• Journal of Integrative Natural Science
• /
• 제5권3호
• /
• pp.190-194
• /
• 2012

Human P-gp is one of the protein responsible for the multidrug resistance (MDR) develpment. MDR is a major cause of the cancer chemotherapy. In this paper, we performed homology modeling, docking study of papayriferic acid into the P-gp nucleotide binding domain (NBD2). For human P-gp, X-ray crystal structure is not known yet. We developed homology model for human NBD2 using HlyB ABC transporter structure (PDB code: 1XEF, resolution 2.5 ${\AA}$). Docking study was performed using Autodock. Docking result was analyzed, which shows that ligand docks into steroid binding site and interacts through hydrophobic and hydrophilic interactions.

• Clinics in Shoulder and Elbow
• /
• 제26권2호
• /
• pp.126-130
• /
• 2023

Background: Arm swing plays a role in gait by accommodating forward movement through trunk balance. This study evaluates the biomechanical characteristics of arm swing during gait. Methods: The study performed computational musculoskeletal modeling based on motion tracking in 15 participants without musculoskeletal or gait disorder. A three-dimensional (3D) motion tracking system using three Azure Kinect (Microsoft) modules was used to obtain information in the 3D location of shoulder and elbow joints. Computational modeling using AnyBody Modeling System was performed to calculate the joint moment and range of motion (ROM) during arm swing. Results: Mean ROM of the dominant elbow was 29.7°±10.2° and 14.2°±3.2° in flexion-extension and pronation-supination, respectively. Mean joint moment of the dominant elbow was 56.4±12.7 Nm, 25.6±5.2 Nm, and 19.8±4.6 Nm in flexion-extension, rotation, and abduction-adduction, respectively. Conclusions: The elbow bears the load created by gravity and muscle contracture in dynamic arm swing movement.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• 제11권10호
• /
• pp.3917-3922
• /
• 2010

In this paper, 3 stage amplifier MMIC was designed and fabricated with U-band optimized epitaxal pHEMT that produced by large signal characterization and modeling for 60 GHz band. The pHEMT used in this paper, the gate $0.12\;{\mu}m$ length and total gate width of $100\;{\mu}m$, $200\;{\mu}m$ has been modeled using the large signal designed with negative feedback and MCLF instead of MIM capacitor for improving stability. Fabricated MMIC $2.5{\times}1.5mm^2$ size, current about 40 mA, operating frequency 59.5~60.5 GHz, gain 19.9~18.6 dB, input matching characteristics -14.6~-14.7 dB, output matching characteristics -11.9~-16.3 dB and output -5 dBm characteristics were obtained.

• Journal of Korea Trade
• /
• 제25권2호
• /
• pp.22-45
• /
• 2021

Purpose - This study aims to identify new attributes by analyzing reviews conducted by global automaker customers and to examine the influence of these attributes on satisfaction ratings in the U.S. automobile sales market. The present study used J.D. Power for customer responses, which is the largest online review site in the USA. Design/methodology - Automobile customer reviews are valid data available to analyze the brand personality of the automaker. This study collected 2,998 survey responses from automobile companies in the U.S. automobile sales market. Keyword analysis, topic modeling, and the multiple regression analysis were used to analyze the data. Findings - Using topic modeling, the author analyzed 2,998 responses of the U.S. automobile brands. As a result, Topic 1 (Competence), Topic 5 (Sincerity), and Topic 6 (Prestige) attributes had positive effects, and Topic 2 (Sophistication) had a negative effect on overall customer responses. Topic 4 (Conspicuousness) did not have any statistical effect on this research. Topic 1, Topic 5, and Topic 6 factors also show the importance of buying factors. This present study has contributed to identifying a new attribute, personality. These findings will help global automakers better understand the impacts of Topic 1, Topic 5, and Topic 6 on purchasing a car. Originality/value - Contrary to a traditional approach to brand analysis using questionnaire survey methods, this study analyzed customer reviews using text mining. This study is timely research since a big data analysis is employed in order to identify direct responses to customers in the future.

• Journal of the Computational Structural Engineering Institute of Korea
• /
• 제29권5호
• /
• pp.447-454
• /
• 2016

In the meantime, looking at the present status of how to estimationte the quantity of rebar based on 3D BIM getting the limelight in these days, commercial BIM tools provide rebar modeling functions however it takes a vast amount of modeling time for modeling of rebar in use of that function hence there is no BIM software at present for practical use. Therefore, in this study, we organized and presented a practical rebar quantity estimationtion process in BIM-based design work-site and intended to develop a program named Rebar Automatic Arrangement Program - hereinafter called RAAP - which enables automatic rebar arrangement based on much more precise cross-sectional information of bars in column, beam, slab and wall than the one from existing 2D method under the conditions without any cross-sectional information in the initial design phase. In addition, we intended to establish rebar quantity estimationtion process in the initial design phase through interworking of modeling & quantity estimationtion functions in consideration of joint, anchoring length of BuilderHUB as a BIM software with RAAP. The results from this study are practical in developing a technology that is able to estimationte quantity with more improved reliability than the one from existing 2D-based methods with less effort when the quantity of framework is estimationted in the uncompleted state of cross-sectional design for structural members in the initial design phase of a construction project. And it is expected that it could be utilized as a basic study from which a reasonable quantity estimationtion program can be established in the initial design phase.

• Computers and Concrete
• /
• 제5권3호
• /
• pp.175-194
• /
• 2008

Increasingly numerical (finite element) modeling of concrete hinges on our ability to develop a representative volume element with all its heterogeneity properly discretized. Yet, despite all the sophistication of the ensuing numerical models, the initial discretization has been for the most part simplistic. Whenever the heterogeneity of the concrete is to be accounted for, a mesh is often manually crafted through the arbitrary inclusion of the particles (aggregates and/or voids) in an ad-hoc manner. This paper develops a mathematical strategy to precisely address this limitation. Algorithms for the random generation and placement of elliptical (2D) or ellipsoid (3D) inclusions, with possibly radiating cracks, in a virtual concrete model are presented. Collision detection algorithms are extensively used.

• Journal of Microbiology and Biotechnology
• /
• 제22권6호
• /
• pp.788-792
• /
• 2012

We report the computational structural simulation of the Cry1Ab19 toxin molecule from B. thuringiensis BtX-2 based on the structure of Cry1Aa1 deduced by x-ray diffraction. Validation results showed that 93.5% of modeled residues are folded in a favorable orientation with a total energy Z-score of -8.32, and the constructed model has an RMSD of only $1.13{\AA}$. The major differences in the presented model are longer loop lengths and shortened sheet components. The overall result supports the hierarchical three-domain structural hypothesis of Cry toxins and will help in better understanding the structural variation within the Cry toxin family along with facilitating the design of domain-swapping experiments aimed at improving the toxicity of native toxins.

• Proceedings of the Korea Water Resources Association Conference
• /
• 한국수자원학회 2005년도 학술발표회 논문집
• /
• pp.1184-1188
• /
• 2005

The impacts of turbidity flow induced by summer rainfall events on water supply, aquatic ecosystems, and socioeconomics are significant and major concerns in most of reservoirs operations. As a decision support tool, the real-time turbidity flow monitoring and modeling system RTMMS is under development using a laterally integrated two-dimensional (2D) hydrodynamic and water quality model. The objectives of this paper is to present the preliminary field observation results on the characteristics of rainfall-induced turbidity flows and their density flow regimes, and the model performance in replicating the fate and transport of turbidity plume in a reservoir. The rainfall-induced turbidity flows caused significant drop of river water temperature by 5 to $10^{\circ}C$ and resulted in density differences of 1.2 to $2.6kg/m^3$ between inflow water and ambient reservoir water, which consequently led development of density flows such as plunge flow and interflow in the reservoir. The 2D model was set up for the reservoir. and applied to simulate the temperature stratification, density flow regimes, and temporal and spatial turbidity distributions during flood season of 2004 After intensive refinements on grid resolutions , the model showed efficient and satisfactory performance in simulating the observed reservoir thermal stratification and turbidity profiles that all are essentially required to enhance the performance of RTMMS.

• Anatomy and Cell Biology
• /
• 제57권2호
• /
• pp.172-182
• /
• 2024

This study aimed to evaluate the superficial anatomy, kinesiology, and functions of the hand to reveal its morphometry and apply the findings in various fields such as prosthetic hand and protective hand support product design. We examined 51 young adults (32 females, 19 males) aged between 18-30. Hand photographs were taken, and measurements were conducted using ImageJ software. Pearson correlation analysis was performed to determine the relationship between personal information and the parameters. The results of the measurements showed the average lengths of finger segments: thumb (49.5±5.5 mm), index finger (63.9±4.1 mm), middle finger (70.7±5.2 mm), ring finger (65.5±4.8 mm), and little finger (53.3±4.3 mm). Both females and males, the left index finger was measured longer than the right index finger. The right ring finger was found to be longer than the left in both sexes. Additionally, length differences between fingers in extended and maximally adducted positions were determined: thumb-index finger (56.1±6.2 mm), index-middle finger (10.7±4.1 mm), middle-ring finger (10.8±1.4 mm), and ring-little finger (25.6±2.7 mm). Other findings included the average radial natural angle (56.4°±10.5°), ulnar natural angle (23.4°±7.1°), radial deviation angle (65.2°±8.2°), ulnar deviation angle (51.2°±9.6°), and grasping/gripping angle (49.1°±5.8°). The average angles between fingers in maximum abduction positions were also measured: thumb-index finger (53.4°±6.5°), index-middle finger (17.2°±2.6°), middle-ring finger (14.3°±2.3°), and ring-little finger (32.1°±7.0°). The study examined the variability in the positioning of proximal interphalangeal joints during maximum metacarpophalangeal and proximal interphalangeal flexion, coinciding with maximum distal interphalangeal extension movements. The focal points of our observations were the asymmetrical and symmetrical arches formed by these joints. This study provides valuable hand parameters in young adults, which can be utilized in various applications such as prosthetic design, ergonomic product development, and hand-related research. The results highlight the significance of considering individual factors when assessing hand morphology and function.

• The KIPS Transactions:PartD
• /
• 제15D권5호
• /
• pp.647-658
• /
• 2008

Customers' requirements written in a natural language are rewritten to modeling language in development phases. In many cases, those who participate in development cannot understand requirements written in modeling language. This paper proposes the translation technique from the requirement model which is written by REED(REquirement EDitor) tool into a natural language in order to help for the customer understanding requirement model. This technique consists of three phases: $1^{st}$ phase is generating the IORT(Input-Output Relation Tree), $2^{nd}$ phase is generating the RTT(Requirement Translation Tree), $3^{rd}$ phase is translating into a natural language.