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The Structure of Econazole Nitrate (에코나졸 나이트레이트의 구조)

  • Seo, Il-Hwan;Jo, Seong-Il;Park, Gwon-Il
    • Korean Journal of Crystallography
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    • v.1 no.1
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    • pp.14-18
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    • 1990
  • Econazole nitrate, 1-{2-[(4-chlorophenyl)methoxy]-2-(2,4-dichlorophenyl) ethy1}-1H-imidazole mono-nitrate.C18 H16 CI13 N3 O4 Mw=444.7 Monoclinic P/2₁c,a=17.337(4)A, b=15.191(5), c=7.601(3)A, β=91.72(2)', V=2000.9A3, Z=4, Dc=1.49g/cm3, Dm=1.45g/cm3(mo-ka)= 0.7107A, μ=4.31cm-1, F(000)=912.0, T=298'K, final R=0.061 for 1330 unique observed reflection. Each of the three ring system for the stars with B,A and C ring in order whilst A and C ring of econazole lie close to the same plane which is nearly 60˚with B ring. The hydrogen binding nitrogen of C ring and oxygen of nitrate contributes to stailization of econazole nitrate. Intr and intermolecular distances and angles are within the values recorded for simiar compounds.

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Deposition of Alkali Metal Ions at Polypyrrole Film Electrodes Modified with Fullerene (플러렌으로 수식된 피를 고분자 피막전극에 알카리 금속이온의 포집)

  • Cha Seong-Keuck;Lee Sangchun
    • Journal of the Korean Electrochemical Society
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    • v.7 no.1
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    • pp.16-20
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    • 2004
  • To electropolymerize Polypyrrole(ppy) film modified with fullerene $ions(full^-)$ the cell, Au/5 mM pyrrole, 1mM fullerene, 0.1M $TBABF_4,\;CH_2Cl_2/Pt$, was employed to Prepare the wafer-like type of $electrode/ppy(full^-)ppy(full^-){\ldots}$ electrodes. They were applied to deposit alkali metal ions with the cell of Au(quartz crystal analyzer; QCA)/ppy$(full^-)$, 0.01M metal ion(aq.)/Pt. The depositing rate constant of each ion for $Li^+,\;Na^+,\;K^+,\;Rb^+\;and\;Cs^+$, determined from the first order equation was $1.60\times10^{-8},\;3.13\times10^{-11},\;1.38\times10^{-9},\;2.71\times10^{-11}\;and\;2.98\times10^{-12}mo1.s^{-1}$ respectively. The calculated stoichiometry of the ions determined by quartz crystal microbalance(QCM) at the electrodes was $Li_7C_{60},\;Na_4C_{60},\;K_3C_{60},\;Rb_1C_{60}\;and\;Cs_1C_{60}$ respectively.

COUNTING FORMULA FOR SOLUTIONS OF DIAGONAL EQUATIONS

  • Moon, Young-Gu;Lee, June-Bok;Park, Young-Ho
    • Bulletin of the Korean Mathematical Society
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    • v.37 no.4
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    • pp.803-810
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    • 2000
  • Let N($d_1,...,{\;}d_n;c_1,...,{\;}c_n$) be the number of solutions $(x_1,...,{\;}x_n){\in}F^{n}_p$ of the diagonal equation $c_lx_1^{d_1}+c_2x_2^{d_2}+{\cdots}+c_nx_n^{d_n}{\;}={\;}0{\;}n{\geq},{\;}c_j{\;}{\in}{\;}F^{*}_q,{\;}j=1,2,...,{\;}n$ where $d_j{\;}>{\;}1{\;}and{\;}d_j{\;}$\mid${\;}q{\;}-{\;}1$ for all j = 1,2,..., n. In this paper, we find all n-tuples ($d_1,...,{\;}d_n$) such that the reduced form of ($d_1,...,{\;}d_n$) and N($d_1,...,{\;}d_n;c_1,...,{\;}c_n$) are the same as in the theorem obtained by Sun Qi [3]. Improving this, we also get an explicit formula for the number of solutions of the diagonal equation, unver a certain natural restriction on the exponents.

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THE SYMMETRY OF spin DIRAC SPECTRUMS ON RIEMANNIAN PRODUCT MANIFOLDS

  • HONG, KYUSIK;SUNG, CHANYOUNG
    • Journal of the Korean Mathematical Society
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    • v.52 no.5
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    • pp.1037-1049
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    • 2015
  • It is well-known that the spectrum of a $spin^{\mathbb{C}}$ Dirac operator on a closed Riemannian $spin^{\mathbb{C}}$ manifold $M^{2k}$ of dimension 2k for $k{\in}{\mathbb{N}}$ is symmetric. In this article, we prove that over an odd-dimensional Riemannian product $M^{2p}_1{\times}M^{2q+1}_2$ with a product $spin^{\mathbb{C}}$ structure for $p{\geq}1$, $q{\geq}0$, the spectrum of a $spin^{\mathbb{C}}$ Dirac operator given by a product connection is symmetric if and only if either the $spin^{\mathbb{C}}$ Dirac spectrum of $M^{2q+1}_2$ is symmetric or $(e^{{\frac{1}{2}}c_1(L_1)}{\hat{A}}(M_1))[M_1]=0$, where $L_1$ is the associated line bundle for the given $spin^{\mathbb{C}}$ structure of $M_1$.

MONOTONICITY PROPERTIES OF THE GENERALIZED STRUVE FUNCTIONS

  • Ali, Rosihan M.;Mondal, Saiful R.;Nisar, Kottakkaran S.
    • Journal of the Korean Mathematical Society
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    • v.54 no.2
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    • pp.575-598
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    • 2017
  • This paper introduces and studies a generalization of the classical Struve function of order p given by $$_aS_{p,c}(x):=\sum\limits_{k=0}^{\infty}\frac{(-c)^k}{{\Gamma}(ak+p+\frac{3}{2}){\Gamma}(k+\frac{3}{2})}(\frac{x}{2})^{2k+p+1}$$. Representation formulae are derived for $_aS_{p,c}$. Further the function $_aS_{p,c}$ is shown to be a solution of an (a + 1)-order differential equation. Monotonicity and log-convexity properties for the generalized Struve function $_aS_{p,c}$ are investigated, particulary for the case c = -1. As a consequence, $Tur{\acute{a}}n$-type inequalities are established. For a = 2 and c = -1, dominant and subordinant functions are obtained for the Struve function $_2S_{p,-1}$.

The Results and Complications of the C1-C2 Transarticular Screw Fixation Methods (축추-환추간 경관절 나사못 고정술 치료의 결과 및 합병증)

  • Choi, Jun-Woong;Yoon, Seung-Hwan;Park, Hyung-Chun;Park, Hyeon-Seon;Kim, Eun-Young;Ha, Yoon
    • Journal of Korean Neurosurgical Society
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    • v.37 no.3
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    • pp.201-206
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    • 2005
  • Objective: To evaluate the accuracy and safety of C1-C2 transarticular screw insertion, we retrospectively review surgical records and postoperative radiological findings. Methods: From January 2001 to October 2003, the C1-C2 transarticular screw fixation and posterior wiring with iliac bone grafts was performed in 16 patients. 6 patients had rheumatoid arthritis which caused cervical instability, 3 patients had os odontoideum, 3 patients had type 2 odontoid process fracture, 3 patients had traumatic transverse ligament injury and 1 patients who had been managed with C1-C2 wire fixation had psoriatic arthritis. Results: Osseous fusion was documented in 15 patients(93.8%). Only one patient was recorded screw loosening because of postoperative infection. One patient had only one screw placed because of abnormal anatomical structure, one patients was breakage of a Kirschner wire, and one screw was medial location to lateral mass of C1, but clinical results was excellent and radiological instability was not noted. Conclusion: The author's experience demonstrates that C1-C2 transarticular screw fixation with wired bone graft is a safe procedure with higher fusion rate but precaution is needed to avoid the neural damage, vertebral artery injury, and hardware failure.

Identification of GATA2 and AP-1 Activator Elements within the Enhancer VNTR Occurring in Intron 5 of the Human SIRT3 Gene

  • Bellizzi, Dina;Covello, Giuseppina;Di Cianni, Fausta;Tong, Qiang;De Benedictis, Giovanna
    • Molecules and Cells
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    • v.28 no.2
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    • pp.87-92
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    • 2009
  • Human SIRT3 gene contains an intronic VNTR enhancer. A T > C transition occurring in the second repeat of each VNTR allele implies the presence/absence of a putative GATA binding motif. A partially overlapping AP-1 site, not affected by the transition, was also identified. Aims of the present study were: 1) to verify if GATA and AP-1 sites could bind GATA2 and c-Jun/c-Fos factors, respectively; 2) to investigate whether such sites modulate the enhancer activity of the SIRT3-VNTR alleles. DAPA assay proved that GATA2 and c-Jun/c-Fos factors are able to bind the corresponding sites. Moreover, co-transfection experiments showed that the over-expression of GATA2 and c-Jun/c-Fos factors boosts the VNTR enhancer activity in an allelic-specific way. Furthermore, we established that GATA2 and c-Jun/c-Fos act additively in modulating the SIRT3-VNTR enhancer function. Therefore, GATA2 and AP-1 are functional sites and the T > C transition of the second VNTR repeat affects their activity.

ON CHARACTERIZATIONS OF SOME LINEAR COMBINATIONS INVOLVING THE MATRICES Q AND R

  • Ozdemir, Halim;Karakaya, Sinan;Petik, Tugba
    • Honam Mathematical Journal
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    • v.42 no.2
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    • pp.235-249
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    • 2020
  • Let Q and R be the well-known matrices associated with Fibonacci and Lucas numbers, and k, m, and n be any integers. It is mainly established all solutions of the matrix equations c1Qn + c2Qm = Qk, c1Qn + c2Qm = RQk, and c1Qn + c2RQm = Qk with unknowns c1, c2 ∈ ℂ*. Moreover, using the obtained results, it is presented many identities, some of them are available in the literature, and the others are new, related to the Fibonacci and Lucas numbers.

Synthesis and Anti Bacterial and Anti-ulcer Evaluation of New S-mannich Bases of 4,6-diaryl-3,4-dihydropyrimidin-2(1H)-thiones

  • Kodhati, Venkateshwarlu;Vanga, Malla Reddy;Yellu, Narsimha Reddy
    • Journal of the Korean Chemical Society
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    • v.57 no.2
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    • pp.234-240
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    • 2013
  • The synthesis of title compounds were accomplished by synthetic sequence shown in Scheme 1. Chalcones on cyclocondensation with thiourea in ethanol and potassium hydroxide under reflux yielded the respective dihydropyramidin-2(1H)-thiones. Each of the dihydropyrimidin thiones was, then subjected to the Mannich condensation in alkaline medium using three different secondary amines, viz., dimethylamine, diethylamine and morpholine to obtain a new series of S-Mannich bases. All the synthesised compounds ($C_1-C_{15}$) were evaluated for their antiulcer and antibacterial activities. Compounds $C_4$, $C_5$, $C_6$, $C_{14}$ and $C_{15}$ exhibited relatively more potent antiulcer activity but not comparable to the standard; Omeprazole, while $C_1$, $C_2$, $C_3$ and $C_{13}$ were moderate in activity at 100 mg/kg p.o. All the compounds ($C_1-C_{15}$) showed mild to moderate activity against both Gram-positive (S.aureus, L.delbrueckii) and Gram-negative (P.vulgaris, E.coli) bacteria. Amongst the compounds tested, only $C_6$, $C_9$, $C_{12}$ and $C_{15}$ were found to be potent.

Structure of a Spiro Orthocarbonate, 3,3'-Spirobi[1H, 5H-naphtho [1,8-ef] [1,3] dioxocin] (Spiro Orthocarbonate, 3,3'-Spirobi[1H, 5H-naphtho[1,8-ef] [1,3] dioxocin]의 분자구조)

  • Young Mi Song;Jung Mi Shin;Young Ja Park
    • Journal of the Korean Chemical Society
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    • v.36 no.4
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    • pp.536-539
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    • 1992
  • Eight-membered ring spiro orthocarbonate (C$_{25}H_{20}O_4$, M$_r$ = 384) is monoclinic, space group C2/c, with a = 15.319(4), b = 9.057(3), c = 13.168(3)${\AA}$, ${\beta}$ = 98.53(3)$^{\circ}$, Z = 4, F(000) = 808, T = 290 K, ${\mu}$(Mo-K${\alpha}$) = 0.55 cm$_1$, D$_c$ = 1.36 g/cm$^3$ and D$_m$ = 1.40 g/cm$^3$. The intensity data were collected with Mo-K${\alpha}$ radiation (${\lambda}$ = 0.7107 ${\AA}$) on an automatic four-circle diffractometer with a graphite monochromater. The structure was solved by direct methods and refined by full matrix least-squares methods. The final R value was 0.052 for 1412 observed reflections. The molecule has C$_2$point symmetry. The eight-membered ring has a chair conformation with pseudo-C$_s$ symmetry. The naphthyl ring is planar with the C-C bond lengths being in the range of 1.352∼1.444${\AA}$ and bond angles of 117.2∼123.5$^{\circ}$. The bond lengths of C(1)-C(9), C(8)-C(9) and C(9)-C(10) are somewhat longer than those of the other C-C bonds.

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