• 대한비뇨기종양학회지
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• 제15권3호
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• pp.103-110
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• 2017

Cancer is the tissue complex consisted with heterogeneous cellular compositions, and microenvironmental cues. During the various stages of cancer initiation, development, and metastasis, cell-cell interactions as well as cell-extracellular matrix play major roles. Conventional cancer models both 2-dimensional and 3-dimensional (3D) present numerous limitations, which restrict their use as biomimetic models for drug screening and fundamental cancer biology studies. Recently, bioprinting biofabrication platform enables the creation of high-resolution 3D structures. Moreover this platform has been extensively used to model multiple organs and diseases, and this versatile technique has further found its creation of accurate models that figure out the complexity of the cancer microenvironment. In this review we will focus on cancer biology and limitations with current cancer models and we discuss vascular structures bioprinting that are critical to the construction of complex 3D cancer organoids. We finally conclude with current literature on bioprinting cancer models and propose future perspectives.

• 산업경영시스템학회지
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• 제38권3호
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• pp.29-38
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• 2015

In this paper, scale efficiencies and relative efficiencies of R&D projects in Industrial Technology Program, sponsored by Ministry of Trade, Industry and Energy, Korea, are calculated and compared. For the process, various DEA (Data Envelopment Analysis) models are adopted as major techniques. For DEA, two stage input oriented models are utilized for calculating the efficiencies. Next, the calculated efficiencies are grouped according to their subprograms (Industrial Material, IT Fusion, Nano Fusion, Energy Resources, and Resources Technology) and recipient types (Public Enterprise, Large Enterprise, Medium Enterprise, Small Enterprise, Lab., Univ., and etc.) respectively. Then various subprograms and recipient types are compared in terms of scale efficiencies (CCR models) and relative efficiencies (BCC models). In addition, the correlation between the 1st stage relative efficiencies and the 2nd stage relative efficiencies is calculated, from which the causal relationship between them can be inferred. Statistical analysis shows that the amount of input, in general, should increase in order to be scale efficient (CCR models) regardless of the subprograms and recipient types, that the 1st and 2nd stage relative efficiencies are different in terms of the programs and recipient types (BCC models), and that there is no significant correlation between the 1st stage relative efficiencies and the 2nd stage relative efficiencies. However, the results should be used only as reference because the goal each and every subprogram has is different and the situation each and every recipient type faces is different. In addition, the causal link between the 1st stage relative efficiencies and the 2nd relative efficiencies is not considered, which, in turn, is the limitation of this paper.

• The Journal of Advanced Prosthodontics
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• 제10권5호
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• pp.367-373
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• 2018

PURPOSE. To evaluate the fit of a crown produced based on a 3D printed model and to investigate its clinical applicability. MATERIALS AND METHODS. A master die was fabricated with epoxy. Stone dies were fabricated from conventional impressions (Conventional stone die group: CS, n=10). Digital virtual dies were fabricated by making digital impressions (Digital Virtual die group: VD, n=10). 3D data obtained from the digital impression was used to fabricate 3D printed models (DLP die group: DD, n=10, PolyJet die group: PD, n=10). A total of 40 crowns were fabricated with a milling machine, based on CS, VD, DD and PD. The inner surface of all crowns was superimposed with the master die files by the "Best-fit alignment" method using the analysis software. One-way and 2-way ANOVA were performed to identify significant differences among the groups and areas and their interactive effects (${\alpha}=.05$). Tukey's HSD was used for post-hoc analysis. RESULTS. One-way ANOVA results revealed a significantly higher RMS value in the 3D printed models (DD and PD) than in the CS and DV. The RMS values of PD were the largest among the four groups. Statistically significant differences among groups (P<.001) and between areas (P<.001) were further revealed by 2-way ANOVA. CONCLUSION. Although the fit of crowns fabricated based on the 3D printed models (DD and PD) was inferior to that of crowns prepared with CS and DV, the values of all four groups were within the clinically acceptable range (<$120{\mu}m$).

• 대한공간정보학회지
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• 제15권3호
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• pp.27-32
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• 2007

도시의3차원적인 성장 및 건물의 대형화, 복잡화에 따라 3차원 정보에 대한 요구가 증가하고 있다. 이와 더불어 위치기반안내, 경로탐색 또는 비상탈출 등과 같은 유비쿼터스 컴퓨팅의 기초데이터로써 3차원 GIS의 활용에 대한 관심 또한 증가하고 있다. 반면에 대부분의3차원 모델링 기술은 건물이나 지형의 시각적인 표현에 초점을 맞추고 있으며 공간분석에서 요구되는 위상구조는 갖고 있지 않다. 본 연구에서는3차원 모델에 위상구조를 적용하는 방법으로 2차원 GIS와 3차원 모델의 연동을 제시하고자 한다. 3차원 모델의 공간별로 분리된 객체를 상응하는 2차원 GIS 레이어의 피쳐와 데이터베이스의 레코드를 통해 연계하고 이로써 3차원 객체간의 관계를 정의하였다. 또한 2차원과 3차원이 연동된 건물모델의 복도네트워크를 구축하였다. 마지막으로 연동된 3D모델을 이용하여 건물내부에서 최적 경로분석을 몇 가지 시나리오를 통해 실시하였다.

• 약학회지
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• 제55권2호
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• pp.98-105
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• 2011

To search the minimum structural requirement of tricyclic isoxazole analogues (1~30) as new class potent antidepressant, thee-dimensional quanti- tative-structure relationship (3D-QSAR) models between substituents ($R_1{\sim}R_5$) of tricyclic isoxazoles and their antidepressant activity against medetomidine-induced loss of righting were performed and discussed quantitatively using comparative molecular field analysis (CoMFA) and comparative molecular similarity indies analysis (CoMSIA) methods. The correlativity and predictability ($r^2$=0.484 and $q^2$=0.947) of CoMSIA-2 model were higher than those of the rest models. The inhibitory activity against medetomidine-induced loss of righting was dependent on electrostatic field (43.4%), hydrophobic field (35.3%), and steric field (21.2%) of tricyclic isoxazoles. From the CoMSIA-2 contour maps, it is predicted that the antidepressant activity of potent antidepressants against medetomidine-induced loss of righting will be able to increase by the substituents ($R_1{\sim}R_5$) which were in accord with CoMSIA field.

• 한국정밀공학회지
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• 제21권8호
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• pp.164-170
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• 2004

The skin movement artifacts are referred to as the relative motion of skin with respect to the motion of underlying bones. This is of great importance in joint biomechanics or internal kinematics of human body. This paper describes a novel experiment that measures the skin movement of a hand based on MR(magnetic resonance) images in conjunction with surface modeling techniques. The proposed approach consists of 3 phases: (1) MR scanning of a hand with surface makers, (2) 3D reconstruction from the MR images, and (3) registration of the 3D models. The MR images of the hand are captured by 3 different postures. And the surface makers which are attached to the skin are employed to trace the skin motion. After reconstruction of 3D models from the scanned MR images, the global registration is applied to the 3D models based on the particular bone shape of different postures. The results of registration are then used to trace the skin movement by measuring the positions of the surface markers.

• 한국의류산업학회지
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• 제19권5호
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• pp.635-645
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• 2017

The industry of character toys is increasing and new characters are constantly being developed. However, the development of 2D cover patterns for toys is time-consuming due to frequent pattern modifications made through trial and error. Studies are now underway to obtain 2D clothing patterns from 3D body data, however, little research has been done on 2D pattern of character toys. This study suggests efficient guidelines to develop 2D cover patterns with a reasonable accuracy and processing time. Two 3D models of a dog and rabbit were used to develop 2D cover patterns. Independent variables of this study are set as 3 levels of triangle area (small, medium, and large) that influence the efficacy of 3D and 2D pattern development. The determination of the appropriate triangular area was based on the area and shape change of the 2D pattern. A medium or large triangle area was shown to be suitable for a character dog with a smooth curved surface. However, the appropriate triangle area was small if the characteristics of the curved surface are complicated as in the case of rabbit. The head of a dog (a double-curved surface) and the curved forepaw of a rabbit (a triangular area) should be small when the characteristics of the curved surface (such as the hind leg of a rabbit having a large convex surface and a small surface area) are complicated. Grouping by 3D surface characteristics could be a suitable guideline for the triangle area selection.

• 천문학회보
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• 제38권2호
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• pp.38.2-38.2
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• 2013

Several studies have reported the presence of sodium excess objects having neutral atomic absorption lines at $5895{\AA}$ (NaD) and $8190{\AA}$ that are deeper than expected based on stellar population models that match the stellar continuum. The origin of these lines is therefore hotly debated. van Dokkum & Conroy proposed that low-mass stars (0.3M) are more prevalent in massive early-type galaxies, which may lead to a strong NaI 8190 line strength. It is necessary to test this prediction, however, against other prominent optical line indices such as NaD, Mgb, and Fe5270, which can be measured with a significantly higher signal-to-noise ratio than NaI 8190. We identified a new sample of roughly one thousand NaD excess objects (NEOs; ~8% of galaxies in the sample) based on NaD line strength in the redshift range 0.00${\alpha}$-enhanced" ([${\alpha}/Fe$] ~ 0.3), "metal-rich" ([Z/H] ~ 0.3), and, especially, "Na-enhanced" ([Na/Fe] ~ 0.3).

• 한국구조물진단유지관리공학회 논문집
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• 제27권5호
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• pp.30-39
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• 2023

국가의 중요 방재시설인 대형 댐 시설물은 노후화와 홍수, 지진 등의 위험으로 디지털 전환 기술을 적용한 보다 나은 댐 안전점검 및 진단이 필수적이다. 종래의 인력에 의한 육안 안전점검 방식은 인력 접근의 어려움과 고소작업의 위험성, 노하우 중심의 점검에서 오는 데이터의 신뢰성 등의 문제가 있었다. 본 연구에서는 2개 대규모 댐 시설물을 대상으로 드론 photogrammetry에 의한 디지털 데이터 기반 댐 안전점검의 적용성을 검토하고, 지속적 활용을 위한 데이터 관리 방법론을 제시하였다. 댐 높이 42 m 및 99.9 m의 댐들에 대해 수면 및 전자기장 간섭, 심한 고저차에도 불구하고 평면적 더블그리드 및 수동 촬영 방식으로 GSD 2.5 cm/pixel 이내의 양호한 3D 디지털 모델을 생성하였다. 생성된 3D 메쉬 모델, 정사영상, 수치표면모형으로 as-built 조건의 종단 및 횡단 선형을 손쉽게 추출하여 댐의 변형 모니터링에 효과적임을 확인하였다. 댐 여수로 등 콘크리트 시설물에 대한 디지털 3D 모델로부터 균열 및 손상부를 효과적으로 검출하고 시각화하였으며, 이는 고소작업의 위험성 및 접근 제약 시설의 안전점검에 활용가능하다. 또한 댐의 안전점검 시 외관 조사망도를 3D 디지털 모델 상에서 매핑하는 방법과 손상 정보 이력 관리를 위한 관계형 데이터베이스 구조화 방안을 제안하였다. SYG댐 여수로 안전점검에 대한 투입 노동력과 시간을 실측한 결과, 드론 photogrammetry 방법은 기존 인력 육안점검에 비해 48%의 생산성 향상 효과를 확인하였다. 드론 photogrammetry 기반 댐 안전점검 디지털 전환은 업무의 생산성과 데이터 신뢰성 향상에 매우 효과적인 것으로 판단된다.

• Spatial Information Research
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• 제20권4호
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• pp.1-16
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• 2012

도시열섬 현상은 도심지의 가장 큰 환경문제로 대두되고 있으며, 이는 온도상승, 대기오염, 에너지 수요에 영향을 준다. 이러한 열섬현상에 대하여 많은 건물과 복잡한 공간적/입체적 패턴을 가진 지역의 경우에는 3차원 분석이 전적으로 수행되어야 한다. 본 연구는 2차원자료와 3차원 공간자료를 이용하여 도시열섬 인자를 파악함에 있다. 또한 공간 통계기법을 이용하여 열섬인자들의 공간적 영향력을 추출한다. 따라서, 도시온도의 예측, 3차원 모델의 생성, 도시인자의 추출, 일반회귀모형과 공간회귀모형의 구축을 통하여 본 연구를 수행한다. 결과적으로 3차원 도시인자와 인접한 공간영향력들이 도시열섬 현상에 미치는 효과는 크다는 것을 확인할 수 있다. 이를 바탕으로 도시온도 저감을 위한 정책수립에 방향을 효과적으로 제시할 수 있을 것이다.