• The Korean Journal of Nuclear Medicine Technology
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• v.14 no.1
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• pp.18-23
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• 2010

Purpose: PET/CT combines functional and morphologic data and increases diagnostic accuracy in a variety of malignancies. Especially reconstructed Fusion PET/CT images or MIP (Maximum Intensity Projection) images from a 2-dimensional image to a 3-dimensional one are useful in visualization of the lesion. But in Fusion & MIP 3D reconstruction image, due to hot uptake by urine or urostomy bag, lesion is overlapped so it is difficult that we can distinguish the lesion with the naked eye. This research tries to improve a distinction by removing parts of hot uptake. Materials and Methods: This research has been conducted the object of patients who have went to our hospital from September 2008 to March 2009 and have a lot of urine of remaining volume as disease of uterus, bladder, rectum in the result of PET/CT examination. We used GE Company's Advantage Workstation AW4.3 05 Version Volume Viewer program. As an analysis method, set up ROI in region of removal in axial volume image, select Cut Outside and apply same method in coronal volume image. Next, adjust minimum value in Threshold of 3D Tools, select subtraction in Advanced Processing. It makes Fusion & MIP images and compares them with the image no using Region Cut Definition. Results: In Fusion & MIP 3D reconstruction image, it makes Fusion & MIP images and compares them by using Advantage Workstation AW4.3 05's Region Cut Subtraction, parts of hot uptake according to patient's urine can be removed. Distinction of lesion was clearly reconstructed in image using Region Cut Definition. Conclusion: After examining the patients showing hot uptake on account of volume of urine intake in bladder, in process of reconstruction image, if parts of hot uptake would be removed, it could contribute to offering much better diagnostic information than image subtraction of conventional method. Especially in case of disease of uterus, bladder and rectum, it will be helpful for qualitative improvement of image.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.10 no.3
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• pp.1159-1181
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• 2016

This study introduces an image-based 2D-to-3D conversion system that provides significant stereoscopic visual effects for humans. The linear and atmospheric perspective cues that compensate each other are employed to estimate depth information. Rather than retrieving a precise depth value for pixels from the depth cues, a direction angle of the image is estimated and then the depth gradient, in accordance with the direction angle, is integrated with superpixels to obtain the depth map. However, stereoscopic effects of synthesized views obtained from this depth map are limited and dissatisfy viewers. To obtain impressive visual effects, the viewer's main focus is considered, and thus salient object detection is performed to explore the significance region for visual attention. Then, the depth map is refined by locally modifying the depth values within the significance region. The refinement process not only maintains global depth consistency by correcting non-uniform depth values but also enhances the visual stereoscopic effect. Experimental results show that in subjective evaluation, the subjectively evaluated degree of satisfaction with the proposed method is approximately 7% greater than both existing commercial conversion software and state-of-the-art approach.

• Microbiology and Biotechnology Letters
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• v.32 no.2
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• pp.190-194
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• 2004

The gene product of dctD (DctD) activates transcription from the dctA promoter regulatory region by the $\sigma^{54}$ -holoenzyme form ofRNA polymerase ($E\sigma^{54}$ ) in Rhizobium meliloti and R. leguminosarum. The Escherichia coli integration host factor (IHF) stimulated DctD-mediated activation from the dctA promoter regulatory region of R. leguminosarum but not R. meliloti. In the absence of UAS, IHF inhibited DctD-mediated activation from both of these promoter regulatory regions. IHF also inhibited activation from R. leguminosarum dctA by nitrogen regulatory protein C (NtrC), another activator of $E\sigma^{54}$ but not by one which lacks a specific binding site in this promoter regulatory region. IHF, however, stimulated NtrC-mediated activation from the R. meliloti dctA promoter. Upon removal of the UAS, IHF inhibited NtrC-mediated transcription activation from the R. meliloti dctA promoter regulatory region. These data suggest that IHF likely faciliates productive contacts between the activators NtrC or DctD and $E\sigma^{54}$ to stimulate activation from dctA promoter.

• Smart Media Journal
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• v.5 no.1
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• pp.49-54
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• 2016

Medical image processing is a compulsory process to diagnose many kinds of disease. Therefore, an automatic algorithm for this task is highly demanded as an important part to construct a computer-aided diagnosis system. In this paper, we introduce an automatic method to segment the liver region from 3D abdominal CT images using Otsu method. First, we choose a 2D slice which has most liver information from the whole 3D image. Secondly, on the chosen slice, we enhanced the image based on its intensity using Otsu method with multiple thresholds and use the threshold to enhance the whole 3D image. Then, we apply a liver mask to mark the candidate liver region. After that, we execute the Otsu method again to segment the liver region from the chosen slice and propagate the result to the whole 3D image. Finally, we apply preprocessing on the frontal side of 3D images to crop only the liver region from the image.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.32 no.2B
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• pp.103-111
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• 2012

This study is to analyze the spatio-temporal trend of snowfall using 30 years (1980-2010) data for 5 selected heavy snowfall areas (Ulleungdo (a), Northeastern Region (b), Western Taebaek Range Inland Region (c), Northwestern Sobaek Range Inland Region (d) and Southern Coastal Region (e)). The snow depth and snowfall frequency during 30 years showed some decreasing trend in parts of c and d. From the spatial comparison for 2 periods between 1980-2000 (A) and 1990-2010 (B), we could identified that the frequency of advisory for heavy snowfall from A to B decreased in c and d showing clear bounds for some areas in period B. For the average snow depth from A to B, the area d decreased while the area b increased with enlarging the areal range.

• Bulletin of the Korean Chemical Society
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• v.28 no.8
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• pp.1341-1345
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• 2007

The surface chemistry of D2O dosed Zircaloy-4 (Zry-4) surface followed by Ar-ion bombardment and annealing was studied by means of X-ray photoelectron spectroscopy (XPS) and Ultraviolet photoelectron spectroscopy (UPS). In the XPS study, Ar-ion bombardment caused decrease of the oxygen on the surface region of Zry-4 and therefore led to change the oxidation states of the zirconium from oxide to metallic form. In addition, oxidation states of zirconium were changed to lower oxidation states of zirconium due to depopulation of oxygen on the surface region by annealing. Up to about 787 K, the bulk oxygen diffused out to the subsurface region and after this temperature, the oxygen on the surface of Zry-4 was depopulated. UPS study showed that the valence band spectrum of the D2O exposed Zry-4 exhibited a dominant peak at around 13 eV and no clear Fermi edge was detected. After stepwise Ar+ sputtering processes, the decrease of the oxygen on the surface of Zry-4 led to suppress the dominant peak around 13 eV, the peak around 9 eV and develop a new peak of the metallic Zr 4d state (20.5-21.0 eV) at the Fermi level.

• Magazine of the Korean Society of Agricultural Engineers
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• v.32 no.3
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• pp.56-66
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• 1990

To investigate the status of irrigation water use and the degree of repeated use of irrigation water, observations for water balance analysis were made during the irrigation periods in 1986 and 1987 crop year. The total area of studied site is 1,441 ha. The site is a major portion of Jedaecheon basin which is located in Bubuk-myeon, Miryang-gun, Gyeongnam Province. The studied area was subdivided into six small blocks. The water balance analysis for these subdivided blocks were carried out considering characteristics of each block. Obtained results are as follow: 1.In mountainous sloppy paddy area(less than 7% slope), the surface inflow was 5A mm/day in average that is one third of the surface inflow into plain paddy area ; 16.7 mm/day. 2.The surface inflows at the vegetative stage and the ripening stage were 15.5 mm/day and 10.4 mm/day, respectively. Those figures were larger than the actual consumptive use at respective same stages ; 13.3 mm/day and 9.2 mm/day, respectively. Whereas, the surface inflow at generative stage was 12.5 mm/day which was less than 14.0 mm/day ; the actual consumptive use. 3.The range of the variation of water storage term was 1 mm/day. This means that there were no change in depth of ponded water on paddy fields. The relationship between the variation of water storage(AS) and the variation of ground water table(H) could be expressed as follow: : AS=0.14H+0.26 4.The ground water inflow: into the transition region ; paddy fields which are located continuously from the mountainous area to the plain area, was larger than the out flow from this region, in general. Rowever, in the plain region where the ground water utilization was predominant, the ground water outflow from this region was larger than inflow: to this region. The relationship between the ground water flow(G2- G1) and the consumptive use in large paddy area(D1-D2) could be expressed as follow: (G2-G1) =0.95(D1-D2) -3.79

• IMMUNE NETWORK
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• v.3 no.2
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• pp.89-95
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• 2003

Background: Unusually high amounts of N region addition and CDR3 length diversity were found in immunoglobulin (Ig) light chain Vk and Jk joins in patients with rheumatoid arthritis (RA). We sought to determine whether this finding is due to excessive activity of the enzyme responsible for N region addition (terminal deoxynucleotidyl transferase [TdT]) in B lineage cells in bone marrow or from positive antigenic selection of B cells with long CDR3 lengths. Methods: We used FACS to isolate $IgM^+/IgD^+$ B cells (predominantly naive) and $IgM^-/IgD^-$ B cells (predominantly class-switched) B cells from peripheral blood of a patient with RA known to have enrichment for long Vk CDR3s and from that of two normal controls. RT-PCR of VkIII transcripts was performed, followed by sequencing of individual cDNA clones. We analyzed the CDR3 lengths and N region additions in 97 clones. Results: There was enrichment for long CDR3 lengths (11 or 12 amino acids) in both $IgM^+/IgD^+$ and $IgM^-/IgD^-$ B cells in RA compared to B cell subsets in the normal controls. The $IgM^+/IgD^+$ B cell subset in RA was markedly enriched for N region addition and was similar to that seen in the $IgM^-/IgD^-$ subset. Conclusion: These data suggest that enrichment for N region addition and long CDR3 lengths in RA may result from unusually high or prolonged activity of TdT in bone marrow.

• The Korean Journal of Physiology and Pharmacology
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• v.23 no.6
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• pp.475-482
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• 2019

Glioma is the most common brain tumor with a dismal prognosis. While temozolomide (TMZ) based chemotherapy significantly improves survival in glioma patients, resistance against this compound commonly leads to glioma treatment failure. Overexpression of long-noncoding RNA (LncRNA) FoxD2 adjacent opposite strand RNA 1 (FoxD2-AS1) was identified to promote glioma development, but the role in TMZ resistance remains unclear. In this paper, we found that FoxD2-AS1 was overexpressed in recurrent glioma, high FoxD2-AS1 expression was significantly correlated with poor patient outcome. Methylation of $O^6$-methylguanine-DNA methyltransferase (MGMT) is significantly less frequent in high FoxD2-AS1 expression patients. Knockdown of FoxD2-AS1 decreased the proliferation, metastatic ability of glioma cells and promote the sensitivity to TMZ in glioma cells. Furthermore, knockdown of FoxD2-AS1 induced hypermethylation of the promoter region of MGMT. Our data suggested that FoxD2-AS1 is a clinical relevance LncRNA and mediates TMZ resistance by regulating the methylation status of the MGMT promoter region.

• The Transactions of the Korean Institute of Electrical Engineers D
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• v.53 no.2
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• pp.118-126
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• 2004

The modified Wiener filtering method is proposed for effective noise suppression in edge region of images corrupted by additive white gaussian noise. Although the pixels classified as a edge region in the conventional Wiener filter have lots of noise components, the conventional Wiener filter cannot remove noise effectively due to the preserving of edges. To reduce noise well in edge region, we modify filter coefficients of the conventional Wiener filter. The modified filter coefficients increase in noise suppression effect in edge region, while they preserve edges for strong edge region. From simulation (256${\times}$256 size, 256 graylevel images) filtered images by the proposed method show much improved subjective image quality with higher peak signal-to-noise ratio compared to those by the conventional Wiener filtering.