• Korean Journal of Clinical Pharmacy
• /
• v.18 no.1
• /
• pp.11-17
• /
• 2008

아미카신은 그람음성균 감염에 사용하는 아미노글리코사이드계 항생제로 이독성 및 신독성 등의 부작용과 큰 개인차로 혈중농도 모니터를 통한 투여계획이 필요한 약물이다. 본 연구에서는 16명의 위암환자에서 비선형최소자승 회귀분석과 베이시안 분석에 의한 아미카신의 약물동태에 분석오차의 영향을 연구하였다. 약물투여는 아미카신 7.5 mg/kg을 30분에 걸쳐 12시간 간격으로 등속 주입하였으며, 혈액 채취는 정상상태에 도달되었다고 판단되는 첫 약물투여 72시간 후에, 약물 주입 5분전과 주입이 끝난 뒤 30분과 2시간에서 세차례 채취하였다. 혈청중 약물농도는 형광편광면역법으로 측정하였다. 분석오차를 위해 0, 5, 15, 30, 60 및 $80\;{\mu}g/ml$에 해당하는 아미카신 혈중농도(C)을 네차례 측정하여 각 혈중농도의 표준편차 (SD)을 구하였다 아미카신 분석오차를 위한 다항식이 $SD=0.3017+(0.00538C)+(0.00112C^2)$, $R^2=0.974$이었다 이 식에서 구한 SD 값으로 분석시 가중치를 주었을 때, 비선형최소자승 회귀분석에 의한 아미카신의 약물동태학적 파라메타($V_d$, $K_{el}$, $K_{slpoe}$, $t_{1/2}$)에 유의성있는 영향을 주었으나, 베이시안 분석에 의한 아미카신의 약물동태학적 파라메타에는 영향이 없었다. 이 다항식에 의한 분석오차를 비선형최소자승 회귀분석에 의한 아미카신 약물동태학적 파라메타 분석시 적절히 사용하면 안전하고 효율적인 투여계획을 할 수 있다.

• The Korean Journal of Applied Statistics
• /
• v.27 no.7
• /
• pp.1163-1170
• /
• 2014

The concepts and structure of intermittent panel time series data are introduced. We suggest a Wald test statistic for the test of homogeneity for intermittent panel first order autoregressive model and its limit distribution is derived. We consider the fitting the model with pooling data using sample mean at the time point if homogeneity for intermittent panel AR(1) is satisfied. We performed simulations to examine the limit distribution of the homogeneity test statistic for intermittent panel AR(1). In application, we fit the intermittent panel AR(1) for panel Mumps data and investigate the test of homogeneity.

• The KIPS Transactions:PartB
• /
• v.8B no.5
• /
• pp.477-484
• /
• 2001

This paper proposes a hybrid learning algorithm combined momentum and kernel-adatron for improving the performance of regression support vector machine. The momentum is utilized for high-speed convergence by restraining the oscillation in the process of converging to the optimal solution, and the kernel-adatron algorithm is also utilized for the capability by working in nonlinear feature spaces and the simple implementation. The proposed algorithm has been applied to the 1-dimension and 2-dimension nonlinear function regression problems. The simulation results show that the proposed algorithm has better the learning speed and performance of the regression, in comparison with those quadratic programming and kernel-adatron algorithm.

• Proceedings of the Korea Society for Simulation Conference
• /
• 2004.05a
• /
• pp.41-47
• /
• 2004

중심합성계획(central composite design: ccd)은 반응 표면이 곡면적인 특성을 나타낼때 반응 공간을 추정하기 위해 사용되는 실험계획이다. 반응공간이 2차 회귀모형으로 나타나는 경우에 반응곡면의 변화량을 알기 위해서는 변수의 수준이 3이상이 되어야하는데 ccd는 적은 횟수의 실험으로 곡면을 효과적으로 추정하기 위해 2$^{k}$ 요인실험에 추가적으로 중심점(central point)과 축점(axial point)을 표본점에 포함시키는 계획이다. 본 연구에서는 시뮬레이션 실험에서 반응변수가 2차 회귀모형으로 근사되는 경우에 cod를 이용하여 관심 성과치의 반응표면을 추정하고자 한다. 일반적인 실험에서와는 달리 시뮬레이션 실험에서는 두개의 표본점(인자 수준의 조합)에서 분석자가 공통 난수계열(common random number series)을 부여하여 시뮬레이션 시스템 요소의 변화과정을 유사하게 통제할 수 있다. 일반적으로 공통난수법(common random number method)에 의해 얻어지는 두 표본점에서의 반응변수는 서로 양의 상관관계를 가지며 대조 난수(antithetic random number)에 의한 두 반응변수는 음의 상관성을 가지는 것으로 알려졌다. 본 연구는 ccd의 표본점에 공통난수와 대조난수 법을 이용하여 회귀모형의 파라미터를 효과적으로 추정하는 방법을 조사하고 이를 (s, S) 재고관리 모형에 적용하여 그 효율성을 평가하고자 한다.

• Proceedings of the Korea Contents Association Conference
• /
• 2016.05a
• /
• pp.351-352
• /
• 2016

조선소의 생산계획 담당자가 기존 실적 정보를 이용하여 관심 대상인 미래의 생산계획 상황을 보다 쉽게 예측하여 생산계획의 적중률을 높일 수 있도록 할 예정이다. 2006년에서 2016년의 S조선사의 2차 데이터를 이용하여 요인 분석을 하고 다중회귀분석 모형을 설계하여 활용하는 프로세스를 설계한다. 사례 연구를 통해 연구 모형이 적절한지를 검증할 계획이다.

• Fire Science and Engineering
• /
• v.17 no.1
• /
• pp.26-32
• /
• 2003

Inert gases, Af, $N_2$, $CO_2$, as a Halon alternative, the empirical equations were correlated in terms of saturated pressure, density and viscosity, They were obtained by regression analysis from the experimental data in the literature. The empirical equations of saturated pressure were expressed as the second and third order function of temperature. The empirical equation for Ar and $N_2$ of density were expressed as the first order function of temperature. And $CO_2$ was expressed as the second and third order function of temperature. The empirical equation of viscosity was formulated as a power function with temperature. This empirical equations would allow us to predict pure component state.

• The Korean Journal of Applied Statistics
• /
• v.12 no.2
• /
• pp.605-619
• /
• 1999

본 논문은 회귀분석에서 오차항의 1차 자기상관 존재 여부 및 그 값을 검정하는 방법을 베이지안 접근법으로 제안하였다. 이 방법은 모수공간의 다중분할로 인해 얻어진 여러 가설들에 대한 다중결정문제를 다중 베이즈요인에 관한 이론과 일반화 Savage-Dickey 밀도비를 이용한 사후확률 추정법을 합성하여 개발되었다. 이 방법은 기존의 검정법들에서 가능한 검정 뿐 아니라 이들이 해결할 수 없는 자기상관에 대한 다중결정문제에도 사용이 가능한데 그 효용성이 있다. 모의실험을 통하여 제안된 검정법의 유효성을 평가하였다.

• KOREAN JOURNAL OF CROP SCIENCE
• /
• v.68 no.4
• /
• pp.225-235
• /
• 2023

Critical temperature for grain filling of three Korean japonica rice varieties was analyzed by late transplantation to induce a low temperature during grain filling period in a field study. The grain filling percentage (GFP) and grain dry weight (GDW) showed a sigmoid development for the first and second transplants in 2020 and first to third transplants in 2021. For the third transplant in 2020 and fourth transplant in 2021, the GFP and GDW reached a peak at 42 days after heading (DAH), and then decreased or remained unchanged. In non-linear regression analyses, 95% of the final GFP and GDW appeared at 49 - 62 DAH for the second transplant in 2020 and at 37 - 46 DAH and 30 - 36 DAH for the second and third transplants in 2021, respectively. At these time points, the critical seven-day moving temperature (7dMovT) was 8.4~9.4℃ for the second transplant in 2020 and 9.4~10.9℃ for the second and third transplants in 2021, depending on the grain filling traits and varieties of rice. The lowest 7dMovT was 8.4 - 8.7℃ in the three varieties. The observed lowest 7-day mean temperature (7dMT) accompanying increases in the GFP and GDW was 9.4 - 10.1℃, depending on the varieties in the third transplant of 2020 and fourth transplant of 2021. In the two transplants mentioned above, the highest 7dMT that showed no increase or decrease in grain filling traits was 8.7 - 9.1℃. The critical temperature for grain filling of japonica rice was 8.4 - 8.7℃ based on the 7dMovT and 9.1 - 9.4℃ based on the 7dMT. The previous 7dMT of 10℃ is recommended to determine the marginal harvest time for safe rice cropping since the temperature was the highest among the lowest temperature that accompanied an increase in grain filling traits.

• Journal of Embryo Transfer
• /
• v.18 no.3
• /
• pp.215-225
• /
• 2003

This study was carried out to investigate the change of blood compositions by age in Hanwoo, and a total of 866 of Hanwoo, which consisted with 638 of steer and 228 of bulls, were used to measure serum concentrations. A multiple regression equation was estimated with collection age and blood composition as independent and dependent variables, respectively. Complicated regression equations for blood compositions in steer and bulls were IGF-I(cubic), calcium (linear), and IP(linear). Linear and cubic equations were fitted to testosterone in steer and creatinine in bulls, respectively. A cubic equation in steer and linear equation in bulls were fitted to HDLC. Equations of quadratic in steer and cubic in bulls were fitted to concentration of triglyceride, globulin, and A/G ratio. BUN was fitted by equations of cubic in steer and quadratic in bulls. TP and albumin were fitted by equations of quadratic in steer and linear in bulls. A cubic regression equation did not explain the change of cortisol by age in steer and bulls. A cubic regression equation did explain the change of glucose by age in steer, but not in bulls. Higher R-square values (R-SQUARE>0.1) were estimated to IGF-1, albumin, creatinine, Inorganic phosphorous(IP) and HDLC in steer, and testosterone, IGF-I, TP, albumin, glucose, creatinine, IP, and HDLC in bulls for the fitted regression equations of blood compositions. Therefore, IGF-I, albumin, creatinine, IP, and HDLC were regarded as comparatively large variation by age in steer and bulls.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.19 no.2
• /
• pp.155-163
• /
• 2018

This study was conducted to investigate the factors related to smoking and smoking differences among adolescents who have experienced smoking using data from the 11th (2015) Korean Youth Risk Behavior Web-based Survey. The data used in this study were from 5,347 middle and high school students who had cigarette smoking and electronic cigarette smoking experience among 68,043 respondents to the 11th (2015) Korean Youth Risk Behavior Web-based Survey. The data were evaluated by frequency analysis, the ${\chi}^2$ test and logistic regression analysis using weighted composite sample analysis. Overall 20% of the total smoking adolescents were dual users and 85.6% of the users of electronic cigarettes used nicotine. The results from multinomial regressions show that: male students (OR 1.63; 95% CI 1.15-2.31), living in the metropolitan area (OR 1.76; 95% CI 1.32-2.33), an average consumption of fast food of once or twice a day (OR 2.48; 95% CI 1.33-4.64), first started smoking during high school (OR 0.76; 95% CI 0.58-0.98), having experience with passive smoking (OR 1.24; 95% CI 1.07-1.44), experience drinking alcohol (OR 2.03; 95% CI 1.65-2.48) and those with higher weekly allowances were more likely to be at risk than dual users. This study provides basic data regarding the dual use of electronic cigarettes and cigarettes by adolescents. The results presented herein will facilitate development of a smoking cessation program and policy.