• 대한소화기학회지
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• 제72권6호
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• pp.318-321
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• 2018

Primary neuroendocrine tumors originating from the extrahepatic bile duct are rare. Among these tumors, large cell neuroendocrine carcinomas (NECs) are extremely rare. A 59-year-old man was admitted to Sanggye Paik Hospital with jaundice that started 10 days previously. He had a history of laparoscopic cholecystectomy, which he had undergone 12 years previously due to chronic calculous cholecystitis. Laboratory data showed abnormally elevated levels of total bilirubin 15.3 mg/dL (normal 0.2-1.2 mg/dL), AST 200 IU (normal 0-40 IU), ALT 390 IU (normal 0-40 IU), and gamma-glutamyl transferase 1,288 U/L (normal 0-60 U/L). Serum CEA was normal, but CA 19-9 was elevated 5,863 U/mL (normal 0-37 U/mL). Abdominal CT revealed a 4.5 cm sized mass involving the common bile duct and liver hilum and dilatation of both intrahepatic ducts. Percutaneous transhepatic drainage in the left hepatic duct was performed for preoperative biliary drainage. The patient underwent radical common bile duct and Roux-en-Y hepaticojejunostomy for histopathological diagnosis and surgical excision. On histopathological examination, the tumor exhibited large cell NEC (mitotic index >20/10 high-power field, Ki-67 index >20%, CD56 [+], synaptophysin [+], chromogranin [+]). Adjuvant concurrent chemotherapy and radiotherapy were started because the tumor had invaded the proximal resection margin. No recurrence was detected at 10 months by follow-up CT.

• 한국전자파학회논문지
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• 제30권3호
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• pp.223-228
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• 2019

본 논문에서는 국내 해안지역인 제주도-진도에서의 실제 기상데이터와 지형정보를 이용하여 각 대기 굴절 기울기에 따른 전파 경로손실을 분석하고, 실측결과와 비교하여 결과가 유사함을 확인하였다. 시뮬레이션 결과를 토대로 하여 트랩의 위치와 두께에 따라 덕트맵을 구성하고, 송 수신 안테나의 고도에 따라 영역을 분할하여, 제주 해안지역에서 자주 발생하는 덕트에 대해 분석을 진행하였다. 이러한 덕트맵의 유효성을 확인하기 위해 실제 2018년 5월의 기상데이터 중 대표적인 2개 날짜의 데이터를 선택하여 덕트맵 상에서 해당되는 위치를 확인하고, 전파 경로손실을 계산한 후, 실측데이터와 비교하였다. 시뮬레이션을 통해 얻어진 경로손실 값은 각각 167.7 dB, 192.3 dB로서 측정 결과 164.4 dB, 194.9 dB와 유사함을 확인할 수 있다.

• 대한기계학회논문집B
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• 제28권4호
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• pp.441-448
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• 2004

A numerical study was conducted to show the effect of aspect ratio on the analogy of the developing laminar flows between in orthogonally rotating straight duct and in a stationary curved duct of rectangular cross-section. In order. to clarify the similarity of two nows, dimensionless parameters (equation omitted) and Rossby Ro= $w_{m}$$\Omega$ $d_{h}$, in a rotating straight duct were used as a set corresponding to Dean number, (equation omitted), and curvature ratio, λ=R/ $d_{h}$, in a stationary curved duct. Four. different aspect ratios A=0.25, 0.5, 2 and 4 were considered. Under the condition that the magnitudes of Ro and λ were large enough to satisfy the 'asymptotic invariance property' and the aspect ratio was larger than 1, there were strong quantitative similarities between the two flows such as flow patterns, friction factors, and maximum axial velocity magnitudes fur the same values of $K_{LR}$ and $K_{LC}$ . On the other hand, as the aspect ratio decreased below 1 (A=0.25 and 0.5), the difference of the secondary flow intensity between these two flows was enhanced and therefore the analogy of two flows was not so evident as that of the larger aspect ratio (A=2 and 4). 4).nd 4).

• 대한기계학회논문집B
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• 제22권9호
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• pp.1325-1334
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• 1998

The objectives of the present study are to develop a systematic method rather than a conventional trial-and-error method for an optimal shape design using a mathematical theory, and to apply it to engineering problems. In the present study, an optimal condition for a minimum pressure loss in a two-dimensional curved duct flow is derived and then an optimal shape of the curved duct is designed from the optimal condition. In the design procedure, one needs to solve the adjoint Navier-Stokes equations which are derived from the Navier-Stokes equations and the cost function. Therefore, a computer code of solving both the Navier-Stokes and adjoint Navier-Stokes equations together with an automatic grid generation is developed. In a curved duct flow, flow separation occurs due to an adverse pressure gradient, resulting in an additional pressure loss. Optimal shapes of a curved duct are obtained at three different Reynolds numbers of 100, 300 and 800, respectively. In the optimally shaped curved ducts, the separation region does not exist or is significantly reduced, and thus the pressure loss along the curved duct is significantly reduced.

• 대한기계학회논문집B
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• 제29권10호
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• pp.1092-1100
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• 2005

In the present study, characteristics of steady state laminar flows of a straight duct connected to a 180$^{o}$ curved duct were examined in the entrance region through experimental and numerical analyses. For the analysis, the governing equations of laminar flows in the Cartesian coordinate system were applied. Flow characteristics such as velocity profiles and secondary flows were investigated numerically and experimentally in a square cross-sectional straight duct by the PIV system and a CFD code(STAR CD). For the PIV measurement, smoke particles produced from mosquito coils. The experimental data were obtained at 9 points dividing the test sections by 400 3m. Experimental and numerical results can be summarized as follows. 1) Reynolds number, Re was increased, dimensionless velocity profiles at the outer wall were increased due to the effect of the centrifugal force and secondary flows. 2) The intensity of a secondary flow became stronger at the inner wall rather than the outer wall regardless of Reynolds number. Especially, fluid dynamic phenomenon called conner impact were observed at dimensionless axial position, x/D$_{h}$=50.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2008년도 추계학술대회논문집
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• pp.497-502
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• 2008

In this paper, we studied on an attenuation effect of automobile exhaust noise according to the direction of secondary sound source in duct ANC system. Automobile exhaust noise was recorded at 800rpm. 3500rpm and 5000rpm of a diesel engine. Directions of loudspeaker(second sound source) can be exchanged to $30^{\circ}$, $90^{\circ}$ and $150^{\circ}$ against the primary noise flow by acrylic ducts to be made for experimentation. DSP board with TMS320C6416 chip of Texas Instrument Co used to control adaptive ANC system. This ANC system is based on the single-channel FxLMS algorithm. In experiment result, when the loud speaker direction was $150^{\circ}$, the attenuation effect showed largely. In case of $90^{\circ}$ duct, the noise was a little increased. In case of $30^{\circ}$ duct, the noise was a little increased or decreased according to the frequency range and the sound pressure(dB) of exhaust noise to comply with engine rpm.

• Applied Microscopy
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• 제26권3호
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• pp.305-313
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• 1996

Acinous gland cells (A, B, C, D and E-type cells) and duct cell (G-type cell) are observed in acinus and in duct of salivary gland of Korean Slug respectively by electron microscope. The type-A gland cells are numerous and are packed with medium electron dense granules (diameter, $3{\mu}m$) in cytoplasm. The circular shaped nucleolus and evenly developed chromatins are observed in the nucleus of type-B cell, and cytoplasm includes medium electron dense granules (diameter, $2.5X3.7{\mu}m$). The type-C gland cell has a round nucleus, and thin elongated-shaped heterochromatins are evenly distributed in the nucleoplasm and many net shaped endoplasmic reticulums and oval serous granules of middle electron density (diameter, $3.5X5{\mu}m$) fill the cytoplasm. The type-D gland cell is the largest and the most numerous of the gland cells consisting the salivary gland and heterochromatins in nucleus are well developed in the nucleoplasm. Most of granules (diameter, $0.8X2.5{\mu}m$) in cytoplasm are round, and look dark for the high electron density, and cytoplasm is filled with net-shaped endoplasmic reticulums. The type-E gland cells are rarely existent around the salivary gland, and the granules of those cells are irregular in shape and size and are vacuolized in cytoplasm. Intralobular salivary duct is composed of the high electron dense squamus endotheliums, while the other interlobular salivary duct is filled with irregular columnar epitheliums. The interlobular duct cell contains the high electron dense granules (size, $0.3{\sim}1.5{\mu}m$) in cytoplasm and those granules are secreted into cilia of salivary lumen.

• 대한기계학회논문집B
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• 제30권2호
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• pp.126-135
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• 2006

The pressure drop characteristics in a rotating two-pass duct with rib turbulators are investigated in the present study. The square duct has a hydraulic diameter $(D_h)$ of 26.7 mm, and $1.5mm{\times}1.5mm$ square $90^{\circ}-rib$ turbulators are attached on the leading and trailing walls. The pitch-to-rib height ratio (p/e) is 10. The distance between the tip of the divider and the outer wall of the duct is $1.0D_h$ and the width of divider wall is 6.0mm or $0.225D_h$. The Reynolds number (Re) based on the hydraulic diameter is kept constant at 10,000 to exclude the Reynolds effect, and the rotation number (Ro) is varied from 0.0 to 0.20. The pressure drop distribution, the friction factor and thermal performance are presented for the leading, trailing and the outer surfaces. It is found that the curvature of the $180^{\circ}$-turn produces Dean vortices that cause high pressure drop in the turn. The channel rotation results in pressure drop discrepancy between leading and trailing surfaces so that non-dimensional pressure drops are higher on the trailing surface in the first-pass and on the leading and side surfaces in the second-pass. In the turning region, Dean vortices shown in the stationary case transform into one large asymmetric vortex cell, and subsequent pressure drop characteristics also change. As the rotation number increases, the pressure drop discrepancy enlarges.

• Journal of Korean Society for Atmospheric Environment
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• 제15권E호
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• pp.17-28
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• 1999

Gas-liquid contact tests above a perforated-plate were conducted with air and water at flooding gas-flow conditions in order to study two-phase flow characteristics in a limestone-gypsum SO2 absorber. Gas layers were in the form of air pockets and confined to the limited areas around each duct pipe, while the remaining tary area were in the wet condition. The liquid above the tray was always in the flooded and even fluidized conditions at gas flows over the range studied, although vigorous bubbly or churn-turbulent two-phase regime was only observed in the immediate vicinity of the gas hole exit at low gas loads. The froth zone was extremely active to provide intimate contact between gas and liquid so that the necessary mass transfer operation can take place, which is the primary purpose of high-performance SO2 absorbers. Howefer, the absorber $\Delta$P was 250mmH2O for the initial water level at 150mm, which is an important issue to be resolved for economical operation of the SO2 absorber. It was seen in the liquid level-and gas flow-transient tests that changes in the absorber liquid inventory were much more pronounced for intimate gas-liquid contact than changes in the gas flow. Based on the 4- and 8-duct pipe test results, grouping the duct pipes near the center of the test tray seemed to promote better recirulation of liquid from gas-liquid contact zone back to the reaction tank so that the absorbed SO2 can be neutralized.

• 대한의생명과학회지
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• 제10권2호
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• pp.93-98
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• 2004

The effects of intravenously administered of high concentration of taurocholic acid (TCA) on $\alpha$-D- and $\beta$-D-mannosidase activities in rat liver lysosomes were studied. These liver lysosomal enzymes, and serum lysosomal $\alpha$-D- and $\beta$-D-mannosidase isozymes activities were determined in experimental rats with common bile duct ligation (CBDL). The liver lysosomal $\beta$-D-mannosidase activity as well as the serum lysosomal $\alpha$-D- and $\beta$-D-mannosidase isozymes activities were found to be significantly increased in the CBDL plus TCA injected group than in the control group such as CBDL alone group. However, the liver lysosomal $\alpha$-D-mannosidase activity was found to be significantly decreased in the CBDL plus TCA injected group. The above results suggest that TCA repress the biosynthesis of the lysosomal $\alpha$-D-mannosidase and induce the biosynthesis of the lysosomal $\beta$-D-mannosidase in the liver. And that the elevated serum lysosomal $\alpha$-D- and $\beta$-D-mannosidase isozymes activities are most likely due to increased hepatocyte membrane permeability caused by TCA mediated liver cell necrosis.