• Journal of the Korean Society of Propulsion Engineers
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• v.22 no.2
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• pp.66-73
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• 2018

A computational fluid dynamics simulation of pyrotechnic material combustion inside a cylindrical closed vessel was carried out using the Eulerian-Lagrangian method. The 5th order upwind WENO scheme and the improved delayed detached eddy turbulence model were implemented to capture shock waves. The flow structure was analyzed inside the cylindrical vessel with a pressure sensor installed at the side wall center. The analysis revealed that the pressure oscillated because of the shock wave vibration. Additionally, the simulation results with four different sensor tab depths implied that, inside the sensor tab, eddies were generated by the excessively large gap between the sensor diaphragm and the side wall. These eddies caused irregularity to the measured time-pressure curve, which is an undesirable characteristic.

• Journal of the Korean Geotechnical Society
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• v.35 no.7
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• pp.5-14
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• 2019

In this study, a prototype abutment was constructed to establish a safety assessment technique of pier and a series of non-destructive tests using impact load. The surcharge load was loaded from 0 tonf to 2.5 tonf on the prototype abutment, and maximum surcharge load was up to 25 tonf. To analyze the behavior of the piers according to the direction of impact, a total of three types of analysis were performed: the direction of the pier, the direction perpendicular to the pier, and the outer direction of the pier. The height of the impact was also tested at each top and bottom. The measuring instrument used an accelerometer to measure the acceleration response when impacted. Based on the series of experimental results, specific values were calculated according to the direction of an impact and the surcharge load using the Fast Fourier Transform (FFT). In addition, the phase difference was used to analyze the pier from the primary 1st mode to the 4th mode.

• Journal of Ginseng Research
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• v.43 no.4
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• pp.618-624
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• 2019

Background: Ginsenoside Re (Re) is one of the major components of Panax ginseng Meyer. Ginsenoside $Rk_3$ ($Rk_3$) is a secondary metabolite of Re. The aim of this study was to investigate and compare the effects and underlying mechanisms of Re and $Rk_3$ on cyclophosphamide-induced myelosuppression. Methods: The mice myelosuppression model was established by intraperitoneal (i.p.) injection of cyclophosphamide. Peripheral blood cells, bone marrow nucleated cells, and colony yield of hematopoietic progenitor cells in vitro were counted. The levels of erythropoietin, thrombopoietin, and granulocyte macrophage colony-stimulating factor in plasma were measured by enzyme-linked immunosorbent assay. Bone marrow cell cycle was performed by flow cytometry. The expression of apoptotic protein bcl-2, bax, and caspase-3 was detected by Western blotting. Results: Both Re and $Rk_3$ could improve peripheral blood cells, bone marrow nucleated cell counts, thymus index, and spleen index. Furthermore, they could enhance the yield of colonies cultured in vitro and make the levels of granulocyte macrophage colony-stimulating factor, erythropoietin, and thrombopoietin normal, reduce the ratio of $G_0/G_1$ phase cells, and increase the proliferation index. Finally, Re and $Rk_3$ could upregulate the expression of bcl-2, whereas they could downregulate the expression of bax and caspase-3. Conclusion: Re and $Rk_3$ could improve the hematopoietic function of myelosuppressed mice. The effect of $Rk_3$ was superior to that of Re at any dose. Regulating the levels of cytokines, promoting cells enter the normal cell cycle, regulating the balance of bcl-2/bax, and inhibiting the expression of caspase-3 may be the effects of Re and $Rk_3$ on myelosuppression.

• Nuclear Engineering and Technology
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• v.54 no.10
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• pp.3855-3863
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• 2022

An evaluation of the radiation shielding performance of high-Z-particle-loaded polylactic acid (PLA) composite materials was pursued. Specimens were produced via fused deposition modeling (FDM) using copper-PLA, steel-PLA, and BaSO₄-PLA composite filaments containing 82.7, 75.2, and 44.6 wt% particulate phase contents, respectively, and were tested under broad-band flash x-ray conditions at the Sandia National Laboratories HERMES III facility. The experimental results for the mass attenuation coefficients of the composites were found to be in good agreement with GEANT4 simulations carried out using the same exposure conditions and an atomistic mixture as a model for the composite materials. Further simulation studies, focusing on the Cu-PLA composite system, were used to explore a shield design parameter space (in this case, defined by Cu-particle loading and shield areal density) to assess performance under both high-energy photon and electron fluxes over an incident energy range of 0.5-15 MeV. Based on these results, a method is proposed that can assist in the visualization and isolation of shield parameter coordinate sets that optimize performance under targeted radiation characteristics (type, energy). For electron flux shielding, an empirical relationship was found between areal density (AD), electron energy (E), composition and performance. In cases where ${\frac{E}{AD}}{\geq}2MeV{\bullet}cm{\bullet}g^{-1}$, a shield composed of >85 wt% Cu results in optimal performance. In contrast, a shield composed of <10 wt% Cu is anticipated to perform best against electron irradiation when ${\frac{E}{AD}}<2MeV{\bullet}cm{\bullet}g^{-1}$.

• Journal of Gastric Cancer
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• v.23 no.2
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• pp.289-302
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• 2023

Purpose: Liver metastasis (LM) is reported in approximately 40% of patients with advanced/metastatic gastric/gastroesophageal junction adenocarcinoma (metastatic esophagogastric adenocarcinoma; mGEA) and is associated with a worse prognosis. This post-hoc analysis from the RAINBOW trial reported the efficacy, safety, and biomarker outcomes of ramucirumab and paclitaxel combination treatment (RAM+PAC) in patients with (LM+) and without (LM-) LM at baseline. Materials and Methods: Patients (n=665) were randomly assigned on a 1:1 basis to receive either RAM+PAC (LM+: 150, LM-: 180) or placebo and paclitaxel (PL+PAC) (LM+: 138, LM-: 197). The overall survival (OS) and progression-free survival (PFS) were evaluated using stratified Kaplan-Meier and Cox regression models. The correlation of dichotomized biomarkers (VEGF-C, D; VEGFR-1,2) with efficacy in the LM+ versus LM- subgroups was analyzed using the Cox regression model with reported interaction P-values. Results: The presence of LM was associated with earlier progression than those without LM, particularly in patients receiving PL+PAC (hazard ratio [HR], 1.68). RAM+PAC treatment improved OS and PFS irrespective of LM status but showed greater improvement in LM+ than that in LM- (OS HR, 0.71 [LM+] vs. 0.88 [LM-]; PFS HR, 0.47 [LM+] vs. 0.76 [LM-]). Treatment-emergent adverse events were similar between patients with and without LM. No predictive relationship was observed between biomarker levels (VEGF-C, D; VEGFR-1,2) and efficacy outcome (OS, PFS) (all interaction P-values >0.05). Conclusions: RAM provided a significant benefit, irrespective of LM status; however, its effect was numerically stronger in patients with LM. Therefore, RAM+PAC is a clinically meaningful therapeutic option for patients with mGEA and LM.

• Journal of The Korean Astronomical Society
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• v.56 no.2
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• pp.293-299
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• 2023

The Wide-Angle Polarimetric Camera (PolCam) is installed on the Korea's lunar orbiter, Danuri, which launched on August 5, 2022. The mission objectives of PolCam are to construct photometric maps at a wavelength of 336 nm and polarization maps at 461 and 748 nm, with a phase angle range of 0°-135° and a spatial resolution of less than 100 m. PolCam is an imager using the push-broom method and has two cameras, Cam 1 and Cam 2, with a viewing angle of 45° to the right and left of the spacecraft's direction of orbit. We conducted performance tests in a laboratory setting before installing PolCam's flight model on the spacecraft. We analyzed the CCD's dark current, flat-field frame, spot size, and light flux. The dark current was obtained during thermal / vacuum test with various temperatures and the flat-field frame data was also obtained with an integrating sphere and tungsten light bulb. We describe the calibration method and results in this study.

• Advances in nano research
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• v.16 no.5
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• pp.501-508
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• 2024

In this study, nanotoxicity tests were made by exposure of Artemia salina to copper (Cu 60-80 nm) and copper oxide (CuO 40 nm) nanoparticles (NPs) at different concentrations (0.2, 1, 5, 10, 25, and 50 mg/L). The LC₅₀ value of Cu (60-80 nm) NPs on the A. salina individuals at the beginning (0), 24^th, 48^th and 72^nd hours and elimination period was 52.37 mg/L while the LC₅₀ value of CuO (40 nm) NPs was 55.39 mg/L. The results of UV-Vis absorbance values showed that all statistical data revealed that maximum effect was observed between 24-30 hours and 25 ppm absorbance concentration was more effective. The multiple R, correlation coefficient (R2) and adjusted R2 values of Cu NP for the suitable Quadratic model were, respectively; 92.96 %, 86.42 % and 76.71 % while they are 98.31 %, 96.64 % and 94.25 % for CuO NP. Also, the data, was indicated effect size significantly changed based on the type and size of NP. Considering the microscope results, it was clearly noticed that A. salina organisms took the NPs in to their body. The accumulation in the gut of A. salina was observed and the images were taken with phase contrast microscope for both of NPs. The highest decrease for survival rates of A. salina individuals exposed to Cu NP was observed in the 10 ppm concentration (43.47 %) and in the 5 ppm concentration (46.20 %) for CuO NP. The results revealed that Cu and CuO NPS showed different toxic effects and that Cu NPs were more toxic than CuO.

• Structural Monitoring and Maintenance
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• v.11 no.2
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• pp.101-126
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• 2024

To avoid irregularities in buildings, design codes worldwide have introduced detailed guidelines for their check and rectification. However, the criteria used to define and identify each of the plan and vertical irregularities are specific and may vary between codes of different countries, thus making their implementation difficult. This short communication paper proposes a novel approach for quantifying different types of structural irregularities using a common parameter named as unified identification factor, which is exclusively defined for the columns based on their axial loads and tributary areas. The calculation of the identification factor is demonstrated through the analysis of rectangular and circular reinforced concrete models using ETABS v18.0.2, which are further modified to generate plan irregular (torsional irregularity, cut-out in floor slab and non-parallel lateral force system) and vertical irregular (mass irregularity, vertical geometric irregularity and floating columns) models. The identification factor is calculated for all the columns of a building and the range within which the value lies is identified. The results indicate that the range will be very wide for an irregular building when compared to that with a regular configuration, thus implying a strong correlation of the identification factor with the structural irregularity. Further, the identification factor is compared for different columns within a floor and between floors for each building model. The findings suggest that the value will be abnormally high or low for a column in the vicinity of an irregularity. The proposed factor could thus be used in the preliminary structural design phase, so as to eliminate the complications that might arise due to the geometry of the structure when subjected to lateral loads. The unified approach could also be incorporated in future revisions of codes, as a replacement for the numerous criteria currently used for classifying different types of irregularities.

• Asia-Pacific Journal of Business Venturing and Entrepreneurship
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• v.9 no.1
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• pp.119-132
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• 2014

This study analyzed the failure prediction model of the firms listed on the KOSDAQ by considering whether there are embezzlement, malpractice and the largest shareholder changes or not. This study composed a total of 166 firms by using two-paired sampling method. For sample of failed firm, 83 manufacturing firms which delisted on KOSDAQ market for 4 years from 2009 to 2012 are selected. For sample of normal firm, 83 firms (with same item or same business as failed firm) that are listed on KOSDAQ market and perform normal business activities during the same period (from 2009 to 2012) are selected. This study selected 80 financial ratios for 5 years immediately preceding from delisting of sample firm above and conducted T-test to derive 19 of them which emerged for five consecutive years among significant variables and used forward selection to estimate logistic regression model. While the precedent studies only analyzed the data of three years immediately preceding the delisting, this study analyzes data of five years immediately preceding the delisting. This study is distinct from existing previous studies that it researches which significant financial characteristic influences the insolvency from the initial phase of insolvent firm with time lag and it also empirically analyzes the usefulness of data by building a firm's fail prediction model which considered embezzlement/malpractice and the largest shareholder changes as dummy variable(non-financial characteristics). The accuracy of classification of the prediction model with dummy variable appeared 95.2% in year T-1, 88.0% in year T-2, 81.3% in year T-3, 79.5% in year T-4, and 74.7% in year T-5. It increased as year of delisting approaches and showed generally higher the accuracy of classification than the results of existing previous studies. This study expects to reduce the damage of not only the firm but also investors, financial institutions and other stakeholders by finding the firm with high potential to fail in advance.

• Korean Journal of Optics and Photonics
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• v.14 no.1
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• pp.23-32
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• 2003

The spectroe-ellipsometric constant $\Delta$, Ψ and the ellipsometric growth curves at the wavelength of 632.8 nm are collected. These are critically examined to find out the optimum growth condition of phase change $Ge_2Sb_2Te_5(GST)$ thin films as an optical recording medium. GST films are prepared using DC magnetron sputtering technique, under the selected experimental conditions of Ar gas pressure (5 mTorr, 7 mTorr and 10 mTorr), DC power of sputtering gun (15 W, 30 W and 45 W), and substrate temperature (from room temperature to 18$0^{\circ}C$). Based on the three film model, the density distribution of deposited GST films are obtained versus Ar gas pressure and DC power by analyzing spectro-ellipsometric data. The calculated evolution curves at the wavelength of 632.8 nm, are fit into the in situ observed ones to get information about the evolution of density distribution during film growth. The density distribution showed different evolution curves depending on deposition conditions. The GST films fabricated at DC power of 30 W or 45 W, and at Ar gas pressure of 7 mTorr turned out to be the most homogeneous one out of those prepared at room temperature, even though the maximum density difference between the dense region and the dilute region of the GST film was still significant (~50%). Finally, in order to find the optimum growth condition of homogeneous GST thin films, the substrate temperature is varied while Ar gas pressure is fixed at 7 mTorr and DC power at 30 W and 45 W respectively. A monotonic decrease of void fraction except for a slight increase at 18$0^{\circ}C$ is observed as the substrate temperature increases. Decrease of void fraction indicates an increase of film density and hence an improvement of film homogeneity. The optimum condition of the most homogeneous GST film growth turned out to be 7 mTorr of Ar gas pressure, 15$0^{\circ}C$ of substrate temperature. and 45 W of DC power. The microscopic images obtained using scanning electron microscope, of the samples prepared at the optimum growth condition, confirmed this conclusion. It is believed that the fabrication of homogeneous GST films will be quite beneficial to provide a reliable optical recording medium compatible with repeated write/erase cycles.