• Title/Summary/Keyword: 3차원 인공지지체

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A Study on Fabrication of 3D Porous Scaffold Combined with Polymer Deposition System and a Salt Leaching Method (폴리머 적층 시스템과 염 침출법을 결합한 3차원 다공성 인공지지체 제작)

  • Shim, Hae-Ri;Sa, Min-Woo;Kim, Jong Young
    • Journal of the Korean Society of Manufacturing Process Engineers
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    • v.15 no.5
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    • pp.86-92
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    • 2016
  • In this study, we used a polymer deposition system, based on fused deposition modeling, to fabricate the 3D scaffold and then fabricated micro-pores on a 3D scaffold using a salt leaching method. Materials included polycaprolactone (PCL) and sodium chloride (NaCl). The 3D porous scaffolds were fabricated according to blending ratio such as PCL (70 wt%)/NaCl (30 wt%) and PCL (50 wt%)/NaCl (50 wt%). The 3D porous scaffolds were observed by scanning electron microscopy. The results showed that 3D porous scaffolds had a deposition width of $500{\mu}m$, contained a pore size of $500{\mu}m$ and below $100{\mu}m$. To evaluate the 3D porous scaffolds for bone tissue engineering, we carried out the cell proliferation experiment using a CCK-8 and a mechanical strength test using a universal testing machine. In summary, the 3D porous scaffold was found to be suitable for cancellous bone of human in accordance with the result of in-vitro cell proliferation and mechanical strength. Thus, a 3D porous scaffold could be a promising approach for effective bone regeneration.

Evaluation of Freezing Rate of Marine Clay by Artificial Ground Freezing Method with Liquid Nitrogen (액화질소를 이용한 인공동결공법 적용시 해성 점토지반의 동결속도 평가)

  • Choi, Hyun-Jun;Lee, Dongseop;Lee, Hyobum;Choi, Hangseok
    • KSCE Journal of Civil and Environmental Engineering Research
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    • v.38 no.4
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    • pp.555-565
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    • 2018
  • Nowadays, the artificial ground freezing (AGF) method has been used in many geotechnical engineering applications such as temporary excavation support, underpinning, and groundwater cutoff. The AGF method conducts the freezing process by employing a refrigerant circulating through a set of embedded freezing pipes to form frozen walls serving as an excavation support and cutoff wall. Two refrigerants of brine with the freezing temperature of $-20{\sim}-40^{\circ}C$ and liquid nitrogen with the freezing (evaporating) temperature of $-196^{\circ}C$ are commonly being used in geotechnical applications. This paper performed a series of field experiments to evaluate the freezing rate of marine clay in application of the AGF method. The field experiments consisted of the single freezing-pipe test and the frozen-wall formation test by circulating liquid nitrogen, which is a cryogenic refrigerant, into freezing pipes constructed at a depth of 3.2 m in the ground. The temperature of discharged liquid nitrogen was maintained through the automatic valve, and the temperature change induced by AGF method was measured at the freezing pipes and in the ground with time. According to the experimental results, the single freezing-pipe test consumed about 11.9 tons of liquid nitrogen for 3.5 days to form a cylindrical frozen body with the volume of about $2.12m^3$. In addition, the frozen-wall formation test used about 18 tons of liquid nitrogen for 4.1 days to form a frozen wall with the volume of about $7.04m^3$. The radial freezing rate decreased with increasing the radius of frozen body because the frozen area at a certain depth is proportional to the square of the radius. The radial freezing rate was formulated as a simple equation.

Fabrication of 3D PCL/PLGA/TCP Bio-scaffold using Multi-head Deposition System and Design of Experiment (다축 적층 시스템과 실험 계획법을 이용한 3차원 PCL/PLGA/ICP 바이오 인 공지지체 제작)

  • Kim, Jong-Young;Yoon, Jun-Jin;Park, Eui-Kyun;Kim, Shin-Yoon;Cho, Dong-Woo
    • Journal of the Korean Society for Precision Engineering
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    • v.26 no.1
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    • pp.146-154
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    • 2009
  • In recent tissue engineering field, it is being reported that the fabrication of 3D scaffolds having high porous and controlled internal/external architectures can give potential contributions in cell adhesion, proliferation and differentiation. To fabricate these scaffolds, various solid free-form fabrication technologies are being applied. The solid free-form fabrication technology has made it possible to fabricate solid free-form 3D microstructures in layer-by-layer manner. In this research, we developed a multi-head deposition system (MHDS) and used design of experiment (DOE) to fabricate 3D scaffold having an optimized internal/external shape, Through the organization of experimental approach using DOE, the fabrication process of scaffold, which is composed of blended poly-caprolactone (PCL), poly-lactic-co-glycolic acid (PLGA) and tricalcium phosphate (TCP), is established to get uniform line width, line height and porosity efficiently Moreover, the feasibility of application to the tissue engineering of MHDS is demonstrated by human bone marrow stromal cells (hBMSCs) proliferation test.

Geotechnical Characterization of Artificial Aggregate made from Recycled Resources of Gwangyang Bay Area as a Drainage Material (광양만권 순환자원으로 제조된 배수재용 인공골재의 지반공학적 특성)

  • Kim, Youngsang;Kim, Wonbong
    • Journal of the Korean GEO-environmental Society
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    • v.14 no.10
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    • pp.49-57
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    • 2013
  • Recently, recycling of the industrial by-products has been an important issue of the Yeosu bay, where large industrial complex is located. Major industrial by-products which are produced from Yeosu industrial complex area are phosphogypsum and flyash, which are about 82% and 10% of the 1.6 million tons industrial by-products. Moreover since the Yeosu industrial complex is located at seaside, phosphogypsum has been pointed as cause of serious environmental contaminant from the regional society. Therefore recycling study can't be delayed anymore. In this paper, artificial aggregate was manufactured by non-sintering process from industrial byproducts - e.g., phosphogypsum and slag - as a geotechnical drainage material. To show the feasibility of the artificial aggregate as a geotechnical drainage material, geotechnical experiments including particle size analysis, permeability test, and large scale direct shear test were carried out. Test results show that the permeability of the artificial aggregates range from $6.94{\times}10^{-1}cm/sec$ to $8.86{\times}10^{-1}cm/sec$, which is much larger value than those are required for the drainage material from the construction specification in Korea, and the friction angle of the artificial aggregate is as large as that of sand in water immersion conditions. From the test results, it was concluded that artificial aggregate made from industrial by-products can be used successfully as a geotechnical drainage material.

Fabrication of complete denture using 3D printing: a case report (3D 프린팅을 이용한 양악 총의치 제작 증례)

  • Lee, Eunsu;Park, Chan;Yun, Kwidug;Lim, Hyun-Pil;Park, Sangwon
    • The Journal of Korean Academy of Prosthodontics
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    • v.60 no.2
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    • pp.202-210
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    • 2022
  • Recently with the advance in digital dentistry, the fabrication of dentures using computer-aided design and computer-aided manufacturing (CAD-CAM) is on the rise. The denture designed through a CAD software can be produced in a 3-dimensional manufacturing process. This process includes a subtractive processing method such as milling and an additive processing method such as 3D printing and in which it can be applied efficiently in more complex structures. In this case, complete dentures were fabricated using Stereolithography (SLA)-based 3D printing to shorten the production time and interval of visits in patient with physical disabilities due to cerebral infarction. For definitive impression, the existing interim denture was digitally replicated and used as an individual tray. The definitive impression obtained with polyvinyl siloxane impression material was including information about the inclination and length of the maxillary anterior teeth, vertical dimension, and centric relation. In addition, facial scan data with interim denture was obtained so that it can be used as a reference in determination of the occlusal plane and in arrangement of artificial teeth during laboratory work. Artificial teeth were arranged through a CAD program, and a gingival festooning was performed. The definitive dentures were printed by SLA-based 3D printer using a FDA-approved liquid photocurable resin. The denture showed adequate retention, support, and stability, and results were satisfied functionally and aesthetically.

Development of Biomimetic Scaffold for Tissue Engineering (조직공학을 위한 생체모사용 스캐폴드 개발)

  • Park, Su-A;Lee, Jun-Hee;Kim, Wan-Doo
    • Elastomers and Composites
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    • v.44 no.2
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    • pp.106-111
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    • 2009
  • Tissue engineering is a research field for artificial substitutes to improve or replace biological functions. Scaffolds play a important role in tissue engineering. Scaffold porosity and pore size provide adequate space, nutrient transportation and cell penetration throughout the scaffold structure. Scaffold structure is directly related to fabrication methods. This review will introduce the current technique of 3D scaffold fabrication for tissue engineering. The conventional technique for scaffold fabrication includes salt leaching, gas foaming, fiber bonding, phase seperation, melt moulding, and freeze drying. These conventional scaffold fabrication has the limitations of cell penetration and interconnectivity. In this paper, we will present the solid freeform fabrication (SFF) such as stereolithography (SLA), selective laser sintering (SLS), and fused deposition modeling (FDM), and 3D printing (3DP).

Fabrication of complete denture using digital technology in patient with mandibular deviation: a case report (하악 편위 환자에서 디지털 방식을 이용한 총의치 제작 증례)

  • Lee, Eunsu;Park, Juyoung;Park, Chan;Yun, Kwi-Dug;Lim, Hyun-Pil;Park, Sangwon
    • Journal of Dental Rehabilitation and Applied Science
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    • v.38 no.1
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    • pp.34-41
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    • 2022
  • Recently, digital technology and computer-aided design/computer-aided manufacturing (CAD/CAM) environment have changed the clinician treatment method in the fabrication of dentures. The denture manufacturing method with CAD/CAM technology simplifies the treatment and laboratory process to reduce the occurrence of errors and provides clinical efficiency and convenience. In this case, complete dentures were fabricated using stereolithography (SLA)-based 3D printing in patient with mandibular deviation. Recording base were produced in a digital model obtained with an intraoral scanner, and after recording a jaw relation in the occlusal rim, a definitive impression was obtained with polyvinyl siloxane impression material. In addition, facial scan data with occlusal rim was obtained so that it can be used as a reference in determination of the occlusal plane and in arrangement of artificial teeth during laboratory work. Artificial teeth were arranged through a CAD program, and a gingival festooning was performed. The definitive dentures were printed by SLA-based 3D printer using a Food and Drug Administration (FDA)-approved liquid photocurable resin. The denture showed adequate retention, support and stability, and results were satisfied functionally and aesthetically.