• Journal of the Korean BIBLIA Society for library and Information Science
• /
• v.35 no.1
• /
• pp.5-26
• /
• 2024

The school library work support system was newly developed as 2024 Doksero DLS, but the DLS-compliant cataloging rules have not changed significantly since it was initially developed, and the current developed cataloging guidelines in 2020 also need to be updated. This study is to propose the considerations for developing guidelines for applying the DLS cataloging rules based on KCR4 by comparing the existing DLS (Ver. 2.0) cataloging rules, the 2024 DLS cataloging rules, and the 2020 bibliographic registration guidelines (Ver. 2.2). On this basis, considerations were suggested in terms of changing and expanding data elements, revising content rules for cataloging, method for recording access point, and developing controlled vocabularies. This study will allow to implement revision of DLS cataloging rules, development of guidelines, and system improvements.

• Journal of Pharmacopuncture
• /
• v.27 no.1
• /
• pp.1-13
• /
• 2024

Background: Diabetic nephropathy (DN) is one of the major complications of chronic hyperglycaemia affecting normal kidney functioning. The ayurvedic medicine curcumin (CUR) is pharmaceutically accepted for its vast biological effects. Objectives: The Curcuma-derived diferuloylmethane compound CUR, loaded on Poly (lactide-co-glycolic) acid (PLGA) nanoparticles was utilized to combat DN-induced renal apoptosis by selectively targeting and modulating Bcl2. Methods: Upon in silico molecular docking and screening study CUR was selected as the core phytocompound for nanoparticle formulation. PLGA-nano-encapsulated-curcumin (NCUR) were synthesized following standard solvent displacement method. The NCUR were characterized for shape, size and other physico-chemical properties by Atomic Force Microscopy (AFM), Dynamic Light Scattering (DLS) and Fourier-Transform Infrared (FTIR) Spectroscopy studies. For in vivo validation of nephro-protective effects, Mus musculus were pre-treated with CUR at a dose of 50 mg/kg b.w. and NCUR at a dose of 25 mg/kg b.w. (dose 1), 12.5 mg/kg b.w (dose 2) followed by alloxan administration (100 mg/kg b.w) and serum glucose levels, histopathology and immunofluorescence study were conducted. Results: The in silico study revealed a strong affinity of CUR towards Bcl2 (dock score -10.94 Kcal/mol). The synthesized NCUR were of even shape, devoid of cracks and holes with mean size of ~80 nm having -7.53 mV zeta potential. Dose 1 efficiently improved serum glucose levels, tissue-specific expression of Bcl2 and reduced glomerular space and glomerular sclerosis in comparison to hyperglycaemic group. Conclusion: This study essentially validates the potential of NCUR to inhibit DN by reducing blood glucose level and mitigating glomerular apoptosis by selectively promoting Bcl2 protein expression in kidney tissue.