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Screening of Vietnamese Herbal Medicines with Inhibitory Effect on Aldose Reductase (XI) (베트남 약용식물 추출물의 알도즈 환원 효소 억제 효능 검색(XI))

  • Choi, So-Jin;Kim, Young Sook;Kim, Joo Hwan;Kim, Jin Sook
    • Korean Journal of Pharmacognosy
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    • v.45 no.4
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    • pp.366-375
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    • 2014
  • Aldose reductase (AR) has been indicated the critical enzyme of the polyol pathway in the development of the diabetic complications. In this study, 119 Vietnamese herbal medicines have been investigated for inhibitory activities on AR. Among them, 7 herbal medicines, Synedrella nodiflora (stems and leaves), Combretum sundaicum (stems and leaves), Argyreia acuta (stems and leaves), Platea latifolia (whole plants), Linociera sangda (whole plants), Rhaphiolepis indica (whole plants), Harrisonia perforata (stems and leaves) and 2 fractions from Harrisonia perforata (stems and leaves) with EtOAc and BuOH, exhibited a significant inhibitory activity against AR. Particularly, S. nodiflora, A. acuta and H. perforata (stems and leaves) showed 1.0-1.8 times more potent inhibitory activity than the positive control, 3,3-tetramethyleneglutaric acid (TMG).

Antioxidative and Anti-Inflammatory Activities of Salvia plebeia R. Br Extracts (배암차즈기(Salvia plebeia R. Br.)의 항산화 활성 및 항염증효과)

  • Lee, Yeong-Ye;Kang, Soon Ah
    • The Korean Journal of Food And Nutrition
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    • v.33 no.5
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    • pp.483-492
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    • 2020
  • This study provides data to explore functional medicinal food materials that can prevent adult diseases, and verified antioxidant and anti-inflammatory of each solvent fraction of the methanol extract of Salvia plebeia R. Br. in Korea. In the analysis of total phenol content, DPPH radical scavenging ability, and FRAP reduction ability as indicators of antioxidant activity, the methanol fraction and ethyl acetate fraction of the Salvia plebeia R. Br. group showed high antioxidant activity. Ethyl acetate fraction of Salvia plebeia R. Br. methanol extract also showed excellent antioxidative activity as compared with BHT. In the mouse macrophage line Raw 264.7 cells, the NO production ability by LPS treatment was significantly increased in the LPS treatment group compared to the untreated group. In inflammatory reactions induced by LPS treatment in Raw 264.7 cells, inflammatory cytokines (TNF-α, PGE2, IL-1β) and NO production were decreased in the EtOAc fraction and MeOH fraction of the methanol extract of Salvia plebeia R. Br. compared to the case of LPS treatment alone. The anti-inflammatory effect was proved by significantly inhibiting the production of inflammatory cytokines. The present results suggest that Salvia plebeia R. Br. supplementation is beneficial for the suppression of antioxidant and anti-inflammation.

Sm-Nd Isotopic Study of the Ogcheon Amphibolite, Korea: Priliminary Report (옥천 각섬암의 Sm-Nd 동위원소연구 : 예비보고서)

  • Kwon, Sung-Tack;Lan, Ching-Ying
    • Economic and Environmental Geology
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    • v.24 no.3
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    • pp.277-285
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    • 1991
  • We applied Sm-Nd isotopic system to so-called amphibolites occurring within the Ogcheon group to provide constraints on the age of the metasedimentary rocks and to characterize tectonic environment of basaltic magmatism. An internal mineral isochron age of $677{\pm}91Ma({\sigma})$ was obtained from a coarse-grained, intrusive, amphibolite near Mungyeong. Considering previous studies on the age of the Ogcheon group, we interpret that the isochron represents either early metamorphic or emplacement age. The depositional age of the metasedimentary rocks intruded by the amphibolite would be prior to late Proterozoic. The present study and Cambro-Ordovician fossil evidences of previous workers suggest that both Precambrian and Phanerozoic rocks are present in the Ogcheon group. Positive ${\varepsilon}$ Nd values(+2.4 to +3.5) of four whole rocks indicate mantle origin for the amphibolite. These isotopic data, along with published immobile trace element data of Cluzel et al.(1989), strongly suggest that parental rocks of the amphibolite formed in an intraplate environment rather than in island arc or midocean ridge. The age and tectonic environment of amphibolites in the Ogcheon belt suggest that the basaltic magmatism may be related to the late Proterozoic break-up of a presumed supercontinent, but not to the Triassic(?) collision between North and South China continents.

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Differences in Preschool Children's Perceptions of Artificial Intelligence according to their Experiences with AI Robots in daycare centers (어린이집내 인공지능 로봇 사용경험 여부에 따른 유아의 인공지능 인식 차이)

  • Boram, Lee;Soojung, Kim
    • Korean Journal of Childcare and Education
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    • v.19 no.2
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    • pp.43-59
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    • 2023
  • Objective: This study investigated the differences in preschool children's perceptions of artificial intelligence (AI) and their distribution by latent profiles according to their experience with AI robots in daycare centers. Methods: The participants included 119 five-year-old children, 52 of whom had experience with AI robots in daycare centers and 67 of whom did not. Children's perceptions of AI were measured using the Godspeed scale from Bartneck et al.(2009). Data were analyzed using a t-test, latent profile analysis, and chi-square test. Results: The results showed that compared to the inexperienced group, the experienced group reported lower levels of animacy and perceived intelligence of AI robots, indicating higher levels of AI knowledge and understanding. In addition, the experienced group had a higher probability of belonging to the 'machine recognition' type than 'organism recognition' type, although the difference was not statistically significant. Conclusion/Implications: The findings suggest that experience with AI robots in daycare centers can improve children's AI knowledge and understanding. To further enhance this effect, it is necessary to increase the number of robots put into classrooms, and to consider various teaching media that reflect children's preferences.

Two-round ID-based Group Key Agreement Fitted for Pay-TV System (유료 방송 시스템에 적합한 ID기반의 2 라운드 그룹키 동의 프로토콜)

  • Kim Hyunjue;Nam Junghyun;Kim Seungjoo;Won Dongho
    • Journal of the Korea Institute of Information Security & Cryptology
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    • v.15 no.1
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    • pp.41-55
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    • 2005
  • A group key agreement protocol allows a group of user to share a key which may later be used to achieve certain cryptographic goals. In this paper, we propose a new scalable two-round ID-based group key agreement protocol which would be well fit to a Pay-TV system, additionally. to the fields of internet stock quotes, audio and music deliveries, software updates and the like. Our protocol improves the three round poop key agreement protocol of Nam et al., resulting in upgrading the computational efficiency by using the batch verification technique in pairing-based cryptography. Also our protocol simplifies the key agreement procedures by utilizing ID-based system. We prove the security of our protocol under the Computational Diffie-Hellman assumption and the Bilinear Decisional Diffie-Hellman assumption. Also we analyze its efficiency.

A Study of Halo-Galaxy Correspondence from the Horizon Run 4

  • Park, Jisook;Kim, Juhan;Park, Changbom;Kim, Sungsoo S.
    • The Bulletin of The Korean Astronomical Society
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    • v.40 no.2
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    • pp.50.2-50.2
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    • 2015
  • The Horizon Run 4 is a huge cosmological simulation intended for the study of evolution of dark matter halos in a side of volume of 3150 h-1 Mpc. Using the halo merger trees of most bound particles, we test various models on the survivals of satellites in clusters and will compare them with observed satellite galaxies in a one-to-one correspondence model. We estimate the abundances of central and satellite subhalos, and compare them with the SDSS main-galaxy group catalogue provided by Tempel et al. (2014). Based on these comparisons we will study the mass-to-light relations, environmental effects on morphology and luminosity function, halo occupations in clusters, and nonlinear dynamics of clusters of galaxies.

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The Globular Cluster NGC 6273: Another Candidate for the Milky Way Building Blocks

  • Lim, Dongwook;Han, Sang-Il;Lee, Young-Wook
    • The Bulletin of The Korean Astronomical Society
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    • v.40 no.2
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    • pp.40.2-40.2
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    • 2015
  • In our recent investigation (Lim et al. 2015), we have shown that the combination of narrow-band Ca photometry and low-resolution spectroscopy can effectively search for globular clusters (GCs) with supernovae (SNe) enrichments. We apply this technique to the metal-poor bulge GC NGC 6273 and find two distinct subpopulations having different light and heavy element abundances. Our result suggests that NGC 6273 was massive enough to retain SNe ejecta, which would place this cluster in the growing group of GCs with Galactic building block characteristics, such as ${\omega}$ Centauri and M22.

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Mosaic Disease of Black Locust on Rodinia pseudo-acacja L.(Par. 2) (아까시아나무 모자익병에 관한 연구 2)

  • 김종진
    • Korean Journal of Microbiology
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    • v.3 no.2
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    • pp.22-26
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    • 1965
  • In order to investigate the host range of the mosaic disease of black locust in the Chunchon area, the sap of the mosaic-diseased leaves of black locust itself and the cowpea leaves infected with the above mentioned sap, were inoculated to 53 species of plants belong to 12 families. As to the result, no difference in infection was found as related to the virus sources, and the infection was recognized in 4 species of the family Chenopodiaceae and 8 species of the family Leguminosae. The plants recognized as hosts are as follows: the plants which showed local infection are Chenopodium album, Ch. ambrosioides, Ch. quinoa; the plants which showed systemic infection are Chenopodium amaranticolor, Phaseolus vulgaris, Robinia pseudo-acacia, Vigna sinensis; and Astragalus sinicus, Melilotus indicus, Phaseolus angularis, Pisum sativum and Vicia faba were recognized as carriers. Through investigating its host ranges and symptoms, this mosaic virus of black locust seems not to be regarded as the group of the black locust mosaic virus in southeastern Europe reported by Milinko et al (1961). And, too, it is thought hardly to exist in combination with the cowpea mosaic virus. It appears, therefore, that this mosaic virus was confined to that of black locust.

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Research on Depression in Married Immigrant Women: Trends in Korea (여성결혼이민자의 우울에 관한 연구 동향)

  • Byun, Seong Won
    • Journal of Korean Academy of Rural Health Nursing
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    • v.6 no.2
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    • pp.69-77
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    • 2011
  • Purpose: This study was done to identify the current status of research on depression in married immigrant women and to suggest directions for future nursing research. Method: Sixteen articles for the period between 2001 and 2010 were selected by key words such as "Married Immigrant Women" and "Depression" from the databases (RISS4U et al). Results: Twelve of the research reports were related to correlations and 4 were related to interventions. Depression level was measured using BDI or CES-D. Depression levels were as follows: 20-30% reported major depression and less than 10%, severe depression. Factors which influenced depression included: socio-demographic factors, and family, economic, psychological and situational characteristics. Psychological treatment prevailed in the intervention research, for example, art therapy, and horticultural therapy. In 2 papers significant improvement in the state of depression among participants in the intervention group were reported. Conclusion: The next phase of nursing research related to married immigrant women is to reconsider the importance of the concept of depression to reexamine research methods and directions.

Magnetic Anisotropy Energy Distribution and Magnetization of CoPt Nanoparticles Encaged in Protein Shell

  • Lee, T.H.;Suh, B.J.;Jang, Z.H.
    • Journal of Magnetics
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    • v.22 no.1
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    • pp.1-6
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    • 2017
  • Magnetic properties of CoPt nanoparticles (average size = 2.1 nm) encapsulated in synthesized protein shell have been investigated with SQUID (Superconducting Quantum Interference Device) magnetometer and analyzed by the recently developed non-equilibrium magnetization calculation by our group [T. H. Lee et al., Phys. Rev. B 90, 184411 (2014)]. Field dependence of magnetization measured at 2 K was successfully analyzed with modified Langevin function. In addition, small hysteresis loops having the coercive field of 890 Oe were observed at 2 K. Temperature dependence of magnetization has been measured with zero field cooled (ZFC) and field cooled (FC) protocol with slightly modified sequence in accordance with non-equilibrium magnetization calculation. The analysis on the M vs. T data revealed that the anisotropy energy barrier distribution is found to be very different from the log-normal distribution found in a size distribution. Zero temperature coercive field and Bloch coefficient have also been extracted from the analysis and the validity of those values is checked.