• Bulletin of the Korean Chemical Society
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• v.30 no.5
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• pp.1107-1112
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• 2009

The aim of this study is to develop and synthesize $5-HT_{1A}$ receptor imaging agents with WAY-100635 moiety and $^{99m}Tc(CO)_3$ core. WAY-100635 is commonly known as $5-HT_{1A}$ antagonist and its labeled compound ([$^{11}C$] WAY-100635) has been used as effective radioligand for imaging brain $5-HT_{1A}$ receptors with PET(Positron Emission Tomography). However, there are several restrictions in using a radioisotope of C-11 and requires for more effective radioisotopes and ligands. In order to produce a structure most similar to WAY-100635, WAY-100635 derivatives containing a cysteine chelator were designed and confirmed by using in silico (Hyperchem). The novel compounds (7a, 7b, 7c) were prepared in five or 7 steps with yields of 16%, 36% and 42%, respectively and radiolabeled with $[^{99m}Tc(CO)_3(H_2O)_3]^{+}$. The labeling yield was 99% for all the newly synthesized compounds. [$^{99m}Tc(CO)_3$]- WAY-100635 derivatives show a neutral charge which were confirmed by paper electrophoresis.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.40 no.4
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• pp.260-267
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• 2017

Quantum-inspired Genetic Algorithm (QGA) is a probabilistic search optimization method combined quantum computation and genetic algorithm. In QGA, the chromosomes are encoded by qubits and are updated by quantum rotation gates, which can achieve a genetic search. Asset-based weapon target assignment (WTA) problem can be described as an optimization problem in which the defenders assign the weapons to hostile targets in order to maximize the value of a group of surviving assets threatened by the targets. It has already been proven that the WTA problem is NP-complete. In this study, we propose a QGA and a hybrid-QGA to solve an asset-based WTA problem. In the proposed QGA, a set of probabilistic superposition of qubits are coded and collapsed into a target number. Q-gate updating strategy is also used for search guidance. The hybrid-QGA is generated by incorporating both the random search capability of QGA and the evolution capability of genetic algorithm (GA). To observe the performance of each algorithm, we construct three synthetic WTA problems and check how each algorithm works on them. Simulation results show that all of the algorithm have good quality of solutions. Since the difference among mean resulting value is within 2%, we run the nonparametric pairwise Wilcoxon rank sum test for testing the equality of the means among the results. The Wilcoxon test reveals that GA has better quality than the others. In contrast, the simulation results indicate that hybrid-QGA and QGA is much faster than GA for the production of the same number of generations.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.40 no.4
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• pp.237-245
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• 2017

Our research is aimed at predicting recent trend and leading technology for the future and providing optimal Nano technology trend information by analyzing Nano technology trend. Under recent global market situation, Users' needs and the technology to meet these needs are changing in real time. At this point, Nano technology also needs measures to reduce cost and enhance efficiency in order not to fall behind the times. Therefore, research like trend analysis which uses search data to satisfy both aspects is required. This research consists of four steps. We collect data and select keywords in step 1, detect trends based on frequency and create visualization in step 2, and perform analysis using data mining in step 3. This research can be used to look for changes of trend from three perspectives. This research conducted analysis on changes of trend in terms of major classification, Nano technology of 30's, and key words which consist of relevant Nano technology. Second, it is possible to provide real-time information. Trend analysis using search data can provide information depending on the continuously changing market situation due to the real-time information which search data includes. Third, through comparative analysis it is possible to establish a useful corporate policy and strategy by apprehending the trend of the United States which has relatively advanced Nano technology. Therefore, trend analysis using search data like this research can suggest proper direction of policy which respond to market change in a real time, can be used as reference material, and can help reduce cost.

• Proceedings of the Korea Concrete Institute Conference
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• 2008.04a
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• pp.725-728
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• 2008

This study was to establish 3 levels of high fineness fly ash like 4000, 6000, and 8000 class and 30% replacement ratio in order to analyze mechanics and shrinkage properties of concrete by using high fineness fly ash. Furthermore, this study was to make a plan in two levels of water-binder ratio like 40% and 50%. In addition, as a result of measurement by the establishment of combined condition of ternary system as 20% replacement ratio level of three sorts of ground granulated blast furnace slag, there was a tendency to be equal or higher to the plain concrete as the fineness of fly ash increased in strength property. Simultaneously, this study had a tendency in the relationship between the compressive strength and elastic modulus that the more the fineness of fly ash, the more the elastic modulus increased a little. In addition, this study had a tendency that the more elastic modulus moved to the long-term aged one, the more it increased definitely. The effect on the fineness of fly ash remained at a low level in the drying shrinkage. This study has shown that the more the fineness increased, the more the elastic modulus decreased.

• The Journal of the Korea institute of electronic communication sciences
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• v.4 no.2
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• pp.108-115
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• 2009

Thanks to the development of computer graphics, Animation can be easily accessed through movies or games. The users can meet various contents and are asking for high quality animations that resembles reality to a near perfection. The research is proceeded to observe the fish shapes and swimming movements through cyber aquariums, fish ecology museums and fish encyclopedias. The core of expressing undersea scenery is the natural and dynamic movements of the fish. In this thesis in order to achieve the natural shape of fish swimming, it is necessary to design a fish growth process system based on environmental factors and apply different standard points depending on the various swimming types of fish species to express the fish as near reality as possible. And by calculating the different swimming velocities of different standard points, a natural swimming shape will be achieved.

• Journal of Technologic Dentistry
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• v.23 no.1
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• pp.31-43
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• 2001

This study was performed to observe the micro-structure change of surface, behavior of oxide change of element, the component transformation of the alloy and the bonding strength between the porcelain interface in order to investigate effects of indium, tin on interfacial properties of porcelain fused to low gold alloy. Hardness of castings was measured with a micro-Vicker's hardness tester. The compositional change of the surface of heat-treated specimen was analyzed with an EDS and an EPMA. The interfacial shear bonding strength between alloy specimen and fused porcelain was measured with a mechanical testing system(MTS 858.20). The results were as follows: 1) The hardness value of alloy increased as increasing amount of indium addition. 2) The formation of oxidation increased as increasing indium and tin contents after heat treatment. 3) Diffusion of indium and tin elements increased as increasing indium and tin contents in metal-porcelain surface after porcelain fused to metal firing. 4) The most interfacial shear bonding strength was increased as increasing a composition of adding elements, and a heat-treatment time, and an oxygen partial pressure. From the results of this study it was found that the addition of alloying elements such as indium and tin increase hardness of as-cast alloy, produce surface oxide layer of adding elements by heat-treatment which may improve interfacial bonding strength between alloy and porcelain.

• Journal of the Korean Home Economics Association
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• v.41 no.6
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• pp.1-12
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• 2003

The purpose of this study were to analyze the anthropometric data of feet of Korean women with aging, to categorize the women's foot shapes, and to compare the shoe size according to the foot shapes in order to provide the basic information for more comfortable shoes. Subjects of this study were 181 women over age 20. They were measured with the direct measurement method and the indirect measurement method. 26 items were measured from the right foot and 6 items were taken on foot outline. Factor analysis, cluster analysis, analysis of variance, post-hoc test, and cross tabs were peformed for statistical analysis of the data by SPSS program. There were significant differences in height items, breadth items, girth items, and angle items by subjects' age. The older subjects' feet were wide and thick with big deformity on toes. The arch height of the older ones was low. This implicates that the degree of deformity on toes, the foot ratio, the foot girth, the foot breath and the arch height as well as the foot length are needed to be considered in developing comfortable shoes. Nine foot construction factors were extracted by the factor analysis of anthropometric measurements; foot size factor, heel and instep factor, malleolus lateralis factor, malleolus medialis factor, foot shape factor, shape of toes factor, heel height factor, big toe height factor, and internal factor. On the basis of the cluster analysis, three different foot shapes were categorized. Type 1 was large and wide foot with little deformity on little toe. Type 2 was medium foot with deformation of big toe, and with the lowest arch height. Type 3 was small and narrow foot with the highest arch height. Distribution of shoe size according to the foot shape was analyzed. The ball of foot breath was of wide distribution than the ball of foot girth. This implicates that girth items and breath items of the foot should be enclosed for the same foot length in the shoe sizing system.

• Culinary science and hospitality research
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• v.13 no.4
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• pp.92-106
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• 2007

The most important factor in hotel business is the management system of human resources, and focuses on the role of a manager who successfully achieves the business objective. This study is based on a survey conducted on staff members from five-star hotels in Seoul and Gyeonggi Province. It aims to look into the influence of leadership and confidence on a Department Chief in terms of overall business achievement. As a result of the verified analysis of this study is as follows: First, the influence of the Department Chief's leadership on confidence(Estimate=1.083, C.R.=12.977) was the highest. Second, the influence of the Department Chief's leadership on business achievement(Estimate=0.651, C.R.=5.864) was relevantly high. Third, the influence of confidence of the Department Chief on business achievement(Estimate=0.217, C.R.=2.054) was relevantly low, but still beneficial. As a result of this study concludes that in order to enhance business achievement, both leadership and confidence of the Department Chief were crucial. Especially, the Department Chief's leadership had an effect on the level of staff members' satisfaction, devotion and intention to change one's occupation in the form of having trust on the Department Chief. Such a result indicates that the Department Chief's leadership plays an active role in elevating the staff members' satisfaction on their job. An elevated satisfaction level will further enhance trust, business performance, devotion to company, cohesion, and productivity.

• Proceedings of the Korea Committee for Ocean Resources and Engineering Conference
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• 2001.05a
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• pp.119-126
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• 2001

The potential pollution problems resulting from tanker collision necessitate the requirement for an effective structural design and the development of relevant safety regulation. During a few decades, the great effort has been made by International Maritime Organization and the Administration, etc, to reduce oil spillage from collision accidents. However there is still a need for investigation in the light of structural evaluation method for the experiments and rational analysis, and design development for an operational purpose of ships. This study is aimed at investigating a complicated structural response of bow structures of oil carriers for assessing the energy dissipation and crushing mechanics of striking vessel through a methodology of the numerical analysts for the various models and its design changes. Through this study an optimal bow construction absorbing great portion of kinetic energy in the least penetration depth prior to reach to the cargo area and an effective location of collision bulkhead are investigated. In order to obtain a rational results in this study, three stages of response analysis procedures are performed as follows; 1). 16 simplified ship models are used to investigate the structural response against bow collision with variation of primary and secondary members. Mass and speed are also varied in two conditions. 2). 21 models conisted of 5 size of full scaled oil carriers are used to perform the collision simulation with the various sizes and deadweight delivered in a recent which are complied with SOLAS and MARPOL. 3). 36 models of 100k oil carrier are used to investigate the structural response and its influence to the collision bulkhead against bow collision in variation with location of collision bulkhead, primary mombers, framing system and colliding conditions, etc.

• Journal of Korean Association for Spatial Structures
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• v.18 no.3
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• pp.93-103
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• 2018

This study showed that experimental study of inelastic nonlinear behavior of two-way beam string structures. General large span structures consisting of beam members have large moment and long cross section of area. In order to decrease these excessive moment and deflection, the two-way beam string structures composed of H-Beam, strut, and cable elements were proposed. In the two-way string beam, the cable with the prestress improves force distribution of some weight reduction. Two systems made of structural steel and cables were tested. The nonlinear behaviour of the two-way beam string structures studied by using finite element model and compared to experimental results. The displacement of the LVDT in the center of the beam correspond with the ABAQUS results. 2,200MPa cable can afford to bear breaking load than 1,860MPa cable. The two-way beam string structures is correlated to the finite element model and the experimental results. In consequence, It showed that the system with two-way cables exhibits much better structural performances than H-Beam structures and beam with cable.