• Journal of the Korean association of regional geographers
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• v.10 no.2
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• pp.267-285
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• 2004

Globalization has been the buzzword during the past couple of decades, embroiling humankind into the inescapable maelstrom of homogenization. Some critics identify the globalization process undergoing in the realms of politics, economy, culture and ecology with Americanization which entails Neoconservatives' scheme to stretch out the hegemony of the United States. The top-down transcontinental movement, however, deems to confront localization or a reasoned resistance from the local driven by the spiritual attachment to places and, in that sense, regional identity. What is needed to cope with this complex circumstance of glocalization is to be acquainted with beth the global sense of the local and the localized sense of the global at once. For this, it seems indispensible to do justice to area studies. As far as American studies are concerned, this research field has so far been tainted by an overdose of politics, economics, business administration, law and sociology. Regional analysis which constitutes the reason d'etre of the discipline of geography has remained marginal to the political economic mainstream. It is the mounting concerns about America and enhanced research caliber that raises the regional geographical studies of America on the right track. Particularly, a number of articles have been published since the mid-1990s owing to the combined efforts of practitioners, institutions and periodicals. It is expected that systematic training of new generation of American specialists, advance in research infrastructure, and generous funding will stimulate geographical investigation of America in the coming future.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.15 no.9
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• pp.5763-5768
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• 2014

Maintaining a voice color is important when compounding both the normal voice because an emotion is not expressed with various emotional voices in a single synthesizer. When a synthesizer is developed using the recording data of too many expressed emotions, a voice color cannot be maintained and each synthetic speech is can be heard like the voice of different speakers. In this paper, the speech data was recorded and the change in the voice color was analyzed to develop an emotional HMM-based speech synthesizer. To realize a speech synthesizer, a voice was recorded, and a database was built. On the other hand, a recording process is very important, particularly when realizing an emotional speech synthesizer. Monitoring is needed because it is quite difficult to define emotion and maintain a particular level. In the realized synthesizer, a normal voice and three emotional voice (Happiness, Sadness, Anger) were used, and each emotional voice consists of two levels, High/Low. To analyze the voice color of the normal voice and emotional voice, the average spectrum, which was the measured accumulated spectrum of vowels, was used and the F1(first formant) calculated by the average spectrum was compared. The voice similarity of Low-level emotional data was higher than High-level emotional data, and the proposed method can be monitored by the change in voice similarity.

• Clinical and Experimental Reproductive Medicine
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• v.33 no.4
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• pp.253-263
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• 2006

Objective: Identification of the regulatory mechanism for arrest and initiation of primordial follicular growth is crucial for female fertility. Previously, we found 15 expressed sequence tags (ESTs) that were specifically abundant in the day-S-subtracted cDNA library and that the B357 clone was novel. The present study was conducted to obtain the whole sequence of the novel gene including B357 and to characterize its mRNA and protein expression in mouse ovary and testis. Methods: The extended sequence of the 2,965-bp cDNA fragment for the clone B357 was named ${\underline{5}}-{\underline{d}}ay-{\underline{o}}vary-{\underline{s}}pecific\;gene-{\underline{1}}$ (5DOS1) and submitted to GenBank (accession number ${\underline{AY751521}}$). Expression of 5DOS1 was characterized in both female and male gonads at various developmental stages by Northern blotting, real-time RT-PCR, in situ hybridization, Western blotting, and immunohistochemistry. Results: The 5DOS1 transcript was highly expressed in the adult testis, brain, and muscle as compared to the other tissues. In the ovary, the 5DOS1 transcript was detected in all oocytes from primordial to antral follicles, and highly expressed at day 5 after birth and decreased thereafter. In contrast, expression of 5DOS1 showed a gradual increase during testicular development and its expression was limited to various stages of male germ cells except spermatogonia. Conclusions: This is the first report on the expression and characterization of the 5DOS1 gene in the mouse gonads. Further functional analysis of the 5DOS1 protein will be required to predict its role in gametogenesis.

• Journal of Korean Tunnelling and Underground Space Association
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• v.8 no.2
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• pp.151-163
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• 2006

Although various methods for effective modeling of pre-reinforced zones have been suggested for numerical analysis of large section tunnels, tunnel designers refer to empirical cases and literature reviews rather than engineering methods because ones who use commercial programs are unfamiliar with a macro-scale approach in general. Therefore, this paper suggests a simple micro-scale approach combined with the macro-scale approach to determine equivalent design parameters for effective numerical modeling of pre-reinforced zones in tunnel. This new approach is to determine the equivalent stiffness of pre-reinforced zones with combination of ground, bulb, and steel in series or/and parallel. For verification, 3-D numerical results from the suggested approach are compared with those of a realistic model. The comparison suggests that two cases make best approximation to a realistic solution: One is related to the series-parallel stiffness system (hereafter SPSS) in which bulb and steel are coupled in parallel and then connected to the ground in series, and the other is the series stiffness system (hereafter SSS) in which only bulb and steel are coupled in series. The SPSS is recommended for stiffness calculation of pre-reinforced zones because the SSS is inconvenient and time-consuming. The SPSS provides slightly bigger vertical displacement at tunnel crown in weathered rock than other cases and give almost identical results to a realistic model for horizontal displacement at tunnel spring line and ground surface settlement. Displacement trends on weathered rock and weathered soil are similar. The SPSS which is suggested in this paper represents the behavior mechanism of pre-reinforced area effectively.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.14 no.12
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• pp.6447-6454
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• 2013

Seawater intake systems have significant problems due to seawater pollution, suspended solids, unstable intake and maintenance etc. An underground type seawater intake system was newly developed to overcome the existing weaknesses and was facilitated in Gyukpo port. In this study, to check the performance of the new system, the samples for water quality and the 3-D numerical modeling test were conducted. The five times test included the COD, total nitrogen, total phosphorus, pH, and suspended solid for the intake system. The analyses show that the COD, total nitrogen, total phosphorus, PH showedminor changes before and after. On the other hand, the change in suspended solids was significant and water was purified below 5 mg/l, first level fisheries water, after. The numerical model adopted the RNG $k-{\epsilon}$ algorithm and the CFX model based on the finite volume method. The porosity algorithm was used to reproduce filtered-sand, outer diameter, and thickness. The numerical results showed that the double pipe is advantageous in that it provides a uniform pressure between the inner and outer pipe for the flow to be stable. In addition, the use of multiple intake pipes did not interfere with the discharge reduction of 0.98 at the both intake pipes compared with the central intake pipe.

• Journal of Microbiology and Biotechnology
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• v.12 no.1
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• pp.114-120
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• 2002

A 1,989-bp genomic region encoding nickel resistance genes was isolated from Legionella pneumophila, a pathogen for legionellosis. From a sequencing and computer analysis, the region was found to harbor two structural genes, a nreB-like protein gene (1,149 bp) and a nreA-like protein gene (270 bp), in a row. Both genes exhibited a significant degree of similarity to the corresponding genes from Synechocystis sp. PCC6803 ($54\%$ amino acid sequence identity) and Achromobacter xylosoxidans 31A ($76\%$). The gene was successfully expressed in E. coli MG1655 and conferred a nickel resistance of up to 5 mM in an LB medium and 3 mM in a TMS medium including gluconate as the sole carbon source. E. coli harboring the nickel resistance gene also exhibited a substantial resistance to cobalt, yet no resistance to cadmium or zinc. Since the extracellular concentration of nickel remained constant during the whole period of cultivation, it was confirmed that the nickel resistance was provided by an efflux system like the $Ni^2＋$permease (nrsD) of Synechocystis sp. strain PCC6803. Since polyphosphate (poly-P) is known as a global regulator for gene expression as well as a potential virulence factor in E. coli, the nickel resistance of a ppk mutant of E. coli MG 1655 harboring the nickel resistance gene from L. pneumophila was compared with that of its parental strain. The nickel resistance was significantly attenuated by ppk inactivation, which was more pronounced in an LB medium than in a TMS medium.

• The Korean Journal of Pharmacology
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• v.8 no.1
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• pp.49-57
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• 1972

Ginseng, the Korean medicinal radix, has been widely used in the Chinese medicine as well as in the folk remedies for many centuries. It is claimed from experience that ginseng exerts multiple therapeutic effects in a large variety of disorders. Despite of its popularity, the chemical analysis and pharmacological study of ginseng are not firmly established. Although there are some scattered reports of ginseng effects on blood pressure, there are few reports on hypertension especially. Recently, Lee & Cho (1971) reported that the administration of ginseng significantly supresses the production of renal hypertension. This study was undertaken to reevaluate the effect of ginseng on renal hypertension and to determine whether ginseng also supresses on neurogenic hypertension, and to clarify the mechanism of this antihypertensive effect. Male rats, weighing around 180 gm on an average were used. Renal hypertension was induced by Grollman's method under general anesthesia with 35mg/kg of pentobarbital sodium. Ginseng effect on blood pressure was observed on normal, renal hypertensive and neurogenic hypertensive rats respectively. Ginseng alcohol extract (40mg/kg) was administered daily subcutaneously from 3 days prior to producing hypertension. And in renal hypertensive rats, the effects of histamine and Avil on blood pressure were also observed. Histamine (0.05mg/kg) and Avil (0.025mg/kg) were also administered daily I.M. from 3 days prior to kidney-8-ligature. The results of the experiments are as follows: 1) No significant difference was observed in blood pressure between the normotensive control and ginseng-treated normotensive rats. 2) In renal hypertensive control, the mean blood pressure already was significantly elevated on 15th day and gradually elevated. The administration of ginseng significantly supresses the production of renal hypertension from 30th day as compared with control rats. 3) The mean blood pressure in neurogenic hypertensive control was average 143.1 mmHg on 7th day. On the other hand, in ginseng treated-neurogenic hypertensive rats, the mean blood pressure was average 125.5mmHg. The administration of ginseng significantly supresses the production of neurogenic hypertension as compared with control rats. 4) In renal hypertensive rats, the administration of histamine and Avil did not differ with control rats. 5) In ginseng-treated renal hypertensive rats, cholesterol contents of plasma, adrenal, kidney and spleen were slightly decreased.

• Journal of Korea Technology Innovation Society
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• v.18 no.1
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• pp.98-125
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• 2015

This study will show the determinants of research productivity by fields in science and engineering. However, we present the differences between fields by personal attributes, research resources, and research productivities. The data includes 1,383 researchers who participated in the BK21 PLUS program during 2010-2012. The fields are physics, chemistry, biology, mechanics, electricity and electronics and chemical engineering. As for research productivity, 3 indices are used such as the number of papers publicized, patents and combination of papers and patents. As for explanation factors, two kinds of variables are used. The personal factors include sex, age, academic rank, location of affiliation, and country of PhD acquisition, and the resource factors are the number of graduate students, 3 types of research funds such as government fund, industrial fund and overseas fund. This study is unique in several aspects; Dealing with 3 productivity indices, and using massive official data, 6 different fields, and determinants of research productivity. The results are as follows; 1) there is a big difference in determinants by fields. 2) No variables affect the research productivity of all the fields at the same time. 3) In science, the number of determinants are quite low than engineering. 4) The ratio between papers and patents are different by fields. 5) The correlations between paper and patent by fields are different; no relationship in the field of physics and chemistry and positive relationship in the other 4 fields.

• Journal of rehabilitation welfare engineering & assistive technology
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• v.5 no.1
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• pp.125-132
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• 2011

The Comprehensive Assistive Technology services delivery was devised to describe the full social and engineering context of assistive technology devices, systems, applications, and provision. It is based on a detailed decomposition of the four attributes: Person, Context, Activities, and Assistive Technology. The paper commences will a brief discussion of the different representations of the services delivery, including rental of devices, modification of manufacture goods and customized production and the use of engineering to supplement some elements of the description. The main contribution of the paper is the presentation of two case studies of different applications of the assistive technology services. These are the identification of accessibility barriers, the analysis and synthesis of assistive technology systems and the provision of a framework for identitying end-user requirements, providing assistive technology and assessing the associated outcomes. This case study involves the presentation of the concept of a personal assistive technology profile.

• Korean Journal of Applied Biomechanics
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• v.18 no.4
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• pp.31-39
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• 2008

The purposes of this study were to compare and analyze the world elite hurdler and the domestic hurdler 3-D kinematic and kinetic techniques about hurdling motion in the 110m hurdles. After analyzing variables in the 110m hurdle run the following conclusions were obtained; In a preparation phase, the domestic hurdler came out running more 0.13m then world elite hurdler from grounding to taking off in the height of center of gravity and the distance by 1.04m. In a flight phase, the domestic hurdler came out taking off 0.33m less then world elite hurdler from taking off to flight peak in the height of center of gravity and the distance by 1.63m. In a flight peak phase, domestic hurdler came out landing more 0.37m then world elite hurdler by 159m. More over, during the hurdling, the horizontal velocity of center of gravity came out decreasing from taking off to landing with domestic hurdler by 0.75m/s. the take off percentage and the landing percentage is 53:47. In a acceleration phase, domestic hurdler came out going slower 0.54m/s than world elite hurdler from landing in the horizontal velocity of center of gravity by 8.78m/s.