• Tuberculosis and Respiratory Diseases
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• v.41 no.1
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• pp.11-19
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• 1994

Background: Mycobacterium tuberculosis is a facultative intracellular pathogen which persists and multiplies within macrophage. Competent cell mediated immunity by cooperation of both T lymphocyte and macrophage of the host is required to kill the Mycobacterium tuberculosis. But a precise understanding of the pathogenesis of tuberculosis infection in pulmonary alveolar macrophage has not been achived. Research on the macrophage's basic microbicidal mechanism has elucidated the importance of oxygen-dependent or oxygen-independent components. Oxygen dependent processing begins with the reduction of oxygen by NADPH oxidase and generation of superoxide. In this study, the oxidative metabolic status of blood monocyte and pulmonary alveolar macrophage in patients with active pulmonary tuberculosis was accessed and compared with that of healthy control subjects to know whether there was a basic difference in superoxide generation by mononuclear cells between two groups. Methods: Pulmonary alveolar macrophage was purified after performing BAL(bronchoalveolar lavage) through the bronchi of infected lesion by plastic adhesion method. Blood monocyte was purified by Ficoll-Hypaque method. Superoxide generation by blood monocyte and pulmonary alveolar macrophage was measured by ferricytochrome-C reduction method after either stimulated with PMA(phorbol myristate acerate) or non-stimulated states. We also measured the effect of pulmonary tuberculosis patient's serum on superoxide generation by monocyte. Results: 1) Generation of superoxide by alveolar macrophage obtained from patients with pulmonary tuberculosis was little higher than those of controls, and PMA enhanced the generation of 2) Generation of superoxide by blood monocyte obtained from patients with pulmonary tuberculosis was little higher than those of control(p>0.05), and PMA more enhanced the generation of superoxide in patientswith pulmonary tuberculosis than those in controls(p<0.02). 3) Patient's serum enhanced the generation of superoxide by blood monocyte obtained from patients with pulmonary tuberculosis and controls, but not in the case of PMA stimulated blood monocyte. Conclusion: The present study suggest that the phenomenon of M.tuberculosis escape the microbicidal action of macrophage was not result of suppressed superoxide generation by blood monocyte and pulmonary alveolar macrophage, rather there might be a factor to stimulate the generation of superoxide by blood monocyte in pulmonary tuberculosis patient serum, but the comparision with effect of control's serum on superoxide generation needs further elucidation.

• Proceedings of the Acoustical Society of Korea Conference
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• spring
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• pp.107-110
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• 2000

음성 신호는 시간에 따라 변하지만 일정 구간에서는 특성이 변하지 않는다고 가정하여 윈도우를 취해 단구간 분석을 한다. 이 때 윈도우의 적용은 필수적이다. 하지만 단구간 분석을 위해서 사용되는 윈도우에 의해 생기는 누설에너지 때문에 음성신호의 스펙트럼 정보가 왜곡되어 버린다. 본 논문에서는 스펙트럼 분석 시 발생되는 누설에너지를 최소화하는 방법을 제안하고자 한다. 음성신호에 고정된 크기의 rectangular Window를 취한 후 처음 샘플과 차이가 가장 작은 샘플을 프레임 크기의 3/4인 지점에서부터 검색하여 최소인 부분까지 시간 축 스케일링을 한 후 기존의 윈도우 크기와 같은 크기로 만든다. interpolation과 decimation을 조합하여 시간 축 스케일링을 한다. 이렇게 윈도우가 적용된 신호를 처리 후 위의 역 과정을 수행한다. 제안한 윈도우의 SNRseg는 rectangular window보다 평균 7.88dB 낮고, kaiser window보다 평균 1.65dB 높았다. 또한 제안한 윈도우의 SD는 rectangular window 보다 평균 $1.73dB^\2$ 낮았다.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1994.04a
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• pp.249-249
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• 1994

PAF (Platelet-activating factor: 혈소판 활성화인자)는 1972년 Benveniste등에 의해 토끼의 호중구 배양 상청액중에서 발견되어 1979년 그 구조가 1-alkyl-2-acethyl-sn glycero-3-phosphocholine의 구조를 갖는 에테르형 인 지질임이 밝혀졌다. 그후 혈소판 이외 과립구, 단구나 macrophage, 혈관내피세포등 조직의 염증담당세포가 다양한 자극에 응하여 PAF를 생성됨이 보고되었다. PAF가 나타내는 대표적 활성으로는 혈소판, 호중구, 단구들의 활성화, 호중구의 유주 활성, 혈관투과성 항진, 혈압강하작용. 기관지 수축 등이 알려졌으며. 또한 염증, 알러지, 천식 endotoxin shock 등 여러질병에 직·간접적으로 관여함이 알려졌다. 이와같은 여러 생리 현상은 PAF의 특이적수용체를 개재하여 일어난다는 것이 밝혀졌다. 따라서 PAF의 다양한 질병의 관여가 밝혀짐으로서, PAF길항제의 개발이 활발히 진행되어왔다. 지금까지 PAF길항제의 개발은 PAF 구조 유사체. benzodiazepam유도체, thiazole유도체 등과 같은 합성품과 ginkolide, kadsurenone과 같은 천연물 유리의 것이 알려져 in vivo model에서도 그 효능이 확인되었다. 본 연구는 이와 같은 배경에서 20여 종의 생약에서 PAF 길항제를 검색하던 중 5종류의 생약에서 PAF 길항작용을 갖는 분획을 찾았기에 이에 보고한다.

• Proceedings of the Korea Institute of Convergence Signal Processing
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• 2000.08a
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• pp.289-292
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• 2000

선형 자귀회귀(AR) 모델을 근거로한 HRV 파워 스펙트럼해석은 비침습적으로 자율신경의 반응을 정량화하는데 폭넓게 사용된다. 본 연구는 단구간(2분 미만)의 심전도와 맥파 신호로부터 시계열 HRV의 파워스펙트럼을 추정한다. 시계열은 정상인을 대상으로 검출한 심전도와 맥파신호의 특징점 시간간격(RRI, PPI)으로부터 구하였다. 발생된 시계열은 다항식 보간법에 의해 AR모델에 적합하게 재구성하였으며, AR모델 계수는 Burg법에 의해 계산하였다. AR모델을 적용한 단구간의 심전도와 맥파의 심박변동에 대한 파워스펙트럼밀도는 저주파수(LF)와 고주파수(HF)에서 매끄러운 스펙트럼 파워를 나타내고 있다. 또한 동일한 피험자의 심전도와 맥파의 파워스펙트럼밀도를 비교한 결과 동일한 모양을 나타내었다.

• Journal of The Geomorphological Association of Korea
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• v.18 no.1
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• pp.101-112
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• 2011

Coastal terrace was developed at 7.2m height near Shinchon village in Geoje Island. It is located on the east side of southern coast in Korean Peninsula, where sea-level changes caused by ebb and flow of the tide, embayment are relatively low. Due to the breccia layer by mass-movement, dark grayish clayey formation, marine origin's rounded gravel are deposited sequentially in a cross-section of coastal terrace, so it provides a good example which understand Holocene sea level changes to determine the effect on the various sedimentary environments. For the purpose of identifying the morphogenetic process, Grain size, Roundness, XRD, AMS dating analysis was attempted. As a result, after last glacial age, Holocene sea level rise to +5.6m(4,740±100yrs BP). At that time, various geomorphological features are considered to be formed.

• Journal of the Korean Geographical Society
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• v.30 no.2
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• pp.103-119
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• 1995

This Paper aims to compare the lower marine terraces distributed from Muckho to Gangneung in the mid-eastern coast of Korean peninsula by the geomorphic method of using characteristies of terrace features and terrace deposits, paleosol, and fossil cryogenic structures, and to estimate the age of the lower marine terraces on the basis of the comparisons of those with the characteristics of thalassostatic terrace in adjacent rivers. The 1ower marine terraces in this area can be classified into two levels, i.e., lower marine terrace I and II surfaces, in desending order, according to the difference of former shoreline altitude. The former shoreline heights of the lowerm marine terrace I and II surfaces are 18m and 10m, respectiveiy. The width of the I surface is broader and distributed more continuousiy than that of II surface. Daejin I surface in Muckho coast, and Myeongju and Anin terrace in Gangneung coast could be classified into the lower marine terrace I surface, and Daejin II surfaCe into II surface. The Surface of ancient shore platform of the lower marine terrace I and II surfaces were weathered, and the color of the terrace deposit ranges from red to reddish brown. And this terrace deposit is covered with slope deposit of Last Glacial or fossil periglacial structures (platy structure and vecicle) of Last Glacial are formed in terrace deposit. These facts indicate that the lower marine terrace I and II surfaces had been formed before the Last Glacial, and then affected by chemical weathering under warm environment, finally followed by cold period. But the deposit of the lower marine terrace I surface is more weathered than that of II surface. And pseudogleyed red soil, which is developed in I but not in II surface, could be judged to have been formed in the Last Interglacial culmination stage (Oxygen isotope stage 5e). Therefore, in terms of the degree of weathering of the terrace deposit and the existence of pseudogleyed red soil, the age of both terrace is thought to be a little different. And the characteristics of the above mentioned II surface are accord with those of thalassostatic terrace formed in middle or late period of the Last Interglacial (5e or 5a). Thus on the basis of above all points, the lower marine terrace I and II surfaces in this area could be seen to have formed in the Last Interglacial culmination stage and middle or late period of the Last Interglacial, respectively. Because the lower mamine terrace I surface is broadry distributed in the eastern coast of Korea nPeninsula, the surface could be used to be a key surface in studying Quaternary marine terraces.

• The Proceeding of the Korean Institute of Electromagnetic Engineering and Science
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• v.4 no.2
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• pp.4-10
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• 1993

In mobile radio communication, propagation paths are time or spacial varying because of the motion of mobile unit. The propagation path loss not only involves frequency and distance but also the antenna height at both the base station and the mobile unit, terrain configuration, and the man made en- vironment. Thhese additional factors make the prediction of propagation path loss of mobile radio signals more difficult. In this paper, it is measured field strenght of mobile radio signals in Daejeon and Seoul area, also calculated local median, 500m sample mean, and stadard deviation. As the result of analysis, it can be seen that propagation path loss of measured data is similiar to predicted field strength, especially local median is dependent upon base antenna height, terrain configuration and the man-made environment. The standard deviation has been noted to lie between 2 and 10 dBuV.

• Journal of Veterinary Clinics
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• v.25 no.2
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• pp.73-78
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• 2008

Ketamine is a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist and a short-acting general anaesthetic agent for human and veterinary use. We previously reported that treatment with ketamine impairs oxidative burst activity of canine peripheral blood leukocytes. In this study, the effect of ketamine on phagocytic capacity of canine peripheral blood leukocytes was examined in vitro. Phagocytic capacity was analyzed by using a flow cytometry. Ketamine directly decreased the phagocytic capacity of peripheral blood polymorphonuclear cells (PMN) and monocytes but not total peripheral blood mononuclear cells (PBMC). In addition, the phagocytic capacity of PMN and monocytes was inhibited by the ketamine-treated PBMC but not PMN culture supernatant. These results suggest that ketamine has a direct inhibitory effect on the phagocytic capacity of canine peripheral blood phagocytes and involves the production of soluble factor(s) from canine PBMC, which may suppress the phagocytic capacity.

• Journal of Veterinary Clinics
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• v.7 no.1
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• pp.429-438
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• 1990

The cytochemical characteristics of the hematopoietic cells in blood and bone marrow from 3 clinically healthy dogs were examined using a battery of cytochemical stains. Alkaline phosphotase activity was demonstrated in eosinophilic series and occassionally in progranulocytes. A variety of cells exhibited acid phosphatase activity, but tartrate-resistant acid phosphatase activity was seen only in eosinophilic series. Peroxidase activity was observed in myeloblasts to segmented cells of granulocytic series and in monocytes. ${\alpha}$-naphthyl acetate esterase activity was found in monocytes and occassionally in lymphocytes. Naphthyl-AS-D-chloroacetate esterase marked neutrophilic series from myeloblasts to segmented cells. ${\beta}$-Glucuronidase activity was detected in a variety of cells except the cells of erythrocytic series. Periodic acid Schiff stain-positive granules were demonstrated in the neutrophilic and eosinophilic series from myelocytes to segmented cells and in monocytes and occassionally in lymphocytes. Sudan black B stain-positive granules marked granulocytic series from myeloblasts to segmented tells and monocytes.

• Journal of The Geomorphological Association of Korea
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• v.24 no.2
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• pp.15-25
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• 2017

Subi basin is located at the crestline of Taebaek mountains. This paper aims to elucidate the geomorphic development of Subi basin through the analysis of river terraces built in Wangpi-cheon and Banbyeon-cheon. Wangpi-cheon flows northeastward from Subi basin, and Banbyeon-cheon flows southward at the west of Subi basin. Absolute age of terrace is measured by means of OSL methodology, long profile of Wangpi-cheon is made up with 10m interval contour line, and the elevation above river bed of high terraces is measured at the end part of terrace. The results are as follow: Firstly, high river terraces of Subi basin, Wangpi-cheon and Banbyeon-cheon are formed about 40 kyr(MIS 3) being interstadial stage of last glacial period. Secondly, the elevation above river bed of high terraces of Wangpi-cheon and Banbyeon-cheon tends to increase toward upstream. It means that the uplift of Taebaek Mountains influences considerably the formation of their terraces. Thirdly, the elevation above river bed of high terraces at the reach from Seomchon to Suha-ri of Wangpi-cheon tends to decrease toward upstream. This section is captured from Banbyeon-cheon flowing in the opposite direction. River piracy has occurred from the time of formation of Suha-ri high terrace to the time of formation of Hantee wind gap. Finally, for fluvial system of Wangpi-cheon to establish dynamic equilibrium, topographic axis will move toward Banbyeon-cheon.