire Dynamics Simulator) is validated by comparison with previously published experimental results. For temperature and combustion gas concentrations at two positions located in the upper layer of compartment, the predicted results with and without water-mist are compared each other. The results show that under the water-mist operation, the predicted temperature and carbon monoxide concentration reduce as $300{\sim}400^{\circ}C$ and about 20%, respectively, compared to those without water-mist.

• 한국원자력학회:학술대회논문집
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• 한국원자력학회 1997년도 추계학술발표회논문집(1)
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• pp.495-500
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• 1997

For hydrogen management in severe accidents with degraded nuclear core of PWR's, several experiments have been performed in the SNU hydrogen mixing facility. The objectives are understanding the extent of hydrogen mixing and analyzing the effects of factors which dominate uniform or non-uniform mixing at compartments in the containment building. The facility represents on a 1/11th linearly scaled model of the YGN unit 3&4, hydrogen was simulated by helium. Because there are the gaps between safety injection tank and compartment layers in the containment, the test facility was constructed in three dimentinal mode for analyzing of mixture behavior through the gaps. From the experimental results we could conclude that overall hydrogen concentration distributed uniformly in the free volume of the test compartment, but fluctuated in the gaps. This paper is focused on experimental result from several experiment.

• 대한약학회:학술대회논문집
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• 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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• pp.218-219
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• 2002

In the past, the development of pharmacokinetic/pharmacodynamic (PK/PD) models for quantitating the time course of drug responses was mainly based on two types of models, the empirical effect compartment model that simply accounts for the delay between effect and plasma concentration (hysteresis) and the mechanism-based so-called indirect response model. The first approach traces back to a paper by Segre (1) and its application was popularized by Holford and Sheiner (2); indirect response models were introduced by Jusko's group (3). (omitted)

• 약학회지
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• 제43권2호
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• pp.160-168
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• 1999

The purpose of this study was to determine pharmacokinetic parameters of vancomycin using peak and trough plasma level (PTL) and Bayesian analysis in 20 Korean normal volunteers, 16 gastric cancer and 12 lymphoma patients and also using the compartment model dependent (nonlinear least squares regression: NLSR) and compartment model independent (Lagrange) analysis in 10 ovarian cancer patients. Nonparametric expected maximum (NPEM) algorithm for calculation of the population pharmacokinetic parameters was used, and these parameters were applied for clinical pharmacokinetic parameters by Bayesian analysis. Vancomycin was administered as dose of 1.0 g every 12 hrs for 3 days by IV infusion over 60 minutes in normal volunteers, gastric cancer and lymphoma patients. Population pharmacokinetic parameters, K and Vd in gastric cancer and lymphoma patients using NPEM algorithm were $0.158{\pm}0.014{\;}hr^{-1},{\;}0.630{\pm}0.043{\;}L/kg{\;}and{\;}0.131{\pm}0.0261{\;}hr^{-1},{\;}0.631{\pm}0.089{\;}L/kg$ respectively. The K and Vd in gastric cancer and lymphoma patients using Bayesian analysis were $0.151{\pm}0.027,{\;}0.126{\pm}0.056{\;}hr^{-1}{\;}and{\;}0.62{\pm}0.105,{\;}0.63{\pm}0.095{\;}L/kg$. The K and Vd in ovarian cancer patient using the NLSR and Lagrange analysis were $0.109{\pm}0.008,{\;}0.126{\pm}0.012{\;}hr^{-1}{\;}and{\;} 0.76{\pm}0.08,{\;}0.69{\pm}0.19{\;}L/kg$, respectively. It is necessary for effective dosage regimen of vancomycin in cancer patients to use these population parameters.